{"id":"https://openalex.org/W2737025620","doi":"https://doi.org/10.1186/s12918-017-0446-9","title":"Combination therapy for melanoma with BRAF/MEK inhibitor and immune checkpoint inhibitor: a mathematical model","display_name":"Combination therapy for melanoma with BRAF/MEK inhibitor and immune checkpoint inhibitor: a mathematical model","publication_year":2017,"publication_date":"2017-07-19","ids":{"openalex":"https://openalex.org/W2737025620","doi":"https://doi.org/10.1186/s12918-017-0446-9","mag":"2737025620","pmid":"https://pubmed.ncbi.nlm.nih.gov/28724377"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-017-0446-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0446-9","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-017-0446-9","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-017-0446-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033033981","display_name":"Xiulan Lai","orcid":"https://orcid.org/0000-0002-2764-8937"},"institutions":[{"id":"https://openalex.org/I78988378","display_name":"Renmin University of China","ror":"https://ror.org/041pakw92","country_code":"CN","type":"education","lineage":["https://openalex.org/I78988378"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiulan Lai","raw_affiliation_strings":["Institute for Mathematical Sciences, Renmin University of China, Beijing, 100872, People's Republic of China. xiulanlai@ruc.edu.cn","Institute for Mathematical Sciences, Renmin University of China, Beijing, 100872, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Mathematical Sciences, Renmin University of China, Beijing, 100872, People's Republic of China. xiulanlai@ruc.edu.cn","institution_ids":[]},{"raw_affiliation_string":"Institute for Mathematical Sciences, Renmin University of China, Beijing, 100872, People's Republic of China","institution_ids":["https://openalex.org/I78988378"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027260022","display_name":"Avner Friedman","orcid":"https://orcid.org/0000-0002-7875-174X"},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Avner Friedman","raw_affiliation_strings":["Mathematical Bioscience Institute & Department of Mathematics, Ohio State University, Columbus, 43210, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mathematical Bioscience Institute & Department of Mathematics, Ohio State University, Columbus, 43210, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033033981"],"corresponding_institution_ids":["https://openalex.org/I78988378"],"apc_list":null,"apc_paid":null,"fwci":2.1309,"has_fulltext":true,"cited_by_count":50,"citation_normalized_percentile":{"value":0.87810363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"11","issue":"1","first_page":"70","last_page":"70"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9782999753952026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9782999753952026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"Melanoma","score":0.6461183428764343},{"id":"https://openalex.org/keywords/mek-inhibitor","display_name":"MEK inhibitor","score":0.6207650899887085},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.49063625931739807},{"id":"https://openalex.org/keywords/immune-checkpoint","display_name":"Immune checkpoint","score":0.4635080397129059},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.43153998255729675},{"id":"https://openalex.org/keywords/programmed-cell-death-1","display_name":"Programmed cell death 1","score":0.4288158714771271},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.4218406677246094},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3417378067970276},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.3279019892215729},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.32224392890930176},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.28829196095466614},{"id":"https://openalex.org/keywords/mapk/erk-pathway","display_name":"MAPK/ERK pathway","score":0.12805703282356262},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.1244976818561554},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.09999540448188782},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.07675710320472717}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6461183428764343},{"id":"https://openalex.org/C2781249067","wikidata":"https://www.wikidata.org/wiki/Q17142288","display_name":"MEK inhibitor","level":4,"score":0.6207650899887085},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49063625931739807},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.4635080397129059},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.43153998255729675},{"id":"https://openalex.org/C169382597","wikidata":"https://www.wikidata.org/wiki/Q21208025","display_name":"Programmed cell death 