{"id":"https://openalex.org/W2790730158","doi":"https://doi.org/10.1186/s12918-018-0542-5","title":"Genome-scale model-driven strain design for dicarboxylic acid production in Yarrowia lipolytica","display_name":"Genome-scale model-driven strain design for dicarboxylic acid production in Yarrowia lipolytica","publication_year":2018,"publication_date":"2018-03-01","ids":{"openalex":"https://openalex.org/W2790730158","doi":"https://doi.org/10.1186/s12918-018-0542-5","mag":"2790730158","pmid":"https://pubmed.ncbi.nlm.nih.gov/29560822"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-018-0542-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0542-5","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-018-0542-5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-018-0542-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104275259","display_name":"Pranjul Mishra","orcid":null},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Pranjul Mishra","raw_affiliation_strings":["NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute, National University of Singapore, 28 Medical Drive, Singapore, 117456, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute, National University of Singapore, 28 Medical Drive, Singapore, 117456, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058007321","display_name":"Na\u2010Rae Lee","orcid":"https://orcid.org/0000-0002-1985-0692"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Na-Rae Lee","raw_affiliation_strings":["NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute, National University of Singapore, 28 Medical Drive, Singapore, 117456, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute, National University of Singapore, 28 Medical Drive, Singapore, 117456, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029580669","display_name":"Meiyappan Lakshmanan","orcid":"https://orcid.org/0000-0003-2356-3458"},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I4210137615","display_name":"Bioprocessing Technology Institute","ror":"https://ror.org/049fnxe71","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210137615"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Meiyappan Lakshmanan","raw_affiliation_strings":["Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, #06-01, Centros, Singapore, 138668, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, #06-01, Centros, Singapore, 138668, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210137615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100786199","display_name":"Minsuk Kim","orcid":"https://orcid.org/0000-0001-9958-0380"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Minsuk Kim","raw_affiliation_strings":["School of Chemical and Biological Engineering, Institute of Molecular Biology and Genetics, and Bioengineering Institute, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering, Institute of Molecular Biology and Genetics, and Bioengineering Institute, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052315121","display_name":"Byung\u2010Gee Kim","orcid":"https://orcid.org/0000-0002-3776-1001"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byung-Gee Kim","raw_affiliation_strings":["School of Chemical and Biological Engineering, Institute of Molecular Biology and Genetics, and Bioengineering Institute, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical and Biological Engineering, Institute of Molecular Biology and Genetics, and Bioengineering Institute, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 151-742, Republic of Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011206845","display_name":"Dong\u2010Yup Lee","orcid":"https://orcid.org/0000-0003-0901-708X"},"institutions":[{"id":"https://openalex.org/I115228651","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09","country_code":"SG","type":"government","lineage":["https://openalex.org/I115228651"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4210137615","display_name":"Bioprocessing Technology Institute","ror":"https://ror.org/049fnxe71","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210137615"]},{"id":"https://openalex.org/I848706","display_name":"Sungkyunkwan University","ror":"https://ror.org/04q78tk20","country_code":"KR","type":"education","lineage":["https://openalex.org/I848706"]}],"countries":["KR","SG"],"is_corresponding":true,"raw_author_name":"Dong-Yup Lee","raw_affiliation_strings":["Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, #06-01, Centros, Singapore, 