{"id":"https://openalex.org/W2567713598","doi":"https://doi.org/10.1186/s12918-016-0362-4","title":"Screening lifespan-extending drugs in Caenorhabditis elegans via label propagation on drug-protein networks","display_name":"Screening lifespan-extending drugs in Caenorhabditis elegans via label propagation on drug-protein networks","publication_year":2016,"publication_date":"2016-12-01","ids":{"openalex":"https://openalex.org/W2567713598","doi":"https://doi.org/10.1186/s12918-016-0362-4","mag":"2567713598","pmid":"https://pubmed.ncbi.nlm.nih.gov/28155715"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-016-0362-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-016-0362-4","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-016-0362-4","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-016-0362-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100387512","display_name":"Hui Liu","orcid":"https://orcid.org/0000-0001-7158-913X"},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I4210153482","display_name":"Changzhou University","ror":"https://ror.org/04ymgwq66","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210153482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Liu","raw_affiliation_strings":["Changzhou NO. 7 People's Hospital, Changzhou, Jiangsu, 213011, China","Changzhou University, Jiangsu, 213164, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changzhou NO. 7 People's Hospital, Changzhou, Jiangsu, 213011, China","institution_ids":["https://openalex.org/I4210151861"]},{"raw_affiliation_string":"Changzhou University, Jiangsu, 213164, China","institution_ids":["https://openalex.org/I4210153482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102819243","display_name":"Mengmeng Guo","orcid":"https://orcid.org/0000-0001-5280-245X"},"institutions":[{"id":"https://openalex.org/I4210153482","display_name":"Changzhou University","ror":"https://ror.org/04ymgwq66","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210153482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengmeng Guo","raw_affiliation_strings":["Changzhou University, Jiangsu, 213164, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changzhou University, Jiangsu, 213164, China","institution_ids":["https://openalex.org/I4210153482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059605597","display_name":"Ting Xue","orcid":"https://orcid.org/0000-0003-0727-9158"},"institutions":[{"id":"https://openalex.org/I4210153482","display_name":"Changzhou University","ror":"https://ror.org/04ymgwq66","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210153482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Xue","raw_affiliation_strings":["Changzhou University, Jiangsu, 213164, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changzhou University, Jiangsu, 213164, China","institution_ids":["https://openalex.org/I4210153482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086316879","display_name":"Jihong Guan","orcid":"https://orcid.org/0000-0003-2313-7635"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jihong Guan","raw_affiliation_strings":["Department of Computer Science and Technology, Tongji University, Shanghai, 201804, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Technology, Tongji University, Shanghai, 201804, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038464664","display_name":"Libo Luo","orcid":null},"institutions":[{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Libo Luo","raw_affiliation_strings":["Changzhou NO. 7 People's Hospital, Changzhou, Jiangsu, 213011, China. @fudan.edu.cn","Changzhou NO. 7 People\u2019s Hospital, Changzhou, Jiangsu, 213011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changzhou NO. 7 People's Hospital, Changzhou, Jiangsu, 213011, China. @fudan.edu.cn","institution_ids":["https://openalex.org/I4210151861"]},{"raw_affiliation_string":"Changzhou NO. 7 People\u2019s Hospital, Changzhou, Jiangsu, 213011, China","institution_ids":["https://openalex.org/I4210151861"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102437949","display_name":"Ziheng Zhuang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210144214","display_name":"Jiangsu University of Technology","ror":"https://ror.org/04jabhf80","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210144214"]},{"id":"https://openalex.org/I4210151861","display_name":"Changzhou No.2 People's Hospital","ror":"https://ror.org/04bkhy554","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210151861"]},{"id":"https://openalex.org/I4210153482","display_name":"Changzhou University","ror":"https://ror.org/04ymgwq66","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210153482"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ziheng Zhuang","raw_affiliation_strings":["Changzhou NO. 7 People's