1","level":5,"score":0.4288158714771271},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4218406677246094},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3417378067970276},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3279019892215729},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32224392890930176},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28829196095466614},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.12805703282356262},{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.1244976818561554},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09999540448188782},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.07675710320472717}],"mesh":[{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D048493","descriptor_name":"Proto-Oncogene Proteins B-raf","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D061026","descriptor_name":"Programmed Cell Death 1 Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12918-017-0446-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0446-9","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-017-0446-9","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:28724377","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28724377","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:f46777474bbc47f5bff9273186468f57","is_oa":false,"landing_page_url":"https://doaj.org/article/f46777474bbc47f5bff9273186468f57","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 11, Iss 1, Pp 1-18 (2017)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5517842","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5517842","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-017-0446-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0446-9","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-017-0446-9","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7200000286102295,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G485075357","display_name":null,"funder_award_id":"11501568","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8094647107","display_name":null,"funder_award_id":"0931642","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8606623886","display_name":null,"funder_award_id":"DMS 0931642","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322499","display_name":"Renmin University of China","ror":"https://ror.org/041pakw92"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2737025620.pdf","grobid_xml":"https://content.openalex.org/works/W2737025620.grobid-xml"},"referenced_works_count":95,"referenced_works":["https://openalex.org/W196287517","https://openalex.org/W410947787","https://openalex.org/W608295237","https://openalex.org/W1592596551","https://openalex.org/W1752668680","https://openalex.org/W1823780969","https://openalex.org/W1834409279","https://openalex.org/W1855030145","https://openalex.org/W1928871450","https://openalex.org/W1960778855","https://openalex.org/W1963851958","https://openalex.org/W1967000639","https://openalex.org/W1975248353","https://openalex.org/W1977735548","https://openalex.org/W1978321168","https://openalex.org/W1983470887","https://openalex.org/W1989552966","https://openalex.org/W1989673842","https://openalex.org/W1997388726","https://openalex.org/W1997851555","https://openalex.org/W2003810128","https://openalex.org/W2004313569","https://openalex.org/W2010121426","https://openalex.org/W2011582933","https://openalex.org/W2013166385","https://openalex.org/W2015789827","https://openalex.org/W2019188656","https://openalex.org/W2021356485","https://openalex.org/W2027440437","https://openalex.org/W2028808247","https://openalex.org/W2041441588","https://openalex.org/W2045263076","https://openalex.org/W2048942846","https://openalex.org/W2050216284","https://openalex.org/W2061136308","https://openalex.org/W2063629620","https://openalex.org/W2063871323","https://openalex.org/W2067504868","https://openalex.org/W2090031443","https://openalex.org/W2092939107","https://openalex.org/W2095598060","https://openalex.org/W2099044540","https://openalex.org/W2100677570","https://openalex.org/W2100738068","https://openalex.org/W2102282878","https://openalex.org/W2103335284","https://openalex.org/W2103675014","https://openalex.org/W2106949373","https://openalex.org/W2107484016","https://openalex.org/W2109550365","https://openalex.org/W2114903025","https://openalex.org/W2127437403","https://openalex.org/W2129482327","https://openalex.org/W2130066229","https://openalex.org/W2130621814","https://openalex.org/W2130650675","https://openalex.org/W2135915203","https://openalex.org/W2137626178","https://openalex.org/W2138972371","https://openalex.org/W2141494367","https://openalex.org/W2142019721","https://openalex.org/W2144308584","https://openalex.org/W2145871366","https://openalex.org