{"id":"https://openalex.org/W2604791900","doi":"https://doi.org/10.1186/s12918-017-0424-2","title":"Quantitative evaluation and reversion analysis of the attractor landscapes of an intracellular regulatory network for colorectal cancer","display_name":"Quantitative evaluation and reversion analysis of the attractor landscapes of an intracellular regulatory network for colorectal cancer","publication_year":2017,"publication_date":"2017-04-05","ids":{"openalex":"https://openalex.org/W2604791900","doi":"https://doi.org/10.1186/s12918-017-0424-2","mag":"2604791900","pmid":"https://pubmed.ncbi.nlm.nih.gov/28381275"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-017-0424-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0424-2","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0424-2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0424-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057737838","display_name":"Yunseong Kim","orcid":null},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Yunseong Kim","raw_affiliation_strings":["Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033615709","display_name":"Sea R. Choi","orcid":"https://orcid.org/0000-0001-8066-7187"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sea Choi","raw_affiliation_strings":["Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075594656","display_name":"Dongkwan Shin","orcid":"https://orcid.org/0000-0002-6925-1081"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dongkwan Shin","raw_affiliation_strings":["Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034286632","display_name":"Kwang\u2010Hyun Cho","orcid":"https://orcid.org/0000-0002-7380-7142"},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kwang-Hyun Cho","raw_affiliation_strings":["Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea. ckh@kaist.ac.kr","Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea. ckh@kaist.ac.kr","institution_ids":[]},{"raw_affiliation_string":"Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5057737838"],"corresponding_institution_ids":["https://openalex.org/I157485424"],"apc_list":null,"apc_paid":null,"fwci":1.0094,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.7503675,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"11","issue":"1","first_page":"45","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.2660999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.2660999894142151,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.2581999897956848,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.09790000319480896,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reversion","display_name":"Reversion","score":0.8801771402359009},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.6853243708610535},{"id":"https://openalex.org/keywords/attractor","display_name":"Attractor","score":0.6535254120826721},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.6468005776405334},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6124604344367981},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"Colorectal cancer","score":0.598145067691803},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5889722108840942},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"Carcinogenesis","score":0.5840601325035095},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5396438241004944},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.515482485294342},{"id":"https://openalex.org/keywords/boolean-network","display_name":"Boolean network","score":0.48098576068878174},{"id":"https://openalex.org/keywords/network-analysis","display_name":"Network analysis","score":0.4559415578842163},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.4334165155887604},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.40021610260009766},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3925071358680725},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.26487094163894653},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.21405616402626038},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.192058265209198},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.18284830451011658},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.10827690362930298},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.10283571481704712},{"id":"https://openalex.org/keywords/boolean-function","display_name":"Boolean function","score":0.08958187699317932}],"concepts":[{"id":"https://openalex.org/C70883133","wikidata":"https://www.wikidata.org/wiki/Q7318316","display_name":"Reversion","level":4,"score":0.8801771402359009},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.6853243708610535},{"id":"https://openalex.org/C164380108","wikidata":"https://www.wikidata.org/wiki/Q507187","display_name":"Attractor","level":2,"score":0.6535254120826721},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.6468005776405334},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6124604344367981},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.598145067691803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5889722108840942},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5840601325035095},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5396438241004944},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.515482485294342},{"id":"https://openalex.org/C134444547","wikidata":"https://www.wikidata.org/wiki/Q585230","display_name":"Boolean network","level":3,"score":0.48098576068878174},{"id":"https://openalex.org/C32946077","wikidata":"https://www.wikidata.org/wiki/Q618079","display_name":"Network analysis","level":2,"score":0.4559415578842163},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4334165155887604},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40021610260009766},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3925071358680725},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26487094163894653},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21405616402626038},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.192058265209198},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.18284830451011658},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.10827690362930298},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.10283571481704712},{"id":"https://openalex.org/C187455244","wikidata":"https://www.wikidata.org/wiki/Q942353","display_name":"Boolean