{"id":"https://openalex.org/W2727082118","doi":"https://doi.org/10.1186/s12918-017-0439-8","title":"Gene expression profiles and signaling mechanisms in \u03b12B-adrenoceptor-evoked proliferation of vascular smooth muscle cells","display_name":"Gene expression profiles and signaling mechanisms in \u03b12B-adrenoceptor-evoked proliferation of vascular smooth muscle cells","publication_year":2017,"publication_date":"2017-06-28","ids":{"openalex":"https://openalex.org/W2727082118","doi":"https://doi.org/10.1186/s12918-017-0439-8","mag":"2727082118","pmid":"https://pubmed.ncbi.nlm.nih.gov/28659168"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-017-0439-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0439-8","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0439-8","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0439-8","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082650517","display_name":"Anna Huhtinen","orcid":"https://orcid.org/0000-0003-0080-2153"},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Anna Huhtinen","raw_affiliation_strings":["Department of Pharmacology, Drug Development and Therapeutics, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI-20520, Turku, Finland. anna.huhtinen@utu.fi","Unit of Clinical Pharmacology, Turku University Hospital, Turku, Finland. anna.huhtinen@utu.fi","Department of Pharmacology, Drug Development and Therapeutics, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI-20520, Turku, Finland"],"raw_orcid":"https://orcid.org/0000-0003-0080-2153","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Drug Development and Therapeutics, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI-20520, Turku, Finland. anna.huhtinen@utu.fi","institution_ids":["https://openalex.org/I155660961"]},{"raw_affiliation_string":"Unit of Clinical Pharmacology, Turku University Hospital, Turku, Finland. anna.huhtinen@utu.fi","institution_ids":["https://openalex.org/I2801970007"]},{"raw_affiliation_string":"Department of Pharmacology, Drug Development and Therapeutics, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI-20520, Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035142029","display_name":"Vesa Hongisto","orcid":"https://orcid.org/0000-0002-0010-1296"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vesa Hongisto","raw_affiliation_strings":["Toxicology Division, Misvik Biology Oy, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Toxicology Division, Misvik Biology Oy, Turku, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024804309","display_name":"Asta Laiho","orcid":null},"institutions":[{"id":"https://openalex.org/I130217899","display_name":"\u00c5bo Akademi University","ror":"https://ror.org/029pk6x14","country_code":"FI","type":"education","lineage":["https://openalex.org/I130217899"]},{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I4210140120","display_name":"Turku Centre for Biotechnology","ror":"https://ror.org/0421ba211","country_code":"FI","type":"facility","lineage":["https://openalex.org/I4210140120"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Asta Laiho","raw_affiliation_strings":["Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Turku Centre for Biotechnology, University of Turku and \u00c5bo Akademi University, Turku, Finland","institution_ids":["https://openalex.org/I155660961","https://openalex.org/I130217899","https://openalex.org/I4210140120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062493600","display_name":"Eliisa L\u00f6yttyniemi","orcid":"https://orcid.org/0000-0002-7278-6511"},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Eliisa L\u00f6yttyniemi","raw_affiliation_strings":["Department of Biostatistics, Department of Clinical Medicine, University of Turku, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Department of Clinical Medicine, University of Turku, Turku, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080651962","display_name":"Dirk Pijnenburg","orcid":null},"institutions":[{"id":"https://openalex.org/I4210131596","display_name":"PamGene (Netherlands)","ror":"https://ror.org/03c9hf945","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210131596"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Dirk Pijnenburg","raw_affiliation_strings":["PamGene International BV, Wolvenhoek 10, 5211HH, s'Hertogenbosch, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"PamGene International BV, Wolvenhoek 10, 5211HH, s'Hertogenbosch, The Netherlands","institution_ids":["https://openalex.org/I4210131596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078460231","display_name":"Mika Scheinin","orcid":"https://orcid.org/0000-0001-7579-9126"},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]},{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Mika