{"id":"https://openalex.org/W2761748232","doi":"https://doi.org/10.1186/s12918-017-0470-9","title":"Paracrine and autocrine regulation of gene expression by Wnt-inhibitor Dickkopf in wild-type and mutant hepatocytes","display_name":"Paracrine and autocrine regulation of gene expression by Wnt-inhibitor Dickkopf in wild-type and mutant hepatocytes","publication_year":2017,"publication_date":"2017-10-13","ids":{"openalex":"https://openalex.org/W2761748232","doi":"https://doi.org/10.1186/s12918-017-0470-9","mag":"2761748232","pmid":"https://pubmed.ncbi.nlm.nih.gov/29029622"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-017-0470-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0470-9","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0470-9","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0470-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079013658","display_name":"Niklas Hartung","orcid":"https://orcid.org/0000-0002-4000-6525"},"institutions":[{"id":"https://openalex.org/I176453806","display_name":"University of Potsdam","ror":"https://ror.org/03bnmw459","country_code":"DE","type":"education","lineage":["https://openalex.org/I176453806"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Niklas Hartung","raw_affiliation_strings":["University of Potsdam, Institute of Mathematics, Karl-Liebknecht-Str. 24, Potsdam, 14476, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Potsdam, Institute of Mathematics, Karl-Liebknecht-Str. 24, Potsdam, 14476, Germany","institution_ids":["https://openalex.org/I176453806"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054989157","display_name":"Uwe Benary","orcid":"https://orcid.org/0000-0001-7801-8639"},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Uwe Benary","raw_affiliation_strings":["Mathematical Modelling of Cellular Processes, Max Delbrueck Center for Molecular Medicine, Robert-Roessle-Str. 10, Berlin, 13125, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mathematical Modelling of Cellular Processes, Max Delbrueck Center for Molecular Medicine, Robert-Roessle-Str. 10, Berlin, 13125, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011931952","display_name":"Jana Wolf","orcid":"https://orcid.org/0000-0003-3254-5868"},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jana Wolf","raw_affiliation_strings":["Mathematical Modelling of Cellular Processes, Max Delbrueck Center for Molecular Medicine, Robert-Roessle-Str. 10, Berlin, 13125, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mathematical Modelling of Cellular Processes, Max Delbrueck Center for Molecular Medicine, Robert-Roessle-Str. 10, Berlin, 13125, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090121202","display_name":"Bente Kofahl","orcid":null},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Bente Kofahl","raw_affiliation_strings":["Current address: Institute of Physics, University of Freiburg, Hermann-Herder-Str. 3, Freiburg i. Br., 79104, Germany. bente.kofahl@mdc-berlin.de","Mathematical Modelling of Cellular Processes, Max Delbrueck Center for Molecular Medicine, Robert-Roessle-Str. 10, Berlin, 13125, Germany. bente.kofahl@mdc-berlin.de","Current address: Institute of Physics, University of Freiburg, Hermann-Herder-Str. 3, Freiburg i. Br., 79104, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Current address: Institute of Physics, University of Freiburg, Hermann-Herder-Str. 3, Freiburg i. Br., 79104, Germany. bente.kofahl@mdc-berlin.de","institution_ids":[]},{"raw_affiliation_string":"Mathematical Modelling of Cellular Processes, Max Delbrueck Center for Molecular Medicine, Robert-Roessle-Str. 10, Berlin, 13125, Germany. bente.kofahl@mdc-berlin.de","institution_ids":[]},{"raw_affiliation_string":"Current address: Institute of Physics, University of Freiburg, Hermann-Herder-Str. 3, Freiburg i. Br., 79104, Germany","institution_ids":["https://openalex.org/I161046081"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5079013658"],"corresponding_institution_ids":["https://openalex.org/I176453806"],"apc_list":null,"apc_paid":null,"fwci":0.224,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.570452,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"11","issue":"1","first_page":"98","last_page":"98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.4203000068664551,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.4203000068664551,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.40220001339912415,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13223","display_name":"Connective Tissue Growth Factor Research","score":0.033799998462200165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autocrine-signalling","display_name":"Autocrine signalling","score":0.9637224674224854},{"id":"https://openalex.org/keywords/paracrine-signalling","display_name":"Paracrine signalling","score":0.9327126741409302},{"id":"https://openalex.org/keywords/wnt-signaling-pathway","display_name":"Wnt signaling