{"id":"https://openalex.org/W2591785836","doi":"https://doi.org/10.1186/s12918-017-0407-3","title":"Physiological fidelity or model parsimony? The relative performance of reverse-toxicokinetic modeling approaches","display_name":"Physiological fidelity or model parsimony? The relative performance of reverse-toxicokinetic modeling approaches","publication_year":2017,"publication_date":"2017-03-11","ids":{"openalex":"https://openalex.org/W2591785836","doi":"https://doi.org/10.1186/s12918-017-0407-3","mag":"2591785836","pmid":"https://pubmed.ncbi.nlm.nih.gov/28284215"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-017-0407-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0407-3","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0407-3","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0407-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014170799","display_name":"Michael A. Rowland","orcid":"https://orcid.org/0000-0002-6759-8225"},"institutions":[{"id":"https://openalex.org/I4389425366","display_name":"Oak Ridge Institute for Science and Education","ror":"https://ror.org/040vxhp34","country_code":null,"type":"education","lineage":["https://openalex.org/I1281378812","https://openalex.org/I1330989302","https://openalex.org/I4389425366"]},{"id":"https://openalex.org/I1281378812","display_name":"Oak Ridge Associated Universities","ror":"https://ror.org/0526p1y61","country_code":"US","type":"education","lineage":["https://openalex.org/I1281378812"]},{"id":"https://openalex.org/I87303767","display_name":"U.S. Army Engineer Research and Development Center","ror":"https://ror.org/027mhn368","country_code":"US","type":"facility","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1306490931","https://openalex.org/I1330347796","https://openalex.org/I87303767"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael A. Rowland","raw_affiliation_strings":["Environmental Laboratory, US Army Engineer Research and Development Center, Vicksburg, MS, USA","Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Laboratory, US Army Engineer Research and Development Center, Vicksburg, MS, USA","institution_ids":["https://openalex.org/I87303767"]},{"raw_affiliation_string":"Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA","institution_ids":["https://openalex.org/I1281378812","https://openalex.org/I4389425366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075371599","display_name":"Edward J. Perkins","orcid":"https://orcid.org/0000-0003-1693-7714"},"institutions":[{"id":"https://openalex.org/I87303767","display_name":"U.S. Army Engineer Research and Development Center","ror":"https://ror.org/027mhn368","country_code":"US","type":"facility","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1306490931","https://openalex.org/I1330347796","https://openalex.org/I87303767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward J. Perkins","raw_affiliation_strings":["Environmental Laboratory, US Army Engineer Research and Development Center, Vicksburg, MS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Laboratory, US Army Engineer Research and Development Center, Vicksburg, MS, USA","institution_ids":["https://openalex.org/I87303767"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045705423","display_name":"Michael L. Mayo","orcid":"https://orcid.org/0000-0001-9014-1859"},"institutions":[{"id":"https://openalex.org/I87303767","display_name":"U.S. Army Engineer Research and Development Center","ror":"https://ror.org/027mhn368","country_code":"US","type":"facility","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1306490931","https://openalex.org/I1330347796","https://openalex.org/I87303767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L. Mayo","raw_affiliation_strings":["Environmental Laboratory, US Army Engineer Research and Development Center, Vicksburg, MS, USA. michael.l.mayo@usace.army.mil","Environmental Laboratory, US Army Engineer Research and Development Center, Vicksburg, MS, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Laboratory, US Army Engineer Research and Development Center, Vicksburg, MS, USA. michael.l.mayo@usace.army.mil","institution_ids":[]},{"raw_affiliation_string":"Environmental Laboratory, US Army Engineer Research and Development Center, Vicksburg, MS, USA","institution_ids":["https://openalex.org/I87303767"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5014170799"],"corresponding_institution_ids":["https://openalex.org/I1281378812","https://openalex.org/I4389425366","https://openalex.org/I87303767"],"apc_list":null,"apc_paid":null,"fwci":1.0353,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.73536099,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"11","issue":"1","first_page":"35","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.29350000619888306,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.29350000619888306,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.13500000536441803,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.12999999523162842,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extrapolation","display_name":"Extrapolation","score":0.700000524520874},{"id":"https://openalex.org/keywords/fidelity","display_name":"Fidelity","score":0.6598132848739624},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.5837382674217224},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.5253840684890747},{"id":"https://openalex.org/keywords/consistency","display_name":"Consistency (knowledge bases)","score":0.5245614051818848},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5176770687103271},{"id":"https://openalex.org/keywords/organism","display_name":"Organism","score":0.5123361349105835},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4469284117221832},{"id":"https://openalex.org/keywords/steady-state","display_name":"Steady state (chemistry)","score":0.42922818660736084},{"id":"https://openalex.org/keywords/toxicokinetics","display_name":"Toxicokinetics","score":0.41305282711982727},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4117283821105957},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2784491181373596},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.24872875213623047},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.20836305618286133},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.20489880442619324},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.1705198585987091},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.10410156846046448},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.092863529920578}],"concepts":[{"id":"https://openalex.org/C132459708","wikidata":"https://www.wikidata.org/wiki/Q744069","display_name":"Extrapolation","level":2,"score":0.700000524520874},{"id":"https://openalex.org/C2776459999","wikidata":"https://www.wikidata.org/wiki/Q2119376","display_name":"Fidelity","level":2,"score":0.6598132848739624},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.5837382674217224},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.5253840684890747},{"id":"https://openalex.org/C2776436953","wikidata":"https://www.wikidata.org/wiki/Q5163215","display_name":"Consistency (knowledge bases)","level":2,"score":0.5245614051818848},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5176770687103271},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.5123361349105835},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4469284117221832},{"id":"https://openalex.org/C8171440","wikidata":"https://www.wikidata.org/wiki/Q903414","display_name":"Steady state (chemistry)","level":2,"score":0.42922818660736084},{"id":"https://openalex.org/C195289149","wikidata":"https://www.wikidata.org/wiki/Q2256694","display_name":"Toxicokinetics","level":3,"score":0.41305282711982727},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4117283821105957},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2784491181373596},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.24872875213623047},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20836305618286133},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.20489880442619324},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.1705198585987091},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.10410156846046448},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.092863529920578},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003530","descriptor_name":"Cyprinidae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003530","descriptor_name":"Cyprinidae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003530","descriptor_name":"Cyprinidae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015027","descriptor_name":"Zebrafish","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066007","descriptor_name":"Toxicokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066007","descriptor_name":"Toxicokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066007","descriptor_name":"Toxicokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12918-017-0407-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0407-3","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0407-3","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:28284215","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28284215","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:osti.gov:1626881","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1626881","pdf_url":"https://www.osti.gov/servlets/purl/1626881","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:5346271","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5346271","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-017-0407-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-017-0407-3","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-017-0407-3","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15","score":0.4099999964237213}],"awards":[],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332382","display_name":"Oak Ridge Institute for Science and Education","ror":"https://ror.org/0526p1y61"},{"id":"https://openalex.org/F4320338258","display_name":"Engineer Research and Development Center","ror":"https://ror.org/027mhn368"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2591785836.pdf","grobid_xml":"https://content.openalex.org/works/W2591785836.