{"id":"https://openalex.org/W2606575226","doi":"https://doi.org/10.1186/s12918-017-0420-6","title":"An additional k-means clustering step improves the biological features of WGCNA gene co-expression networks","display_name":"An additional k-means clustering step improves the biological features of WGCNA gene co-expression networks","publication_year":2017,"publication_date":"2017-04-11","ids":{"openalex":"https://openalex.org/W2606575226","doi":"https://doi.org/10.1186/s12918-017-0420-6","mag":"2606575226","pmid":"https://pubmed.ncbi.nlm.nih.gov/28403906"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-017-0420-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0420-6","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0420-6","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0420-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025988686","display_name":"Juan A. Bot\u00eda","orcid":"https://orcid.org/0000-0002-6992-598X"},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I4210153400","display_name":"King's College Hospital","ror":"https://ror.org/044nptt90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111135","https://openalex.org/I4210153400"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Juan A. Bot\u00eda","raw_affiliation_strings":["Department of Medical & Molecular Genetics, School of Medical Sciences, King's College London, Guy's Hospital, London, SE1 9RT, UK. j.botia@ucl.ac.uk","Department of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London, WC1N, UK. j.botia@ucl.ac.uk","Department of Medical & Molecular Genetics, School of Medical Sciences, King's College London, Guy's Hospital, London, SE1 9RT, UK","Department of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London, WC1N, UK"],"raw_orcid":"https://orcid.org/0000-0002-6992-598X","affiliations":[{"raw_affiliation_string":"Department of Medical & Molecular Genetics, School of Medical Sciences, King's College London, Guy's Hospital, London, SE1 9RT, UK. j.botia@ucl.ac.uk","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I183935753","https://openalex.org/I4210153400"]},{"raw_affiliation_string":"Department of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London, WC1N, UK. j.botia@ucl.ac.uk","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Department of Medical & Molecular Genetics, School of Medical Sciences, King's College London, Guy's Hospital, London, SE1 9RT, UK","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I183935753"]},{"raw_affiliation_string":"Department of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London, WC1N, UK","institution_ids":["https://openalex.org/I4210151618","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057145376","display_name":"Jana Vandrovcov\u00e1","orcid":"https://orcid.org/0000-0001-9508-0477"},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jana Vandrovcova","raw_affiliation_strings":["Department of Medical & Molecular Genetics, School of Medical Sciences, King's College London, Guy's Hospital, London, SE1 9RT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical & Molecular Genetics, School of Medical Sciences, King's College London, Guy's Hospital, London, SE1 9RT, UK","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010552635","display_name":"Paola Forabosco","orcid":"https://orcid.org/0000-0002-2006-2693"},"institutions":[{"id":"https://openalex.org/I4210116388","display_name":"Institute of Genetic and Biomedical Research","ror":"https://ror.org/02dr63s31","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210116388","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Forabosco","raw_affiliation_strings":["Istituto di Ricerca Genetica e Biomedica, CNR, Cittadella Universitaria di Monserrato, Monserrato, 09042, CA, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto di Ricerca Genetica e Biomedica, CNR, Cittadella Universitaria di Monserrato, Monserrato, 09042, CA, Italy","institution_ids":["https://openalex.org/I4210116388"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051204041","display_name":"Sebastian Guelfi","orcid":"https://orcid.org/0000-0002-0256-2686"},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sebastian Guelfi","raw_affiliation_strings":["Department of Medical & Molecular Genetics, School of Medical Sciences, King's College London, Guy's Hospital, London, SE1 9RT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical & Molecular Genetics, School of Medical Sciences, King's College London, Guy's Hospital, London, SE1 9RT, UK","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008997142","display_name":"Karishma D\u2019Sa","orcid":"https://orcid.org/0000-0003-1266-419X"},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Karishma D\u2019Sa","raw_affiliation_strings":["Department of Medical & Molecular Genetics, School of Medical Sciences, King\u2019s College London, Guy\u2019s Hospital, London, SE1 9RT, UK","Department of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London, WC1N, UK","Department of Medical & Molecular Genetics, School of Medical Sciences, King's College London, Guy's Hospital, London, SE1 9RT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical & Molecular Genetics, School of Medical Sciences, King\u2019s College London, Guy\u2019s Hospital, London, SE1 9RT, UK","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I183935753"]},{"raw_affiliation_string":"Department of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London, WC1N, UK","institution_ids":["https://openalex.org/I4210151618","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Department of Medical & Molecular Genetics, School of Medical Sciences, King's College London, Guy's Hospital, London, SE1 9RT, UK","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020514779","display_name":"John Hardy","orcid":"https://orcid.org/0000-0002-3122-0423"},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"John Hardy","raw_affiliation_strings":["Department of Medical & Molecular Genetics, School of Medical Sciences, King's