Hospital, Changzhou, Jiangsu, 213011, China. llb213001@163.com","Changzhou University, Jiangsu, 213164, China. llb213001@163.com","Changzhou NO. 7 People\u2019s Hospital, Changzhou, Jiangsu, 213011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Changzhou NO. 7 People's Hospital, Changzhou, Jiangsu, 213011, China. llb213001@163.com","institution_ids":["https://openalex.org/I4210151861"]},{"raw_affiliation_string":"Changzhou University, Jiangsu, 213164, China. llb213001@163.com","institution_ids":["https://openalex.org/I4210144214","https://openalex.org/I4210153482"]},{"raw_affiliation_string":"Changzhou NO. 7 People\u2019s Hospital, Changzhou, Jiangsu, 213011, China","institution_ids":["https://openalex.org/I4210151861"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5038464664","https://openalex.org/A5102437949"],"corresponding_institution_ids":["https://openalex.org/I4210144214","https://openalex.org/I4210151861","https://openalex.org/I4210153482"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":1.203,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.77487961,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"10","issue":"S4","first_page":"131","last_page":"131"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9822999835014343,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9822999835014343,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caenorhabditis-elegans","display_name":"Caenorhabditis elegans","score":0.8483750224113464},{"id":"https://openalex.org/keywords/longevity","display_name":"Longevity","score":0.618026077747345},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.5557655692100525},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5363593697547913},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5187395215034485},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4837610721588135},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.4337818920612335},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3310582637786865},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.31872284412384033},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.2677462697029114},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.16280633211135864},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.14327219128608704}],"concepts":[{"id":"https://openalex.org/C2778944004","wikidata":"https://www.wikidata.org/wiki/Q91703","display_name":"Caenorhabditis elegans","level":3,"score":0.8483750224113464},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.618026077747345},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5557655692100525},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5363593697547913},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5187395215034485},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4837610721588135},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4337818920612335},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3310582637786865},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.31872284412384033},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2677462697029114},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16280633211135864},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14327219128608704}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020407","descriptor_name":"Internet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029742","descriptor_name":"Caenorhabditis elegans Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/s12918-016-0362-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-016-0362-4","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-016-0362-4","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:28155715","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28155715","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:5260106","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5260106","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-016-0362-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-016-0362-4","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-016-0362-4","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6390086971","display_name":"\u57fa\u4e8e\u764c\u7ec6\u80de\u5206\u5b50\u7f51\u7edc\u7684\u7ec4\u5408\u836f\u7269\u7b5b\u9009\u7814\u7a76","funder_award_id":"61672113","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8060661363","display_name":null,"funder_award_id":"31300707","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2567713598.pdf","grobid_xml":"https://content.openalex.org/works/W2567713598.