{"id":"https://openalex.org/W2510621697","doi":"https://doi.org/10.1186/s12918-016-0328-6","title":"Dynamic optimization of biological networks under parametric uncertainty","display_name":"Dynamic optimization of biological networks under parametric uncertainty","publication_year":2016,"publication_date":"2016-08-31","ids":{"openalex":"https://openalex.org/W2510621697","doi":"https://doi.org/10.1186/s12918-016-0328-6","mag":"2510621697","pmid":"https://pubmed.ncbi.nlm.nih.gov/27580913"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-016-0328-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-016-0328-6","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-016-0328-6","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-016-0328-6","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038131502","display_name":"Philippe Nimmegeers","orcid":"https://orcid.org/0000-0002-2086-7694"},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Philippe Nimmegeers","raw_affiliation_strings":["KU Leuven, Department of Chemical Engineering, BioTeC+ & OPTEC, Gebroeders De Smetstraat 1, Ghent, 9000, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Department of Chemical Engineering, BioTeC+ & OPTEC, Gebroeders De Smetstraat 1, Ghent, 9000, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038345028","display_name":"Dries Telen","orcid":null},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Dries Telen","raw_affiliation_strings":["KU Leuven, Department of Chemical Engineering, BioTeC+ & OPTEC, Gebroeders De Smetstraat 1, Ghent, 9000, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Department of Chemical Engineering, BioTeC+ & OPTEC, Gebroeders De Smetstraat 1, Ghent, 9000, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069635982","display_name":"Filip Logist","orcid":"https://orcid.org/0000-0001-8621-7531"},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Filip Logist","raw_affiliation_strings":["KU Leuven, Department of Chemical Engineering, BioTeC+ & OPTEC, Gebroeders De Smetstraat 1, Ghent, 9000, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Department of Chemical Engineering, BioTeC+ & OPTEC, Gebroeders De Smetstraat 1, Ghent, 9000, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003764514","display_name":"Jan Van Impe","orcid":"https://orcid.org/0000-0002-5904-1638"},"institutions":[{"id":"https://openalex.org/I4210114974","display_name":"IMEC","ror":"https://ror.org/02kcbn207","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I4210114974"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Jan Van Impe","raw_affiliation_strings":["KU Leuven, Department of Chemical Engineering, BioTeC+ & OPTEC, Gebroeders De Smetstraat 1, Ghent, 9000, Belgium. jan.vanimpe@kuleuven.be","KU Leuven, Department of Chemical Engineering, BioTeC+ & OPTEC, Gebroeders De Smetstraat 1, Ghent, 9000, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"KU Leuven, Department of Chemical Engineering, BioTeC+ & OPTEC, Gebroeders De Smetstraat 1, Ghent, 9000, Belgium. jan.vanimpe@kuleuven.be","institution_ids":["https://openalex.org/I4210114974"]},{"raw_affiliation_string":"KU Leuven, Department of Chemical Engineering, BioTeC+ & OPTEC, Gebroeders De Smetstraat 1, Ghent, 9000, Belgium","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.1004,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.94296141,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"86","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.663100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.663100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.17000000178813934,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11053","display_name":"Process Optimization and Integration","score":0.055799998342990875,"subfield":{"id":"https://openalex.org/subfields/2207","display_name":"Control and Systems Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5841594934463501},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.572741687297821},{"id":"https://openalex.org/keywords/parametric-statistics","display_name":"Parametric statistics","score":0.5483869910240173},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5383672714233398},{"id":"https://openalex.org/keywords/robust-optimization","display_name":"Robust optimization","score":0.524495542049408},{"id":"https://openalex.org/keywords/uncertainty-quantification","display_name":"Uncertainty