/W2150544967","https://openalex.org/W2152803686","https://openalex.org/W2152948584","https://openalex.org/W2159170430","https://openalex.org/W2161225385","https://openalex.org/W2165831623","https://openalex.org/W2168711434","https://openalex.org/W2177971463","https://openalex.org/W2183615895","https://openalex.org/W2184588837","https://openalex.org/W2199953088","https://openalex.org/W2273004055","https://openalex.org/W2309932682","https://openalex.org/W2335844855","https://openalex.org/W2338890931","https://openalex.org/W2340409592","https://openalex.org/W2389398856","https://openalex.org/W2397068902","https://openalex.org/W2464506247","https://openalex.org/W2515020216","https://openalex.org/W2536662789","https://openalex.org/W2540613192","https://openalex.org/W2546466212","https://openalex.org/W2556495987","https://openalex.org/W2557511697","https://openalex.org/W2560367415","https://openalex.org/W2572174216","https://openalex.org/W2604391908","https://openalex.org/W2765939742","https://openalex.org/W6684641524","https://openalex.org/W6829260022","https://openalex.org/W7073948520"],"related_works":["https://openalex.org/W3114858086","https://openalex.org/W3107665329","https://openalex.org/W4308629200","https://openalex.org/W2806922401","https://openalex.org/W4309657772","https://openalex.org/W2993566705","https://openalex.org/W3215809663","https://openalex.org/W2996934095","https://openalex.org/W2515434604","https://openalex.org/W4384925092"],"abstract_inverted_index":{"The":[0,132,178],"B-raf":[1],"gene":[2],"is":[3,19,59,84,180,190,207,242],"mutated":[4],"in":[5,36,129,271,312,318],"up":[6],"to":[7,52,56,116,192,291,314],"66%":[8],"of":[9,23,27,39,67,99,120,185,230,262,273,303],"human":[10],"malignant":[11],"melanomas,":[12],"and":[13,41,55,101,126,136,141,153,157,159,170,189,219],"its":[14],"protein":[15],"product,":[16],"BRAF":[17,53],"kinase,":[18],"a":[20,113,183],"key":[21],"part":[22],"RAS-RAF-MEK-ERK":[24],"(MAPK)":[25],"pathway":[26],"cancer":[28,137],"cell":[29],"proliferation.":[30],"BRAF-targeted":[31],"therapy":[32],"induces":[33],"significant":[34],"responses":[35],"the":[37,42,50,63,82,118,121,160,198,210,228,231,245,248,274,279,301],"majority":[38],"patients,":[40],"combination":[43,98],"BRAF/MEK":[44,57,100,124,163],"inhibitor":[45,54,58,125,128,164,172],"enhances":[46],"clinical":[47,299,321],"efficacy,":[48],"but":[49,81],"response":[51,79,83],"short":[60],"lived.":[61],"On":[62,244],"other":[64,246],"hand,":[65,247],"treatment":[66],"melanoma":[68,130],"with":[69],"an":[70,194,269],"immune":[71],"checkpoint":[72],"inhibitor,":[73],"such":[74],"as":[75],"anti-PD-1,":[76],"has":[77],"lower":[78],"rate":[80],"much":[85],"more":[86,319],"durable,":[87],"lasting":[88],"for":[89,197],"years.":[90],"For":[91],"this":[92],"reason,":[93],"it":[94],"was":[95],"suggested":[96],"that":[97,209,226,257],"PD-1":[102,127,156,171],"inhibitors":[103],"will":[104,277,288],"significantly":[105],"improve":[106],"overall":[107],"survival":[108],"time.":[109],"This":[110],"paper":[111],"develops":[112],"mathematical":[114],"model":[115,133,179],"address":[117],"question":[119],"correlation":[122],"between":[123],"therapy.":[131],"includes":[134],"dendritic":[135],"cells,":[138,145,147],"CD":[139,142],"4+":[140],"8+":[143],"T":[144],"MDSC":[146],"interleukins":[148],"IL-12,":[149],"IL-2,":[150],"IL-6,":[151],"IL-10":[152],"TGF-":[154],"\u03b2,":[155],"PD-L1,":[158],"two":[161,211,249,275],"drugs:":[162],"(with":[165,173],"concentration":[166,174],"\u03b3":[167,175,217,220,237,240],"B":[168,202,218,238,264,305],")":[169,267,308],"A":[176,204,221,241,266,307],").":[177,205],"represented":[181],"by":[182,293,297],"system":[184],"partial":[186],"differential":[187],"equations,":[188],"used":[191],"develop":[193],"efficacy":[195],"map":[196],"combined":[199],"concentrations":[200],"(\u03b3":[201,263,304],",\u03b3":[203,265,306],"It":[206,287],"shown":[208],"drugs":[212,250,276],"are":[213,222,251,260],"positively":[214],"correlated":[215],"if":[216,235],"at":[223,253],"low":[224],"doses,":[225,256],"is,":[227,258],"growth":[229],"tumor":[232,280],"volume":[233,281],"decreases":[234],"either":[236],"or":[239,296],"increased.":[243],"antagonistic":[252],"some":[254],"high":[255],"there":[259],"zones":[261,302,317],"where":[268,309],"increase":[270,278],"one":[272],"growth,":[282],"rather":[283],"than":[284],"decrease":[285],"it.":[286],"be":[289],"important":[290],"identify,":[292],"animal":[294],"experiments":[295],"early":[298],"trials,":[300],"antagonism":[310],"occurs,":[311],"order":[313],"avoid":[315],"these":[316],"advanced":[320],"trials.":[322]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":1}],"updated_date":"2026-05-16T08:24:45.110214","created_date":"2025-10-10T00:00:00"}
