{"id":"https://openalex.org/W2339938878","doi":"https://doi.org/10.1186/s12918-016-0278-z","title":"Vascular endothelial growth factor A as predictive marker for mTOR inhibition in relapsing high-grade serous ovarian cancer","display_name":"Vascular endothelial growth factor A as predictive marker for mTOR inhibition in relapsing high-grade serous ovarian cancer","publication_year":2016,"publication_date":"2016-04-18","ids":{"openalex":"https://openalex.org/W2339938878","doi":"https://doi.org/10.1186/s12918-016-0278-z","mag":"2339938878","pmid":"https://pubmed.ncbi.nlm.nih.gov/27090655"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-016-0278-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-016-0278-z","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12918-016-0278-z.pdf","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12918-016-0278-z.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102311064","display_name":"Peter Andorfer","orcid":null},"institutions":[{"id":"https://openalex.org/I4210145989","display_name":"EmergenTec (Austria)","ror":"https://ror.org/04f8y1a51","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210145989"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Peter Andorfer","raw_affiliation_strings":["emergentec biodevelopment GmbH, Gersthofer Strasse 29-31, 1180, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"emergentec biodevelopment GmbH, Gersthofer Strasse 29-31, 1180, Vienna, Austria","institution_ids":["https://openalex.org/I4210145989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048253124","display_name":"Alexander Heuwieser","orcid":null},"institutions":[{"id":"https://openalex.org/I4210145989","display_name":"EmergenTec (Austria)","ror":"https://ror.org/04f8y1a51","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210145989"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Alexander Heuwieser","raw_affiliation_strings":["emergentec biodevelopment GmbH, Gersthofer Strasse 29-31, 1180, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"emergentec biodevelopment GmbH, Gersthofer Strasse 29-31, 1180, Vienna, Austria","institution_ids":["https://openalex.org/I4210145989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051084819","display_name":"Andreas Heinzel","orcid":"https://orcid.org/0000-0002-8447-1795"},"institutions":[{"id":"https://openalex.org/I4210145989","display_name":"EmergenTec (Austria)","ror":"https://ror.org/04f8y1a51","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210145989"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Andreas Heinzel","raw_affiliation_strings":["emergentec biodevelopment GmbH, Gersthofer Strasse 29-31, 1180, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"emergentec biodevelopment GmbH, Gersthofer Strasse 29-31, 1180, Vienna, Austria","institution_ids":["https://openalex.org/I4210145989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021203671","display_name":"Arno Lukas","orcid":"https://orcid.org/0000-0003-0936-1649"},"institutions":[{"id":"https://openalex.org/I4210145989","display_name":"EmergenTec (Austria)","ror":"https://ror.org/04f8y1a51","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210145989"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Arno Lukas","raw_affiliation_strings":["emergentec biodevelopment GmbH, Gersthofer Strasse 29-31, 1180, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"emergentec biodevelopment GmbH, Gersthofer Strasse 29-31, 1180, Vienna, Austria","institution_ids":["https://openalex.org/I4210145989"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101559215","display_name":"Bernd Mayer","orcid":"https://orcid.org/0000-0001-5502-9167"},"institutions":[{"id":"https://openalex.org/I4210145989","display_name":"EmergenTec (Austria)","ror":"https://ror.org/04f8y1a51","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210145989"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Bernd Mayer","raw_affiliation_strings":["emergentec biodevelopment GmbH, Gersthofer Strasse 29-31, 1180, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"emergentec biodevelopment GmbH, Gersthofer Strasse 29-31, 1180, Vienna, Austria","institution_ids":["https://openalex.org/I4210145989"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019700420","display_name":"Paul Perco","orcid":"https://orcid.org/0000-0003-2087-5691"},"institutions":[{"id":"https://openalex.org/I4210145989","display_name":"EmergenTec (Austria)","ror":"https://ror.org/04f8y1a51","country_code":"AT","type":"company","lineage":["https://openalex.org/I4210145989"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Paul Perco","raw_affiliation_strings":["emergentec biodevelopment GmbH, Gersthofer Strasse 29-31, 1180, Vienna, Austria. paul.perco@emergentec.com","emergentec biodevelopment GmbH, Gersthofer Strasse 29-31, 1180, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"emergentec biodevelopment GmbH, Gersthofer Strasse 29-31, 1180, Vienna, Austria. paul.perco@emergentec.com","institution_ids":["https://openalex.org/I4210145989"]},{"raw_affiliation_string":"emergentec biodevelopment GmbH, Gersthofer Strasse 29-31, 1180, Vienna, Austria","institution_ids":["https://openalex.org/I4210145989"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5019700420"],"corresponding_institution_ids":["https://openalex.org/I4210145989"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":1745,"currency":"EUR","value_usd":1881},"fwci":3.5937,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.91638212,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"10","issue":"1","first_page":"33","last_page":"33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.19169999659061432,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.19169999659061432,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.12160000205039978,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.11509999632835388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serous-ovarian-cancer","display_name":"Serous