{"id":"https://openalex.org/W2493185170","doi":"https://doi.org/10.1186/s12918-016-0294-z","title":"Extending rule-based methods to model molecular geometry and 3D model resolution","display_name":"Extending rule-based methods to model molecular geometry and 3D model resolution","publication_year":2016,"publication_date":"2016-08-01","ids":{"openalex":"https://openalex.org/W2493185170","doi":"https://doi.org/10.1186/s12918-016-0294-z","mag":"2493185170","pmid":"https://pubmed.ncbi.nlm.nih.gov/27490268"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-016-0294-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-016-0294-z","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-016-0294-z","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-016-0294-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054293772","display_name":"Brittany R. Hoard","orcid":"https://orcid.org/0000-0002-1897-1388"},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brittany Hoard","raw_affiliation_strings":["Department of Computer Science, University of New Mexico, Albuquerque, 87131, New Mexico, USA","Department of Computer Science, University of New Mexico, Albuquerque, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of New Mexico, Albuquerque, 87131, New Mexico, USA","institution_ids":["https://openalex.org/I169521973"]},{"raw_affiliation_string":"Department of Computer Science, University of New Mexico, Albuquerque, USA","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024549284","display_name":"Bruna Jacobson","orcid":"https://orcid.org/0000-0001-7718-9794"},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruna Jacobson","raw_affiliation_strings":["Department of Computer Science, University of New Mexico, Albuquerque, 87131, New Mexico, USA","Department of Computer Science, University of New Mexico, Albuquerque, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of New Mexico, Albuquerque, 87131, New Mexico, USA","institution_ids":["https://openalex.org/I169521973"]},{"raw_affiliation_string":"Department of Computer Science, University of New Mexico, Albuquerque, USA","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079697685","display_name":"Kasra Manavi","orcid":null},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kasra Manavi","raw_affiliation_strings":["Department of Computer Science, University of New Mexico, Albuquerque, 87131, New Mexico, USA","Department of Computer Science, University of New Mexico, Albuquerque, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of New Mexico, Albuquerque, 87131, New Mexico, USA","institution_ids":["https://openalex.org/I169521973"]},{"raw_affiliation_string":"Department of Computer Science, University of New Mexico, Albuquerque, USA","institution_ids":["https://openalex.org/I169521973"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060753774","display_name":"Lydia Tapia","orcid":"https://orcid.org/0000-0002-7822-7091"},"institutions":[{"id":"https://openalex.org/I169521973","display_name":"University of New Mexico","ror":"https://ror.org/05fs6jp91","country_code":"US","type":"education","lineage":["https://openalex.org/I169521973"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lydia Tapia","raw_affiliation_strings":["Department of Computer Science, University of New Mexico, Albuquerque, 87131, New Mexico, USA. tapia@cs.unm.edu","Department of Computer Science, University of New Mexico, Albuquerque, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of New Mexico, Albuquerque, 87131, New Mexico, USA. tapia@cs.unm.edu","institution_ids":["https://openalex.org/I169521973"]},{"raw_affiliation_string":"Department of Computer Science, University of New Mexico, Albuquerque, USA","institution_ids":["https://openalex.org/I169521973"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5060753774"],"corresponding_institution_ids":["https://openalex.org/I169521973"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":1.3039,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.80045069,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"10","issue":"S2","first_page":"48","last_page":"48"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8449000120162964,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8449000120162964,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.019200000911951065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6029037237167358},{"id":"https://openalex.org/keywords/monte-carlo-method","display_name":"Monte Carlo method","score":0.5528035163879395},{"id":"https://openalex.org/keywords/curvature","display_name":"Curvature","score":0.5445913672447205},{"id":"https://openalex.org/keywords/geometry","display_name":"Geometry","score":0.5021853446960449},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4503839313983917},{"id":"https://openalex.org/keywords/computational-geometry","display_name":"Computational geometry","score":0.4372228980064392},{"id":"https://openalex.org/keywords/computational-model","display_name":"Computational model","score":0.4229726493358612},{"id":"https://openalex.org/keywords/molecular-model","display_name":"Molecular model","score":0.4184318780899048},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2171143889427185},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.17315146327018738}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6029037237167358},{"id":"https://openalex.org/C19499675","wikidata":"https://www.wikidata.org/wiki/Q232207","display_name":"Monte Carlo method","level":2,"score":0.5528035163879395},{"id":"https://openalex.org/C195065555","wikidata":"https://www.wikidata.org/wiki/Q214881","display_name":"Curvature","level":2,"score":0.5445913672447205},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.5021853446960449},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4503839313983917},{"id":"https://openalex.org/C29123130","wikidata":"https://www.wikidata.org/wiki/Q874709","display_name":"Computational geometry","level":2,"score":0.4372228980064392},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.4229726493358612},{"id":"https://openalex.org/C178910836","wikidata":"https://www.wikidata.org/wiki/Q2196961","display_name":"Molecular