{"id":"https://openalex.org/W2950144725","doi":"https://doi.org/10.1186/s12918-017-0412-6","title":"Detection of statistically significant network changes in complex biological networks","display_name":"Detection of statistically significant network changes in complex biological networks","publication_year":2017,"publication_date":"2017-03-04","ids":{"openalex":"https://openalex.org/W2950144725","doi":"https://doi.org/10.1186/s12918-017-0412-6","mag":"2950144725","pmid":"https://pubmed.ncbi.nlm.nih.gov/28259158"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-017-0412-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0412-6","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0412-6","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0412-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055826525","display_name":"Raghvendra Mall","orcid":"https://orcid.org/0000-0003-1779-3150"},"institutions":[{"id":"https://openalex.org/I4210138380","display_name":"Qatar Cardiovascular Research Center","ror":"https://ror.org/038vyt185","country_code":"QA","type":"healthcare","lineage":["https://openalex.org/I4210138380"]}],"countries":["QA"],"is_corresponding":true,"raw_author_name":"Raghvendra Mall","raw_affiliation_strings":["QCRI - Qatar Computing Research Institute, HBKU, Doha, Qatar. rmall@qf.org.qa","QCRI - Qatar Computing Research Institute, HBKU, Doha, Qatar"],"affiliations":[{"raw_affiliation_string":"QCRI - Qatar Computing Research Institute, HBKU, Doha, Qatar. rmall@qf.org.qa","institution_ids":[]},{"raw_affiliation_string":"QCRI - Qatar Computing Research Institute, HBKU, Doha, Qatar","institution_ids":["https://openalex.org/I4210138380"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025973233","display_name":"Luigi Cerulo","orcid":"https://orcid.org/0000-0001-8342-3487"},"institutions":[{"id":"https://openalex.org/I4210115745","display_name":"Biogem","ror":"https://ror.org/01ymr5447","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I2801626668","https://openalex.org/I4210115745"]},{"id":"https://openalex.org/I16337185","display_name":"University of Sannio","ror":"https://ror.org/04vc81p87","country_code":"IT","type":"education","lineage":["https://openalex.org/I16337185"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigi Cerulo","raw_affiliation_strings":["BioGeM, Institute of Genetic Research \"Gaetano Salvatore\", Ariano Irpino (AV), Italy","Department of Science and Technology, University of Sannio, Benevento, Italy"],"affiliations":[{"raw_affiliation_string":"BioGeM, Institute of Genetic Research \"Gaetano Salvatore\", Ariano Irpino (AV), Italy","institution_ids":["https://openalex.org/I4210115745"]},{"raw_affiliation_string":"Department of Science and Technology, University of Sannio, Benevento, Italy","institution_ids":["https://openalex.org/I16337185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013350725","display_name":"Halima Bensmail","orcid":"https://orcid.org/0000-0001-6700-5752"},"institutions":[{"id":"https://openalex.org/I4210138380","display_name":"Qatar Cardiovascular Research Center","ror":"https://ror.org/038vyt185","country_code":"QA","type":"healthcare","lineage":["https://openalex.org/I4210138380"]}],"countries":["QA"],"is_corresponding":false,"raw_author_name":"Halima Bensmail","raw_affiliation_strings":["QCRI - Qatar Computing Research Institute, HBKU, Doha, Qatar"],"affiliations":[{"raw_affiliation_string":"QCRI - Qatar Computing Research Institute, HBKU, Doha, Qatar","institution_ids":["https://openalex.org/I4210138380"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078024735","display_name":"Antonio Iavarone","orcid":"https://orcid.org/0000-0002-0683-4634"},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]},{"id":"https://openalex.org/I4210145812","display_name":"Cancer Genetics (United States)","ror":"https://ror.org/05feyya22","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonio Iavarone","raw_affiliation_strings":["Department of Neurology, Department of Pathology, Institute for Cancer Genetics, Columbia University Medical Center, New York, USA"],"affiliations":[{"raw_affiliation_string":"Department of Neurology, Department of Pathology, Institute for Cancer Genetics, Columbia University Medical Center, New York, USA","institution_ids":["https://openalex.org/I2799503643","https://openalex.org/I4210145812"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085527072","display_name":"Michele Ceccarelli","orcid":"https://orcid.org/0000-0002-4702-6617"},"institutions":[{"id":"https://openalex.org/I16337185","display_name":"University of Sannio","ror":"https://ror.org/04vc81p87","country_code":"IT","type":"education","lineage":["https://openalex.org/I16337185"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Ceccarelli","raw_affiliation_strings":["Department of Science and Technology, University of Sannio, Benevento, Italy. mceccarelli@gmail.com","QCRI - Qatar Computing Research Institute, HBKU, Doha, Qatar. mceccarelli@gmail.com","Department of Science and Technology, University of Sannio, Benevento, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Science and Technology, University of Sannio, Benevento, Italy. mceccarelli@gmail.com","institution_ids":[]},{"raw_affiliation_string":"QCRI - Qatar Computing Research Institute, HBKU, Doha, Qatar. mceccarelli@gmail.com","institution_ids":[]},{"raw_affiliation_string":"Department of Science and Technology, University of Sannio, Benevento, Italy","institution_ids":["https://openalex.org/I16337185"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5055826525"],"corresponding_institution_ids":["https://openalex.org/I4210138380"],"apc_list":null,"apc_paid":null,"fwci":4.9748,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.96036107,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"11","issue":"1","first_page":"32","last_page":"32"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pairwise-comparison","display_name":"Pairwise comparison","score":0.6683750152587891},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6416893005371094},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.6223598122596741},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.5372905731201172},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.47253990173339844},{"id":"https://openalex.org/keywords/geometric-networks","display_name":"Geometric networks","score":0.4309839606285095},{"id":"https://openalex.org/keywords/modelling-biological-systems","display_name":"Modelling biological systems","score":0.4256511628627777},{"id":"https://openalex.org/keywords/complex-network","display_name":"Complex