{"id":"https://openalex.org/W2560424365","doi":"https://doi.org/10.1186/s12918-016-0370-4","title":"Integrated single cell data analysis reveals cell specific networks and novel coactivation markers","display_name":"Integrated single cell data analysis reveals cell specific networks and novel coactivation markers","publication_year":2016,"publication_date":"2016-12-01","ids":{"openalex":"https://openalex.org/W2560424365","doi":"https://doi.org/10.1186/s12918-016-0370-4","mag":"2560424365","pmid":"https://pubmed.ncbi.nlm.nih.gov/28105940"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-016-0370-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-016-0370-4","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-016-0370-4","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-016-0370-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087355766","display_name":"Shila Ghazanfar","orcid":"https://orcid.org/0000-0001-7861-6997"},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Shila Ghazanfar","raw_affiliation_strings":["School of Mathematics and Statistics, The University of Sydney, Eastern Avenue, Camperdown, NSW, 2006, Australia. shila.ghazanfar@sydney.edu.au","School of Mathematics and Statistics, The University of Sydney, Eastern Avenue, Camperdown, NSW, 2006, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, The University of Sydney, Eastern Avenue, Camperdown, NSW, 2006, Australia. shila.ghazanfar@sydney.edu.au","institution_ids":["https://openalex.org/I129604602"]},{"raw_affiliation_string":"School of Mathematics and Statistics, The University of Sydney, Eastern Avenue, Camperdown, NSW, 2006, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042267228","display_name":"Adam J Bisogni","orcid":"https://orcid.org/0000-0001-5383-7048"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam J. Bisogni","raw_affiliation_strings":["Department of Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050677327","display_name":"John T. Ormerod","orcid":"https://orcid.org/0000-0002-4650-7507"},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I4210123005","display_name":"ARC Centre of Excellence for Mathematical and Statistical Frontiers","ror":"https://ror.org/02vcqg248","country_code":"AU","type":"facility","lineage":["https://openalex.org/I1337719021","https://openalex.org/I165779595","https://openalex.org/I2801453606","https://openalex.org/I4210123005","https://openalex.org/I4210132349"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"John T. Ormerod","raw_affiliation_strings":["ARC Centre of Excellence for Mathematical & Statistical Frontiers, University of Melbourne, Parkville VIC, 3010, Australia","School of Mathematics and Statistics, The University of Sydney, Eastern Avenue, Camperdown, NSW, 2006, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ARC Centre of Excellence for Mathematical & Statistical Frontiers, University of Melbourne, Parkville VIC, 3010, Australia","institution_ids":["https://openalex.org/I4210123005"]},{"raw_affiliation_string":"School of Mathematics and Statistics, The University of Sydney, Eastern Avenue, Camperdown, NSW, 2006, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059110935","display_name":"David Lin","orcid":"https://orcid.org/0000-0002-9236-8405"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Lin","raw_affiliation_strings":["Department of Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, Cornell University, Ithaca, NY, 14853, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028524705","display_name":"Jean Yang","orcid":"https://orcid.org/0000-0002-5271-2603"},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jean Y. H. Yang","raw_affiliation_strings":["School of Mathematics and Statistics, The University of Sydney, Eastern Avenue, Camperdown, NSW, 2006, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematics and Statistics, The University of Sydney, Eastern Avenue, Camperdown, NSW, 2006, Australia","institution_ids":["https://openalex.org/I129604602"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5087355766"],"corresponding_institution_ids":["https://openalex.org/I129604602"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":2.4067,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.89203593,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"10","issue":"S5","first_page":"127","last_page":"127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9869999885559082,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9869999885559082,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coactivation","display_name":"Coactivation","score":0.8649120330810547},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7145883440971375},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.642799973487854},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5982335805892944},{"id":"https://openalex.org/keywords/cell-type","display_name":"Cell