quantification","score":0.5043677091598511},{"id":"https://openalex.org/keywords/optimization-problem","display_name":"Optimization problem","score":0.45721080899238586},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.4459632933139801},{"id":"https://openalex.org/keywords/biological-network","display_name":"Biological network","score":0.4368531107902527},{"id":"https://openalex.org/keywords/minification","display_name":"Minification","score":0.4331977963447571},{"id":"https://openalex.org/keywords/linearization","display_name":"Linearization","score":0.4143826961517334},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.33255594968795776},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.22172516584396362},{"id":"https://openalex.org/keywords/nonlinear-system","display_name":"Nonlinear system","score":0.15225404500961304},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.13388746976852417},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.12591424584388733},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.10042944550514221}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5841594934463501},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.572741687297821},{"id":"https://openalex.org/C117251300","wikidata":"https://www.wikidata.org/wiki/Q1849855","display_name":"Parametric statistics","level":2,"score":0.5483869910240173},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5383672714233398},{"id":"https://openalex.org/C193254401","wikidata":"https://www.wikidata.org/wiki/Q2160088","display_name":"Robust optimization","level":2,"score":0.524495542049408},{"id":"https://openalex.org/C32230216","wikidata":"https://www.wikidata.org/wiki/Q7882499","display_name":"Uncertainty quantification","level":2,"score":0.5043677091598511},{"id":"https://openalex.org/C137836250","wikidata":"https://www.wikidata.org/wiki/Q984063","display_name":"Optimization problem","level":2,"score":0.45721080899238586},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.4459632933139801},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.4368531107902527},{"id":"https://openalex.org/C147764199","wikidata":"https://www.wikidata.org/wiki/Q6865248","display_name":"Minification","level":2,"score":0.4331977963447571},{"id":"https://openalex.org/C11210021","wikidata":"https://www.wikidata.org/wiki/Q1520713","display_name":"Linearization","level":3,"score":0.4143826961517334},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.33255594968795776},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.22172516584396362},{"id":"https://openalex.org/C158622935","wikidata":"https://www.wikidata.org/wiki/Q660848","display_name":"Nonlinear system","level":2,"score":0.15225404500961304},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.13388746976852417},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.12591424584388733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10042944550514221},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006019","descriptor_name":"Glycolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035501","descriptor_name":"Uncertainty","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12918-016-0328-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-016-0328-6","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-016-0328-6","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:27580913","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27580913","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/547924","is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/547924","pdf_url":null,"source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"BMC Systems Biology, vol. 10 (86), Art.No. ARTN 86, (1-20)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:c:irua:172967","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306401849","display_name":"Institutional Repository University of Antwerp (University of Antwerp)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149213910","host_organization_name":"University of Antwerp","host_organization_lineage":["https://openalex.org/I149213910"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":""},{"id":"pmh:oai:pubmedcentral.nih.gov:5006366","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5006366","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-016-0328-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-016-0328-6","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-016-0328-6","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Affordable