{"id":"https://openalex.org/W2594366819","doi":"https://doi.org/10.1186/s12918-017-0411-7","title":"Systems biology combining human- and animal-data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction","display_name":"Systems biology combining human- and animal-data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction","publication_year":2017,"publication_date":"2017-03-01","ids":{"openalex":"https://openalex.org/W2594366819","doi":"https://doi.org/10.1186/s12918-017-0411-7","mag":"2594366819","pmid":"https://pubmed.ncbi.nlm.nih.gov/28249581"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-017-0411-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0411-7","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0411-7","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0411-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101852860","display_name":"Theofilos Papadopoulos","orcid":"https://orcid.org/0000-0003-1565-3875"},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210147779","display_name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires","ror":"https://ror.org/04d73z393","country_code":"FR","type":"facility","lineage":["https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210147779"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Theofilos Papadopoulos","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases-I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France","Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France","Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases\u2013I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France"],"raw_orcid":"https://orcid.org/0000-0003-1565-3875","affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases-I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210147779"]},{"raw_affiliation_string":"Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France","institution_ids":["https://openalex.org/I134560555"]},{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases\u2013I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I4210147779","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021185927","display_name":"Audrey Casemayou","orcid":null},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210147779","display_name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires","ror":"https://ror.org/04d73z393","country_code":"FR","type":"facility","lineage":["https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210147779"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Audrey Casemayou","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases-I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France","Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France","Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases\u2013I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases-I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210147779"]},{"raw_affiliation_string":"Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France","institution_ids":["https://openalex.org/I134560555"]},{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases\u2013I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I4210147779","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058628391","display_name":"Eric Neau","orcid":null},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210147779","display_name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires","ror":"https://ror.org/04d73z393","country_code":"FR","type":"facility","lineage":["https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210147779"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Eric Neau","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases-I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France","Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France","Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases\u2013I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases-I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210147779"]},{"raw_affiliation_string":"Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France","institution_ids":["https://openalex.org/I134560555"]},{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases\u2013I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I4210147779","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030594603","display_name":"Benjamin Breuil","orcid":null},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210147779","display_name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires","ror":"https://ror.org/04d73z393","country_code":"FR","type":"facility","lineage":["https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210147779"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Benjamin Breuil","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases-I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France","Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France","Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases\u2013I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases-I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210147779"]},{"raw_affiliation_string":"Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France","institution_ids":["https://openalex.org/I134560555"]},{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases\u2013I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I4210147779","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112417730","display_name":"C\u00e9cile Caubet","orcid":null},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210147779","display_name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires","ror":"https://ror.org/04d73z393","country_code":"FR","type":"facility","lineage":["https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210147779"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C\u00e9cile