{"id":"https://openalex.org/W2762353132","doi":"https://doi.org/10.1186/s12918-017-0467-4","title":"System modeling reveals the molecular mechanisms of HSC cell cycle alteration mediated by Maff and Egr3 under leukemia","display_name":"System modeling reveals the molecular mechanisms of HSC cell cycle alteration mediated by Maff and Egr3 under leukemia","publication_year":2017,"publication_date":"2017-10-01","ids":{"openalex":"https://openalex.org/W2762353132","doi":"https://doi.org/10.1186/s12918-017-0467-4","mag":"2762353132","pmid":"https://pubmed.ncbi.nlm.nih.gov/28984203"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-017-0467-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0467-4","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-017-0467-4","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-017-0467-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078383638","display_name":"Rudong Li","orcid":"https://orcid.org/0000-0002-2389-1737"},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rudong Li","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA","institution_ids":["https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064052058","display_name":"Yin Wang","orcid":"https://orcid.org/0000-0002-6973-856X"},"institutions":[{"id":"https://openalex.org/I4210106542","display_name":"Shanghai Public Health Clinical Center","ror":"https://ror.org/01nnwyz44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106542"]},{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yin Wang","raw_affiliation_strings":["Shanghai Center for Bioinformatics Technology, Shanghai, 201203, China","Shanghai Public Health Clinical Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Center for Bioinformatics Technology, Shanghai, 201203, China","institution_ids":["https://openalex.org/I4210162648"]},{"raw_affiliation_string":"Shanghai Public Health Clinical Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200031, China","institution_ids":["https://openalex.org/I4210106542"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012350468","display_name":"Hui Cheng","orcid":"https://orcid.org/0000-0002-1988-6572"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Cheng","raw_affiliation_strings":["Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100412444","display_name":"Gang Liu","orcid":"https://orcid.org/0000-0002-4536-8453"},"institutions":[{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gang Liu","raw_affiliation_strings":["Shanghai Center for Bioinformatics Technology, Shanghai, 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Center for Bioinformatics Technology, Shanghai, 201203, China","institution_ids":["https://openalex.org/I4210162648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060867127","display_name":"Tao Cheng","orcid":"https://orcid.org/0000-0002-5925-2769"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Cheng","raw_affiliation_strings":["Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, 300020, China","institution_ids":["https://openalex.org/I200296433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100337355","display_name":"Yunlong Liu","orcid":"https://orcid.org/0000-0002-2699-626X"},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":null,"type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]},{"id":"https://openalex.org/I55769427","display_name":"Indiana University \u2013 Purdue University Indianapolis","ror":"https://ror.org/05gxnyn08","country_code":"US","type":"education","lineage":["https://openalex.org/I55769427","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunlong Liu","raw_affiliation_strings":["Center for Computational Biology and Bioinformatics, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Computational Biology and Bioinformatics, Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA","institution_ids":["https://openalex.org/I4394709130","https://openalex.org/I55769427"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100715840","display_name":"Lei Liu","orcid":"https://orcid.org/0000-0002-7436-5593"},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210106542","display_name":"Shanghai Public Health Clinical Center","ror":"https://ror.org/01nnwyz44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210106542"]},{"id":"https://openalex.org/I4210162648","display_name":"Shanghai Center For Bioinformation Technology","ror":"https://ror.org/04nyf1f54","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210162648"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Liu","raw_affiliation_strings":["Shanghai Center for Bioinformatics Technology, Shanghai, 201203, China. liulei@fudan.edu.cn","Shanghai Public Health Clinical Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200031, China. liulei@fudan.edu.cn","Shanghai Center for Bioinformatics Technology, Shanghai, 201203, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Center for Bioinformatics Technology, Shanghai, 201203, China. liulei@fudan.edu.cn","institution_ids":["https://openalex.org/I4210162648"]},{"raw_affiliation_string":"Shanghai Public Health Clinical Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200031, China. liulei@fudan.edu.cn","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210106542"]},{"raw_affiliation_string":"Shanghai Center for Bioinformatics Technology, Shanghai, 201203, China","institution_ids":["https://openalex.org/I4210162648"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5100715840"],"corresponding_institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210106542","https://openalex.org/I4210162648"],"apc_list":null,"apc_paid":null,"fwci":1.0117,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.77704838,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"11","issue":"S5","first_page":"91","last_page":"91"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.25279998779296875,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.25279998779296875,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.08760000020265579,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.0723000019788742,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6781277656555176},{"id":"https://openalex.org/keywords/haematopoiesis","display_name":"Haematopoiesis","score":0.5636864304542542},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5626238584518433},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.5339514017105103},{"id":"https://openalex.org/keywords/stem-cell","display_name":"Stem