{"id":"https://openalex.org/W2764262557","doi":"https://doi.org/10.1186/s12918-017-0472-7","title":"A novel interaction perturbation analysis reveals a comprehensive regulatory principle underlying various biochemical oscillators","display_name":"A novel interaction perturbation analysis reveals a comprehensive regulatory principle underlying various biochemical oscillators","publication_year":2017,"publication_date":"2017-10-10","ids":{"openalex":"https://openalex.org/W2764262557","doi":"https://doi.org/10.1186/s12918-017-0472-7","mag":"2764262557","pmid":"https://pubmed.ncbi.nlm.nih.gov/29017496"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-017-0472-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0472-7","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0472-7","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0472-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023305578","display_name":"Jun Hyuk Kang","orcid":"https://orcid.org/0000-0001-8616-4433"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jun Hyuk Kang","raw_affiliation_strings":["Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea","Laboratory for Systems Biology and Bio-inspired Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea","Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea","Laboratory for Systems Biology and Bio-inspired Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"Laboratory for Systems Biology and Bio-inspired Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"Laboratory for Systems Biology and Bio-inspired Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034286632","display_name":"Kwang\u2010Hyun Cho","orcid":"https://orcid.org/0000-0002-7380-7142"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Kwang-Hyun Cho","raw_affiliation_strings":["Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea. ckh@kaist.ac.kr","Laboratory for Systems Biology and Bio-inspired Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea. ckh@kaist.ac.kr","Laboratory for Systems Biology and Bio-inspired Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea","Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea. ckh@kaist.ac.kr","institution_ids":[]},{"raw_affiliation_string":"Laboratory for Systems Biology and Bio-inspired Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea. ckh@kaist.ac.kr","institution_ids":[]},{"raw_affiliation_string":"Laboratory for Systems Biology and Bio-inspired Engineering, Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]},{"raw_affiliation_string":"Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034286632"],"corresponding_institution_ids":["https://openalex.org/I157485424"],"apc_list":null,"apc_paid":null,"fwci":0.6719,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.69581647,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"11","issue":"1","first_page":"95","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.4731999933719635,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.4731999933719635,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11187","display_name":"Nonlinear Dynamics and Pattern Formation","score":0.30239999294281006,"subfield":{"id":"https://openalex.org/subfields/1705","display_name":"Computer Networks and Communications"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.01209999993443489,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oscillation","display_name":"Oscillation (cell signaling)","score":0.5980967283248901},{"id":"https://openalex.org/keywords/perturbation","display_name":"Perturbation (astronomy)","score":0.5581049919128418},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.5377746820449829},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.5228893160820007},{"id":"https://openalex.org/keywords/negative-feedback","display_name":"Negative feedback","score":0.5098108649253845},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.503741443157196},{"id":"https://openalex.org/keywords/amplitude","display_name":"Amplitude","score":0.4814395308494568},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.47745516896247864},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45008060336112976},{"id":"https://openalex.org/keywords/network-analysis","display_name":"Network analysis","score":0.439212441444397},{"id":"https://openalex.org/keywords/network-structure","display_name":"Network structure","score":0.42326828837394714},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.4217239320278168},{"id":"https://openalex.org/keywords/control-theory","display_name":"Control theory (sociology)","score":0.34278637170791626},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3366231918334961},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.2117970585823059},{"id":"https://openalex.org/keywords/quantum-mechanics","display_name":"Quantum mechanics","score":0.12931254506111145},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.10402160882949829},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.10101103782653809},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.09531286358833313},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.0865810215473175}],"concepts":[{"id":"https://openalex.org/C2778439541","wikidata":"https://www.wikidata.org/wiki/Q7106412","display_name":"Oscillation (cell signaling)","level":2,"score":0.5980967283248901},{"id":"https://openalex.org/C177918212","wikidata":"https://www.wikidata.org/wiki/Q803623","display_name":"Perturbation (astronomy)","level":2,"score":0.5581049919128418},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.5377746820449829},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.5228893160820007},{"id":"https://openalex.org/C93586867","wikidata":"https://www.wikidata.org/wiki/Q62527","display_name":"Negative feedback","level":3,"score":0.5098108649253845},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.503741443157196},{"id":"https://openalex.org/C180205008","wikidata":"https://www.wikidata.org/wiki/Q159190","display_name":"Amplitude","level":2,"score":0.4814395308494568},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.47745516896247864},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45008060336112976},{"id":"https://openalex.org/C32946077","wikidata":"https://www.wikidata.org/wiki/Q618079","display_name":"Network analysis","level":2,"score":0.439212441444397},{"id":"https://openalex.org/C2988224531","wikidata":"https://www.wikidata.org/wiki/Q20830730","display_name":"Network