ovarian cancer","score":0.654949426651001},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"Ovarian cancer","score":0.5844113230705261},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"Vascular endothelial growth factor","score":0.5721142292022705},{"id":"https://openalex.org/keywords/pi3k/akt/mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.5494434833526611},{"id":"https://openalex.org/keywords/serous-fluid","display_name":"Serous fluid","score":0.5458772778511047},{"id":"https://openalex.org/keywords/predictive-marker","display_name":"Predictive marker","score":0.4980583190917969},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.49380406737327576},{"id":"https://openalex.org/keywords/discovery-and-development-of-mtor-inhibitors","display_name":"Discovery and development of mTOR inhibitors","score":0.4226638078689575},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4095717668533325},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.40469515323638916},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.37266796827316284},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.35668298602104187},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.3352445960044861},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.29917198419570923},{"id":"https://openalex.org/keywords/vegf-receptors","display_name":"VEGF receptors","score":0.28409144282341003},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.20614376664161682},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.17783749103546143}],"concepts":[{"id":"https://openalex.org/C2993684365","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Serous ovarian cancer","level":4,"score":0.654949426651001},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5844113230705261},{"id":"https://openalex.org/C2777025900","wikidata":"https://www.wikidata.org/wiki/Q29725","display_name":"Vascular endothelial growth factor","level":3,"score":0.5721142292022705},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5494434833526611},{"id":"https://openalex.org/C150173356","wikidata":"https://www.wikidata.org/wiki/Q6144101","display_name":"Serous fluid","level":2,"score":0.5458772778511047},{"id":"https://openalex.org/C2780521871","wikidata":"https://www.wikidata.org/wiki/Q7239671","display_name":"Predictive marker","level":3,"score":0.4980583190917969},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49380406737327576},{"id":"https://openalex.org/C183713625","wikidata":"https://www.wikidata.org/wiki/Q5282002","display_name":"Discovery and development of mTOR inhibitors","level":4,"score":0.4226638078689575},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4095717668533325},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40469515323638916},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37266796827316284},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35668298602104187},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3352445960044861},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29917198419570923},{"id":"https://openalex.org/C167734588","wikidata":"https://www.wikidata.org/wiki/Q4356503","display_name":"VEGF receptors","level":2,"score":0.28409144282341003},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20614376664161682},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.17783749103546143}],"mesh":[{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012008","descriptor_name":"Recurrence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12918-016-0278-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-016-0278-z","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12918-016-0278-z.pdf","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:27090655","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27090655","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:europepmc.org:3804600","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4836190","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:zenodo.org:58928","is_oa":true,"landing_page_url":"https://zenodo.org/record/58928","pdf_url":null,"source":{"id":"https://openalex.org/S4306402478","display_name":"INFM-OAR (INFN Catania)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210116497","host_organization_name":"Istituto Nazionale di Fisica Nucleare, Sezione di Catania","host_organization_lineage":["https://openalex.org/I4210116497"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, 10(1), 33, (2016-04-18)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s12918-016-0278-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-016-0278-z","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12918-016-0278-z.pdf","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8500000238418579}],"awards":[{"id":"https://openalex.org/G2757941496","display_name":null,"funder_award_id":"279113","funder_id":"https://openalex.org/F4320334960","funder_display_name":"Seventh Framework Programme"}],"funders":[{"id":"https://openalex.org/F4320334960","display_name":"Seventh Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2339938878.pdf","grobid_xml":"https://content.openalex.org/works/W2339938878.