{"id":"https://openalex.org/W2338353361","doi":"https://doi.org/10.1186/s12918-016-0275-2","title":"A computational model of invasive aspergillosis in the lung and the role of iron","display_name":"A computational model of invasive aspergillosis in the lung and the role of iron","publication_year":2016,"publication_date":"2016-04-21","ids":{"openalex":"https://openalex.org/W2338353361","doi":"https://doi.org/10.1186/s12918-016-0275-2","mag":"2338353361","pmid":"https://pubmed.ncbi.nlm.nih.gov/27098278"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-016-0275-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-016-0275-2","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-016-0275-2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-016-0275-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110357887","display_name":"Matthew Oremland","orcid":null},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Matthew Oremland","raw_affiliation_strings":["Mathematical Biosciences Institute, Ohio State University, 1735 Neil Ave, Columbus OH, USA. oremland.2@osu.edu","Mathematical Biosciences Institute, Ohio State University, 1735 Neil Ave, Columbus OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mathematical Biosciences Institute, Ohio State University, 1735 Neil Ave, Columbus OH, USA. oremland.2@osu.edu","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Mathematical Biosciences Institute, Ohio State University, 1735 Neil Ave, Columbus OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087043513","display_name":"Kathryn Michels","orcid":"https://orcid.org/0000-0002-8227-8238"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn R. Michels","raw_affiliation_strings":["University of Virginia, Pulmonary and Critical Care Medicine, Charlottesville VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Pulmonary and Critical Care Medicine, Charlottesville VA, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001843304","display_name":"Alexandra M. Bettina","orcid":"https://orcid.org/0000-0003-3511-238X"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexandra M. Bettina","raw_affiliation_strings":["University of Virginia, Pulmonary and Critical Care Medicine, Charlottesville VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Pulmonary and Critical Care Medicine, Charlottesville VA, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056671125","display_name":"Chris Lawrence","orcid":null},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris Lawrence","raw_affiliation_strings":["Virginia Bioinformatics Institute, Virginia Tech, 1015 Life Science Circle, Blacksburg VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virginia Bioinformatics Institute, Virginia Tech, 1015 Life Science Circle, Blacksburg VA, USA","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023183325","display_name":"Borna Mehrad","orcid":"https://orcid.org/0000-0001-5198-065X"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Borna Mehrad","raw_affiliation_strings":["University of Virginia, Pulmonary and Critical Care Medicine, Charlottesville VA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Virginia, Pulmonary and Critical Care Medicine, Charlottesville VA, USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091010756","display_name":"Reinhard Laubenbacher","orcid":"https://orcid.org/0000-0002-9143-9451"},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]},{"id":"https://openalex.org/I4405260184","display_name":"The Jackson Laboratory for Genomic Medicine","ror":"https://ror.org/03cew3973","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reinhard Laubenbacher","raw_affiliation_strings":["Center for Quantitative Medicine, University of Connecticut Health Center, 236 Farmington Ave, Farmington CT, USA","Jackson Laboratory for Genomic Medicine, 236 Farmington Ave, Farmington CT, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Quantitative Medicine, University of Connecticut Health Center, 236 Farmington Ave, Farmington CT, USA","institution_ids":["https://openalex.org/I75929689"]},{"raw_affiliation_string":"Jackson Laboratory for Genomic Medicine, 236 Farmington Ave, Farmington CT, USA","institution_ids":["https://openalex.org/I4210115256","https://openalex.org/I4405260184"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5110357887"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":2.5737,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.88702477,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"34","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9024999737739563,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9024999737739563,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11597","display_name":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","score":0.01140000019222498,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.009200000204145908,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aspergillosis","display_name":"Aspergillosis","score":0.7389086484909058},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.6647197008132935},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6463614702224731},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.5733550786972046},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.5257946848869324},{"id":"https://openalex.org/keywords/innate-immune-system","display_name":"Innate