Scheinin","raw_affiliation_strings":["Department of Pharmacology, Drug Development and Therapeutics, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI-20520, Turku, Finland","Unit of Clinical Pharmacology, Turku University Hospital, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Drug Development and Therapeutics, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, FI-20520, Turku, Finland","institution_ids":["https://openalex.org/I155660961"]},{"raw_affiliation_string":"Unit of Clinical Pharmacology, Turku University Hospital, Turku, Finland","institution_ids":["https://openalex.org/I2801970007"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5082650517"],"corresponding_institution_ids":["https://openalex.org/I155660961","https://openalex.org/I2801970007"],"apc_list":null,"apc_paid":null,"fwci":0.6738,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.68965282,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"11","issue":"1","first_page":"65","last_page":"65"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lyn","display_name":"LYN","score":0.6562376022338867},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6400889158248901},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6262096762657166},{"id":"https://openalex.org/keywords/proto-oncogene-tyrosine-protein-kinase-src","display_name":"Proto-oncogene tyrosine-protein kinase Src","score":0.5782349109649658},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.569068431854248},{"id":"https://openalex.org/keywords/vascular-smooth-muscle","display_name":"Vascular smooth muscle","score":0.5684939622879028},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.48846378922462463},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"Tyrosine kinase","score":0.46015694737434387},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.3656654953956604},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.23535063862800598}],"concepts":[{"id":"https://openalex.org/C175818844","wikidata":"https://www.wikidata.org/wiki/Q2463389","display_name":"LYN","level":4,"score":0.6562376022338867},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6400889158248901},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6262096762657166},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.5782349109649658},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.569068431854248},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.5684939622879028},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.48846378922462463},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.46015694737434387},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3656654953956604},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23535063862800598},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018341","descriptor_name":"Receptors, Adrenergic, alpha-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018341","descriptor_name":"Receptors, Adrenergic, alpha-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018341","descriptor_name":"Receptors, Adrenergic, alpha-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018341","descriptor_name":"Receptors, Adrenergic, alpha-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020927","descriptor_name":"Dexmedetomidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020927","descriptor_name":"Dexmedetomidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020927","descriptor_name":"Dexmedetomidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020927","descriptor_name":"Dexmedetomidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12918-017-0439-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0439-8","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0439-8","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:28659168","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28659168","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:5490158","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5490158","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmh:oai:www.utupub.fi:10024/165616","is_oa":true,"landing_page_url":"https://www.utupub.fi/handle/10024/165616","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1186/s12918-017-0439-8","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0439-8","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0439-8","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6299999952316284,"display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321726","display_name":"Suomen Kulttuurirahasto","ror":"https://ror.org/027xav248"},{"id":"https://openalex.org/F4320322400","display_name":"Magnus Ehrnroothin S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/02cdzet69"},{"id":"https://openalex.org/F4320323313","display_name":"Turun