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1535501505","https://openalex.org/W1868026527","https://openalex.org/W1967187359","https://openalex.org/W1967715255","https://openalex.org/W1968109047","https://openalex.org/W1971995358","https://openalex.org/W1973090827","https://openalex.org/W1975385846","https://openalex.org/W1976643073","https://openalex.org/W1983154518","https://openalex.org/W1985841182","https://openalex.org/W1986764225","https://openalex.org/W1996193504","https://openalex.org/W1996989652","https://openalex.org/W2002710196","https://openalex.org/W2023231438","https://openalex.org/W2023708006","https://openalex.org/W2029922807","https://openalex.org/W2031674672","https://openalex.org/W2034038847","https://openalex.org/W2037927825","https://openalex.org/W2041142934","https://openalex.org/W2042619042","https://openalex.org/W2047475076","https://openalex.org/W2050910224","https://openalex.org/W2051658829","https://openalex.org/W2052456024","https://openalex.org/W2052849209","https://openalex.org/W2054917860","https://openalex.org/W2057158494","https://openalex.org/W2062533676","https://openalex.org/W2068591911","https://openalex.org/W2069188859","https://openalex.org/W2075711878","https://openalex.org/W2076690637","https://openalex.org/W2088845519","https://openalex.org/W2089575637","https://openalex.org/W2095264870","https://openalex.org/W2095484897","https://openalex.org/W2100470338","https://openalex.org/W2102148658","https://openalex.org/W2103540939","https://openalex.org/W2110790042","https://openalex.org/W2112693570","https://openalex.org/W2114365110","https://openalex.org/W2115021142","https://openalex.org/W2115954319","https://openalex.org/W2124185479","https://openalex.org/W2125089526","https://openalex.org/W2126614028","https://openalex.org/W2127063807","https://openalex.org/W2130215449","https://openalex.org/W2130643308","https://openalex.org/W2131545168","https://openalex.org/W2131593373","https://openalex.org/W2136850043","https://openalex.org/W2143862282","https://openalex.org/W2151010413","https://openalex.org/W2153011302","https://openalex.org/W2154122181","https://openalex.org/W2155142785","https://openalex.org/W2157983986","https://openalex.org/W2158217645","https://openalex.org/W2167749003","https://openalex.org/W2184417913","https://openalex.org/W2325622363","https://openalex.org/W2432114750","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2375683817","https://openalex.org/W2783565152","https://openalex.org/W2356273915","https://openalex.org/W2390302961","https://openalex.org/W2122634638","https://openalex.org/W1965859996","https://openalex.org/W2791227180","https://openalex.org/W2496631490","https://openalex.org/W2094531496","https://openalex.org/W2026842096"],"abstract_inverted_index":{"BACKGROUND:":[0],"Development":[1],"of":[2,43,48,61,63,70,79,115,150,167,172,190,200,203,232,256,258],"resistance":[3,53,214,267],"against":[4],"first":[5,146,269],"line":[6,147,270],"drug":[7,24,52,94,116,213,239],"therapy":[8],"including":[9,196],"cisplatin":[10,173,218],"and":[11,73,82,163,174,182,219,248],"paclitaxel":[12,175,230],"in":[13,54,109,122,155,254],"high-grade":[14],"serous":[15,243],"ovarian":[16,44,92,244],"cancer":[17,45,93,245],"(HGSOC)":[18],"presents":[19],"a":[20,66,100,110,156,225],"major":[21],"challenge.":[22],"Identifying":[23],"candidates":[25],"breaking":[26],"resistance,":[27],"ideally":[28],"combined":[29,58],"with":[30,59,91,130,186,251],"predictive":[31,75],"biomarkers":[32],"allowing":[33],"precision":[34,264],"use":[35],"are":[36,153],"needed":[37],"for":[38,68,142,224,265],"prolonging":[39],"progression":[40,134],"free":[41,135],"survival":[42,136],"patients.":[46],"Modeling":[47],"molecular":[49,111,124,139,157,169],"processes":[50],"driving":[51],"tumor":[55],"tissue":[56],"further":[57,221],"mechanism":[60,199,231],"action":[62,168,201,233],"drugs":[64,72],"provides":[65,87],"strategy":[67],"identification":[69],"candidate":[71],"associated":[74],"biomarkers.":[76],"RESULTS:":[77],"Consolidation":[78],"transcriptomics":[80,128],"profiles":[81,129],"biomedical":[83],"literature":[84],"mining":[85],"results":[86,108],"1242":[88],"proteins":[89,121,184],"linked":[90],"resistance.":[95],"Integrating":[96],"this":[97],"set":[98],"on":[99,133,211],"protein":[101],"interaction":[102,228],"network":[103],"followed":[104],"by":[105,217],"graph":[106],"segmentation":[107],"process":[112,158],"model":[113,170],"representation":[114],"resistant":[117,240],"HGSOC":[118],"embedding":[119],"409":[120],"24":[123],"processes.":[125],"Utilizing":[126],"independent":[127],"follow-up":[131],"data":[132],"allows":[137],"deriving":[138],"biomarker-based":[140],"classifiers":[141],"predicting":[143],"recurrence":[144],"under":[145],"therapy.":[148,271],"Biomarkers":[149],"specific":[151,209],"relevance":[152],"identified":[154],"encapsulating":[159],"TGF-beta,":[160],"mTOR,":[161],"Jak-STAT":[162],"Neurotrophin":[164],"signaling.":[165],"Mechanism":[166],"representations":[171],"embed":[176],"the":[177,187,191,204,212,259],"very":[178],"same":[179],"signaling":[180],"components,":[181],"specifically":[183,249],"afflicted":[185],"activation":[188,257],"status":[189],"mTOR":[192,205,252],"pathway":[193,260],"become":[194],"evident,":[195],"VEGFA.":[197],"Analyzing":[198],"interference":[202],"inhibitor":[206],"sirolimus":[207],"shows":[208],"impact":[210],"signature":[215],"imposed":[216],"paclitaxel,":[220],"holding":[222],"evidence":[223],"synthetic":[226],"lethal":[227],"to":[229,268],"involving":[234],"cyclin":[235],"D1.":[236],"CONCLUSIONS:":[237],"Stratifying":[238],"high":[241],"grade":[242],"via":[246],"VEGFA,":[247],"treating":[250],"inhibitors":[253],"case":[255],"may":[261],"allow":[262],"adding":[263],"overcoming":[266]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}