immune system","score":0.5156922936439514},{"id":"https://openalex.org/keywords/lung","display_name":"Lung","score":0.5113484263420105},{"id":"https://openalex.org/keywords/aspergillus","display_name":"Aspergillus","score":0.4791490435600281},{"id":"https://openalex.org/keywords/parenchyma","display_name":"Parenchyma","score":0.4642733931541443},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.41327595710754395},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.4053041338920593},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.27487438917160034},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.18432849645614624}],"concepts":[{"id":"https://openalex.org/C2776391196","wikidata":"https://www.wikidata.org/wiki/Q259626","display_name":"Aspergillosis","level":2,"score":0.7389086484909058},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.6647197008132935},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6463614702224731},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5733550786972046},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5257946848869324},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5156922936439514},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5113484263420105},{"id":"https://openalex.org/C2779175654","wikidata":"https://www.wikidata.org/wiki/Q335130","display_name":"Aspergillus","level":2,"score":0.4791490435600281},{"id":"https://openalex.org/C196822366","wikidata":"https://www.wikidata.org/wiki/Q270524","display_name":"Parenchyma","level":2,"score":0.4642733931541443},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.41327595710754395},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4053041338920593},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.27487438917160034},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18432849645614624},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001228","descriptor_name":"Aspergillosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001228","descriptor_name":"Aspergillosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001228","descriptor_name":"Aspergillosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001228","descriptor_name":"Aspergillosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12918-016-0275-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-016-0275-2","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-016-0275-2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:27098278","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27098278","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4839115","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4839115","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmh:oai:mouseion.jax.org:stfb2016-1079","is_oa":false,"landing_page_url":"https://mouseion.jax.org/stfb2016/78","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Research 2016","raw_type":"text"},{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/95519","is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/95519","pdf_url":null,"source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article - Refereed"}],"best_oa_location":{"id":"doi:10.1186/s12918-016-0275-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-016-0275-2","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-016-0275-2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.6899999976158142}],"awards":[{"id":"https://openalex.org/G3663890866","display_name":null,"funder_award_id":"R01 HL098329","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4312822482","display_name":null,"funder_award_id":"1R21AI101619-01","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4522821816","display_name":null,"funder_award_id":"HL098526","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6782092078","display_name":null,"funder_award_id":"R01 HL098526","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7383312446","display_name":null,"funder_award_id":"HL098329","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8521852055","display_name":null,"funder_award_id":"R21 AI101619","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2338353361.pdf","grobid_xml":"https://content.openalex.org/works/W2338353361.