Caubet","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases-I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France","Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France","Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases\u2013I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases-I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210147779"]},{"raw_affiliation_string":"Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France","institution_ids":["https://openalex.org/I134560555"]},{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases\u2013I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I4210147779","https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049679674","display_name":"Denis Calise","orcid":null},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Denis Calise","raw_affiliation_strings":["Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France","institution_ids":["https://openalex.org/I134560555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045259192","display_name":"Barbara A. Thornhill","orcid":null},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Barbara A. Thornhill","raw_affiliation_strings":["Department of Molecular Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Canada","Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I43406934"]},{"raw_affiliation_string":"Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053934915","display_name":"Magdalena Bachvarova","orcid":null},"institutions":[{"id":"https://openalex.org/I4210121051","display_name":"H\u00f4tel-Dieu de Qu\u00e9bec","ror":"https://ror.org/034sbqc84","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210121051"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Magdalena Bachvarova","raw_affiliation_strings":["Centre de recherche du CHU de Qu\u00e9bec, L'H\u00f4tel-Dieu de Qu\u00e9bec, Qu\u00e9bec, Canada","Department of Molecular Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de recherche du CHU de Qu\u00e9bec, L'H\u00f4tel-Dieu de Qu\u00e9bec, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I4210121051"]},{"raw_affiliation_string":"Department of Molecular Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085429142","display_name":"Julie Belli\u00e8re","orcid":"https://orcid.org/0000-0002-4229-8584"},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210147779","display_name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires","ror":"https://ror.org/04d73z393","country_code":"FR","type":"facility","lineage":["https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210147779"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Julie Belliere","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases-I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France","Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases-I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210147779"]},{"raw_affiliation_string":"Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France","institution_ids":["https://openalex.org/I134560555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073963481","display_name":"Robert L. Chevalier","orcid":"https://orcid.org/0000-0002-7465-482X"},"institutions":[{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]},{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Robert L. Chevalier","raw_affiliation_strings":["Department of Molecular Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Canada","Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I43406934"]},{"raw_affiliation_string":"Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079422639","display_name":"Panagiotis Moulos","orcid":"https://orcid.org/0000-0002-4199-0333"},"institutions":[{"id":"https://openalex.org/I6820528","display_name":"Alexander Fleming Biomedical Sciences Research Center","ror":"https://ror.org/013x0ky90","country_code":"GR","type":"facility","lineage":["https://openalex.org/I6820528"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Panagiotis Moulos","raw_affiliation_strings":["HybridStat Predictive Analytics, Aiolou 19, 10551, Athens, Greece","Institute of Molecular Biology and Genetics, Biomedical Sciences Research Center 'Alexander Fleming', Fleming 34, 16672, Vari, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HybridStat Predictive Analytics, Aiolou 19, 10551, Athens, Greece","institution_ids":[]},{"raw_affiliation_string":"Institute of Molecular Biology and Genetics, Biomedical Sciences Research Center 'Alexander Fleming', Fleming 34, 16672, Vari, Greece","institution_ids":["https://openalex.org/I6820528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091028771","display_name":"Dimcho Bachvarov","orcid":"https://orcid.org/0000-0001-6509-9599"},"institutions":[{"id":"https://openalex.org/I4210121051","display_name":"H\u00f4tel-Dieu de Qu\u00e9bec","ror":"https://ror.org/034sbqc84","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4210121051"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Dimcho Bachvarov","raw_affiliation_strings":["Centre de recherche du CHU de Qu\u00e9bec, L'H\u00f4tel-Dieu de Qu\u00e9bec, Qu\u00e9bec, Canada","Department of Molecular Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre de recherche du CHU de Qu\u00e9bec, L'H\u00f4tel-Dieu de Qu\u00e9bec, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I4210121051"]},{"raw_affiliation_string":"Department of Molecular Medicine, Universit\u00e9 Laval, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050688019","display_name":"B\u00e9n\u00e9dicte Buffin\u2010Meyer","orcid":"https://orcid.org/0000-0002-4805-1558"},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210147779","display_name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires","ror":"https://ror.org/04d73z393","country_code":"FR","type":"facility","lineage":["https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210147779"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Benedicte Buffin-Meyer","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases-I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France","Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases-I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210147779"]},{"raw_affiliation_string":"Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France","institution_ids":["https://openalex.org/I134560555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072330243","display_name":"St\u00e9phane