type","score":0.5760363936424255},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5706575512886047},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.5563331842422485},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5046178102493286},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.4937380254268646},{"id":"https://openalex.org/keywords/single-cell-analysis","display_name":"Single-cell analysis","score":0.46497249603271484},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.45251891016960144},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.44156414270401},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.4117593467235565},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.34359827637672424},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.31051144003868103}],"concepts":[{"id":"https://openalex.org/C2780060146","wikidata":"https://www.wikidata.org/wiki/Q637488","display_name":"Coactivation","level":3,"score":0.8649120330810547},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7145883440971375},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.642799973487854},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5982335805892944},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.5760363936424255},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5706575512886047},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5563331842422485},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5046178102493286},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4937380254268646},{"id":"https://openalex.org/C2776950831","wikidata":"https://www.wikidata.org/wiki/Q15635432","display_name":"Single-cell analysis","level":3,"score":0.46497249603271484},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.45251891016960144},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.44156414270401},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4117593467235565},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34359827637672424},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.31051144003868103},{"id":"https://openalex.org/C2777515770","wikidata":"https://www.wikidata.org/wiki/Q507369","display_name":"Electromyography","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018034","descriptor_name":"Olfactory Receptor Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018034","descriptor_name":"Olfactory Receptor Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018034","descriptor_name":"Olfactory Receptor Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D018034","descriptor_name":"Olfactory Receptor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018034","descriptor_name":"Olfactory Receptor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018034","descriptor_name":"Olfactory Receptor Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1186/s12918-016-0370-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-016-0370-4","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-016-0370-4","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:28105940","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28105940","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:5249008","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5249008","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-016-0370-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-016-0370-4","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-016-0370-4","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2868921350","display_name":"Research and Career Training in Vertebrate Developmental Genomics","funder_award_id":"5t32hd057854-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3130054980","display_name":"Scalable Bayesian model selection for massive data sets","funder_award_id":"DE130101670","funder_id":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council"},{"id":"https://openalex.org/G3543330770","display_name":null,"funder_award_id":"T32 HD057854","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G3914874440","display_name":null,"funder_award_id":"R21 DC015107","funder_id":"https://openalex.org/F4320337352","funder_display_name":"National Institute on Deafness and Other Communication Disorders"},{"id":"https://openalex.org/G6941714863","display_name":null,"funder_award_id":"130100488","funder_id":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council"},{"id":"https://openalex.org/G7546105126","display_name":"New statistical methods for identifying micro-ribonucleic acid (miRNA) regulatory networks","funder_award_id":"FT0991918","funder_id":"https://openalex.org/F4320334704","funder_display_name":"Australian Research Council"}],"funders":[{"id":"https://openalex.org/F4320320386","display_name":"Commonwealth Scientific and Industrial Research Organisation","ror":"https://ror.org/03qn8fb07"},{"id":"https://openalex.org/F4320320966","display_name":"University of Sydney","ror":"https://ror.org/0384j8v12"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334704","display_name":"Australian Research Council","ror":"https://ror.org/05mmh0f86"},{"id":"https://openalex.org/F4320337352","display_name":"National Institute on Deafness and Other Communication Disorders","ror":"https://ror.org/04mhx6838"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2560424365.pdf","grobid_xml":"https://content.openalex.org/works/W2560424365.