{"id":"https://openalex.org/W2745347371","doi":"https://doi.org/10.1186/s12918-017-0469-2","title":"An Integrative multi-lineage model of variation in leukopoiesis and acute myelogenous leukemia","display_name":"An Integrative multi-lineage model of variation in leukopoiesis and acute myelogenous leukemia","publication_year":2017,"publication_date":"2017-08-25","ids":{"openalex":"https://openalex.org/W2745347371","doi":"https://doi.org/10.1186/s12918-017-0469-2","mag":"2745347371","pmid":"https://pubmed.ncbi.nlm.nih.gov/28841879"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-017-0469-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0469-2","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-017-0469-2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-017-0469-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089640499","display_name":"Joyatee M. Sarker","orcid":null},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joyatee M. Sarker","raw_affiliation_strings":["Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, 47906, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, 47906, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034726175","display_name":"Serena M. Pearce","orcid":null},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Serena M. Pearce","raw_affiliation_strings":["Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, 47906, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, 47906, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108440993","display_name":"Robert P. Nelson","orcid":null},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert P. Nelson","raw_affiliation_strings":["Department of Medicine and Pediatrics, Divisions of Hematology/Oncology, Indiana University School of Medicine, 535 Barnhill Dr., Ste. 473, Indianapolis, 46202, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Pediatrics, Divisions of Hematology/Oncology, Indiana University School of Medicine, 535 Barnhill Dr., Ste. 473, Indianapolis, 46202, IN, USA","institution_ids":["https://openalex.org/I55769427","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055742599","display_name":"Tamara L. Kinzer\u2010Ursem","orcid":"https://orcid.org/0000-0001-7343-115X"},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tamara L. Kinzer-Ursem","raw_affiliation_strings":["Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, 47906, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, 47906, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113809368","display_name":"David M. Umulis","orcid":null},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David M. Umulis","raw_affiliation_strings":["Ag. and Biological Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, 47906, IN, USA. dumulis@purdue.edu","Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, 47906, IN, USA. dumulis@purdue.edu","Ag. and Biological Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, 47906, IN, USA"],"raw_orcid":"https://orcid.org/0000-0001-7343-115X","affiliations":[{"raw_affiliation_string":"Ag. and Biological Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, 47906, IN, USA. dumulis@purdue.edu","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, 47906, IN, USA. dumulis@purdue.edu","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Ag. and Biological Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, 47906, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048545593","display_name":"Ann E. Rundell","orcid":null},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann E. Rundell","raw_affiliation_strings":["Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, 47906, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weldon School of Biomedical Engineering, Purdue University, 206 S. Martin Jischke Drive, West Lafayette, 47906, IN, USA","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5113809368"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":null,"apc_paid":null,"fwci":0.711,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.72695574,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"11","issue":"1","first_page":"78","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.8317999839782715,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.8317999839782715,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.033900000154972076,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.025699999183416367,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/haematopoiesis","display_name":"Haematopoiesis","score":0.754837691783905},{"id":"https://openalex.org/keywords/progenitor-cell","display_name":"Progenitor cell","score":0.5624039173126221},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5433261394500732},{"id":"https://openalex.org/keywords/leukemia","display_name":"Leukemia","score":0.5221909880638123},{"id":"https://openalex.org/keywords/mitosis","display_name":"Mitosis","score":0.5173249244689941},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4653506875038147},{"id":"https://openalex.org/keywords/lineage","display_name":"Lineage (genetic)","score":0.4578697681427002},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.41057902574539185},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.37842857837677},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.3623572885990143},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3258736729621887},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2594491243362427},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15480726957321167}],"concepts":[{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.754837691783905},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5624039173126221},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5433261394500732},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5221909880638123},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.5173249244689941},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4653506875038147},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.4578697681427002},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.41057902574539185},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37842857837677},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3623572885990143},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3258736729621887},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2594491243362427},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15480726957321167},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019891","descriptor_name":"Leukopoiesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019891","descriptor_name":"Leukopoiesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019891","descriptor_name":"Leukopoiesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12918-017-0469-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0469-2","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-017-0469-2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:28841879","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28841879","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:cca5159ba3864dbc9e410f1dfa4a86d0","is_oa":false,"landing_page_url":"https://doaj.org/article/cca5159ba3864dbc9e410f1dfa4a86d0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 11, Iss 1, Pp 1-18 (2017)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4468800","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5574150","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:scholarworks.iupui.edu:1805/15288","is_oa":true,"landing_page_url":"http://hdl.handle.net/1805/15288","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/s12918-017-0469-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0469-2","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-017-0469-2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2658369032","display_name":null,"funder_award_id":"R01HD073156","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G840400388","display_name":null,"funder_award_id":"UL1TR001108","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320309408","display_name":"Indiana Clinical and Translational Sciences Institute","ror":"https://ror.org/022t7q367"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2745347371.pdf","grobid_xml":"https://content.openalex.org/works/W2745347371.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W115446058","https://openalex.org/W119711754","https://openalex.org/W140240943","https://openalex.org/W148088249","https://openalex.org/W183545005","https://openalex.org/W1513924279","https://openalex.org/W1551582264","https://openalex.org/W1595296482","https://openalex.org/W1666992241","https://openalex.org/W1969764547","https://openalex.org/W1977905227","https://openalex.org/W1978044917","https://openalex.org/W1980881263","https://openalex.org/W1987951694","https://openalex.org/W1988103510","https://openalex.org/W1989478899","https://openalex.org/W1990038609","https://openalex.org/W1992419399","https://openalex.org/W1992739638","https://openalex.org/W1995867434","https://openalex.org/W2000340009","https://openalex.org/W2004299093","https://openalex.org/W2010334731","https://openalex.org/W2017566105","https://openalex.org/W2022511877","https://openalex.org/W2029510277","https://openalex.org/W2032819570","https://openalex.org/W2038852212","https://openalex.org/W2041326103","https://openalex.org/W2041406732","https://openalex.org/W2052223517","https://openalex.org/W2052542966","https://openalex.org/W2064422200","https://openalex.org/W2068556430","https://openalex.org/W2073009020","https://openalex.org/W2076426515","https://openalex.org/W2077858999","https://openalex.org/W2089344492","https://openalex.org/W2096885361","https://openalex.org/W2101502003","https://openalex.org/W2102407330","https://openalex.org/W2103443944","https://openalex.org/W2104009100","https://openalex.org/W2104858491","https://openalex.org/W2106246606","https://openalex.org/W2107398329","https://openalex.org/W2109078622","https://openalex.org/W2109336877","https://openalex.org/W2116858301","https://openalex.org/W2118815818","https://openalex.org/