138668, Singapore. dongyuplee@skku.edu","NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute, National University of Singapore, 28 Medical Drive, Singapore, 117456, Singapore. dongyuplee@skku.edu","School of Chemical Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea. dongyuplee@skku.edu","Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, #06-01, Centros, Singapore, 138668, Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, #06-01, Centros, Singapore, 138668, Singapore. dongyuplee@skku.edu","institution_ids":["https://openalex.org/I4210137615"]},{"raw_affiliation_string":"NUS Synthetic Biology for Clinical and Technological Innovation (SynCTI), Life Sciences Institute, National University of Singapore, 28 Medical Drive, Singapore, 117456, Singapore. dongyuplee@skku.edu","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"School of Chemical Engineering, Sungkyunkwan University, 2066 Seobu-ro, Jangan-gu, Suwon, Gyeonggi-do, 16419, Republic of Korea. dongyuplee@skku.edu","institution_ids":["https://openalex.org/I848706"]},{"raw_affiliation_string":"Bioprocessing Technology Institute, Agency for Science, Technology and Research (A*STAR), 20 Biopolis Way, #06-01, Centros, Singapore, 138668, Singapore","institution_ids":["https://openalex.org/I115228651","https://openalex.org/I4210137615"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5011206845"],"corresponding_institution_ids":["https://openalex.org/I115228651","https://openalex.org/I165932596","https://openalex.org/I4210137615","https://openalex.org/I848706"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":3.8726,"has_fulltext":true,"cited_by_count":91,"citation_normalized_percentile":{"value":0.94798355,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"12","issue":"S2","first_page":"12","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/yarrowia","display_name":"Yarrowia","score":0.9898454546928406},{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"Metabolic engineering","score":0.8519677519798279},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.703640341758728},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.66180419921875},{"id":"https://openalex.org/keywords/synthetic-biology","display_name":"Synthetic biology","score":0.6615715026855469},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.589900016784668},{"id":"https://openalex.org/keywords/fatty-acid","display_name":"Fatty acid","score":0.5082008838653564},{"id":"https://openalex.org/keywords/gene-knockout","display_name":"Gene knockout","score":0.4866243302822113},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4477456212043762},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.4421154260635376},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.41388311982154846}],"concepts":[{"id":"https://openalex.org/C2779490540","wikidata":"https://www.wikidata.org/wiki/Q10723443","display_name":"Yarrowia","level":3,"score":0.9898454546928406},{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.8519677519798279},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.703640341758728},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.66180419921875},{"id":"https://openalex.org/C191908910","wikidata":"https://www.wikidata.org/wiki/Q862838","display_name":"Synthetic biology","level":2,"score":0.6615715026855469},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.589900016784668},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.5082008838653564},{"id":"https://openalex.org/C77957584","wikidata":"https://www.wikidata.org/wiki/Q1133550","display_name":"Gene knockout","level":3,"score":0.4866243302822113},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4477456212043762},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4421154260635376},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41388311982154846}],"mesh":[{"descriptor_ui":"D003998","descriptor_name":"Dicarboxylic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003998","descriptor_name":"Dicarboxylic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003998","descriptor_name":"Dicarboxylic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025062","descriptor_name":"Yarrowia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025062","descriptor_name":"Yarrowia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025062","descriptor_name":"Yarrowia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025062","descriptor_name":"Yarrowia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025062","descriptor_name":"Yarrowia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025062","descriptor_name":"Yarrowia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060847","descriptor_name":"Metabolic Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1186/s12918-018-0542-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0542-5","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-018-0542-5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5861505","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5861505","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmid:29560822","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29560822","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":"Journal