and clean energy","score":0.800000011920929,"id":"https://metadata.un.org/sdg/7"}],"awards":[{"id":"https://openalex.org/G2405958810","display_name":null,"funder_award_id":"PDM/15/134","funder_id":"https://openalex.org/F4320322681","funder_display_name":"Onderzoeksraad, KU Leuven"},{"id":"https://openalex.org/G3036612203","display_name":null,"funder_award_id":"2015/134","funder_id":"https://openalex.org/F4320322308","funder_display_name":"KU Leuven"},{"id":"https://openalex.org/G320933022","display_name":null,"funder_award_id":"G.0930.13","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G4703497943","display_name":null,"funder_award_id":"G.0930.13","funder_id":"https://openalex.org/F4320322308","funder_display_name":"KU Leuven"},{"id":"https://openalex.org/G485065284","display_name":null,"funder_award_id":"PFV/10/002","funder_id":"https://openalex.org/F4320321454","funder_display_name":"Belgian Federal Science Policy Office"},{"id":"https://openalex.org/G6012662756","display_name":null,"funder_award_id":"KAN2013 1.5.189.13","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G6182351167","display_name":null,"funder_award_id":"PFV/10/002","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G686892195","display_name":null,"funder_award_id":"[DYSCO IAP VII/19]","funder_id":"https://openalex.org/F4320321454","funder_display_name":"Belgian Federal Science Policy Office"},{"id":"https://openalex.org/G6876709308","display_name":null,"funder_award_id":"[G.0930.13 and KAN2013 1.5.189.13","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G8072579189","display_name":null,"funder_award_id":"IAP VII/19","funder_id":"https://openalex.org/F4320322308","funder_display_name":"KU Leuven"},{"id":"https://openalex.org/G8430479742","display_name":null,"funder_award_id":"IAP VII/19","funder_id":"https://openalex.org/F4320321730","funder_display_name":"Fonds Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G8829997307","display_name":null,"funder_award_id":"PFV/10/002","funder_id":"https://openalex.org/F4320322308","funder_display_name":"KU Leuven"}],"funders":[{"id":"https://openalex.org/F4320321454","display_name":"Belgian Federal Science Policy Office","ror":"https://ror.org/01fapfv42"},{"id":"https://openalex.org/F4320321730","display_name":"Fonds Wetenschappelijk Onderzoek","ror":"https://ror.org/03qtxy027"},{"id":"https://openalex.org/F4320322308","display_name":"KU Leuven","ror":"https://ror.org/05f950310"},{"id":"https://openalex.org/F4320322681","display_name":"Onderzoeksraad, KU Leuven","ror":"https://ror.org/05f950310"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2510621697.pdf","grobid_xml":"https://content.openalex.org/works/W2510621697.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W906662883","https://openalex.org/W1529344387","https://openalex.org/W1603888081","https://openalex.org/W1967356337","https://openalex.org/W1967384483","https://openalex.org/W1975385846","https://openalex.org/W1983584318","https://openalex.org/W1994159989","https://openalex.org/W1997188340","https://openalex.org/W1999938932","https://openalex.org/W2001963002","https://openalex.org/W2003835605","https://openalex.org/W2007627108","https://openalex.org/W2009163705","https://openalex.org/W2009265532","https://openalex.org/W2017834848","https://openalex.org/W2018159038","https://openalex.org/W2024008934","https://openalex.org/W2033630480","https://openalex.org/W2036602540","https://openalex.org/W2039477419","https://openalex.org/W2040558572","https://openalex.org/W2050758027","https://openalex.org/W2051821221","https://openalex.org/W2052585066","https://openalex.org/W2058192020","https://openalex.org/W2060016034","https://openalex.org/W2072620509","https://openalex.org/W2085262389","https://openalex.org/W2091198609","https://openalex.org/W2092941724","https://openalex.org/W2108592854","https://openalex.org/W2114725328","https://openalex.org/W2123871098","https://openalex.org/W2124028551","https://openalex.org/W2132105526","https://openalex.org/W2145436499","https://openalex.org/W2192870712","https://openalex.org/W2321957512","https://openalex.org/W2550341318","https://openalex.org/W2593781315","https://openalex.org/W2962880333","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2158714033","https://openalex.org/W78967844","https://openalex.org/W3213185671","https://openalex.org/W4210989272","https://openalex.org/W4206945140","https://openalex.org/W4386