College London, Guy's Hospital, London, SE1 9RT, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical & Molecular Genetics, School of Medical Sciences, King's College London, Guy's Hospital, London, SE1 9RT, UK","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I183935753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045289228","display_name":"Cathryn M. Lewis","orcid":"https://orcid.org/0000-0002-8249-8476"},"institutions":[{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Cathryn M. Lewis","raw_affiliation_strings":["Department of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London, WC1N, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London, WC1N, UK","institution_ids":["https://openalex.org/I4210151618","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042439287","display_name":"Mina Ryten","orcid":"https://orcid.org/0000-0001-9520-6957"},"institutions":[{"id":"https://openalex.org/I1298207432","display_name":"Guy's Hospital","ror":"https://ror.org/04r33pf22","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1298207432","https://openalex.org/I200166805","https://openalex.org/I4210111135"]},{"id":"https://openalex.org/I183935753","display_name":"King's College London","ror":"https://ror.org/0220mzb33","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I183935753"]},{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mina Ryten","raw_affiliation_strings":["Department of Medical & Molecular Genetics, School of Medical Sciences, King's College London, Guy's Hospital, London, SE1 9RT, UK","Department of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London, WC1N, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical & Molecular Genetics, School of Medical Sciences, King's College London, Guy's Hospital, London, SE1 9RT, UK","institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I183935753"]},{"raw_affiliation_string":"Department of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London, WC1N, UK","institution_ids":["https://openalex.org/I4210151618","https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102710705","display_name":"Michael E. Weale","orcid":"https://orcid.org/0000-0003-4593-1186"},"institutions":[{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael E. Weale","raw_affiliation_strings":["Department of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London, WC1N, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Neuroscience, Institute of Neurology, University College London, Queen Square, London, WC1N, UK","institution_ids":["https://openalex.org/I4210151618","https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5025988686"],"corresponding_institution_ids":["https://openalex.org/I1298207432","https://openalex.org/I166337079","https://openalex.org/I183935753","https://openalex.org/I4210151618","https://openalex.org/I4210153400","https://openalex.org/I45129253"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":1647,"currency":"EUR","value_usd":1776},"fwci":11.1486,"has_fulltext":true,"cited_by_count":314,"citation_normalized_percentile":{"value":0.9904201,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"11","issue":"1","first_page":"47","last_page":"47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.703000009059906,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.703000009059906,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.2451000064611435,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.6755812764167786},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6343475580215454},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5816936492919922},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5541735887527466},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.49720314145088196},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.48431649804115295},{"id":"https://openalex.org/keywords/r-package","display_name":"R package","score":0.4731127917766571},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.43646159768104553},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.41687315702438354},{"id":"https://openalex.org/keywords/gene-co-expression-network","display_name":"Gene co-expression network","score":0.416820764541626},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3700917661190033},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.29372096061706543},{"id":"https://openalex.org/keywords/gene-ontology","display_name":"Gene ontology","score":0.2914891541004181},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2312379777431488},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16208836436271667}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.6755812764167786},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6343475580215454},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5816936492919922},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5541735887527466},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.49720314145088196},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.48431649804115295},{"id":"https://openalex.org/C2984074130","wikidata":"https://www.wikidata.org/wiki/Q73539779","display_name":"R package","level":2,"score":0.4731127917766571},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43646159768104553},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.41687315702438354},{"id":"https://openalex.org/C2778022302","wikidata":"https://www.wikidata.org/wiki/Q18207329","display_name":"Gene co-expression network","level":5,"score":0.416820764541626},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3700917661190033},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.29372096061706543},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.2914891541004181},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2312379777431488},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16208836436271667},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0},{"id":"https://openalex.org/C459310","wikidata":"https://www.wikidata.org/wiki/Q117801","display_name":"Computational