{"id":"https://openalex.org/W2611216337","doi":"https://doi.org/10.1186/s12918-017-0428-y","title":"Parameter identifiability analysis and visualization in large-scale kinetic models of biosystems","display_name":"Parameter identifiability analysis and visualization in large-scale kinetic models of biosystems","publication_year":2017,"publication_date":"2017-05-05","ids":{"openalex":"https://openalex.org/W2611216337","doi":"https://doi.org/10.1186/s12918-017-0428-y","mag":"2611216337","pmid":"https://pubmed.ncbi.nlm.nih.gov/28476119"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-017-0428-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0428-y","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0428-y","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0428-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050239570","display_name":"Attila G\u00e1bor","orcid":"https://orcid.org/0000-0002-0776-1182"},"institutions":[{"id":"https://openalex.org/I887968799","display_name":"RWTH Aachen University","ror":"https://ror.org/04xfq0f34","country_code":"DE","type":"education","lineage":["https://openalex.org/I887968799"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Attila G\u00e1bor","raw_affiliation_strings":["BioProcess Engineering Group, IIM-CSIC, Eduardo Cabello 6, Vigo, 36208, Spain","JRC-COMBINE, RWTH Aachen University, Photonics Cluster, Level 4, Campus-Boulevard 79, Aachen, 52074, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioProcess Engineering Group, IIM-CSIC, Eduardo Cabello 6, Vigo, 36208, Spain","institution_ids":[]},{"raw_affiliation_string":"JRC-COMBINE, RWTH Aachen University, Photonics Cluster, Level 4, Campus-Boulevard 79, Aachen, 52074, Germany","institution_ids":["https://openalex.org/I887968799"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032919554","display_name":"Alejandro F. Villaverde","orcid":"https://orcid.org/0000-0001-7401-7380"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alejandro F. Villaverde","raw_affiliation_strings":["BioProcess Engineering Group, IIM-CSIC, Eduardo Cabello 6, Vigo, 36208, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioProcess Engineering Group, IIM-CSIC, Eduardo Cabello 6, Vigo, 36208, Spain","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090264675","display_name":"Julio R. Banga","orcid":"https://orcid.org/0000-0002-4245-0320"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julio R. Banga","raw_affiliation_strings":["BioProcess Engineering Group, IIM-CSIC, Eduardo Cabello 6, Vigo, 36208, Spain. julio@iim.csic.es","BioProcess Engineering Group, IIM-CSIC, Eduardo Cabello 6, Vigo, 36208, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioProcess Engineering Group, IIM-CSIC, Eduardo Cabello 6, Vigo, 36208, Spain. julio@iim.csic.es","institution_ids":[]},{"raw_affiliation_string":"BioProcess Engineering Group, IIM-CSIC, Eduardo Cabello 6, Vigo, 36208, Spain","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5050239570"],"corresponding_institution_ids":["https://openalex.org/I887968799"],"apc_list":null,"apc_paid":null,"fwci":6.0549,"has_fulltext":true,"cited_by_count":136,"citation_normalized_percentile":{"value":0.97211716,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"11","issue":"1","first_page":"54","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.8123999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.8123999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.062199998646974564,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.03240000084042549,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/identifiability","display_name":"Identifiability","score":0.9359843730926514},{"id":"https://openalex.org/keywords/collinearity","display_name":"Collinearity","score":0.8584153056144714},{"id":"https://openalex.org/keywords/estimation-theory","display_name":"Estimation theory","score":0.6048343777656555},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5960428714752197},{"id":"https://openalex.org/keywords/pairwise-comparison","display_name":"Pairwise comparison","score":0.4862324297428131},{"id":"https://openalex.org/keywords/scale","display_name":"Scale (ratio)","score":0.443936824798584},{"id":"https://openalex.org/keywords/visualization","display_name":"Visualization","score":0.4393068552017212},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4315977692604065},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.33547329902648926},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.32922428846359253},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.32122522592544556},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.27056097984313965},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.19968447089195251},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.18170464038848877}],"concepts":[{"id":"https://openalex.org/C122770356","wikidata":"https://www.wikidata.org/wiki/Q1656753","display_name":"Identifiability","level":2,"score":0.9359843730926514},{"id":"https://openalex.org/C106192678","wikidata":"https://www.wikidata.org/wiki/Q1419761","display_name":"Collinearity","level":2,"score":0.8584153056144714},{"id":"https://openalex.org/C167928553","wikidata":"https://www.wikidata.org/wiki/Q1376021","display_name":"Estimation