Article"},{"id":"pmh:oai:scholarbank.nus.edu.sg:10635/174548","is_oa":false,"landing_page_url":"https://scholarbank.nus.edu.sg/handle/10635/174548","pdf_url":null,"source":{"id":"https://openalex.org/S7407052290","display_name":"National University of Singapore","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Unpaywall 20200831","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:9be8559c96aa46c99720d17f52c2dfe3","is_oa":false,"landing_page_url":"https://doaj.org/article/9be8559c96aa46c99720d17f52c2dfe3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 12, Iss S2, Pp 9-20 (2018)","raw_type":"article"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/139758","is_oa":false,"landing_page_url":"http://hdl.handle.net/10371/139758","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/s12918-018-0542-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-018-0542-5","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-018-0542-5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4399999976158142,"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9"}],"awards":[{"id":"https://openalex.org/G120650557","display_name":null,"funder_award_id":"N011500017","funder_id":"https://openalex.org/F4320321681","funder_display_name":"Ministry of Trade, Industry and Energy"},{"id":"https://openalex.org/G1838270891","display_name":null,"funder_award_id":"R-279-000-476-112","funder_id":"https://openalex.org/F4320320698","funder_display_name":"National University of Singapore"},{"id":"https://openalex.org/G5315821802","display_name":null,"funder_award_id":"PJ01334605","funder_id":"https://openalex.org/F4320322035","funder_display_name":"Rural Development Administration"}],"funders":[{"id":"https://openalex.org/F4320320696","display_name":"Agency for Science, Technology and Research","ror":"https://ror.org/036wvzt09"},{"id":"https://openalex.org/F4320320698","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49"},{"id":"https://openalex.org/F4320321681","display_name":"Ministry of Trade, Industry and Energy","ror":"https://ror.org/008nkqk13"},{"id":"https://openalex.org/F4320322035","display_name":"Rural Development Administration","ror":"https://ror.org/03xs9yg50"},{"id":"https://openalex.org/F4320322110","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07"},{"id":"https://openalex.org/F4320335846","display_name":"Biomedical Research Council","ror":"https://ror.org/03xy0wx88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2790730158.pdf","grobid_xml":"https://content.openalex.org/works/W2790730158.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1220320927","https://openalex.org/W1565883763","https://openalex.org/W1821513802","https://openalex.org/W1967084983","https://openalex.org/W1968589180","https://openalex.org/W1970351449","https://openalex.org/W1976247849","https://openalex.org/W1984096521","https://openalex.org/W1988694126","https://openalex.org/W1992844569","https://openalex.org/W1996355791","https://openalex.org/W2003029675","https://openalex.org/W2003686438","https://openalex.org/W2007996759","https://openalex.org/W2009163705","https://openalex.org/W2012746361","https://openalex.org/W2018915837","https://openalex.org/W2040716173","https://openalex.org/W2043028577","https://openalex.org/W2048214825","https://openalex.org/W2056305771","https://openalex.org/W2057945124","https://openalex.org/W2059004353","https://openalex.org/W2062819025","https://openalex.org/W2067317565","https://openalex.org/W2073837631","https://openalex.org/W2076830784","https://openalex.org/W2078355959","https://openalex.org/W2081623272","https://openalex.org/W2085909480","https://openalex.org/W2086592553","https://openalex.org/W2093063735","https://openalex.org/W2093941784","https://openalex.org/W2096202610","https://openalex.org/W2098824895","https://openalex.org/W2101127697","https://openalex.org/W2106576546","https://openalex.org