cell","score":0.5089719295501709},{"id":"https://openalex.org/keywords/leukemia","display_name":"Leukemia","score":0.4447079598903656},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.43101343512535095},{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.4165157079696655},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.294826865196228},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.24685519933700562},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18379583954811096}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6781277656555176},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5636864304542542},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5626238584518433},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5339514017105103},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5089719295501709},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.4447079598903656},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43101343512535095},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.4165157079696655},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.294826865196228},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.24685519933700562},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18379583954811096}],"mesh":[{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051260","descriptor_name":"MafF Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051260","descriptor_name":"MafF Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051260","descriptor_name":"MafF Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051776","descriptor_name":"Early Growth Response Protein 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051776","descriptor_name":"Early Growth Response Protein 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051776","descriptor_name":"Early Growth Response Protein 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12918-017-0467-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0467-4","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-017-0467-4","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:28984203","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28984203","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:europepmc.org:4560012","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5629552","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/15652","is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/15652","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"},{"id":"pmh:oai:scholarworks.iupui.edu:1805/15652","is_oa":true,"landing_page_url":"http://hdl.handle.net/1805/15652","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1186/s12918-017-0467-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0467-4","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-017-0467-4","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4300865399","display_name":null,"funder_award_id":"R21 AA020104","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G7740887638","display_name":null,"funder_award_id":"81090411","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G779064310","display_name":null,"funder_award_id":"2015AA020104","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8635653179","display_name":null,"funder_award_id":"2012AA02A602","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322266","display_name":"Ministry of Agriculture, Forestry and Fisheries","ror":"https://ror.org/02zdz1m23"},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2762353132.pdf","grobid_xml":"https://content.openalex.org/works/W2762353132.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W19721907","https://openalex.org/W1596321532","https://openalex.org/W1970103367","https://openalex.org/W1970854602","https://openalex.org/W1971987125","https://openalex.org/W1972561843","https://openalex.org/W1989277387","https://openalex.org/W1989617311","https://openalex.org/W1998667631","https://openalex.org/W2006848133","https://openalex.org/W2009970436","https://openalex.org/W2013225336","https://openalex.org/W2019562165","https://openalex.org/W2033194496","https://openalex.org/W2033771177","https://openalex.org/W2036828807","https://openalex.org/W2060742288","https://openalex.org/W2063666648","https://openalex.org/W2070188781","https://openalex.org/W2072329780","https://openalex.org/W2073957864","https://openalex.org/W2079651105","https://openalex.org/W2093958228","https://openalex.org/W2108723074","https://openalex.org/W2109336877","https://openalex.org/W2111627225","https://openalex.org/W2113263865","https://openalex.org/W2117392072","https://openalex.org/W2117960203","https://openalex.org/W2129858794","https://openalex.org/W2136242244","https://openalex.org/W2139349129","https://openalex.org/W2143965041","https://openalex.org/W2144702196","https://openalex.org/W2159035471","https://openalex.org/W2159482845","https://openalex.org/W2164055070","https://openalex.org/W2170839629","https://openalex.org/W2346440502","https://openalex.org/W2509432381","https://openalex.org/W4237335579","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W2079838338","https://openalex.org/W2076802652","https://openalex.org/W1991432514","https://openalex.org/W2784395700","https://openalex.org/W2018552733","https://openalex.org/W4298132542","https://openalex.org/W2015726247","https://openalex.org/W2045505363","https://openalex.org/W2592615787","https://openalex.org/W3012964845"],"abstract_inverted_index":{"BACKGROUND:":[0],"Molecular":[1],"mechanisms":[2,51,80,98],"of":[3,7,52,66,81,91,120,141],"the":[4,49,54,63,72,78,89,118,138],"functional":[5,64,92,168],"alteration":[6,65],"hematopoietic":[8],"stem":[9],"cells":[10],"(HSCs)":[11],"in":[12,21,43,135],"leukemic":[13],"environment":[14,140],"attract":[15],"intensive":[16],"research":[17,160],"interests.":[18],"As":[19,144],"known":[20],"previous":[22],"researches,":[23],"Maff":[24,82],"and":[25,83,165,176,181],"Egr3":[26,84],"are":[27,39,99,107],"two":[28],"important":[29],"genes":[30,55],"having":[31,116],"opposite":[32],"functions":[33],"on":[34,57,85],"cell":[35,58,86],"cycle;":[36],"however,":[37],"they":[38],"both":[40],"highly":[41],"expressed":[42],"HSCs":[44,127],"under":[45],"leukemia.":[46,142],"Hence,":[47],"exploring":[48],"molecular":[50,96],"how":[53],"act":[56],"cycle":[59],"will":[60],"help":[61],"revealing":[62],"HSCs.":[67],"RESULTS:":[68],"We":[69],"herein":[70],"utilize":[71],"bioinformatic":[73],"resources":[74],"to":[75,137,183],"computationally":[76],"model":[77,103],"acting":[79,97],"cycle.":[87],"Using":[88],"data":[90,166],"experiments":[93,169],"as":[94],"reference,":[95],"optimally":[100],"enumerated":[101],"through":[102],"selection.":[104],"The":[105],"results":[106,149],"consolidated":[108],"by":[109],"evidences":[110],"from":[111,167],"gene":[112],"sequence":[113],"analysis,":[114],"thus":[115],"enhanced":[117],"confidence":[119],"our":[121,148,159],"pilot":[122,146],"findings,":[123],"which":[124],"suggest":[125],"that":[126],"possibly":[128],"undergo":[129],"a":[130,145],"\"adaptation":[131],"-":[132],"suppression\"":[133],"process":[134],"response":[136],"malignant":[139],"CONCLUSION:":[143],"research,":[147],"may":[150],"provide":[151],"valuable":[152],"insights":[153],"for":[154,173],"further":[155],"experimental":[156],"studies.":[157,186],"Meanwhile,":[158],"method":[161],"combining":[162],"computational":[163],"modeling":[164],"can":[170,178],"be":[171,179],"worthwhile":[172],"knowledge":[174],"discovery;":[175],"it":[177],"generalized":[180],"extended":[182],"other":[184],"biological/biomedical":[185]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}