theory","level":2,"score":0.6048343777656555},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5960428714752197},{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.4862324297428131},{"id":"https://openalex.org/C2778755073","wikidata":"https://www.wikidata.org/wiki/Q10858537","display_name":"Scale (ratio)","level":2,"score":0.443936824798584},{"id":"https://openalex.org/C36464697","wikidata":"https://www.wikidata.org/wiki/Q451553","display_name":"Visualization","level":2,"score":0.4393068552017212},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4315977692604065},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.33547329902648926},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.32922428846359253},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.32122522592544556},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.27056097984313965},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.19968447089195251},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.18170464038848877},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057906","descriptor_name":"Circadian Clocks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057906","descriptor_name":"Circadian Clocks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057906","descriptor_name":"Circadian Clocks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/s12918-017-0428-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0428-y","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0428-y","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:28476119","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28476119","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:digital.csic.es:10261/150582","is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/150582","pdf_url":null,"source":{"id":"https://openalex.org/S4306401639","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Art\u00edculo"},{"id":"pmh:oai:digital.csic.es:10261/149158","is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/149158","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"art\u00edculo"},{"id":"pmh:oai:doaj.org/article:3f227539d39b4dc8a222982aad30b6c0","is_oa":false,"landing_page_url":"https://doaj.org/article/3f227539d39b4dc8a222982aad30b6c0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 11, Iss 1, Pp 1-16 (2017)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5420165","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5420165","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmh:oai:zenodo.org:572417","is_oa":true,"landing_page_url":"https://zenodo.org/record/572417","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology 11(1) 54","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s12918-017-0428-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0428-y","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0428-y","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2579040122","display_name":null,"funder_award_id":"EU FP7","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3031855127","display_name":null,"funder_award_id":"686282","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G4331124372","display_name":"Network for Integrated Cellular Homeostasis","funder_award_id":"289384","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7515004340","display_name":"Generation of the CanPath prototype - a platform for predictive cancer pathway modeling","funder_award_id":"686282","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2611216337.pdf","grobid_xml":"https://content.openalex.org/works/W2611216337.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W19125392","https://openalex.org/W100464641","https://openalex.org/W155156393","https://openalex.org/W178056938","https://openalex.org/W836474583","https://openalex.org/W1485858078","https://openalex.org/W1509329028","https://openalex.org/W1758405515","https://openalex.org/W1847315806","https://openalex.org/W1860450641","https://openalex.org/W1922871238","https://openalex.org/W1965324089","https://openalex.org/W1971663243","https://openalex.org/W1972629843","https://openalex.org/W1974129636","https://openalex.org/W1975383652","https://openalex.org/W1977370000","https://openalex.org/W1985036386","https://openalex.org/W1997774242","https://openalex.org/W1998523300","https://openalex.org/W2002023837","https://openalex.org/W2004322850","https://openalex.org/W2007591867","https://openalex.org/W2010334716","https://openalex.org/W2012985604","https://openalex.org/W2019264851","https://openalex.org/W2019877779","https://openalex.org/W2020425795","https://openalex.org/W2023106695","https://openalex.org/W2027198087","https://openalex.org/W2033783472","https://openalex.org/W2039085300","https://openalex.org/W2040571528","https://openalex.org/W2046915036","https://openalex.org/W2048792111","https://openalex.org/W2053339983","https://openalex.org/W2054189030","https://openalex.org/W2069805373","https://openalex.org/W2081781433","https://openalex.org/W2086309978","https://openalex.org/W2086988962","https://openalex.org/W2101647774","https://openalex.org/W2103641729","https://openalex.org/W2104489368","https://openalex.org/W2109571753","