{"id":"https://openalex.org/W2598113446","doi":"https://doi.org/10.1186/s12918-017-0418-0","title":"Delineating functional principles of the bow tie structure of a kinase-phosphatase network in the budding yeast","display_name":"Delineating functional principles of the bow tie structure of a kinase-phosphatase network in the budding yeast","publication_year":2017,"publication_date":"2017-03-16","ids":{"openalex":"https://openalex.org/W2598113446","doi":"https://doi.org/10.1186/s12918-017-0418-0","mag":"2598113446","pmid":"https://pubmed.ncbi.nlm.nih.gov/28298210"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-017-0418-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0418-0","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0418-0","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0418-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5027376792","display_name":"Diala Abd-Rabbo","orcid":null},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Diala Abd-Rabbo","raw_affiliation_strings":["Centre Robert-Cedergren, Bio-Informatique et G\u00e9nomique, Universit\u00e9 de Montr\u00e9al, C.P. 6128, Succursale centre-ville, Montr\u00e9al, Qu\u00e9bec, H3C 3J7, Canada","D\u00e9partement de Biochimie et M\u00e9decine Mol\u00e9culaire, Universit\u00e9 de Montr\u00e9al, C.P. 6128, Succursale centre-ville, Montr\u00e9al, Qu\u00e9bec, H3C 3J7, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Robert-Cedergren, Bio-Informatique et G\u00e9nomique, Universit\u00e9 de Montr\u00e9al, C.P. 6128, Succursale centre-ville, Montr\u00e9al, Qu\u00e9bec, H3C 3J7, Canada","institution_ids":["https://openalex.org/I70931966"]},{"raw_affiliation_string":"D\u00e9partement de Biochimie et M\u00e9decine Mol\u00e9culaire, Universit\u00e9 de Montr\u00e9al, C.P. 6128, Succursale centre-ville, Montr\u00e9al, Qu\u00e9bec, H3C 3J7, Canada","institution_ids":["https://openalex.org/I70931966"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110170979","display_name":"Stephen W. Michnick","orcid":null},"institutions":[{"id":"https://openalex.org/I70931966","display_name":"Universit\u00e9 de Montr\u00e9al","ror":"https://ror.org/0161xgx34","country_code":"CA","type":"education","lineage":["https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Stephen W. Michnick","raw_affiliation_strings":["Centre Robert-Cedergren, Bio-Informatique et G\u00e9nomique, Universit\u00e9 de Montr\u00e9al, C.P. 6128, Succursale centre-ville, Montr\u00e9al, Qu\u00e9bec, H3C 3J7, Canada. stephen.michnick@umontreal.ca","D\u00e9partement de Biochimie et M\u00e9decine Mol\u00e9culaire, Universit\u00e9 de Montr\u00e9al, C.P. 6128, Succursale centre-ville, Montr\u00e9al, Qu\u00e9bec, H3C 3J7, Canada. stephen.michnick@umontreal.ca","D\u00e9partement de Biochimie et M\u00e9decine Mol\u00e9culaire, Universit\u00e9 de Montr\u00e9al, C.P. 6128, Succursale centre-ville, Montr\u00e9al, Qu\u00e9bec, H3C 3J7, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Robert-Cedergren, Bio-Informatique et G\u00e9nomique, Universit\u00e9 de Montr\u00e9al, C.P. 6128, Succursale centre-ville, Montr\u00e9al, Qu\u00e9bec, H3C 3J7, Canada. stephen.michnick@umontreal.ca","institution_ids":[]},{"raw_affiliation_string":"D\u00e9partement de Biochimie et M\u00e9decine Mol\u00e9culaire, Universit\u00e9 de Montr\u00e9al, C.P. 6128, Succursale centre-ville, Montr\u00e9al, Qu\u00e9bec, H3C 3J7, Canada. stephen.michnick@umontreal.ca","institution_ids":[]},{"raw_affiliation_string":"D\u00e9partement de Biochimie et M\u00e9decine Mol\u00e9culaire, Universit\u00e9 de Montr\u00e9al, C.P. 6128, Succursale centre-ville, Montr\u00e9al, Qu\u00e9bec, H3C 3J7, Canada","institution_ids":["https://openalex.org/I70931966"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5027376792"],"corresponding_institution_ids":["https://openalex.org/I70931966"],"apc_list":null,"apc_paid":null,"fwci":0.4479,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.62539861,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"11","issue":"1","first_page":"38","last_page":"38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.15569999814033508,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/budding-yeast","display_name":"Budding yeast","score":0.8689358830451965},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.7233926653862},{"id":"https://openalex.org/keywords/bow-tie","display_name":"Bow