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1531113262","https://openalex.org/W1575061456","https://openalex.org/W1575590741","https://openalex.org/W1597596512","https://openalex.org/W1598141103","https://openalex.org/W1600813584","https://openalex.org/W1621851081","https://openalex.org/W1837858460","https://openalex.org/W1911091032","https://openalex.org/W1964001262","https://openalex.org/W1967994759","https://openalex.org/W1968782720","https://openalex.org/W1973867627","https://openalex.org/W1984218702","https://openalex.org/W1986033139","https://openalex.org/W1987609401","https://openalex.org/W1989393824","https://openalex.org/W1992054309","https://openalex.org/W2004311884","https://openalex.org/W2004924258","https://openalex.org/W2016984863","https://openalex.org/W2028189711","https://openalex.org/W2034803825","https://openalex.org/W2035816996","https://openalex.org/W2036084890","https://openalex.org/W2040810194","https://openalex.org/W2041833958","https://openalex.org/W2050177408","https://openalex.org/W2064630997","https://openalex.org/W2070164533","https://openalex.org/W2081098704","https://openalex.org/W2082206279","https://openalex.org/W2082653002","https://openalex.org/W2082695689","https://openalex.org/W2086370911","https://openalex.org/W2094308116","https://openalex.org/W2098074535","https://openalex.org/W2105964739","https://openalex.org/W2106040412","https://openalex.org/W2111295218","https://openalex.org/W2114872234","https://openalex.org/W2120781377","https://openalex.org/W2123488224","https://openalex.org/W2125041286","https://openalex.org/W2125130403","https://openalex.org/W2125498475","https://openalex.org/W2128831153","https://openalex.org/W2138907159","https://openalex.org/W2141197648","https://openalex.org/W2141430390","https://openalex.org/W2141890333","https://openalex.org/W2144728717","https://openalex.org/W2146281923","https://openalex.org/W2147582257","https://openalex.org/W2159947094","https://openalex.org/W2160870988","https://openalex.org/W2166798957","https://openalex.org/W2169961781","https://openalex.org/W4211256702"],"related_works":["https://openalex.org/W2048804195","https://openalex.org/W3109733768","https://openalex.org/W2758956803","https://openalex.org/W2283860080","https://openalex.org/W2713406","https://openalex.org/W2086821518","https://openalex.org/W2144370795","https://openalex.org/W2371874439","https://openalex.org/W2322708548","https://openalex.org/W2118242149"],"abstract_inverted_index":{"BACKGROUND:":[0],"Invasive":[1],"aspergillosis":[2,70,225],"is":[3,59,71,194,203],"a":[4,34,80,92,105,164,204,220,259],"severe":[5],"infection":[6,32],"of":[7,14,17,22,36,68,94,104,107,140,151,185,212,223,229,264],"immunocompromised":[8],"hosts,":[9],"caused":[10],"by":[11,181],"the":[12,15,18,23,53,74,146,152,159,168,174,182,192,227,234,256,265],"inhalation":[13,139],"spores":[16,141],"ubiquitous":[19],"environmental":[20],"molds":[21],"Aspergillus":[24,269],"genus.":[25],"The":[26,123],"innate":[27,153],"immune":[28,154,266],"response":[29,267],"in":[30,56,101,130,158,167,209,226,242],"this":[31,89],"entails":[33],"series":[35],"complex":[37],"and":[38,44,51,97,119,136,161,173,179,201,246,249],"inter-related":[39],"interactions":[40],"between":[41],"multiple":[42],"recruited":[43],"resident":[45],"cell":[46],"populations":[47],"with":[48,52,142,196],"each":[49],"other":[50],"fungal":[54,62,131,243],"cell;":[55],"particular,":[57],"iron":[58,177,251],"critical":[60],"for":[61,207,258],"growth.":[63],"RESULTS:":[64],"A":[65],"computational":[66],"model":[67,75,103,126,175,193,222,235,254,263],"invasive":[69,213,224],"presented":[72],"here;":[73],"can":[76],"be":[77],"used":[78],"as":[79,232],"rational":[81],"hypothesis-generating":[82],"tool":[83,206],"to":[84,88,171,198,268],"investigate":[85],"host":[86],"responses":[87],"infection.":[90],"Using":[91,216],"combination":[93],"laboratory":[95,217],"data":[96,218],"published":[98],"literature,":[99],"an":[100,114,208],"silico":[102,210],"section":[106],"lung":[108,121],"tissue":[109,147,162,250],"was":[110],"generated":[111],"that":[112],"includes":[113,176],"alveolar":[115],"duct,":[116],"adjacent":[117],"capillaries,":[118],"surrounding":[120],"parenchyma.":[122],"three-dimensional":[124],"agent-based":[125],"integrates":[127],"temporal":[128],"events":[129],"cells,":[132,134],"epithelial":[133],"monocytes,":[135],"neutrophils":[137],"after":[138],"cellular":[143],"dynamics":[144],"at":[145],"level,":[148],"comprising":[149],"part":[150],"response.":[155],"Iron":[156],"levels":[157],"blood":[160],"play":[163],"key":[165],"role":[166],"fungus'":[169],"ability":[170],"grow,":[172],"recruitment":[178],"consumption":[180],"different":[183],"types":[184],"cells":[186],"included.":[187],"Parameter":[188],"sensitivity":[189],"analysis":[190],"suggests":[191],"robust":[195],"respect":[197],"unvalidated":[199],"parameters,":[200],"thus":[202],"viable":[205],"investigation":[211],"aspergillosis.":[214],"CONCLUSIONS:":[215],"from":[219],"mouse":[221],"context":[228],"transient":[230],"neutropenia":[231],"validation,":[233],"predicted":[236],"qualitatively":[237],"similar":[238],"time":[239],"course":[240],"changes":[241],"burden,":[244],"monocyte":[245],"neutrophil":[247],"populations,":[248],"levels.":[252],"This":[253],"lays":[255],"groundwork":[257],"multi-scale":[260],"dynamic":[261],"mathematical":[262],"species.":[270]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}