https://openalex.org/W2110079127","https://openalex.org/W2111652881","https://openalex.org/W2111807512","https://openalex.org/W2113105229","https://openalex.org/W2127419446","https://openalex.org/W2133068979","https://openalex.org/W2134280223","https://openalex.org/W2143350753","https://openalex.org/W2148321265","https://openalex.org/W2154387393","https://openalex.org/W2159675211","https://openalex.org/W2164898811","https://openalex.org/W2165603655","https://openalex.org/W2170484057","https://openalex.org/W2213612645","https://openalex.org/W2219479419","https://openalex.org/W2320477252","https://openalex.org/W2416901147","https://openalex.org/W2472163094","https://openalex.org/W2487561117","https://openalex.org/W2494911954","https://openalex.org/W2541490590","https://openalex.org/W2561513855","https://openalex.org/W2737993238"],"related_works":["https://openalex.org/W2212594028","https://openalex.org/W1974129636","https://openalex.org/W2552635486","https://openalex.org/W1598584175","https://openalex.org/W3006948849","https://openalex.org/W3214883977","https://openalex.org/W1998523300","https://openalex.org/W2173736524","https://openalex.org/W1972488940","https://openalex.org/W2130590832"],"abstract_inverted_index":{"BACKGROUND:":[0],"Kinetic":[1],"models":[2,234,292],"of":[3,8,18,41,64,84,156,169,187,209,245,290,293,328],"biochemical":[4],"systems":[5],"usually":[6],"consist":[7],"ordinary":[9],"differential":[10],"equations":[11],"that":[12,25,111,204,308,321],"have":[13],"many":[14],"unknown":[15],"parameters.":[16,158,172],"Some":[17],"these":[19],"parameters":[20,55,86,137,188,248],"are":[21,39,257,309],"often":[22],"practically":[23],"unidentifiable,":[24],"is,":[26],"their":[27,88,298],"values":[28],"cannot":[29],"be":[30,57,177,323],"uniquely":[31],"determined":[32],"from":[33,272],"the":[34,44,60,82,121,134,153,162,182,191,195,202,210,242,246,250,286,326],"available":[35,268],"data.":[36],"Possible":[37],"causes":[38],"lack":[40],"influence":[42],"on":[43],"measured":[45],"outputs,":[46],"interdependence":[47],"among":[48,116],"parameters,":[49,117],"and":[50,87,118,184,213,224,230,296,311,316],"poor":[51],"data":[52],"quality.":[53],"Uncorrelated":[54],"can":[56,176,322],"seen":[58],"as":[59,259,269],"key":[61],"tuning":[62],"knobs":[63],"a":[65,109,129,139,142,260],"predictive":[66],"model.":[67],"Therefore,":[68],"before":[69],"attempting":[70],"to":[71,80,98,123,132,151,165,220,305],"perform":[72,99],"parameter":[73,100,214],"estimation":[74,215],"(model":[75],"calibration)":[76],"it":[77,94],"is":[78,92,95,266,280],"important":[79],"characterize":[81],"subset(s)":[83],"identifiable":[85,183],"interplay.":[89],"Once":[90],"this":[91],"achieved,":[93],"still":[96],"necessary":[97],"estimation,":[101],"which":[102,265],"poses":[103],"additional":[104],"challenges.":[105],"METHODS:":[106],"We":[107,127,159,217],"present":[108],"methodology":[110],"(i)":[112],"detects":[113],"high-order":[114],"relationships":[115],"(ii)":[119],"visualizes":[120],"results":[122,174],"facilitate":[124],"further":[125],"analysis.":[126],"use":[128,161],"collinearity":[130,163],"index":[131,164],"quantify":[133],"correlation":[135],"between":[136],"in":[138,141,194,325],"group":[140],"computationally":[143],"efficient":[144],"way.":[145],"Then":[146,239],"we":[147,240],"apply":[148],"integer":[149],"optimization":[150,223],"find":[152],"largest":[154],"groups":[155,168,186],"uncorrelated":[157],"also":[160],"identify":[166],"small":[167],"highly":[170],"correlated":[171],"The":[173,253,300],"files":[175],"visualized":[178],"using":[179,249],"Cytoscape,":[180],"showing":[181],"non-identifiable":[185],"together":[189],"with":[190,235,319],"model":[192],"structure":[193],"same":[196],"graph.":[197],"RESULTS:":[198],"Our":[199,278],"contributions":[200],"alleviate":[201],"difficulties":[203],"appear":[205],"at":[206],"different":[207],"stages":[208],"identifiability":[211,244,254,288],"analysis":[212,255,289],"process.":[216],"show":[218],"how":[219],"combine":[221],"global":[222],"regularization":[225],"techniques":[226,256],"for":[227],"calibrating":[228],"medium":[229],"large":[231,294],"scale":[232],"biological":[233],"moderate":[236],"computation":[237],"times.":[238],"evaluate":[241],"practical":[243,287],"estimated":[247],"proposed":[251],"methodology.":[252],"implemented":[258],"MATLAB":[261],"toolbox":[262],"called":[263],"VisId,":[264],"freely":[267],"open":[270],"source":[271],"GitHub":[273],"(":[274],"https://github.com/gabora/visid":[275],").":[276],"CONCLUSIONS:":[277],"approach":[279],"geared":[281],"towards":[282],"scalability.":[283],"It":[284],"enables":[285],"dynamic":[291],"size,":[295],"accelerates":[297],"calibration.":[299],"visualization":[301],"tool":[302],"allows":[303],"modellers":[304],"detect":[306],"parts":[307],"problematic":[310],"need":[312],"refinement":[313],"or":[314],"reformulation,":[315],"provides":[317],"experimentalists":[318],"information":[320],"helpful":[324],"design":[327],"new":[329],"experiments.":[330]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":18},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":4}],"updated_date":"2026-05-23T08:51:43.019350","created_date":"2025-10-10T00:00:00"}