tie","score":0.6700552701950073},{"id":"https://openalex.org/keywords/yeast","display_name":"Yeast","score":0.5883162021636963},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5578669309616089},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5521954298019409},{"id":"https://openalex.org/keywords/budding","display_name":"Budding","score":0.542884349822998},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5259861350059509},{"id":"https://openalex.org/keywords/phosphatase","display_name":"Phosphatase","score":0.46042394638061523},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.43720579147338867},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3965774476528168},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.3106617033481598},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.209575355052948},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"Phosphorylation","score":0.11264055967330933},{"id":"https://openalex.org/keywords/telecommunications","display_name":"Telecommunications","score":0.10606461763381958}],"concepts":[{"id":"https://openalex.org/C2992884146","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Budding yeast","level":4,"score":0.8689358830451965},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.7233926653862},{"id":"https://openalex.org/C2777652565","wikidata":"https://www.wikidata.org/wiki/Q4950686","display_name":"Bow tie","level":3,"score":0.6700552701950073},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.5883162021636963},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5578669309616089},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5521954298019409},{"id":"https://openalex.org/C198410946","wikidata":"https://www.wikidata.org/wiki/Q845312","display_name":"Budding","level":2,"score":0.542884349822998},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5259861350059509},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.46042394638061523},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.43720579147338867},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3965774476528168},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.3106617033481598},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.209575355052948},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.11264055967330933},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.10606461763381958},{"id":"https://openalex.org/C21822782","wikidata":"https://www.wikidata.org/wiki/Q131214","display_name":"Antenna (radio)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010744","descriptor_name":"Phosphoric Monoester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/s12918-017-0418-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0418-0","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0418-0","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:28298210","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28298210","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:5353956","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5353956","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-017-0418-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0418-0","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0418-0","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16","score":0.75}],"awards":[{"id":"https://openalex.org/G1417291516","display_name":null,"funder_award_id":"MOP-GMX-231013","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G1508359733","display_name":null,"funder_award_id":"MOP-GMX-152556","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"},{"id":"https://openalex.org/G7818972876","display_name":null,"funder_award_id":"GMX-152556","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2598113446.pdf","grobid_xml":"https://content.openalex.org/works/W2598113446.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1499476884","https://openalex.org/W1576464279","https://openalex.org/W1797459856","https://openalex.org/W1972172786","https://openalex.org/W1973582015","https://openalex.org/W1983736629","https://openalex.org/W1987422410","https://openalex.org/W1993009001","https://openalex.org/W1995346417","https://openalex.org/W2001554877","https://openalex.org/W2013326913","https://openalex.org/W2016786878","https://openalex.org/W2017740015","https://openalex.org/W2024291796","https://openalex.org/W2035175399","https://openalex.org/W2043191021","https://openalex.org/W2043794217","https://openalex.org/W2044881936","https://openalex.org/W2051349181","https://openalex.org/W2053673723","https://openalex.org/W2075420324","https://openalex.org/W2079347458","https://openalex.org/W2084974221","https://openalex.org/W2096536093","https://openalex.org/W2097032828","https://openalex.org/W2099551325","https://openalex.org/W2101296410","https://openalex.org/W2102247469","https://openalex.org/W2106647330","https://openalex.org/W2109281577","https://openalex.org/W2120744225","https://openalex.org/W2123721271","https://openalex.org/W