network","score":0.4030821621417999},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.37278681993484497},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.3654540181159973},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.32661953568458557},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.28987282514572144},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.27708959579467773}],"concepts":[{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.6683750152587891},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6416893005371094},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.6223598122596741},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5372905731201172},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.47253990173339844},{"id":"https://openalex.org/C49777392","wikidata":"https://www.wikidata.org/wiki/Q5535495","display_name":"Geometric networks","level":3,"score":0.4309839606285095},{"id":"https://openalex.org/C137866125","wikidata":"https://www.wikidata.org/wiki/Q4299308","display_name":"Modelling biological systems","level":3,"score":0.4256511628627777},{"id":"https://openalex.org/C34947359","wikidata":"https://www.wikidata.org/wiki/Q665189","display_name":"Complex network","level":2,"score":0.4030821621417999},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37278681993484497},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.3654540181159973},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.32661953568458557},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.28987282514572144},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27708959579467773},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12918-017-0412-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0412-6","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0412-6","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:28259158","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28259158","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:figshare.com:article/27087997","is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Detection_of_statistically_significant_network_changes_in_complex_biological_networks/27087997","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5336651","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5336651","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-017-0412-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0412-6","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0412-6","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309815","display_name":"Qatar Foundation","ror":"https://ror.org/01cawbq05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2950144725.pdf","grobid_xml":"https://content.openalex.org/works/W2950144725.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W251835054","https://openalex.org/W571060166","https://openalex.org/W642020218","https://openalex.org/W1503941663","https://openalex.org/W1568213684","https://openalex.org/W1580723244","https://openalex.org/W1596515083","https://openalex.org/W1740618102","https://openalex.org/W1743429370","https://openalex.org/W1812256879","https://openalex.org/W1901309112","https://openalex.org/W1964039615","https://openalex.org/W1970737407","https://openalex.org/W1971421925","https://openalex.org/W1975594892","https://openalex.org/W1988756388","https://openalex.org/W1990435776","https://openalex.org/W2017776363","https://openalex.org/W2023639434","https://openalex.org/W2025543856","https://openalex.org/W2029837328","https://openalex.org/W2031947549","https://openalex.org/W2051793286","https://openalex.org/W2059742013","https://openalex.org/W2060705109","https://openalex.org/W2061971803","https://openalex.org/W2064340336","https://openalex.org/W2069733150","https://openalex.org/W2080418553","https://openalex.org/W2080925589","https://openalex.org/W2092300972","https://openalex.org/W2092939357","https://openalex.org/W2094593900","https://openalex.org/W2105528101","https://openalex.org/W2107665951","https://openalex.org/W2108156593","https://openalex.org/W2110265246","https://openalex.org/W2112348586","https://openalex.org/W2112811019","https://openalex.org/W2115022330","https://openalex.org/W2119507177","https://openalex.org/W2125170903","https://openalex.org/W2128962304","https://openalex.org/W2129999614","https://openalex.org/W2131681506","https://openalex.org/W2142498761","https://openalex.org/W2143744820","https://openalex.org/W2145126338","https://openalex.org/W2152202842","https://openalex.org/W2154452346","https://openalex.org/W2156905199","https://openalex.org/W2163296115","https://openalex.org/W2163296727","https://openalex.org/W2167717760","https://openalex.org/W2169604162","https://openalex.org/W2171662214","https://openalex.org/W2175110005","https://openalex.org/W2184483246","https://openalex.org/W2233485858","https://openalex.org/W2263206910","https://openalex.org/W2293732938","https://openalex.org/W3099289621","https://openalex.org/W3099768174","https://openalex.org/W4248776151","https://openalex.org/W4249655497","https://openalex.org/W4254726060","https://openalex.org/W4301474483","https://openalex.org/W6681029592"],"related_works":["https://openalex.org/W2158714033","https://openalex.org/W4386628104","https://openalex.org/W1975586684","https://openalex.org/W2063941210","https://openalex.org/W2127864418","https://openalex.org/W4206945140","https://openalex.org/W2606847111","https://openalex.org/W2598362101","https://openalex.org/W2947028852","https://openalex.org/W2212032968"],"abstract_inverted_index":{"We":[0],"show":[1],"that":[2,57],"our":[3],"network":[4,14],"differencing":[5],"procedure":[6],"can":[7],"effectively":[8],"and":[9,31],"efficiently":[10],"detect":[11,22],"statistical":[12],"significant":[13],"re-wirings":[15],"in":[16],"different":[17,47],"conditions.":[18],"When":[19],"applied":[20],"to":[21],"the":[23,27],"main":[24],"differences":[25],"between":[26],"networks":[28],"of":[29,44],"IDH-mutant":[30],"IDH-wild-type":[32],"glioma":[33],"tumors,":[34],"it":[35],"correctly":[36],"selects":[37],"sub-networks":[38],"centered":[39],"on":[40],"important":[41],"key":[42],"regulators":[43],"these":[45],"two":[46],"subtypes.":[48],"In":[49],"addition,":[50],"its":[51],"application":[52],"highlights":[53],"several":[54],"novel":[55],"candidates":[56],"cannot":[58],"be":[59],"detected":[60],"by":[61],"standard":[62],"single":[63],"network-based":[64],"approaches.":[65]},"counts_by_year":[{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":4}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}