{"id":"https://openalex.org/W2609276452","doi":"https://doi.org/10.1186/s12918-017-0425-1","title":"Parameter inference for stochastic single-cell dynamics from lineage tree data","display_name":"Parameter inference for stochastic single-cell dynamics from lineage tree data","publication_year":2017,"publication_date":"2017-04-26","ids":{"openalex":"https://openalex.org/W2609276452","doi":"https://doi.org/10.1186/s12918-017-0425-1","mag":"2609276452","pmid":"https://pubmed.ncbi.nlm.nih.gov/28446158"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-017-0425-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0425-1","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0425-1","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0425-1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014486763","display_name":"Irena Kuzmanovska","orcid":null},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Irena Kuzmanovska","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, Basel, 4058, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, Basel, 4058, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003041168","display_name":"Andreas Milias\u2010Argeitis","orcid":"https://orcid.org/0000-0002-4291-4228"},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH","NL"],"is_corresponding":false,"raw_author_name":"Andreas Milias-Argeitis","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, Basel, 4058, Switzerland","Groningen Biomolecular Sciences and Biotechnology, University of Groningen, Nijenborgh 4, Groningen, 9747, AG, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, Basel, 4058, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Groningen Biomolecular Sciences and Biotechnology, University of Groningen, Nijenborgh 4, Groningen, 9747, AG, Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022921421","display_name":"Jan Mikelson","orcid":"https://orcid.org/0000-0001-5233-4756"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jan Mikelson","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, Basel, 4058, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, Basel, 4058, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084982232","display_name":"Christoph Zechner","orcid":"https://orcid.org/0000-0003-1300-6076"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I4210159854","display_name":"Max Planck Institute of Molecular Cell Biology and Genetics","ror":"https://ror.org/05b8d3w18","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210159854"]}],"countries":["CH","DE"],"is_corresponding":false,"raw_author_name":"Christoph Zechner","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, Basel, 4058, Switzerland","Max Planck Institute of Molecular Cell Biology and Genetics and Center for Systems Biology, Pfotenhauerstrasse 108, Dresden, 01307, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, Basel, 4058, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"Max Planck Institute of Molecular Cell Biology and Genetics and Center for Systems Biology, Pfotenhauerstrasse 108, Dresden, 01307, Germany","institution_ids":["https://openalex.org/I4210159854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018485369","display_name":"Mustafa Khammash","orcid":"https://orcid.org/0000-0002-4855-9220"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mustafa Khammash","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, Basel, 4058, Switzerland. mustafa.khammash@bsse.ethz.ch","Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, Basel, 4058, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, Basel, 4058, Switzerland. mustafa.khammash@bsse.ethz.ch","institution_ids":[]},{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, Basel, 4058, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5014486763"],"corresponding_institution_ids":["https://openalex.org/I35440088"],"apc_list":null,"apc_paid":{"value":1507,"currency":"EUR","value_usd":1625},"fwci":1.1215,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.76989613,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"11","issue":"1","first_page":"52","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.6261000037193298,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.6261000037193298,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.2021999955177307,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.043800000101327896,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.6645858287811279},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5494781732559204},{"id":"https://openalex.org/keywords/tree","display_name":"Tree (set theory)","score":0.5441187620162964},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.537581205368042},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4868023097515106},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.45984944701194763},{"id":"https://openalex.org/keywords/lineage","display_name":"Lineage (genetic)","score":0.44863763451576233},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4290218949317932},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.36668962240219116},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2634429931640625},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2013651728630066},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.14562207460403442},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.09398883581161499},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08599096536636353},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.0829990804195404}],"concepts":[{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.6645858287811279},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5494781732559204},{"id":"https://openalex.org/C113174947","wikidata":"https://www.wikidata.org/wiki/Q2859736","display_name":"Tree (set theory)","level":2,"score":0.5441187620162964},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.537581205368042},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4868023097515106},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.45984944701194763},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.44863763451576233},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4290218949317932},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.36668962240219116},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2634429931640625},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2013651728630066},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14562207460403442},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.09398883581161499},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08599096536636353},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0829990804195404},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000074021","descriptor_name":"Interatrial Block","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074021","descriptor_name":"Interatrial Block","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074021","descriptor_name":"Interatrial