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W26234536","https://openalex.org/W615204457","https://openalex.org/W1768488937","https://openalex.org/W1835137027","https://openalex.org/W1967977080","https://openalex.org/W1974267872","https://openalex.org/W1977710838","https://openalex.org/W1980670658","https://openalex.org/W1991326458","https://openalex.org/W2003343666","https://openalex.org/W2005205901","https://openalex.org/W2013258146","https://openalex.org/W2053673739","https://openalex.org/W2059390515","https://openalex.org/W2061650979","https://openalex.org/W2063941210","https://openalex.org/W2074691440","https://openalex.org/W2077555199","https://openalex.org/W2085632989","https://openalex.org/W2093343711","https://openalex.org/W2096979824","https://openalex.org/W2110465433","https://openalex.org/W2128396525","https://openalex.org/W2131056563","https://openalex.org/W2165494629","https://openalex.org/W2166751342","https://openalex.org/W2289264651","https://openalex.org/W2324201396","https://openalex.org/W3214968550","https://openalex.org/W4255235899"],"related_works":["https://openalex.org/W1968270095","https://openalex.org/W2220129715","https://openalex.org/W4296478327","https://openalex.org/W2042397106","https://openalex.org/W4361730764","https://openalex.org/W1965029248","https://openalex.org/W2333625343","https://openalex.org/W1960072520","https://openalex.org/W2023776155","https://openalex.org/W2387596242"],"abstract_inverted_index":{"BACKGROUND:":[0],"Physiologically-based":[1],"toxicokinetic":[2],"(PBTK)":[3],"models":[4,73,131,163,196],"are":[5],"often":[6],"developed":[7],"to":[8,12,37,79,91,136],"facilitate":[9],"in":[10,13,77,133,147,159,178,216,220],"vitro":[11,148,221],"vivo":[14,217],"extrapolation":[15,214],"(IVIVE)":[16],"using":[17],"a":[18],"top-down,":[19],"compartmental":[20],"approach,":[21],"favoring":[22],"architectural":[23],"simplicity":[24],"over":[25],"physiological":[26,115,157],"fidelity":[27,116],"despite":[28,105],"the":[29,43,119,124,129,165,184],"lack":[30],"of":[31,45,68,74,114,128,161,215],"general":[32],"guidelines":[33],"relating":[34],"model":[35,87],"design":[36,46],"dynamical":[38],"predictions.":[39],"Here":[40],"we":[41],"explore":[42],"impact":[44],"choice":[47],"(high":[48],"vs.":[49],"low":[50],"fidelity)":[51],"on":[52],"chemical":[53,80,173],"distribution":[54],"throughout":[55],"an":[56],"animal's":[57],"organ":[58],"system.":[59],"RESULTS:":[60],"We":[61],"contrast":[62],"transient":[63],"dynamics":[64,167],"and":[65,168],"steady":[66,83,169],"states":[67,84],"three":[69],"previously":[70],"proposed":[71],"PBTK":[72],"varying":[75,112],"complexity":[76],"response":[78,143],"exposure.":[81],"The":[82],"for":[85,172,183,197],"each":[86],"were":[88],"determined":[89],"analytically":[90],"predict":[92],"exposure":[93,134,139,185],"conditions":[94],"from":[95,111,146,219],"tissue":[96],"measurements.":[97,150],"Steady":[98],"state":[99,170],"whole-body":[100],"concentrations":[101],"differ":[102],"between":[103],"models,":[104],"identical":[106],"environmental":[107],"conditions,":[108],"which":[109],"originates":[110],"levels":[113],"captured":[117],"by":[118],"models.":[120],"These":[121],"differences":[122],"affect":[123],"relative":[125],"predictive":[126,204],"accuracy":[127],"inverted":[130],"used":[132],"reconstruction":[135,186],"link":[137],"effects-based":[138],"data":[140,222],"with":[141],"whole-organism":[142],"thresholds":[144],"obtained":[145],"assay":[149],"CONCLUSIONS:":[151],"Our":[152],"results":[153],"demonstrate":[154],"how":[155],"disregarding":[156],"fideltiy":[158],"favor":[160],"simpler":[162],"affects":[164],"internal":[166],"estimates":[171],"accumulation":[174],"within":[175],"tissues,":[176],"which,":[177],"turn,":[179],"poses":[180],"significant":[181],"challenges":[182],"efforts":[187],"that":[188],"underlie":[189],"many":[190],"IVIVE":[191],"methods.":[192],"Developing":[193],"standardized":[194],"systems-level":[195],"ecological":[198],"organisms":[199],"would":[200],"not":[201],"only":[202],"ensure":[203,212],"consistency":[205],"among":[206],"future":[207],"modeling":[208,224],"studies,":[209],"but":[210],"also":[211],"pragmatic":[213],"effects":[218],"or":[223],"exposure-response":[225],"relationships.":[226]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}