function","level":2,"score":0.08958187699317932},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12918-017-0424-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0424-2","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0424-2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:28381275","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28381275","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:c7a3333c4f9040fe8d24fa639b50e0e7","is_oa":false,"landing_page_url":"https://doaj.org/article/c7a3333c4f9040fe8d24fa639b50e0e7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, Vol 11, Iss 1, Pp 1-11 (2017)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5382366","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5382366","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-017-0424-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0424-2","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0424-2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5199999809265137,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G3809761278","display_name":null,"funder_award_id":"2014R1A2A1A10052404","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2604791900.pdf","grobid_xml":"https://content.openalex.org/works/W2604791900.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1515045756","https://openalex.org/W1521309811","https://openalex.org/W1604468403","https://openalex.org/W1655178001","https://openalex.org/W1886063157","https://openalex.org/W1927360907","https://openalex.org/W1934094702","https://openalex.org/W1964405387","https://openalex.org/W1971224531","https://openalex.org/W1977198605","https://openalex.org/W1981409633","https://openalex.org/W1991980854","https://openalex.org/W1994540622","https://openalex.org/W1996949194","https://openalex.org/W2000896073","https://openalex.org/W2002404925","https://openalex.org/W2005868479","https://openalex.org/W2006485696","https://openalex.org/W2008353852","https://openalex.org/W2010873488","https://openalex.org/W2018159884","https://openalex.org/W2042933379","https://openalex.org/W2044013267","https://openalex.org/W2053374287","https://openalex.org/W2056062576","https://openalex.org/W2057769265","https://openalex.org/W2065769502","https://openalex.org/W2066808368","https://openalex.org/W2069593816","https://openalex.org/W2074185075","https://openalex.org/W2086333179","https://openalex.org/W2087422732","https://openalex.org/W2088245621","https://openalex.org/W2091321756","https://openalex.org/W2093182480","https://openalex.org/W2094025864","https://openalex.org/W2094564316","https://openalex.org/W2106548070","https://openalex.org/W2108516575","https://openalex.org/W2110980999","https://openalex.org/W2111326065","https://openalex.org/W2117692326","https://openalex.org/W2119779058","https://openalex.org/W2132935366","https://openalex.org/W2138908323","https://openalex.org/W2139836283","https://openalex.org/W2144916771","https://openalex.org/W2146750548","https://openalex.org/W2154799239","https://openalex.org/W2163480486","https://openalex.org/W2167437179","https://openalex.org/W2464985146","https://openalex.org/W2535389011","https://openalex.org/W2594463419","https://openalex.org/W3101634756","https://openalex.org/W3103071483","https://openalex.org/W6650796741"],"related_works":["https://openalex.org/W2402814600","https://openalex.org/W2158714033","https://openalex.org/W2171835071","https://openalex.org/W78967844","https://openalex.org/W2097450978","https://openalex.org/W3213185671","https://openalex.org/W4210989272","https://openalex.org/W2128085946","https://openalex.org/W4386628104","https://openalex.org/W4323921938"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cancer":[1],"reversion,":[2],"converting":[3],"the":[4,83,87,91,105,119,130,152],"phenotypes":[5],"of":[6,12,47,90,104,132,154,158,161],"a":[7,13,36,43,73],"cancer":[8],"cell":[9],"into":[10],"those":[11],"normal":[14,74],"cell,":[15],"has":[16,26],"been":[17,27],"sporadically":[18],"observed":[19],"throughout":[20],"history.":[21],"However,":[22],"no":[23],"systematic":[24],"analysis":[25,148],"attempted":[28],"so":[29],"far.":[30],"RESULTS:":[31],"To":[32],"investigate":[33],"this":[34],"from":[35,58],"systems":[37,147],"biological":[38],"perspective,":[39],"we":[40],"have":[41],"constructed":[42],"logical":[44],"network":[45,84,124],"model":[46],"colorectal":[48],"tumorigenesis":[49,155],"by":[50,76],"integrating":[51],"key":[52],"regulatory":[53,140],"molecules":[54],"and":[55,85,100,156],"their":[56],"interactions":[57],"previous":[59,113],"experimental":[60],"data.":[61],"We":[62,115],"identified":[63,106,120],"molecular":[64,80],"targets":[65,107,121],"that":[66,118,126],"can":[67],"reverse":[68],"cancerous":[69,135],"cellular":[70,136],"states":[71,137],"to":[72,96,128,151],"state":[75],"systematically":[77],"perturbing":[78],"each":[79],"activity":[81],"in":[82,110,134],"evaluating":[86],"resulting":[88],"changes":[89],"attractor":[92],"landscape":[93],"with":[94,112],"respect":[95],"uncontrolled":[97],"proliferation,":[98],"EMT,":[99],"stemness.":[101],"Intriguingly,":[102],"many":[103],"were":[108],"well":[109],"accord":[111],"studies.":[114],"further":[116],"revealed":[117],"constitute":[122],"stable":[123],"motifs":[125],"contribute":[127],"enhancing":[129],"robustness":[131],"attractors":[133],"against":[138],"diverse":[139],"signals.":[141],"CONCLUSIONS:":[142],"The":[143],"proposed":[144],"framework":[145],"for":[146],"is":[149],"applicable":[150],"study":[153],"reversion":[157],"other":[159],"types":[160],"cancer.":[162]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}