Block","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1186/s12918-017-0425-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0425-1","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0425-1","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:28446158","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28446158","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pure.rug.nl:openaire_cris_publications/81043014-cb0b-4d77-b720-a07cd365bbaf","is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/81043014-cb0b-4d77-b720-a07cd365bbaf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kuzmanovska, I, Milias Argeitis, A, Mikelson, J, Zechner, C & Khammash, M 2017, 'Parameter inference for stochastic single-cell dynamics from lineage tree data', BMC Systems Biology, vol. 11, no. 52, 52. https://doi.org/10.1186/s12918-017-0425-1","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:pure.rug.nl:publications/81043014-cb0b-4d77-b720-a07cd365bbaf","is_oa":true,"landing_page_url":"https://hdl.handle.net/11370/81043014-cb0b-4d77-b720-a07cd365bbaf","pdf_url":"https://pure.rug.nl/ws/files/44603946/document.pdf","source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Kuzmanovska, I, Milias Argeitis, A, Mikelson, J, Zechner, C & Khammash, M 2017, 'Parameter inference for stochastic single-cell dynamics from lineage tree data', BMC Systems Biology, vol. 11, no. 52, 52. https://doi.org/10.1186/s12918-017-0425-1","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:d3bd0104bd6f4a849b7378ec10a23a99","is_oa":false,"landing_page_url":"https://doaj.org/article/d3bd0104bd6f4a849b7378ec10a23a99","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 11, Iss 1, Pp 1-13 (2017)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4254644","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5406901","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pure.mpg.de:item_2642570","is_oa":false,"landing_page_url":"http://hdl.handle.net/21.11116/0000-0002-8CFB-6","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC systems biology","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/191159","is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/191159","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, 11","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"doi:10.3929/ethz-b-000191159","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000191159","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/s12918-017-0425-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0425-1","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0425-1","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2609276452.pdf","grobid_xml":"https://content.openalex.org/works/W2609276452.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1697620700","https://openalex.org/W1978319180","https://openalex.org/W1979969656","https://openalex.org/W1990119892","https://openalex.org/W2033540576","https://openalex.org/W2042382417","https://openalex.org/W2053644777","https://openalex.org/W2070423493","https://openalex.org/W2081970839","https://openalex.org/W2086128646","https://openalex.org/W2091860746","https://openalex.org/W2103029525","https://openalex.org/W2108174382","https://openalex.org/W2111787305","https://openalex.org/W2122028584","https://openalex.org/W2124055046","https://openalex.org/W2127006594","https://openalex.org/W2168282770","https://openalex.org/W2171280873","https://openalex.org/W2224825994","https://openalex.org/W2262285937","https://openalex.org/W2337712693","https://openalex.org/W2550226555","https://openalex.org/W2550701680","https://openalex.org/W3099969635","https://openalex.org/W3100622648"],"related_works":["https://openalex.org/W2506149209","https://openalex.org/W2352153050","https://openalex.org/W2140071436","https://openalex.org/W2055243143","https://openalex.org/W4210395781","https://openalex.org/W2393965794","https://openalex.org/W2091678252","https://openalex.org/W1972233104","https://openalex.org/W2319071804","https://openalex.org/W2578129866"],"abstract_inverted_index":{"BACKGROUND:":[0],"With":[1],"the":[2,12,24,48,52,56,80,83,117,140,149,161,172,197,207,246,258,267],"advance":[3],"of":[4,14,36,39,67,82,111,180,226,248,260],"experimental":[5],"techniques":[6],"such":[7,183,224],"as":[8,184,253],"time-lapse":[9,100],"fluorescence":[10],"microscopy,":[11],"availability":[13],"single-cell":[15,44,99,241],"trajectory":[16],"data":[17,101,244],"has":[18,23],"vastly":[19],"increased,":[20],"and":[21,51,121,158,233,251,263],"so":[22],"demand":[25],"for":[26,30,95,115,126,223,245,257],"computational":[27],"methods":[28,42,213],"suitable":[29],"parameter":[31,96,118,127,249],"inference":[32,97,132,212,250],"with":[33],"this":[34,60,88,216],"type":[35,225],"data.":[37],"Most":[38],"currently":[40],"available":[41],"treat":[43],"trajectories":[45],"independently,":[46],"ignoring":[47],"mother-daughter":[49],"relationships":[50],"information":[53,61,143,205,217],"provided":[54],"by":[55],"population":[57],"structure.":[58],"However,":[59],"is":[62,144,200],"essential":[63],"if":[64,74],"a":[65,92,109,231,254],"process":[66],"interest":[68],"happens":[69],"at":[70,155],"cell":[71,84,150,156,162,186,198],"division,":[72],"or":[73,189],"it":[75],"evolves":[76],"slowly":[77,165],"compared":[78],"to":[79,202,220,237],"duration":[81],"cycle.":[85],"RESULTS:":[86],"In":[87],"work,":[89],"we":[90],"propose":[91],"Bayesian":[93],"framework":[94,133],"on":[98,108,134],"from":[102],"lineage":[103,141,242],"trees.":[104],"Our":[105,228],"method":[106,229],"relies":[107],"combination":[110],"Sequential":[112],"Monte":[113,124],"Carlo":[114,125],"approximating":[116],"likelihood":[119],"function":[120],"Markov":[122],"Chain":[123],"exploration.":[128],"We":[129],"demonstrate":[130],"our":[131],"two":[135],"simple":[136,232],"examples":[137,179],"in":[138,147,194,266],"which":[139,148],"tree":[142,243],"crucial:":[145],"one":[146],"phenotype":[151],"can":[152],"only":[153],"switch":[154],"division":[157],"another":[159],"where":[160,196],"state":[163],"fluctuates":[164],"over":[166],"timescales":[167],"that":[168,214],"extend":[169],"well":[170],"beyond":[171],"cell-cycle":[173],"duration.":[174],"CONCLUSION:":[175],"There":[176],"exist":[177],"several":[178],"biological":[181],"processes,":[182],"stem":[185],"fate":[187],"decisions":[188],"epigenetically":[190],"controlled":[191],"phase":[192],"variation":[193],"bacteria,":[195],"ancestry":[199],"expected":[201,219],"contain":[203],"important":[204],"about":[206],"underlying":[208],"system":[209],"dynamics.":[210],"Parameter":[211],"discard":[215],"are":[218],"perform":[221],"poorly":[222],"processes.":[227],"provides":[230],"computationally":[234],"efficient":[235],"way":[236],"take":[238],"into":[239],"account":[240],"purpose":[247],"serves":[252],"starting":[255],"point":[256],"development":[259],"more":[261],"sophisticated":[262],"powerful":[264],"approaches":[265],"future.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