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W17281879","https://openalex.org/W962147124","https://openalex.org/W1604997335","https://openalex.org/W1963753120","https://openalex.org/W1965923082","https://openalex.org/W1967327758","https://openalex.org/W1973688965","https://openalex.org/W1979283544","https://openalex.org/W1984073321","https://openalex.org/W1988715808","https://openalex.org/W1993609830","https://openalex.org/W1999780106","https://openalex.org/W2028910306","https://openalex.org/W2033072655","https://openalex.org/W2033822105","https://openalex.org/W2039521726","https://openalex.org/W2042515814","https://openalex.org/W2047687007","https://openalex.org/W2055958441","https://openalex.org/W2056944867","https://openalex.org/W2069295116","https://openalex.org/W2085680244","https://openalex.org/W2088264073","https://openalex.org/W2090204462","https://openalex.org/W2098587725","https://openalex.org/W2102212449","https://openalex.org/W2105512180","https://openalex.org/W2107018762","https://openalex.org/W2107665951","https://openalex.org/W2108141605","https://openalex.org/W2108234281","https://openalex.org/W2109890799","https://openalex.org/W2110768394","https://openalex.org/W2119185338","https://openalex.org/W2134526812","https://openalex.org/W2139357174","https://openalex.org/W2141688036","https://openalex.org/W2145748272","https://openalex.org/W2146217238","https://openalex.org/W2156232598","https://openalex.org/W2169456326","https://openalex.org/W2179438025","https://openalex.org/W2191006082","https://openalex.org/W2195967731","https://openalex.org/W2211603551","https://openalex.org/W2231058499","https://openalex.org/W2268971953","https://openalex.org/W2306630387","https://openalex.org/W2307634823","https://openalex.org/W2337340335","https://openalex.org/W2341685921","https://openalex.org/W2343956310","https://openalex.org/W2466175120","https://openalex.org/W2950420695","https://openalex.org/W2952877818"],"related_works":["https://openalex.org/W2156421048","https://openalex.org/W2135896045","https://openalex.org/W2032799661","https://openalex.org/W4289637626","https://openalex.org/W2884256268","https://openalex.org/W2131025197","https://openalex.org/W4294862307","https://openalex.org/W2171763327","https://openalex.org/W2154615478","https://openalex.org/W2031892952"],"abstract_inverted_index":{"BACKGROUND:":[0],"Large":[1],"scale":[2],"single":[3,33,53,234],"cell":[4,34,54,89,117,235],"transcriptome":[5],"profiling":[6],"has":[7,13],"exploded":[8],"in":[9,47,134,153],"recent":[10],"years":[11],"and":[12,45,107,119,193,205,223],"enabled":[14],"unprecedented":[15],"insight":[16],"into":[17,203,228],"the":[18,160,201,230],"behavior":[19],"of":[20,28,60,84,130,164,180,195,214,219,233],"individual":[21],"cells.":[22],"Identifying":[23],"genes":[24,44,148,192,222],"with":[25],"high":[26,61],"levels":[27],"expression":[29,104],"using":[30],"data":[31,202],"from":[32],"RNA":[35],"sequencing":[36],"can":[37],"be":[38,151],"useful":[39],"to":[40,76,100,110,120,168,184,190,217],"characterize":[41,111],"very":[42],"active":[43,102,204],"cells":[46],"which":[48],"this":[49],"occurs.":[50],"In":[51],"particular":[52],"RNA-Seq":[55],"allows":[56],"for":[57,86,113,210],"cell-specific":[58,122,161,224],"characterization":[59],"gene":[62,67,103,207],"expression,":[63],"as":[64,66,80,82,141,143],"well":[65,81,142],"coexpression.":[68],"RESULTS:":[69],"We":[70,94,125,156,197],"offer":[71],"a":[72,96,170],"versatile":[73],"modeling":[74],"framework":[75],"identify":[77,101,191],"transcriptional":[78],"states":[79,208],"structures":[83],"coactivation":[85,123,162],"different":[87],"neuronal":[88,154],"types":[90],"across":[91,105],"multiple":[92,131,181],"datasets.":[93],"employed":[95],"gamma-normal":[97],"mixture":[98],"model":[99],"cells,":[106],"used":[108],"these":[109],"markers":[112,138],"olfactory":[114],"sensory":[115],"neuron":[116],"maturity,":[118],"build":[121],"networks.":[124],"found":[126,198],"that":[127,149,159,199],"combined":[128],"analysis":[129],"datasets":[132,182],"results":[133],"more":[135,187,211],"known":[136],"maturity":[137,220],"being":[139],"identified,":[140],"pointing":[144],"towards":[145],"some":[146],"novel":[147],"may":[150],"involved":[152],"maturation.":[155],"also":[157],"observed":[158],"networks":[163],"mature":[165],"neurons":[166],"tended":[167],"have":[169],"higher":[171],"centralization":[172],"network":[173,225],"measure":[174],"than":[175],"immature":[176],"neurons.":[177],"CONCLUSION:":[178],"Integration":[179],"promises":[183],"bring":[185],"about":[186],"statistical":[188],"power":[189],"patterns":[194],"interest.":[196],"transforming":[200],"inactive":[206],"allowed":[209],"direct":[212],"comparison":[213],"datasets,":[215],"leading":[216],"identification":[218],"marker":[221],"observations,":[226],"taking":[227],"account":[229],"unique":[231],"characteristics":[232],"transcriptomics":[236],"data.":[237]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-08-06T08:24:18.245995","created_date":"2025-10-10T00:00:00"}