science","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1186/s12918-017-0420-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0420-6","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0420-6","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:28403906","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28403906","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:5389000","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5389000","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-017-0420-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0420-6","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0420-6","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1492513106","display_name":null,"funder_award_id":"MR/K01417X/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G241875673","display_name":"Using genetic variability in whole transcriptome expression in cells and tissues to understand the pathogenesis of Parkinson's and Alzheimer's disease","funder_award_id":"MR/K01417X/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G3700906957","display_name":null,"funder_award_id":"MR/N008324/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G4261184745","display_name":null,"funder_award_id":"ACF-2012-17-017","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320321081","display_name":"Alzheimer\u2019s Research UK","ror":"https://ror.org/02ymzm013"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2606575226.pdf","grobid_xml":"https://content.openalex.org/works/W2606575226.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W388419421","https://openalex.org/W1490161904","https://openalex.org/W1508717233","https://openalex.org/W1533942137","https://openalex.org/W1891414773","https://openalex.org/W1966327575","https://openalex.org/W1974033269","https://openalex.org/W1977556410","https://openalex.org/W1979283544","https://openalex.org/W1989921625","https://openalex.org/W1993754619","https://openalex.org/W1995875735","https://openalex.org/W1999722941","https://openalex.org/W2019607502","https://openalex.org/W2032148328","https://openalex.org/W2033403400","https://openalex.org/W2048238468","https://openalex.org/W2061971803","https://openalex.org/W2071934167","https://openalex.org/W2072245877","https://openalex.org/W2073459066","https://openalex.org/W2095565380","https://openalex.org/W2104724027","https://openalex.org/W2109214922","https://openalex.org/W2116219421","https://openalex.org/W2124940469","https://openalex.org/W2124954099","https://openalex.org/W2130392987","https://openalex.org/W2135230352","https://openalex.org/W2139511828","https://openalex.org/W2139802966","https://openalex.org/W2141215651","https://openalex.org/W2156247618","https://openalex.org/W2156909104","https://openalex.org/W2158198121","https://openalex.org/W2209106767","https://openalex.org/W2236822143","https://openalex.org/W3105265400","https://openalex.org/W4230674625"],"related_works":["https://openalex.org/W2587303152","https://openalex.org/W2379232404","https://openalex.org/W2130939068","https://openalex.org/W3163717165","https://openalex.org/W2114466827","https://openalex.org/W249159571","https://openalex.org/W2791736663","https://openalex.org/W2806770614","https://openalex.org/W2129949791","https://openalex.org/W2131550814"],"abstract_inverted_index":{"BACKGROUND:":[0],"Weighted":[1],"Gene":[2,130],"Co-expression":[3],"Network":[4],"Analysis":[5],"(WGCNA)":[6],"is":[7],"a":[8,25,28,158],"widely":[9],"used":[10],"R":[11,54],"software":[12],"package":[13,55],"for":[14],"the":[15,53],"generation":[16],"of":[17,31,33,117,129,160],"gene":[18,59,196],"co-expression":[19,60],"networks":[20,70,81,96],"(GCN).":[21],"WGCNA":[22],"generates":[23],"both":[24],"GCN":[26],"and":[27,93,148],"derived":[29,97],"partitioning":[30],"clusters":[32,119],"genes":[34],"(modules).":[35],"We":[36,65,101],"propose":[37],"k-means":[38,173],"clustering":[39],"as":[40,176,195],"an":[41,177],"additional":[42],"processing":[43],"step":[44],"to":[45,58,157,179],"conventional":[46],"WGCNA,":[47,181],"which":[48],"we":[49],"have":[50],"implemented":[51],"in":[52,120,134,144,153,183],"km2gcn":[56],"(k-means":[57],"network,":[61],"https://github.com/juanbot/km2gcn":[62],").":[63],"RESULTS:":[64],"assessed":[66],"our":[67,168,172],"method":[68],"on":[69,80,94,124],"created":[71,82],"from":[72,83,98,167],"UKBEC":[73],"data":[74,85,155],"(10":[75],"different":[76],"human":[77,87],"brain":[78,91,146],"tissues),":[79,92],"GTEx":[84,99],"(42":[86],"tissues,":[88],"including":[89],"13":[90],"simulated":[95,154],"data.":[100],"observed":[102],"substantially":[103],"improved":[104,127,138,188],"module":[105],"properties,":[106],"including:":[107],"(1)":[108],"few":[109],"or":[110],"zero":[111],"misplaced":[112],"genes;":[113],"(2)":[114],"increased":[115],"counts":[116],"replicable":[118],"alternate":[121],"tissues":[122],"(x3.1":[123],"average);":[125],"(3)":[126],"enrichment":[128,141],"Ontology":[131],"terms":[132],"(seen":[133,143],"48/52":[135],"GCNs)":[136],"(4)":[137],"cell":[139],"type":[140],"signals":[142],"21/23":[145],"GCNs);":[147],"(5)":[149],"more":[150,191,199],"accurate":[151],"partitions":[152,189],"according":[156],"range":[159],"similarity":[161],"indices.":[162],"CONCLUSIONS:":[163],"The":[164],"results":[165,182],"obtained":[166],"investigations":[169],"indicate":[170],"that":[171],"method,":[174],"applied":[175],"adjunct":[178],"standard":[180],"better":[184],"network":[185],"partitions.":[186],"These":[187],"enable":[190],"fruitful":[192],"downstream":[193],"analyses,":[194],"modules":[197],"are":[198],"biologically":[200],"meaningful.":[201]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":37},{"year":2023,"cited_by_count":36},{"year":2022,"cited_by_count":52},{"year":2021,"cited_by_count":59},{"year":2020,"cited_by_count":51},{"year":2019,"cited_by_count":25},{"year":2018,"cited_by_count":23},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-29T09:40:50.615796","created_date":"2025-10-10T00:00:00"}