2128881595","https://openalex.org/W2128928441","https://openalex.org/W2129178024","https://openalex.org/W2130253098","https://openalex.org/W2132744522","https://openalex.org/W2133403209","https://openalex.org/W2138782665","https://openalex.org/W2144842227","https://openalex.org/W2147023594","https://openalex.org/W2150078352","https://openalex.org/W2150541721","https://openalex.org/W2151449689","https://openalex.org/W2153624566","https://openalex.org/W2157421521","https://openalex.org/W2160125167","https://openalex.org/W2161199282","https://openalex.org/W2163485494","https://openalex.org/W2163571800","https://openalex.org/W2165421630","https://openalex.org/W2168433427","https://openalex.org/W2169015768","https://openalex.org/W2170111518","https://openalex.org/W2170276985","https://openalex.org/W2171948041","https://openalex.org/W2296679604","https://openalex.org/W3122876266","https://openalex.org/W4211017114","https://openalex.org/W4241115518"],"related_works":["https://openalex.org/W2188534709","https://openalex.org/W2207860391","https://openalex.org/W2010133910","https://openalex.org/W2059360384","https://openalex.org/W2003224401","https://openalex.org/W769743217","https://openalex.org/W1993004680","https://openalex.org/W2326695086","https://openalex.org/W2165557504","https://openalex.org/W2092073653"],"abstract_inverted_index":{"BACKGROUND:":[0],"Kinases":[1],"and":[2,26,43,67,109,173,177,186,195,258,267,289,300],"phosphatases":[3,124],"(KP)":[4],"form":[5,42,167],"complex":[6],"self-regulating":[7],"networks":[8,40,61],"essential":[9],"for":[10,79,292],"cellular":[11],"signal":[12,265,270],"processing.":[13],"In":[14],"spite":[15],"of":[16,20,34,37,57,85,142,146,164,220,274,295],"having":[17],"a":[18,113,118,243,290],"wealth":[19],"data":[21],"about":[22,50],"interactions":[23],"among":[24,179],"KPs":[25,183,191],"their":[27,52],"substrates,":[28],"we":[29,205,240,286],"have":[30],"very":[31],"limited":[32],"models":[33],"the":[35,38,55,69,80,86,92,129,143,151,161,180,201,208,217,221,250,259,275],"structures":[36],"directed":[39],"they":[41,133],"consequently":[44],"our":[45],"ability":[46],"to":[47,77,96,126,254,263],"formulate":[48],"hypotheses":[49],"how":[51],"structure":[53,100,116,247],"determines":[54],"flow":[56],"information":[58,296],"in":[59,101,170,174,200,248,298,302],"these":[60],"is":[62,227],"restricted.":[63],"RESULTS:":[64],"We":[65],"assembled":[66],"studied":[68],"largest":[70,162],"bona":[71],"fide":[72],"kinase-phosphatase":[73],"network":[74],"(KP-Net)":[75],"known":[76],"date":[78],"yeast":[81,276,299],"Saccharomyces":[82],"cerevisiae.":[83],"Application":[84],"vertex":[87],"sort":[88,127],"(VS)":[89],"algorithm":[90,210,226],"on":[91,212],"KP-Net":[93,152,238,277],"allowed":[94],"us":[95],"elucidate":[97],"its":[98,283],"hierarchical":[99,246],"which":[102,249],"nodes":[103],"are":[104,134,178,192],"sorted":[105,222],"into":[106,128,282],"top,":[107],"core":[108,121,156,260],"bottom":[110,202],"layers,":[111],"forming":[112],"bow":[114,244],"tie":[115,245],"with":[117],"strongly":[119],"connected":[120],"layer.":[122,203],"Surprisingly,":[123],"tend":[125],"top":[130,189,251],"layer,":[131],"implying":[132],"less":[135,196],"regulated":[136,182],"by":[137],"phosphorylation":[138],"than":[139,198],"kinases.":[140],"Superposition":[141],"widest":[144],"range":[145],"KP":[147],"biological":[148,218],"properties":[149],"over":[150],"hierarchy":[153],"shows":[154],"that":[155,207],"layer":[157,190,252,261],"KPs:":[158],"(i),":[159],"receive":[160],"number":[163],"inputs;":[165],"(ii),":[166],"bottlenecks":[168],"implicated":[169],"multiple":[171],"pathways":[172],"decision-making;":[175],"(iii),":[176],"most":[181],"both":[184,279],"temporally":[185],"spatially.":[187],"Moreover,":[188],"more":[193],"abundant":[194],"noisy":[197],"those":[199],"Finally,":[204],"showed":[206],"VS":[209,225],"depends":[211],"node":[213],"degrees":[214],"without":[215],"biasing":[216],"results":[219],"network.":[223],"The":[224,237],"available":[228],"as":[229,285],"an":[230],"R":[231],"package":[232],"(":[233],"https://cran.r-project.org/web/packages/VertexSort/index.html":[234],").":[235],"CONCLUSIONS:":[236],"model":[239,273],"propose":[241],"possesses":[242],"appears":[253,262],"ensure":[255],"highest":[256],"fidelity":[257],"mediate":[264],"integration":[266],"cell":[268],"state-dependent":[269],"interpretation.":[271],"Our":[272],"provides":[278],"functional":[280],"insight":[281],"organization":[284],"understand":[287],"today":[288],"framework":[291],"future":[293],"investigation":[294],"processing":[297],"eukaryotes":[301],"general.":[303]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}