/W2108210068","https://openalex.org/W2114417330","https://openalex.org/W2116875566","https://openalex.org/W2120924807","https://openalex.org/W2128089862","https://openalex.org/W2130588190","https://openalex.org/W2135081566","https://openalex.org/W2140874470","https://openalex.org/W2147472054","https://openalex.org/W2152428375","https://openalex.org/W2154797402","https://openalex.org/W2158721838","https://openalex.org/W2159408188","https://openalex.org/W2164733077","https://openalex.org/W2170487377","https://openalex.org/W2170568766","https://openalex.org/W2178907415","https://openalex.org/W2205785247","https://openalex.org/W2213256540","https://openalex.org/W2312868359","https://openalex.org/W2324359686","https://openalex.org/W2333535089"],"related_works":["https://openalex.org/W2884144545","https://openalex.org/W2560066302","https://openalex.org/W1152640001","https://openalex.org/W2896192124","https://openalex.org/W2790730158","https://openalex.org/W2126646394","https://openalex.org/W4224924643","https://openalex.org/W3047447888","https://openalex.org/W2053717739","https://openalex.org/W2801379887"],"abstract_inverted_index":{"BACKGROUND:":[0],"Recently,":[1],"there":[2],"have":[3],"been":[4],"several":[5,128,240],"attempts":[6],"to":[7,25,32,43,115,138,182,194,238,265],"produce":[8],"long-chain":[9,146],"dicarboxylic":[10],"acids":[11,205],"(DCAs)":[12],"in":[13,76,129,168,226,247],"various":[14],"microbial":[15],"hosts.":[16],"Of":[17],"these,":[18],"Yarrowia":[19],"lipolytica":[20,38,90],"has":[21],"great":[22],"potential":[23],"due":[24],"its":[26,58],"oleaginous":[27,267],"characteristics":[28],"and":[29,54,123,159,163,189],"unique":[30],"ability":[31],"utilize":[33],"hydrophobic":[34],"substrates.":[35],"However,":[36],"Y.":[37,77,89,227,251],"should":[39],"be":[40],"further":[41,197],"engineered":[42],"make":[44],"it":[45],"more":[46],"competitive:":[47],"the":[48,80,95,99,143,183,199,207,254],"current":[49,255],"approaches":[50],"are":[51],"mostly":[52],"intuitive":[53],"cumbersome,":[55],"thus":[56],"limiting":[57],"industrial":[59],"application.":[60],"RESULTS:":[61],"In":[62,230],"this":[63],"study,":[64],"we":[65,82],"proposed":[66],"model-guided":[67],"metabolic":[68,85,241],"engineering":[69,118,242],"strategies":[70,235],"for":[71,120,177,215,222,244,269],"enhanced":[72],"production":[73,141,223],"of":[74,88,106,142,171,201,224],"DCAs":[75,246],"lipolytica.":[78,228,252],"At":[79],"outset,":[81],"reconstructed":[83],"genome-scale":[84],"model":[86,100],"(GSMM)":[87],"(iYLI647)":[91],"by":[92,126,187],"substantially":[93],"expanding":[94],"previous":[96],"models.":[97],"Subsequently,":[98],"was":[101,112],"validated":[102],"using":[103],"three":[104],"sets":[105],"published":[107],"culture":[108],"experiment":[109],"data.":[110],"It":[111],"finally":[113],"exploited":[114],"identify":[116,239],"genetic":[117],"targets":[119,154,243],"overexpression,":[121],"knockout,":[122],"cofactor":[124],"modification":[125],"applying":[127],"silico":[130,169,231],"strain":[131,233],"design":[132,234],"methods,":[133],"which":[134,172,211],"potentially":[135],"give":[136],"rise":[137],"high":[139],"yield":[140],"industrially":[144],"relevant":[145],"DCAs,":[147],"e.g.,":[148],"dodecanedioic":[149],"acid":[150,179,217],"(DDDA).":[151],"The":[152],"resultant":[153],"include":[155],"(1)":[156],"malate":[157],"dehydrogenase":[158,166],"malic":[160],"enzyme":[161],"genes":[162],"(2)":[164],"glutamate":[165],"gene,":[167],"overexpression":[170],"generated":[173],"additional":[174],"NADPH":[175],"required":[176],"fatty":[178,216],"synthesis,":[180,218],"leading":[181],"increased":[184],"DDDA":[185,225],"fluxes":[186],"48%":[188],"22%":[190],"higher,":[191],"respectively,":[192],"compared":[193],"wild-type.":[195],"We":[196],"investigated":[198],"effect":[200],"supplying":[202],"branched-chain":[203],"amino":[204],"on":[206],"acetyl-CoA":[208],"turn-over":[209],"rate":[210],"is":[212,263],"key":[213],"metabolite":[214],"suggesting":[219],"their":[220],"significance":[221],"CONCLUSION:":[229],"model-based":[232],"allowed":[236],"us":[237],"overproducing":[245],"lipid":[248],"accumulating":[249],"yeast,":[250],"Thus,":[253],"study":[256],"can":[257],"provide":[258],"a":[259],"methodological":[260],"framework":[261],"that":[262],"applicable":[264],"other":[266],"yeasts":[268],"value-added":[270],"biochemical":[271],"production.":[272]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3}],"updated_date":"2026-08-26T07:47:46.906454","created_date":"2025-10-10T00:00:00"}
