{"id":"https://openalex.org/W2521906657","doi":"https://doi.org/10.1186/s12918-016-0337-5","title":"Quantifying differences in cell line population dynamics using CellPD","display_name":"Quantifying differences in cell line population dynamics using CellPD","publication_year":2016,"publication_date":"2016-09-21","ids":{"openalex":"https://openalex.org/W2521906657","doi":"https://doi.org/10.1186/s12918-016-0337-5","mag":"2521906657","pmid":"https://pubmed.ncbi.nlm.nih.gov/27655224"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-016-0337-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-016-0337-5","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-016-0337-5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-016-0337-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022985604","display_name":"Edwin F. Juarez","orcid":"https://orcid.org/0000-0003-1062-3642"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Edwin F. Juarez","raw_affiliation_strings":["Department of Electrical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California, USA. juarezro@usc.edu","Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California, Los Angeles, California, USA. juarezro@usc.edu","Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California, USA. juarezro@usc.edu","institution_ids":[]},{"raw_affiliation_string":"Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California, Los Angeles, California, USA. juarezro@usc.edu","institution_ids":[]},{"raw_affiliation_string":"Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002457355","display_name":"Roy Lau","orcid":null},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roy Lau","raw_affiliation_strings":["Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019288997","display_name":"Samuel H. Friedman","orcid":"https://orcid.org/0000-0001-8003-6860"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel H. Friedman","raw_affiliation_strings":["Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031086500","display_name":"Ahmadreza Ghaffarizadeh","orcid":"https://orcid.org/0000-0002-9359-8800"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmadreza Ghaffarizadeh","raw_affiliation_strings":["Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016103839","display_name":"Edmond Jonckheere","orcid":"https://orcid.org/0000-0002-7205-4273"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edmond Jonckheere","raw_affiliation_strings":["Department of Electrical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electrical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012095437","display_name":"David B. Agus","orcid":"https://orcid.org/0000-0002-7499-7822"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David B. Agus","raw_affiliation_strings":["Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079254926","display_name":"Shannon M. Mumenthaler","orcid":"https://orcid.org/0000-0003-2687-3769"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shannon M. Mumenthaler","raw_affiliation_strings":["Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052380564","display_name":"Paul Macklin","orcid":"https://orcid.org/0000-0002-9925-0151"},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Macklin","raw_affiliation_strings":["Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California, Los Angeles, California, USA. Paul.Macklin@MathCancer.org","Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California, Los Angeles, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California, Los Angeles, California, USA. Paul.Macklin@MathCancer.org","institution_ids":[]},{"raw_affiliation_string":"Lawrence J. Ellison Institute for Transformative Medicine, University of Southern California, Los Angeles, California, USA","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5022985604"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":null,"apc_paid":null,"fwci":7.5098,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.96496934,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"92","last_page":"92"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.8382999897003174,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.8382999897003174,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.0364999994635582,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.029100000858306885,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7573680877685547},{"id":"https://openalex.org/keywords/usability","display_name":"Usability","score":0.5931674838066101},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5412506461143494},{"id":"https://openalex.org/keywords/software","display_name":"Software","score":0.535246729850769},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5299217104911804},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.4185715913772583},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3936975300312042},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2828635573387146},{"id":"https://openalex.org/keywords/programming-language","display_name":"Programming language","score":0.09778758883476257}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7573680877685547},{"id":"https://openalex.org/C170130773","wikidata":"https://www.wikidata.org/wiki/Q216378","display_name":"Usability","level":2,"score":0.5931674838066101},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5412506461143494},{"id":"https://openalex.org/C2777904410","wikidata":"https://www.wikidata.org/wiki/Q7397","display_name":"Software","level":2,"score":0.535246729850769},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5299217104911804},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.4185715913772583},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3936975300312042},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2828635573387146},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.09778758883476257},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C107457646","wikidata":"https://www.wikidata.org/wiki/Q207434","display_name":"Human\u2013computer