structure","level":2,"score":0.42326828837394714},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4217239320278168},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.34278637170791626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3366231918334961},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2117970585823059},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.12931254506111145},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.10402160882949829},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.10101103782653809},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.09531286358833313},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0865810215473175},{"id":"https://openalex.org/C165801399","wikidata":"https://www.wikidata.org/wiki/Q25428","display_name":"Voltage","level":2,"score":0.0},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001683","descriptor_name":"Biological Clocks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001683","descriptor_name":"Biological Clocks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001683","descriptor_name":"Biological Clocks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/s12918-017-0472-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0472-7","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0472-7","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:29017496","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29017496","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:5635494","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5635494","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-017-0472-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0472-7","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0472-7","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1668654878","display_name":null,"funder_award_id":"2013M3A9A7046303","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G3312091024","display_name":null,"funder_award_id":"2017R1A2A1A17069642","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G4802185506","display_name":null,"funder_award_id":"2017R1A2A1A17069642, 2015M3A9A7067220, and 2013M3A9A7046303","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G5230596173","display_name":null,"funder_award_id":"2015M3A9A7067220","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"},{"id":"https://openalex.org/F4320324161","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2764262557.pdf","grobid_xml":"https://content.openalex.org/works/W2764262557.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1645305843","https://openalex.org/W1938657618","https://openalex.org/W1969154599","https://openalex.org/W1979385177","https://openalex.org/W1979842236","https://openalex.org/W1985940938","https://openalex.org/W1991163038","https://openalex.org/W2003302378","https://openalex.org/W2015341151","https://openalex.org/W2030945597","https://openalex.org/W2047941733","https://openalex.org/W2051497876","https://openalex.org/W2063346607","https://openalex.org/W2065258621","https://openalex.org/W2067373714","https://openalex.org/W2070646804","https://openalex.org/W2077023123","https://openalex.org/W2081696580","https://openalex.org/W2088907143","https://openalex.org/W2089068724","https://openalex.org/W2089791419","https://openalex.org/W2092462789","https://openalex.org/W2103495696","https://openalex.org/W2106469366","https://openalex.org/W2108957075","https://openalex.org/W2118809524","https://openalex.org/W2124354910","https://openalex.org/W2131448225","https://openalex.org/W2131970968","https://openalex.org/W2135535700","https://openalex.org/W2136120517","https://openalex.org/W2139884531","https://openalex.org/W2142362541","https://openalex.org/W2146750548","https://openalex.org/W2150114634","https://openalex.org/W2164925597","https://openalex.org/W2175518322","https://openalex.org/W2315425187","https://openalex.org/W2320571739","https://openalex.org/W2325598556","https://openalex.org/W2411025585","https://openalex.org/W2437649955","https://openalex.org/W2562432607","https://openalex.org/W2562569288","https://openalex.org/W4233339098","https://openalex.org/W4236335910","https://openalex.org/W4244306953","https://openalex.org/W6808451983","https://openalex.org/W7067524398"],"related_works":["https://openalex.org/W2365690972","https://openalex.org/W2158714033","https://openalex.org/W1809444432","https://openalex.org/W2327627360","https://openalex.org/W2130939068","https://openalex.org/W3211329625","https://openalex.org/W2047987500","https://openalex.org/W2075143087","https://openalex.org/W2007069252","https://openalex.org/W2093094794"],"abstract_inverted_index":{"BACKGROUND:":[0],"Biochemical":[1],"oscillations":[2,21],"play":[3],"an":[4,51],"important":[5],"role":[6],"in":[7,13,38,65,140,150,160,200,220],"maintaining":[8],"physiological":[9],"and":[10,18,53,90,135,205],"cellular":[11],"homeostasis":[12],"biological":[14],"systems.":[15],"The":[16,114],"frequency":[17,134,146,204],"amplitude":[19,136,156],"of":[20,41,50,84,87,107,111,116,129,170,217],"are":[22],"regulated":[23],"to":[24,27,104,125,181,211],"properly":[25],"adapt":[26],"environments":[28],"by":[29],"numerous":[30],"interactions":[31],"within":[32],"biomolecular":[33],"networks.":[34],"Despite":[35],"the":[36,44,47,85,95,105,126,130,161,202,213],"advances":[37],"our":[39],"understanding":[40],"biochemical":[42,172,221],"oscillators,":[43],"relationship":[45,64],"between":[46],"network":[48,127,183,194,218],"structure":[49,128],"oscillator":[52,173],"its":[54,92],"regulatory":[55,96,122,178,198,215],"function":[56],"still":[57],"remains":[58],"unclear.":[59],"To":[60],"investigate":[61],"such":[62,176],"a":[63,66,72,189],"systematic":[67],"way,":[68],"we":[69],"have":[70,99,196],"developed":[71],"novel":[73],"analysis":[74,79,106,119,169],"method":[75,103],"called":[76],"interaction":[77,89,117],"perturbation":[78,118],"that":[80,192],"enables":[81],"direct":[82],"modulation":[83],"strength":[86],"every":[88],"evaluates":[91],"consequence":[93],"on":[94],"function.":[97],"We":[98],"applied":[100],"this":[101],"new":[102],"three":[108],"representative":[109],"types":[110],"oscillators.":[112,166],"RESULTS:":[113],"results":[115,187],"showed":[120],"different":[121,177,193,197],"features":[123,179,199],"according":[124,180],"oscillator:":[131],"(1)":[132],"both":[133],"were":[137],"seldom":[138],"modulated":[139,159],"simple":[141],"negative":[142,152,164],"feedback":[143,153,165],"oscillators;":[144,154],"(2)":[145],"could":[147,157],"be":[148,158],"tuned":[149],"amplified":[151,163],"(3)":[155],"incoherently":[162],"A":[167],"further":[168],"naturally-occurring":[171],"models":[174],"supported":[175],"their":[182],"structures.":[184],"CONCLUSIONS:":[185],"Our":[186,207],"provide":[188],"clear":[190],"evidence":[191],"structures":[195,219],"modulating":[201],"oscillation":[203],"amplitude.":[206],"findings":[208],"may":[209],"help":[210],"elucidate":[212],"fundamental":[214],"roles":[216],"oscillations.":[222]},"counts_by_year":[{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}