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W207735856","https://openalex.org/W1526088293","https://openalex.org/W1634111167","https://openalex.org/W1893639437","https://openalex.org/W1967607617","https://openalex.org/W1973973036","https://openalex.org/W1978370150","https://openalex.org/W1978522315","https://openalex.org/W1979488516","https://openalex.org/W1985425785","https://openalex.org/W1986039855","https://openalex.org/W1989271916","https://openalex.org/W1993513772","https://openalex.org/W1995996719","https://openalex.org/W2004984537","https://openalex.org/W2008856488","https://openalex.org/W2010583480","https://openalex.org/W2021165308","https://openalex.org/W2027171039","https://openalex.org/W2030530458","https://openalex.org/W2034064412","https://openalex.org/W2038120788","https://openalex.org/W2045201133","https://openalex.org/W2048376025","https://openalex.org/W2050068554","https://openalex.org/W2052532053","https://openalex.org/W2058484936","https://openalex.org/W2063649151","https://openalex.org/W2080094749","https://openalex.org/W2080349795","https://openalex.org/W2081003655","https://openalex.org/W2087118969","https://openalex.org/W2107105699","https://openalex.org/W2108574037","https://openalex.org/W2108700752","https://openalex.org/W2109991441","https://openalex.org/W2118852675","https://openalex.org/W2123703699","https://openalex.org/W2126726407","https://openalex.org/W2128080665","https://openalex.org/W2132023322","https://openalex.org/W2132556925","https://openalex.org/W2133990480","https://openalex.org/W2134390575","https://openalex.org/W2142429476","https://openalex.org/W2144489441","https://openalex.org/W2148887342","https://openalex.org/W2153635508","https://openalex.org/W2158217645","https://openalex.org/W2159887157","https://openalex.org/W2162711901","https://openalex.org/W2177317049","https://openalex.org/W2217796615","https://openalex.org/W2420957516"],"related_works":["https://openalex.org/W1585830474","https://openalex.org/W2393707090","https://openalex.org/W2188080485","https://openalex.org/W2539138474","https://openalex.org/W561829362","https://openalex.org/W2017343380","https://openalex.org/W4240441889","https://openalex.org/W2060694610","https://openalex.org/W2165718079","https://openalex.org/W4313855081"],"abstract_inverted_index":{"BACKGROUND:":[0],"One":[1],"of":[2,10,24,27,34,51,73,80,82,88,106,135,178,203,261],"the":[3,8,22,49,71,117,133,136,154,160,169,201,259],"most":[4],"challenging":[5],"tasks":[6],"in":[7,159,175,214,218,244,247],"exploration":[9],"anti-aging":[11],"is":[12,212],"to":[13,30,46,65,121,168,187,230,265],"discover":[14],"drugs":[15,67,81,124,156,171,174,217,232,263],"that":[16,68,153,196,209,252],"can":[17,69,198,255],"promote":[18],"longevity":[19,177],"and":[20,40,53,95,148,163,194,243],"delay":[21,48],"incidence":[23],"age-associated":[25],"diseases":[26],"human.":[28],"Up":[29],"date,":[31],"a":[32,58,78,98,104,189,227],"number":[33],"drugs,":[35,191],"including":[36],"some":[37],"antioxidants,":[38],"metabolites":[39],"synthetic":[41],"compounds,":[42],"have":[43,91,164,250],"been":[44,92],"found":[45,195],"effectively":[47,199,256],"aging":[50],"nematodes":[52],"insects.":[54],"RESULTS:":[55],"We":[56,76,131,150],"proposed":[57,137,226],"label":[59,111],"propagation":[60,112],"algorithm":[61,113,229],"on":[62,85,116,128,236],"drug-protein":[63,100,118],"network":[64,101,120],"infer":[66],"extend":[70,200],"lifespan":[72,86,202],"C.":[74,89,129,179,204,219,237,248],"elegans.":[75,130,180,205,220,238],"collected":[77],"set":[79,105],"which":[83],"functions":[84],"extension":[87],"elegans":[90,249],"reliably":[93],"determined,":[94],"then":[96],"built":[97],"large-scale":[99],"by":[102,139,268],"collecting":[103],"high-confidence":[107],"drugprotein":[108],"interactions.":[109],"A":[110],"was":[114],"run":[115],"bipartite":[119],"predict":[122,231],"new":[123],"with":[125,143,233],"lifespan-extending":[126,234],"effect":[127],"calibrated":[132],"performance":[134,141],"method":[138,211,254],"conducting":[140],"comparison":[142],"two":[144],"classical":[145],"models,":[146],"kNN":[147],"SVM.":[149],"also":[151],"showed":[152,208],"screened":[155,190],"significantly":[157],"mediate":[158],"aging-related":[161],"pathways,":[162],"higher":[165],"chemical":[166],"similarities":[167],"effective":[170,213],"than":[172],"ineffective":[173],"promoting":[176],"Moreover,":[181],"we":[182,225],"carried":[183],"out":[184],"wet-lab":[185],"experiments":[186,246],"verify":[188],"2-":[192],"Bromo-4'-nitroacetophenone,":[193],"it":[197],"These":[206],"results":[207],"our":[210,253],"screening":[215],"lifespanextending":[216],"CONCLUSIONS:":[221],"In":[222,239],"this":[223],"paper,":[224],"semi-supervised":[228],"effects":[235],"silico":[240],"empirical":[241],"evaluations":[242],"vivo":[245],"demonstrated":[251],"narrow":[257],"down":[258],"scope":[260],"candidate":[262],"needed":[264],"be":[266],"verified":[267],"wet":[269],"lab":[270],"experiments.":[271]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}