Decramer","orcid":"https://orcid.org/0000-0001-6984-762X"},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210112439","display_name":"Laboratoire National de R\u00e9f\u00e9rence","ror":"https://ror.org/020nbej04","country_code":"MA","type":"facility","lineage":["https://openalex.org/I4210112439","https://openalex.org/I4210119819","https://openalex.org/I4210145847"]},{"id":"https://openalex.org/I4210146666","display_name":"H\u00f4pital des Enfants","ror":"https://ror.org/044hb6b32","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210146666"]},{"id":"https://openalex.org/I4210147779","display_name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires","ror":"https://ror.org/04d73z393","country_code":"FR","type":"facility","lineage":["https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210147779"]}],"countries":["FR","MA"],"is_corresponding":false,"raw_author_name":"St\u00e9phane Decramer","raw_affiliation_strings":["Centre De R\u00e9f\u00e9rence des Maladies R\u00e9nales Rares du Sud Ouest (SORARE), 31059, Toulouse, France","Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases-I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France","Service de N\u00e9phrologie-M\u00e9decine Interne-Hypertension P\u00e9diatrique, CHU Toulouse, H\u00f4pital des Enfants, 31059, Toulouse, France","Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre De R\u00e9f\u00e9rence des Maladies R\u00e9nales Rares du Sud Ouest (SORARE), 31059, Toulouse, France","institution_ids":["https://openalex.org/I4210112439"]},{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases-I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210147779"]},{"raw_affiliation_string":"Service de N\u00e9phrologie-M\u00e9decine Interne-Hypertension P\u00e9diatrique, CHU Toulouse, H\u00f4pital des Enfants, 31059, Toulouse, France","institution_ids":["https://openalex.org/I4210146666"]},{"raw_affiliation_string":"Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France","institution_ids":["https://openalex.org/I134560555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112951324","display_name":"Fran\u00e7oise Auriol","orcid":null},"institutions":[{"id":"https://openalex.org/I4210146666","display_name":"H\u00f4pital des Enfants","ror":"https://ror.org/044hb6b32","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3019448017","https://openalex.org/I4210146666"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fran\u00e7oise Conte Auriol","raw_affiliation_strings":["Unit\u00e9 de recherche clinique p\u00e9diatrique, Module plurith\u00e9mathique p\u00e9diatrique du Centre d'Investigation Clinique Toulouse 1436 H\u00f4pital des enfants 330 avenue de grande bretagne, 31059, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de recherche clinique p\u00e9diatrique, Module plurith\u00e9mathique p\u00e9diatrique du Centre d'Investigation Clinique Toulouse 1436 H\u00f4pital des enfants 330 avenue de grande bretagne, 31059, Toulouse, France","institution_ids":["https://openalex.org/I4210146666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090325119","display_name":"Jean\u2010Loup Bascands","orcid":"https://orcid.org/0000-0002-1667-5913"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I24715933","display_name":"University of Reunion Island","ror":"https://ror.org/005ypkf75","country_code":"RE","type":"education","lineage":["https://openalex.org/I24715933"]}],"countries":["FR","RE"],"is_corresponding":false,"raw_author_name":"Jean-Loup Bascands","raw_affiliation_strings":["D\u00e9TROI-Inserm U1188-Universit\u00e9 de La R\u00e9union, Diab\u00e8te ath\u00e9rothrombose Th\u00e9rapies R\u00e9union Oc\u00e9an Indien, CYROI, 2, rue Maxime Rivi\u00e8re, 97490, Sainte Clotilde, La R\u00e9union, France","D\u00e9TROI\u2013Inserm U1188\u2013Universit\u00e9 de La R\u00e9union, Diab\u00e8te ath\u00e9rothrombose Th\u00e9rapies R\u00e9union Oc\u00e9an Indien, CYROI, 2, rue Maxime Rivi\u00e8re, 97490, Sainte Clotilde, La R\u00e9union, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9TROI-Inserm U1188-Universit\u00e9 de La R\u00e9union, Diab\u00e8te ath\u00e9rothrombose Th\u00e9rapies R\u00e9union Oc\u00e9an Indien, CYROI, 2, rue Maxime Rivi\u00e8re, 97490, Sainte Clotilde, La R\u00e9union, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I24715933"]},{"raw_affiliation_string":"D\u00e9TROI\u2013Inserm U1188\u2013Universit\u00e9 de La R\u00e9union, Diab\u00e8te ath\u00e9rothrombose Th\u00e9rapies R\u00e9union Oc\u00e9an Indien, CYROI, 2, rue Maxime Rivi\u00e8re, 97490, Sainte Clotilde, La R\u00e9union, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009141968","display_name":"Joost P. Schanstra","orcid":"https://orcid.org/0000-0002-7471-372X"},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210147779","display_name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires","ror":"https://ror.org/04d73z393","country_code":"FR","type":"facility","lineage":["https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210147779"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Joost P. Schanstra","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases-I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France. joost-peter.schanstra@inserm.fr","Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France. joost-peter.schanstra@inserm.fr","Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases-I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France. joost-peter.schanstra@inserm.