pathway","score":0.8478066921234131},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.7265862822532654},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6223665475845337},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.5613784790039062},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"Beta-catenin","score":0.5357972979545593},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.2954740524291992},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.21217304468154907},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.18892982602119446},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.154789537191391}],"concepts":[{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.9637224674224854},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.9327126741409302},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.8478066921234131},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7265862822532654},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6223665475845337},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5613784790039062},{"id":"https://openalex.org/C2779324961","wikidata":"https://www.wikidata.org/wiki/Q1634046","display_name":"Beta-catenin","level":4,"score":0.5357972979545593},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2954740524291992},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21217304468154907},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18892982602119446},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.154789537191391}],"mesh":[{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019898","descriptor_name":"Autocrine Communication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019898","descriptor_name":"Autocrine Communication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019898","descriptor_name":"Autocrine Communication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019899","descriptor_name":"Paracrine Communication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019899","descriptor_name":"Paracrine Communication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019899","descriptor_name":"Paracrine Communication","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/s12918-017-0470-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0470-9","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0470-9","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:29029622","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29029622","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:edoc.mdc-berlin.de:16849","is_oa":false,"landing_page_url":"http://edoc.mdc-berlin.de/16849/2/16849suppl.zip","pdf_url":null,"source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:kobv.de-opus4-uni-potsdam:43077","is_oa":true,"landing_page_url":"https://nbn-resolving.org/urn:nbn:de:kobv:517-opus4-430778","pdf_url":null,"source":{"id":"https://openalex.org/S4306400594","display_name":"publish.UP (University of Potsdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I176453806","host_organization_name":"University of Potsdam","host_organization_lineage":["https://openalex.org/I176453806"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doc-type:article"},{"id":"pmh:oai:kobv.de-opus4-uni-potsdam:46263","is_oa":false,"landing_page_url":"https://publishup.uni-potsdam.de/opus4-ubp/frontdoor/index/index/docId/46263","pdf_url":null,"source":{"id":"https://openalex.org/S4306400594","display_name":"publish.UP (University of Potsdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I176453806","host_organization_name":"University of Potsdam","host_organization_lineage":["https://openalex.org/I176453806"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doc-type:article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5640931","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5640931","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"doi:10.25932/publishup-43077","is_oa":true,"landing_page_url":"https://doi.org/10.25932/publishup-43077","pdf_url":null,"source":{"id":"https://openalex.org/S7407053006","display_name":"Universit\u00e4t Potsdam","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/s12918-017-0470-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0470-9","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0470-9","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320876","display_name":"Helmholtz-Gemeinschaft","ror":"https://ror.org/0281dp749"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2761748232.pdf","grobid_xml":"https://content.openalex.org/works/W2761748232.grobid-xml"},"referenced_works_count":101,"referenced_works":["https://openalex.org/W107868517","https://openalex.org/W141799699","https://openalex.org/W1480035004","https://openalex.org/W1480692184","https://openalex.org/W1508475810","https://openalex.org/W1528266361","https://openalex.org/W1557541313","https://openalex.org/W1589352523","https://openalex.org/W1600236901","https://openalex.org/W1628437161","https://openalex.org/W1956262850","https://openalex.org/W1966824782","https://openalex.org/W1967073403","https://openalex.org/W1968877074","https://openalex.org/W1971196026","https://openalex.org/W1973493635","https://openalex.org/W1974549459","https://openalex.org/W1975866042","https://openalex.org/W1980661496","https://openalex.org/W1981587357","https://openalex.org/W1989011685","https://openalex.org/W1990351024","https://openalex.org/W1990563353","https://openalex.org/W1992127683","https://openalex.org/W1995158897","https://openalex.org/W1996984755","https://openalex.org/W1997208865","https://openalex.org/W1998817605","https://openalex.org/W2006006356","https://openalex.org/W2012986637","https://openalex.org/W2013891209","https://openalex.org/W2017083140","https://openalex.org/W2018458363","https://openalex.org/W2019574453","https://openalex.org/W2023407460","https://openalex.org/W2029307548","https://openalex.org/W2031402631","https://openalex.org/W2037486322","https://openalex.org/W2038927157","https://openalex.org/W2044502190","https://openalex.org/W2046970439","https://openalex.org/W2053300466","https://openalex.org/W2053352622","https://openalex.org/W2055808176","https://openalex.org/W2057199920","https://openalex.org/W2060200034","https://openalex.org/W2061717797","https://openalex.org/W2064027874","https://openalex.org/W2065191902","https://openalex.org/W2068127752","https://openalex.org/W2073969798","https://openalex.org/W2079819294","https://openalex.org/W2080231780","https://openalex.org/W2086320165","https://openalex.org/W2086454839","https://openalex.org/W2091643574","https://openalex.org/W2095540411","https://openalex.org/W2096171021","https://openalex.org/W2097090938","https://openalex.org/W2101407881","https://openalex.org/W2101531288","https://openalex.org/W2104774845","https://openalex.org/W2106362845","https://openalex.org/W2107648723","https://openalex.org/W2111113377","https://openalex.org/W2116315632","https://openalex.org/W2118230770","https://openalex.org/W2118231569","https://openalex.org/W2125418297","https://openalex.org/W2125595479","https://openalex.org/W2128551987","https://openalex.org/W2129391320","https://openalex.org/W2131448225","https://openalex.org/W2131853843","https://openalex.org/W2134835282","https://openalex.org/W2135914580","https://openalex.org/W2137825406","https://openalex.org/W2140094325","https://openalex.org/W2146750548","https://openalex.org/W2148074532","https://openalex.org/W2148305615","https://openalex.org/W2150107698","https://openalex.org/W2154765411","https://openalex.org/W2155933095","https://openalex.org/W2163740253","https://openalex.org/W2167627426","https://openalex.org/W2170619426","https://openalex.org/W2171913567","https://openalex.org/W2171996338","https://openalex.org/W2173366817","https://openalex.org/W2181392322","https://openalex.org/W2317767119","https://openalex.org/W2483281380","https://openalex.org/W2512618608","https://openalex.org/W2575236525","https://openalex.org/W2586451459","https://openalex.org/W2911747611","https://openalex.org/W2963199678","https://openalex.org/W4235971270","https://openalex.org/W4238726034","https://openalex.org/W7073790523"],"related_works":["https://openalex.org/W2091727603","https://openalex.org/W3004047898","https://openalex.org/W2015867957","https://openalex.org/W2085869617","https://openalex.org/W2367035282","https://openalex.org/W1996832816","https://openalex.org/W1963652002","https://openalex.org/W1969354036","https://openalex.org/W3048253040","https://openalex.org/W2105493299"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cells":[1],"are":[2],"able":[3],"to":[4,193,275],"communicate":[5],"and":[6,54,76,106,115,127,138,191,219,253,259,267],"coordinate":[7],"their":[8,278],"function":[9],"within":[10],"tissues":[11,30],"via":[12,136],"secreted":[13],"factors.":[14],"Aberrant":[15],"secretion":[16],"by":[17,83],"cancer":[18],"cells":[19,162],"can":[20],"modulate":[21],"this":[22,146],"intercellular":[23],"communication,":[24],"in":[25,27,51,91,157,189,195,231,251],"particular":[26],"highly":[28],"organised":[29],"such":[31,213,262],"as":[32,88,90,154,214,263],"the":[33,36,41,60,74,92,102,116,142,177,200,210,232,239],"liver.":[34,158],"Hepatocytes,":[35],"major":[37],"cell":[38,169,179],"type":[39],"of":[40,62,79,94,104,118,160,176,183,209,234,241,257],"liver,":[42],"secrete":[43],"Dickkopf":[44],"(Dkk),":[45],"which":[46],"inhibits":[47],"Wnt/":[48,63,112,268],"\u03b2-catenin":[49,64,113,269],"signalling":[50],"an":[52,148],"autocrine":[53,75],"paracrine":[55,77,128],"manner.":[56],"Consequently,":[57],"Dkk":[58,84,105,137,139,172,227,244,264],"modulates":[59],"expression":[61,82,121,182],"target":[65,119],"genes.":[66],"We":[67],"present":[68],"a":[69,133,166,206,235],"mathematical":[70],"model":[71,100,211],"that":[72,164,226],"describes":[73,101],"regulation":[78,117,129],"hepatic":[80],"gene":[81,120,181,279],"under":[85],"wild-type":[86,185,247,273],"conditions":[87],"well":[89],"presence":[93,233],"mutant":[95,161,168,178,236],"cells.":[96],"RESULTS:":[97],"Our":[98,223],"spatial":[99],"competition":[103],"Wnt":[107],"at":[108],"receptor":[109],"level,":[110],"intra-cellular":[111],"signalling,":[114],"for":[122],"21":[123],"individual":[124],"hepatocytes.":[125],"Autocrine":[126],"is":[130,152,187,229,249],"mediated":[131],"through":[132],"feedback":[134,220],"mechanism":[135],"diffusion":[140,215,266],"along":[141],"porto-central":[143],"axis.":[144],"Along":[145],"axis":[147],"APC":[149],"concentration":[150,228],"gradient":[151],"modelled":[153],"experimentally":[155],"detected":[156],"Simulations":[159],"demonstrate":[163],"already":[165],"single":[167],"increases":[170],"overall":[171],"concentration.":[173],"The":[174,255],"influence":[175],"on":[180,246],"surrounding":[184],"hepatocytes":[186,194,248,274],"limited":[188],"magnitude":[190],"restricted":[192],"close":[196],"proximity.":[197],"To":[198],"explore":[199],"underlying":[201],"molecular":[202],"mechanisms,":[203],"we":[204],"perform":[205],"comprehensive":[207],"analysis":[208],"parameters":[212],"coefficient,":[216],"mutation":[217],"strength":[218],"strength.":[221],"CONCLUSIONS:":[222],"simulations":[224],"show":[225],"elevated":[230,243],"cell.":[237],"However,":[238],"impact":[240],"these":[242],"levels":[245],"confined":[250],"space":[252],"magnitude.":[254],"combination":[256],"inter-":[258],"intracellular":[260],"processes,":[261],"feedback,":[265],"signal":[270],"transduction,":[271],"allow":[272],"largely":[276],"maintain":[277],"expression.":[280]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}