Yliopisto","ror":"https://ror.org/05vghhr25"},{"id":"https://openalex.org/F4320323333","display_name":"Syd\u00e4ntutkimuss\u00e4\u00e4ti\u00f6","ror":"https://ror.org/020apt798"},{"id":"https://openalex.org/F4320325163","display_name":"Paavo Nurmen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/009vp0837"},{"id":"https://openalex.org/F4320327840","display_name":"Otto A. Malm Lahjoitusrahasto","ror":"https://ror.org/05srazs86"},{"id":"https://openalex.org/F4320331826","display_name":"Turun Yliopistos\u00e4\u00e4ti\u00f6","ror":null},{"id":"https://openalex.org/F4320336789","display_name":"Turun yliopiston tutkijakoulu","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2727082118.pdf","grobid_xml":"https://content.openalex.org/works/W2727082118.grobid-xml"},"referenced_works_count":324,"referenced_works":["https://openalex.org/W446155","https://openalex.org/W3325316","https://openalex.org/W31313758","https://openalex.org/W49161209","https://openalex.org/W82667506","https://openalex.org/W126778996","https://openalex.org/W158788179","https://openalex.org/W319133514","https://openalex.org/W349473910","https://openalex.org/W1493902576","https://openalex.org/W1508005550","https://openalex.org/W1511840890","https://openalex.org/W1532172174","https://openalex.org/W1545005818","https://openalex.org/W1557560429","https://openalex.org/W1568617917","https://openalex.org/W1589641772","https://openalex.org/W1608179836","https://openalex.org/W1654896704","https://openalex.org/W1768187423","https://openalex.org/W1842491185","https://openalex.org/W1875580551","https://openalex.org/W1891938867","https://openalex.org/W1905490886","https://openalex.org/W1912592877","https://openalex.org/W1958180792","https://openalex.org/W1964184380","https://openalex.org/W1964504843","https://openalex.org/W1966018982","https://openalex.org/W1968515789","https://openalex.org/W1968569156","https://openalex.org/W1969054252","https://openalex.org/W1969149591","https://openalex.org/W1969366437","https://openalex.org/W1970312948","https://openalex.org/W1973716843","https://openalex.org/W1974508733","https://openalex.org/W1975548208","https://openalex.org/W1978642877","https://openalex.org/W1979703755","https://openalex.org/W1980771690","https://openalex.org/W1980843814","https://openalex.org/W1981164988","https://openalex.org/W1982442394","https://openalex.org/W1983366890","https://openalex.org/W1984120481","https://openalex.org/W1984168218","https://openalex.org/W1984666566","https://openalex.org/W1985247335","https://openalex.org/W1986373583","https://openalex.org/W1989516722","https://openalex.org/W1990078228","https://openalex.org/W1990970152","https://openalex.org/W1995819749","https://openalex.org/W1996285297","https://openalex.org/W1997466868","https://openalex.org/W1998023277","https://openalex.org/W1998296919","https://openalex.org/W1998329557","https://openalex.org/W1998783250","https://openalex.org/W1998944225","https://openalex.org/W1999415360","https://openalex.org/W1999477673","https://openalex.org/W1999689296","https://openalex.org/W2001102844","https://openalex.org/W2001885170","https://openalex.org/W2002754026","https://openalex.org/W2003666157","https://openalex.org/W2004918005","https://openalex.org/W2005248412","https://openalex.org/W2005525391","https://openalex.org/W2006973060","https://openalex.org/W2007172597","https://openalex.org/W2009289049","https://openalex.org/W2009687620","https://openalex.org/W2010324176","https://openalex.org/W2011792786","https://openalex.org/W2012159750","https://openalex.org/W2012441637","https://openalex.org/W2013012232","https://openalex.org/W2013514204","https://openalex.org/W2013940160","https://openalex.org/W2014588445","https://openalex.org/W2015325381","https://openalex.org/W2015557944","https://openalex.org/W2016290808","https://openalex.org/W2016320725","https://openalex.org/W2017401660","https://openalex.org/W2019533995","https://openalex.org/W2021256936","https://openalex.org/W2021490796","https://openalex.org/W2021634495","https://openalex.org/W2022519264","https://openalex.org/W2022931586","https://openalex.org/W2023570651","https://openalex.org/W2023833232","https://openalex.org/W2025378619","https://openalex.org/W2025869678","https://openalex.org/W2026297042","https://openalex.org/W2026909572","https://openalex.org/W2027077889","https://openalex.org/W2027220430","https://openalex.org/W2029047992","https://openalex.org/W2029271813","https://openalex.org/W2030049178","https://openalex.org/W2030205108","https://openalex.org/W2030698703","https://openalex.org/W2030994941","https://openalex.org/W2032284763","https://openalex.org/W2034144678","https://openalex.org/W2034379667","https://openalex.org/W2034523856","https://openalex.org/W2034965329","https://openalex.org/W2035995170","https://openalex.org/W2036526259","https://openalex.org/W2036