W2119584141","https://openalex.org/W2120495395","https://openalex.org/W2121651771","https://openalex.org/W2124356165","https://openalex.org/W2124630954","https://openalex.org/W2127088990","https://openalex.org/W2134658700","https://openalex.org/W2138906968","https://openalex.org/W2139719464","https://openalex.org/W2142443607","https://openalex.org/W2142962347","https://openalex.org/W2144278714","https://openalex.org/W2152803686","https://openalex.org/W2154653890","https://openalex.org/W2154856176","https://openalex.org/W2159884655","https://openalex.org/W2162700652","https://openalex.org/W2168989497","https://openalex.org/W2183353764","https://openalex.org/W2262707985","https://openalex.org/W2318980714","https://openalex.org/W2339658711","https://openalex.org/W2347022381","https://openalex.org/W2490110295","https://openalex.org/W2603104800","https://openalex.org/W3101725226","https://openalex.org/W3103689510","https://openalex.org/W4233537820","https://openalex.org/W4236153851","https://openalex.org/W4285719527","https://openalex.org/W6604800836","https://openalex.org/W6645880043","https://openalex.org/W7046172159"],"related_works":["https://openalex.org/W2784395700","https://openalex.org/W2588548568","https://openalex.org/W4311268005","https://openalex.org/W4312527920","https://openalex.org/W2578179644","https://openalex.org/W3132976081","https://openalex.org/W2416660988","https://openalex.org/W2033687970","https://openalex.org/W1993503820","https://openalex.org/W2800863989"],"abstract_inverted_index":{"BACKGROUND:":[0],"Acute":[1],"myelogenous":[2],"leukemia":[3],"(AML)":[4],"progresses":[5],"uniquely":[6],"in":[7,47,127,135,242],"each":[8,156],"patient.":[9],"However,":[10],"patients":[11,71],"are":[12,102,236],"typically":[13],"treated":[14],"with":[15,168,198],"the":[16,40,49,61,87,91,95,106,128,141,169,203,247,259,265,278],"same":[17],"types":[18],"of":[19,39,53,55,97,99,120,157,206,249,251,262,280,301,303],"chemotherapy,":[20,76],"despite":[21],"biological":[22],"differences":[23],"that":[24,43,82,114,166,214,231,245,258,276,297],"lead":[25,180,308],"to":[26,29,179,181,238,309],"differential":[27],"responses":[28,237],"treatment.":[30],"RESULTS:":[31],"Here":[32],"we":[33,77,109,139,161,208,295],"present":[34],"a":[35],"multi-lineage":[36,204],"multi-compartment":[37],"model":[38,62,137,205,234,256],"hematopoietic":[41,56,65],"system":[42],"captures":[44],"patient-to-patient":[45],"variation":[46],"both":[48],"concentration":[50],"and":[51,94,149,164,221],"rates":[52,93,191],"change":[54],"cell":[57,66,129,143],"populations.":[58,130],"By":[59],"constraining":[60],"against":[63],"clinical":[64,174],"recovery":[67],"data":[68],"derived":[69],"from":[70],"who":[72],"have":[73,209],"received":[74],"induction":[75],"identified":[78,150,210],"trends":[79,134],"for":[80,89,269],"parameters":[81,230,275],"must":[83],"be":[84],"met":[85],"by":[86,274],"model;":[88],"example,":[90],"mitosis":[92,222,260,288],"probability":[96,248],"self-renewal":[98,219,250,279,302],"progenitor":[100],"cells":[101,306],"inversely":[103],"related.":[104],"Within":[105],"data-consistent":[107],"models,":[108],"found":[110,165],"22,796":[111],"parameter":[112,122,268],"sets":[113,123],"meet":[115],"chemotherapy":[116],"response":[117],"criteria.":[118],"Simulations":[119],"these":[121,136,158],"display":[124],"diverse":[125],"dynamics":[126,145],"To":[131],"identify":[132],"large":[133],"outputs,":[138],"clustered":[140],"simulated":[142,162],"population":[144],"using":[146],"k-means":[147],"clustering":[148],"thirteen":[151],"'representative":[152],"patient'":[153],"dynamics.":[154],"In":[155],"patient":[159],"clusters,":[160],"AML":[163,233],"clusters":[167],"greatest":[170],"mitotic":[171],"capacity":[172],"experience":[173],"cancer":[175,263,281,304],"outcomes":[176],"more":[177],"likely":[178],"shorter":[182],"survival":[183,199,270,312],"times.":[184,200],"Conversely,":[185],"other":[186],"parameters,":[187],"including":[188,218],"lower":[189],"death":[190],"or":[192],"mobilization":[193,226],"rates,":[194,223],"did":[195],"not":[196,225],"correlate":[197],"CONCLUSIONS:":[201],"Using":[202],"hematopoiesis,":[207],"several":[211],"key":[212],"features":[213],"determine":[215],"leukocyte":[216],"homeostasis,":[217],"probabilities":[220],"but":[224,290],"rates.":[227,313],"Other":[228],"influential":[229],"regulate":[232],"behavior":[235],"cytokines/growth":[239],"factors":[240],"produced":[241],"peripheral":[243],"blood":[244],"target":[246,287],"neutrophil":[252],"progenitors.":[253],"Finally,":[254],"our":[255,293],"predicts":[257],"rate":[261],"is":[264],"most":[266,284],"predictive":[267],"time,":[271],"followed":[272],"closely":[273],"affect":[277],"stem":[282,305],"cells;":[283],"current":[285],"therapies":[286],"rate,":[289],"based":[291],"on":[292],"results,":[294],"propose":[296],"additional":[298],"therapeutic":[299],"targeting":[300],"will":[307],"even":[310],"higher":[311]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-05-19T08:33:51.333923","created_date":"2025-10-10T00:00:00"}