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210147779"]},{"raw_affiliation_string":"Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France. joost-peter.schanstra@inserm.fr","institution_ids":["https://openalex.org/I134560555"]},{"raw_affiliation_string":"Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France","institution_ids":["https://openalex.org/I134560555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045393131","display_name":"Julie Klein","orcid":"https://orcid.org/0000-0002-3279-0559"},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210147779","display_name":"Institut des Maladies M\u00e9taboliques et Cardiovasculaires","ror":"https://ror.org/04d73z393","country_code":"FR","type":"facility","lineage":["https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210147779"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Julie Klein","raw_affiliation_strings":["Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases-I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France. julie.klein@inserm.fr","Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France. julie.klein@inserm.fr","Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), U1048, Institute of Metabolic and Cardiovascular Diseases-I2MC, 1 avenue Jean Poulh\u00e8s, B.P. 84225, 31432, Toulouse Cedex 4, France. julie.klein@inserm.fr","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210147779"]},{"raw_affiliation_string":"Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France. julie.klein@inserm.fr","institution_ids":["https://openalex.org/I134560555"]},{"raw_affiliation_string":"Universit\u00e9 Toulouse III Paul-Sabatier, Toulouse, France","institution_ids":["https://openalex.org/I134560555"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":18,"corresponding_author_ids":["https://openalex.org/A5101852860"],"corresponding_institution_ids":["https://openalex.org/I134560555","https://openalex.org/I154526488","https://openalex.org/I4210147779"],"apc_list":null,"apc_paid":{"value":1800,"currency":"EUR","value_usd":1941},"fwci":2.1481,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.8787196,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"11","issue":"1","first_page":"31","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11174","display_name":"Pediatric Urology and Nephrology Studies","score":0.8253999948501587,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11174","display_name":"Pediatric Urology and Nephrology Studies","score":0.8253999948501587,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12140","display_name":"Renal and related cancers","score":0.027699999511241913,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.027499999850988388,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.6905655860900879},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.648257851600647},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6433638334274292},{"id":"https://openalex.org/keywords/messenger-rna","display_name":"Messenger RNA","score":0.5486831665039062},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5337304472923279},{"id":"https://openalex.org/keywords/developmental-biology","display_name":"Developmental biology","score":0.4276345670223236},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.27530568838119507},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18339872360229492},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.15508818626403809}],"concepts":[{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.6905655860900879},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.648257851600647},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6433638334274292},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5486831665039062},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5337304472923279},{"id":"https://openalex.org/C183074962","wikidata":"https://www.wikidata.org/wiki/Q213713","display_name":"Developmental biology","level":2,"score":0.4276345670223236},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.27530568838119507},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18339872360229492},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15508818626403809}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010388","descriptor_name":"Pelvis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010388","descriptor_name":"Pelvis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010388","descriptor_name":"Pelvis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014517","descriptor_name":"Ureteral Obstruction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014517","descriptor_name":"Ureteral Obstruction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014517","descriptor_name":"Ureteral Obstruction","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014517","descriptor_name":"Ureteral Obstruction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014517","descriptor_name":"Ureteral Obstruction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014517","descriptor_name":"Ureteral Obstruction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12918-017-0411-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0411-7","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0411-7","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:28249581","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28249581","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:HAL:inserm-01480970v1","is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-01480970","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, 2016, 11 (1), pp.31. ⟨10.1186/s12918-017-0411-7⟩","raw_type":"Journal articles"},{"id":"pmh:oai:pubmedcentral.nih.gov:5333413","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5333413","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmh:oai:zenodo.org:345748","is_oa":true,"landing_page_url":"https://zenodo.org/record/345748","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology 11(1) 31","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s12918-017-0411-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0411-7","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0411-7","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3959587581","display_name":null,"funder_award_id":"PEOPLE-ITN-GA-2013\u2013608332","funder_id":"https://openalex.org/F4320334960","funder_display_name":"Seventh Framework Programme"},{"id":"https://openalex.org/G8729734005","display_name":null,"funder_award_id":"U1048","funder_id":"https://openalex.org/F4320320893","funder_display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale"}],"funders":[{"id":"https://openalex.org/F4320310137","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320321589","display_name":"Fondation pour la Recherche M\u00e9dicale","ror":"https://ror.org/04w6kn183"},{"id":"https://openalex.org/F4320326456","display_name":"Universit\u00e9 de La R\u00e9union","ror":"https://ror.org/005ypkf75"},{"id":"https://openalex.org/F4320329299","display_name":"Fondation du Rein","ror":null},{"id":"https://openalex.org/F4320334960","display_name":"Seventh Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2594366819.pdf","grobid_xml":"https://content.openalex.org/works/W2594366819.