628104","https://openalex.org/W2509687359","https://openalex.org/W4212865750","https://openalex.org/W2362023034","https://openalex.org/W2947028852"],"abstract_inverted_index":{"BACKGROUND:":[0],"Micro-organisms":[1],"play":[2],"an":[3,26,34],"important":[4,35],"role":[5],"in":[6,19,37,141,202,212,230,340],"various":[7],"industrial":[8],"sectors":[9],"(including":[10],"biochemical,":[11],"food":[12],"and":[13,50,128,144,182,223,245,323,333,354],"pharmaceutical":[14],"industries).":[15],"A":[16,259],"profound":[17],"insight":[18],"the":[20,51,65,70,93,97,124,132,139,189,214,239,242,246,249,268,271,275,286,289,318,324,327,330,342,372],"biochemical":[21,28],"reactions":[22],"inside":[23],"micro-organisms":[24],"enables":[25],"improved":[27],"process":[29,157],"control.":[30],"Biological":[31],"networks":[32,194],"are":[33,47,60,186,200],"tool":[36],"systems":[38],"biology":[39],"for":[40,138,176,188,267,285,298,351],"incorporating":[41],"microscopic":[42],"level":[43],"knowledge.":[44],"Biochemical":[45],"processes":[46],"typically":[48,61],"dynamic":[49,190],"cells":[52],"have":[53],"often":[54],"more":[55],"than":[56],"one":[57,91,279],"objective":[58,134],"which":[59,168,213,231],"conflicting,":[62],"e.g.,":[63,111],"minimizing":[64],"energy":[66],"consumption":[67],"while":[68],"maximizing":[69],"production":[71],"of":[72,92,99,126,131,192,216,241,248,270,288,326,344,371],"a":[73,146,162,170,207,225,232,254,310,352,355],"specific":[74],"metabolite.":[75],"Therefore":[76],"multi-objective":[77,233,276],"optimization":[78,164,191,234],"is":[79,96,236],"needed":[80],"to":[81,123,161,220,366],"compute":[82,145],"trade-offs":[83],"between":[84,320],"those":[85],"conflicting":[86],"objectives.":[87],"In":[88,101],"model-based":[89],"optimization,":[90],"inherent":[94,112],"problems":[95],"presence":[98],"uncertainty.":[100,197,315],"biological":[102,113,193],"processes,":[103],"this":[104,117,149,293],"uncertainty":[105,118,150,177,305,358,374],"can":[106,295],"be":[107,152,221,296],"present":[108],"due":[109],"to,":[110],"variability.":[114],"Not":[115],"taking":[116],"into":[119,154,376],"account,":[120],"possibly":[121],"leads":[122,160],"violation":[125],"constraints":[127],"erroneous":[129],"estimates":[130],"actual":[133],"function(s).":[135],"To":[136],"account":[137,155],"variance":[140],"model":[142,211,229],"predictions":[143],"prediction":[147],"interval,":[148],"should":[151],"taken":[153],"during":[156],"optimization.":[158],"This":[159,347],"challenging":[163],"problem":[165,235],"under":[166,195,313],"uncertainty,":[167],"requires":[169],"robustified":[171,311],"solution.":[172],"RESULTS:":[173],"Three":[174],"techniques":[175],"propagation:":[178],"linearization,":[179],"sigma":[180,331],"points":[181,332],"polynomial":[183,334,361],"chaos":[184,335,362],"expansion,":[185],"compared":[187,201],"parametric":[196,314,357,373],"These":[198],"approaches":[199],"two":[203],"case":[204,277],"studies:":[205],"(i)":[206],"three-step":[208],"linear":[209],"pathway":[210],"accumulation":[215],"intermediate":[217],"metabolites":[218],"has":[219,264,282,348],"minimized":[222],"(ii)":[224],"glycolysis":[226],"inspired":[227],"network":[228],"considered,":[237],"being":[238],"minimization":[240,247],"enzymatic":[243],"cost":[244],"end":[250],"time":[251,322],"before":[252],"reaching":[253],"minimum":[255],"extracellular":[256],"metabolite":[257],"concentration.":[258],"Monte":[260],"Carlo":[261],"simulation":[262],"procedure":[263],"been":[265,283,349],"applied":[266],"assessment":[269,287],"constraint":[272,290,345],"violations.":[273,291,346],"For":[274],"study":[278],"Pareto":[280,300],"point":[281],"considered":[284],"However,":[292],"analysis":[294],"performed":[297],"any":[299],"point.":[301],"CONCLUSIONS:":[302],"The":[303,360],"different":[304],"propagation":[306],"strategies":[307,337],"each":[308],"offer":[309],"solution":[312],"When":[316],"making":[317],"trade-off":[319],"computation":[321],"robustness":[325],"obtained":[328],"profiles,":[329],"expansion":[336,363],"score":[338],"better":[339],"reducing":[341],"percentage":[343],"investigated":[350],"normal":[353],"uniform":[356],"distribution.":[359],"approach":[364],"allows":[365],"directly":[367],"take":[368],"prior":[369],"knowledge":[370],"distribution":[375],"account.":[377]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":8}],"updated_date":"2026-07-04T07:58:01.006859","created_date":"2025-10-10T00:00:00"}