interaction","level":1,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/s12918-016-0337-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-016-0337-5","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-016-0337-5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:27655224","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27655224","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:5031291","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5031291","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-016-0337-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-016-0337-5","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-016-0337-5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.41999998688697815,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G3437849365","display_name":null,"funder_award_id":"5U54CA143907","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6658740609","display_name":null,"funder_award_id":"1R01CA180149","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306260","display_name":"Breast Cancer Research Foundation","ror":"https://ror.org/0348ff195"},{"id":"https://openalex.org/F4320309558","display_name":"Wake Forest University","ror":"https://ror.org/0207ad724"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2521906657.pdf","grobid_xml":"https://content.openalex.org/works/W2521906657.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1509278136","https://openalex.org/W1738124305","https://openalex.org/W1775367392","https://openalex.org/W1978146924","https://openalex.org/W1979916898","https://openalex.org/W1987777080","https://openalex.org/W1991532100","https://openalex.org/W1995747680","https://openalex.org/W2003656404","https://openalex.org/W2011956460","https://openalex.org/W2020684750","https://openalex.org/W2036318837","https://openalex.org/W2053814546","https://openalex.org/W2059354961","https://openalex.org/W2070441922","https://openalex.org/W2072587226","https://openalex.org/W2073752235","https://openalex.org/W2088363255","https://openalex.org/W2098722656","https://openalex.org/W2106116918","https://openalex.org/W2107996465","https://openalex.org/W2112478769","https://openalex.org/W2119126373","https://openalex.org/W2131715540","https://openalex.org/W2143784594","https://openalex.org/W2151031807","https://openalex.org/W2188887730","https://openalex.org/W2263360618","https://openalex.org/W2345299709","https://openalex.org/W2505317998","https://openalex.org/W4235589356","https://openalex.org/W4251605192"],"related_works":["https://openalex.org/W2250140425","https://openalex.org/W2734587838","https://openalex.org/W2091018730","https://openalex.org/W2099940443","https://openalex.org/W2389064843","https://openalex.org/W2032501302","https://openalex.org/W2020153581","https://openalex.org/W2113904186","https://openalex.org/W2389272265","https://openalex.org/W1543345676"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1],"increased":[2],"availability":[3],"of":[4,49,102,143,195,245,257,266,279],"high-throughput":[5],"datasets":[6],"has":[7],"revealed":[8],"a":[9,84,149,158,234],"need":[10],"for":[11,27],"reproducible":[12],"and":[13,62,72,89,105,179,187,192,215,252,277],"accessible":[14],"analyses":[15],"which":[16],"can":[17,226],"quantitatively":[18],"relate":[19],"molecular":[20],"changes":[21],"to":[22,45,109,138,164,241],"phenotypic":[23],"behavior.":[24],"Existing":[25],"tools":[26],"quantitative":[28,40],"analysis":[29,142,265],"generally":[30],"require":[31],"expert":[32],"knowledge.":[33],"RESULTS:":[34],"CellPD":[35,56,95,126,172,219,258],"(cell":[36],"phenotype":[37,41],"digitizer)":[38],"facilitates":[39],"analysis,":[42],"allowing":[43],"users":[44],"fit":[46],"mathematical":[47,239],"models":[48],"cell":[50,103,160,246,250],"population":[51],"dynamics":[52],"without":[53,211,233],"specialized":[54,212],"training.":[55],"requires":[57],"one":[58],"input":[59],"(a":[60],"spreadsheet)":[61],"generates":[63],"multiple":[64],"outputs":[65],"including":[66],"parameter":[67],"estimation":[68],"reports,":[69],"high-quality":[70],"plots,":[71],"minable":[73,273],"XML":[74],"files.":[75],"We":[76],"validated":[77],"CellPD's":[78,117,136,184],"estimates":[79,97,174,185],"by":[80,229],"comparing":[81],"it":[82],"with":[83,90,203,282],"previously":[85],"published":[86],"tool":[87,224],"(cellGrowth)":[88],"Microsoft":[91,208],"Excel's":[92],"built-in":[93],"functions.":[94],"correctly":[96,127,173],"the":[98,141,175,190],"net":[99,180],"growth":[100,181],"rate":[101],"cultures":[104],"is":[106,162,220],"more":[107],"robust":[108],"data":[110,130,155,270,275,281],"sparsity":[111],"than":[112],"cellGrowth.":[113],"When":[114],"we":[115,147],"tested":[116],"usability,":[118],"biologists":[119],"(without":[120],"training":[121],"in":[122,140,236],"computational":[123,213,237,283],"modeling)":[124,240],"ran":[125],"on":[128],"sample":[129],"within":[131],"30":[132],"min.":[133],"To":[134],"demonstrate":[135],"ability":[137],"aid":[139],"high":[144,151],"throughput":[145],"data,":[146],"created":[148],"synthetic":[150],"content":[152],"screening":[153],"(HCS)":[154],"set,":[156],"where":[157],"simulated":[159],"line":[161],"exposed":[163],"two":[165],"hypothetical":[166],"drug":[167,261],"compounds":[168],"at":[169],"several":[170],"doses.":[171],"drug-dependent":[176],"birth,":[177],"death,":[178],"rates.":[182],"Furthermore,":[183],"quantify":[186,242],"distinguish":[188],"between":[189],"cytostatic":[191],"cytotoxic":[193],"effects":[194],"both":[196],"drugs-analyses":[197],"that":[198,225],"cannot":[199],"readily":[200],"be":[201,227],"performed":[202],"spreadsheet":[204],"software":[205],"such":[206],"as":[207,249],"Excel":[209],"or":[210,232,238],"expertise":[214],"programming":[216],"environments.":[217],"CONCLUSIONS:":[218],"an":[221],"open":[222],"source":[223],"used":[228],"scientists":[230],"(with":[231],"background":[235],"key":[243],"aspects":[244],"phenotypes":[247],"(such":[248],"cycle":[251],"death":[253],"parameters).":[254],"Early":[255],"applications":[256],"may":[259],"include":[260],"effect":[262],"quantification,":[263],"functional":[264],"gene":[267],"knockout":[268],"experiments,":[269],"quality":[271],"control,":[272],"big":[274],"generation,":[276],"integration":[278],"biological":[280],"models.":[284]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}