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W282221905","https://openalex.org/W1598113198","https://openalex.org/W1922006896","https://openalex.org/W1931753315","https://openalex.org/W1973021960","https://openalex.org/W1975015638","https://openalex.org/W1976499306","https://openalex.org/W1976875491","https://openalex.org/W1979207431","https://openalex.org/W1981480973","https://openalex.org/W1983845045","https://openalex.org/W1992157860","https://openalex.org/W2002815072","https://openalex.org/W2009486805","https://openalex.org/W2010040408","https://openalex.org/W2010763857","https://openalex.org/W2011703698","https://openalex.org/W2015399672","https://openalex.org/W2023928613","https://openalex.org/W2026109437","https://openalex.org/W2026697437","https://openalex.org/W2028187264","https://openalex.org/W2032739382","https://openalex.org/W2032945651","https://openalex.org/W2038779553","https://openalex.org/W2046314136","https://openalex.org/W2047071083","https://openalex.org/W2051432715","https://openalex.org/W2051639936","https://openalex.org/W2058320026","https://openalex.org/W2059165036","https://openalex.org/W2060860407","https://openalex.org/W2063740184","https://openalex.org/W2064378035","https://openalex.org/W2067512788","https://openalex.org/W2068811647","https://openalex.org/W2069465596","https://openalex.org/W2070777085","https://openalex.org/W2073049822","https://openalex.org/W2075103447","https://openalex.org/W2077475358","https://openalex.org/W2081722675","https://openalex.org/W2086605453","https://openalex.org/W2089001345","https://openalex.org/W2095835159","https://openalex.org/W2099953660","https://openalex.org/W2107724630","https://openalex.org/W2109674684","https://openalex.org/W2112192177","https://openalex.org/W2118371398","https://openalex.org/W2119729313","https://openalex.org/W2121014368","https://openalex.org/W2122290210","https://openalex.org/W2127263274","https://openalex.org/W2135580384","https://openalex.org/W2142946696","https://openalex.org/W2147575530","https://openalex.org/W2148615664","https://openalex.org/W2152041515","https://openalex.org/W2155285019","https://openalex.org/W2156232364","https://openalex.org/W2159842699","https://openalex.org/W2160530471","https://openalex.org/W2161794856","https://openalex.org/W2162694012","https://openalex.org/W2165160668","https://openalex.org/W2166987908","https://openalex.org/W2259128731","https://openalex.org/W2274431627","https://openalex.org/W2279233628","https://openalex.org/W2299869224","https://openalex.org/W2463624671"],"related_works":["https://openalex.org/W2737319532","https://openalex.org/W3151405604","https://openalex.org/W2565797512","https://openalex.org/W2050308539","https://openalex.org/W2793648706","https://openalex.org/W2019096591","https://openalex.org/W3032012916","https://openalex.org/W3043187607","https://openalex.org/W5284979","https://openalex.org/W4245853730"],"abstract_inverted_index":{"BACKGROUND:":[0],"Although":[1],"renal":[2],"fibrosis":[3,211],"and":[4,35,57,76,81,98,111,121,129,138,140,148,164,201,223],"inflammation":[5],"have":[6,45,63],"shown":[7],"to":[8,41,115,125,178],"be":[9,169,228],"involved":[10,154,206],"in":[11,65,108,130,155,158,161,191,207,212,220],"the":[12,39,67,77,84,116,176,208,216],"pathophysiology":[13],"of":[14,21,32,38,54,70,83,96,106,118,136,183,210,218],"obstructive":[15,33,59,159],"nephropathies,":[16],"molecular":[17],"mechanisms":[18],"underlying":[19],"evolution":[20],"these":[22],"processes":[23],"remain":[24],"undetermined.":[25],"In":[26,127],"an":[27],"attempt":[28],"towards":[29],"improved":[30,36],"understanding":[31],"nephropathy":[34,160],"translatability":[37],"results":[40],"clinical":[42],"practice":[43],"we":[44],"developed":[46],"a":[47,180,192],"systems":[48,194],"biology":[49,195],"approach":[50],"combining":[51],"omics":[52],"data":[53,198],"both":[55,109,162,221],"human":[56,163,188],"mouse":[58,92,181],"nephropathy.":[60],"RESULTS:":[61],"We":[62],"studied":[64],"parallel":[66],"urinary":[68],"miRNome":[69,80],"infants":[71],"with":[72,187],"ureteropelvic":[73],"junction":[74],"obstruction":[75,90,190,214],"kidney":[78],"tissue":[79],"transcriptome":[82],"corresponding":[85],"neonatal":[86,184],"partial":[87,185],"unilateral":[88],"ureteral":[89],"(UUO)":[91],"model.":[93],"Several":[94],"hundreds":[95],"miRNAs":[97,107,120],"mRNAs":[99,113,123],"displayed":[100],"changed":[101],"abundance":[102],"during":[103],"disease.":[104,126],"Combination":[105],"species":[110],"associated":[112,124],"let":[114],"prioritization":[117],"five":[119],"35":[122],"vitro":[128],"vivo":[131],"validation":[132],"identified":[133,170,229],"consistent":[134],"dysregulation":[135],"let-7a-5p":[137],"miR-29-3p":[139],"new":[141],"potential":[142],"targets,":[143],"E3":[144],"ubiquitin-protein":[145],"ligase":[146],"(DTX4)":[147],"neuron":[149],"navigator":[150],"1":[151],"(NAV1),":[152],"potentially":[153,205],"fibrotic":[156],"processes,":[157],"mice":[165,224],"that":[166,225],"would":[167,226],"not":[168,227],"otherwise.":[171,230],"CONCLUSIONS:":[172],"Our":[173,197],"study":[174],"is":[175],"first":[177],"correlate":[179],"model":[182],"UUO":[186],"UPJ":[189,213],"comprehensive":[193],"analysis.":[196],"revealed":[199],"let-7a":[200],"miR-29b":[202],"as":[203],"molecules":[204],"development":[209],"via":[215],"control":[217],"DTX4":[219],"man":[222]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}