970863","https://openalex.org/W2037941010","https://openalex.org/W2039217577","https://openalex.org/W2039991628","https://openalex.org/W2040170245","https://openalex.org/W2041322579","https://openalex.org/W2042477615","https://openalex.org/W2042642856","https://openalex.org/W2044986027","https://openalex.org/W2046176503","https://openalex.org/W2046630742","https://openalex.org/W2049185799","https://openalex.org/W2050041795","https://openalex.org/W2050736024","https://openalex.org/W2051381056","https://openalex.org/W2052750950","https://openalex.org/W2053949431","https://openalex.org/W2054254513","https://openalex.org/W2054508240","https://openalex.org/W2055557483","https://openalex.org/W2055781716","https://openalex.org/W2056113945","https://openalex.org/W2056260331","https://openalex.org/W2059410845","https://openalex.org/W2059562044","https://openalex.org/W2059858274","https://openalex.org/W2060618476","https://openalex.org/W2061910745","https://openalex.org/W2062077365","https://openalex.org/W2062526139","https://openalex.org/W2062673518","https://openalex.org/W2063277519","https://openalex.org/W2064853768","https://openalex.org/W2065242941","https://openalex.org/W2066113694","https://openalex.org/W2066626581","https://openalex.org/W2067332977","https://openalex.org/W2067381539","https://openalex.org/W2068373639","https://openalex.org/W2069576338","https://openalex.org/W2070653958","https://openalex.org/W2072749112","https://openalex.org/W2072829387","https://openalex.org/W2072857554","https://openalex.org/W2073864477","https://openalex.org/W2073895076","https://openalex.org/W2074540763","https://openalex.org/W2075084596","https://openalex.org/W2075497742","https://openalex.org/W2076216271","https://openalex.org/W2077142251","https://openalex.org/W2077399441","https://openalex.org/W2077703012","https://openalex.org/W2078372594","https://openalex.org/W2079436570","https://openalex.org/W2079527824","https://openalex.org/W2080048464","https://openalex.org/W2080202671","https://openalex.org/W2080210308","https://openalex.org/W2080237382","https://openalex.org/W2081276164","https://openalex.org/W2081753462","https://openalex.org/W2082573799","https://openalex.org/W2082608136","https://openalex.org/W2083211216","https://openalex.org/W2083276959","https://openalex.org/W2083647583","https://openalex.org/W2084235775","https://openalex.org/W2085487477","https://openalex.org/W2085936885","https://openalex.org/W2087367550","https://openalex.org/W2087641723","https://openalex.org/W2089375083","https://openalex.org/W2089558162","https://openalex.org/W2090154599","https://openalex.org/W2090513293","https://openalex.org/W2090921124","https://openalex.org/W2092583849","https://openalex.org/W2092842296","https://openalex.org/W2093608596","https://openalex.org/W2094092110","https://openalex.org/W2095062075","https://openalex.org/W2095686773","https://openalex.org/W2096321722","https://openalex.org/W2096963125","https://openalex.org/W2097322142","https://openalex.org/W2097558464","https://openalex.org/W2097702504","https://openalex.org/W2098902378","https://openalex.org/W2099567726","https://openalex.org/W2099588718","https://openalex.org/W2099761715","https://openalex.org/W2100869552","https://openalex.org/W2101318553","https://openalex.org/W2103423185","https://openalex.org/W2104237202","https://openalex.org/W2105269965","https://openalex.org/W2105826748","https://openalex.org/W2107021299","https://openalex.org/W2107277218","https://openalex.org/W2108660541","https://openalex.org/W2108833962","https://openalex.org/W2110858892","https://openalex.org/W2112873780","https://openalex.org/W2113452187","https://openalex.org/W2115625574","https://openalex.org/W2115789412","https://openalex.org/W2115840640","https://openalex.org/W2115978027","https://openalex.org/W2117136455","https://openalex.org/W2118030557","https://openalex.org/W2121822802","https://openalex.org/W2121949727","https://openalex.org/W2123269248","https://openalex.org/W2123846811","https://openalex.org/W2125567150","https://openalex.org/W2127719752","https://openalex.org/W2128131750","https://openalex.org/W2128455103","https://openalex.org/W2128529999","https://openalex.org/W2128543390","https://openalex.org/W2128629032","https://openalex.org/W2130623416","https://openalex.org/W2131399736","https://openalex.org/W2131601314","https://openalex.org/W2132795628","https://openalex.org/W2133293353","https://openalex.org/W2133435888","https://openalex.org/W2133464116","https://openalex.org/W2134665522","https://openalex.org/W2135130157","https://openalex.org/W2136390065","https://openalex.org/W2137146936","https://openalex.org/W2137170558","https://openalex.org/W2137948074","https://openalex.org/W2140217862","https://openalex.org/W2141203222","https://openalex.org/W2142540964","https://