model","level":2,"score":0.4184318780899048},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2171143889427185},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17315146327018738},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/s12918-016-0294-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-016-0294-z","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-016-0294-z","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:27490268","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27490268","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4977479","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4977479","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-016-0294-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-016-0294-z","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-016-0294-z","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2039012806","display_name":null,"funder_award_id":"P50 GM-085273","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G428651850","display_name":"Center for Spatiotemporal Modeling of Cell Signaling","funder_award_id":"5p50gm085273-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G636422908","display_name":null,"funder_award_id":"P20 RR018754","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6582404027","display_name":null,"funder_award_id":"P30\u2010GM110907","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7478777031","display_name":"COBRE Center for Evolutionary and Theoretical Immunology","funder_award_id":"5p20rr018754-07","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320310632","display_name":"Center for Evolutionary and Theoretical Immunology","ror":"https://ror.org/05fs6jp91"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2493185170.pdf","grobid_xml":"https://content.openalex.org/works/W2493185170.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W137961148","https://openalex.org/W1499429477","https://openalex.org/W1563071114","https://openalex.org/W1832276623","https://openalex.org/W1964603087","https://openalex.org/W1969112250","https://openalex.org/W1973846182","https://openalex.org/W1986649132","https://openalex.org/W1987922325","https://openalex.org/W1994344551","https://openalex.org/W2023568310","https://openalex.org/W2034492556","https://openalex.org/W2045598937","https://openalex.org/W2047331390","https://openalex.org/W2052558212","https://openalex.org/W2059654443","https://openalex.org/W2061279689","https://openalex.org/W2073338313","https://openalex.org/W2079704365","https://openalex.org/W2082221311","https://openalex.org/W2086376468","https://openalex.org/W2086928685","https://openalex.org/W2099015579","https://openalex.org/W2118649335","https://openalex.org/W2119232644","https://openalex.org/W2124885315","https://openalex.org/W2125842347","https://openalex.org/W2146099270","https://openalex.org/W2149362274","https://openalex.org/W2163493106","https://openalex.org/W2165700291","https://openalex.org/W2165714871","https://openalex.org/W2168518560","https://openalex.org/W2220901378","https://openalex.org/W2315703236","https://openalex.org/W2381451619","https://openalex.org/W3098157440","https://openalex.org/W4205740352","https://openalex.org/W4313333784"],"related_works":["https://openalex.org/W55883722","https://openalex.org/W2394379345","https://openalex.org/W2079726820","https://openalex.org/W2393870460","https://openalex.org/W3215763795","https://openalex.org/W4288816678","https://openalex.org/W4284894156","https://openalex.org/W2161803855","https://openalex.org/W2118352149","https://openalex.org/W2380616566"],"abstract_inverted_index":{"BACKGROUND:":[0],"Computational":[1],"modeling":[2,42,62,102,134],"is":[3,21,43],"an":[4],"important":[5],"tool":[6],"for":[7,253],"the":[8,34,95,142,155,172,181,199,214,217,223,226,232,235,244,262,269,277,284,292,305],"study":[9,162],"of":[10,29,38,68,73,83,132,138,163,174,180,216,238,256,264],"complex":[11],"biochemical":[12,76],"processes":[13,25,53],"associated":[14],"with":[15,54],"cell":[16],"signaling":[17],"networks.":[18],"However,":[19],"it":[20],"challenging":[22],"to":[23,33,50,89,106,118,154,177,213,242,298],"simulate":[24,51,171],"that":[26,46,97,111,135,276,294,310],"involve":[27],"hundreds":[28],"large":[30],"molecules":[31],"due":[32],"high":[35],"computational":[36,57,109],"cost":[37],"such":[39],"simulations.":[40],"Rule-based":[41],"a":[44,129,161,185,188,209,219,240,258],"method":[45],"can":[47,78,103],"be":[48,104],"used":[49,105],"these":[52,84,299],"reasonably":[55],"low":[56],"cost,":[58],"but":[59],"traditional":[60],"rule-based":[61,101,133,210,271,279],"approaches":[63],"do":[64],"not":[65],"include":[66],"details":[67,82,137],"molecular":[69,114,139,156,315],"geometry.":[70],"The":[71],"incorporation":[72],"geometry":[74,93,115,140,215,316],"into":[75,91,141],"models":[77,280,303],"more":[79],"accurately":[80],"capture":[81],"processes,":[85],"and":[86,123,144,196,222,246,260,266,291,317],"may":[87],"lead":[88],"insights":[90],"how":[92,149],"affects":[94],"products":[96],"form.":[98],"Furthermore,":[99],"geometric":[100],"complement":[107],"other":[108],"methods":[110],"explicitly":[112],"represent":[113],"in":[116,307,314],"order":[117],"quantify":[119,304],"binding":[120,145,173,178,236,247,289],"site":[121],"accessibility":[122],"steric":[124,286],"effects.":[125],"RESULTS:":[126],"We":[127,147,158,170,230,249,274],"propose":[128],"novel":[130,205],"implementation":[131],"encodes":[136],"rules":[143,150,245],"rates.":[146,248],"demonstrate":[148],"are":[151],"constructed":[152],"according":[153,212],"curvature.":[157],"then":[159],"perform":[160,250],"antigen-antibody":[164],"aggregation":[165],"using":[166,187,203],"our":[167,204],"proposed":[168],"method.":[169],"antibody":[175],"complexes":[176],"regions":[179,237,290],"shrimp":[182],"allergen":[183],"Pen":[184,218,239,257],"1":[186,220,241,259],"previously":[189],"developed":[190],"3D":[191],"rigid-body":[192],"Monte":[193,227],"Carlo":[194,228],"simulation,":[195],"we":[197,207],"analyze":[198,261],"aggregate":[200,308],"sizes.":[201],"Then,":[202],"approach,":[206],"optimize":[208,243],"model":[211,319],"molecule":[221],"data":[224],"from":[225,312,318],"simulation.":[229],"use":[231],"distances":[233],"between":[234,288],"this":[251],"procedure":[252],"multiple":[254],"conformations":[255],"impact":[263],"conformation":[265],"resolution":[267],"on":[268],"optimal":[270],"model.":[272],"CONCLUSIONS:":[273],"find":[275],"optimized":[278,302],"provide":[281],"information":[282],"about":[283],"average":[285],"hindrance":[287],"probability":[293],"antibodies":[295],"will":[296],"bind":[297],"regions.":[300],"These":[301],"variation":[306],"size":[309],"results":[311],"differences":[313],"resolution.":[320]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-08-06T08:24:18.245995","created_date":"2025-10-10T00:00:00"}