openalex.org/W2142566866","https://openalex.org/W2144409619","https://openalex.org/W2144434696","https://openalex.org/W2144779602","https://openalex.org/W2146512944","https://openalex.org/W2146765109","https://openalex.org/W2146933358","https://openalex.org/W2148784517","https://openalex.org/W2148803067","https://openalex.org/W2150293865","https://openalex.org/W2151186276","https://openalex.org/W2151383334","https://openalex.org/W2151756203","https://openalex.org/W2152656393","https://openalex.org/W2153026640","https://openalex.org/W2153283289","https://openalex.org/W2154599526","https://openalex.org/W2154874811","https://openalex.org/W2155016470","https://openalex.org/W2155206013","https://openalex.org/W2155910335","https://openalex.org/W2156009622","https://openalex.org/W2157050965","https://openalex.org/W2157279161","https://openalex.org/W2157318743","https://openalex.org/W2159825665","https://openalex.org/W2159926555","https://openalex.org/W2160218010","https://openalex.org/W2160892471","https://openalex.org/W2162225623","https://openalex.org/W2164810943","https://openalex.org/W2166056434","https://openalex.org/W2168392561","https://openalex.org/W2169328538","https://openalex.org/W2172217343","https://openalex.org/W2173905836","https://openalex.org/W2174811462","https://openalex.org/W2180470218","https://openalex.org/W2254262262","https://openalex.org/W2257354462","https://openalex.org/W2278419958","https://openalex.org/W2281563913","https://openalex.org/W2284014607","https://openalex.org/W2294120828","https://openalex.org/W2301367998","https://openalex.org/W2307236318","https://openalex.org/W2319433135","https://openalex.org/W2321943546","https://openalex.org/W2323974245","https://openalex.org/W2333064082","https://openalex.org/W2337480560","https://openalex.org/W2342688438","https://openalex.org/W2369069057","https://openalex.org/W2369567189","https://openalex.org/W2399332972","https://openalex.org/W2399804569","https://openalex.org/W2411420993","https://openalex.org/W2412844774","https://openalex.org/W2415789341","https://openalex.org/W2417524082","https://openalex.org/W2418929032","https://openalex.org/W2419601793","https://openalex.org/W2465881164","https://openalex.org/W2582743722","https://openalex.org/W3142548471","https://openalex.org/W3144416775","https://openalex.org/W4233367940","https://openalex.org/W4236712663","https://openalex.org/W4247904703","https://openalex.org/W4295216797","https://openalex.org/W4297846773"],"related_works":["https://openalex.org/W2011366314","https://openalex.org/W2145023069","https://openalex.org/W2007058418","https://openalex.org/W1993879491","https://openalex.org/W2000911314","https://openalex.org/W2003423830","https://openalex.org/W4245949927","https://openalex.org/W2415251987","https://openalex.org/W1533251160","https://openalex.org/W1963500867"],"abstract_inverted_index":{"BACKGROUND:":[0],"-adrenoceptor-evoked":[1,103],"VSMC":[2,6,40,104],"proliferation.":[3,7],"RESULTS:":[4],"-adrenoceptor-regulated":[5],"They":[8],"included":[9,67],"the":[10,19,39,55,71,78,89,132],"upregulated":[11,31],"genes":[12,21],"Egr1,":[13],"F3,":[14],"Ptgs2":[15],"and":[16,18,26,45,75,77,83,120,125,153],"Serpine1":[17],"downregulated":[20],"Cx3cl1,":[22],"Cav1,":[23],"Rhoa,":[24],"Nppb":[25],"Prrx1.":[27],"The":[28],"most":[29],"highly":[30],"gene,":[32],"Lypd8,":[33],"represents":[34],"a":[35,86,98],"novel":[36,87],"finding":[37],"in":[38,54,114,139],"context.":[41],"Inhibitor":[42],"library":[43],"screening":[44,156],"kinase":[46,92,123],"activity":[47],"profiling":[48],"were":[49,136,147],"applied":[50],"to":[51,108],"identify":[52],"kinases":[53,61,73,81],"involved":[56],"signaling":[57],"pathways.":[58],"Putative":[59],"upstream":[60,100],"identified":[62,96,133],"by":[63,149],"two":[64],"different":[65],"screens":[66],"PKC,":[68],"Raf-1,":[69],"Src,":[70],"MAP":[72],"p38":[74],"JNK":[76],"receptor":[79],"tyrosine":[80],"EGFR":[82],"HGF/HGFR.":[84],"As":[85],"finding,":[88],"Src":[90],"family":[91],"Lyn":[93],"was":[94],"also":[95],"as":[97],"putative":[99],"kinase.":[101],"CONCLUSIONS:":[102],"proliferation":[105],"thus":[106],"appears":[107],"involve":[109],"PKC":[110],"activation,":[111],"subsequent":[112],"changes":[113],"gene":[115],"expression,":[116],"transactivation":[117],"of":[118,122,131,141,145],"EGFR,":[119],"modulation":[121],"activities":[124],"growth":[126],"factor-mediated":[127],"signaling.":[128],"While":[129],"many":[130,144],"individual":[134],"signals":[135],"relatively":[137],"small":[138],"terms":[140],"effect":[142],"size,":[143],"them":[146],"validated":[148],"combining":[150],"pathway":[151],"analysis":[152],"our":[154],"integrated":[155],"approach.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-04-28T14:05:53.105641","created_date":"2025-10-10T00:00:00"}
