{"id":"https://openalex.org/W2191528140","doi":"https://doi.org/10.1186/s12918-015-0235-2","title":"Cellular automaton-based model for radiation-induced bystander effects","display_name":"Cellular automaton-based model for radiation-induced bystander effects","publication_year":2015,"publication_date":"2015-12-01","ids":{"openalex":"https://openalex.org/W2191528140","doi":"https://doi.org/10.1186/s12918-015-0235-2","mag":"2191528140","pmid":"https://pubmed.ncbi.nlm.nih.gov/26642882"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-015-0235-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-015-0235-2","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-015-0235-2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-015-0235-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075344540","display_name":"Yuya Hattori","orcid":"https://orcid.org/0000-0002-6927-980X"},"institutions":[{"id":"https://openalex.org/I117197279","display_name":"Japan Atomic Energy Agency","ror":"https://ror.org/05nf86y53","country_code":"JP","type":"funder","lineage":["https://openalex.org/I117197279"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yuya Hattori","raw_affiliation_strings":["Research Group for Radiation Effect Analysis, Japan Atomic Energy Agency, 2-4, Shirakata Shirane, Tokai, Ibaraki, 319-1195, Japan. hattori.yuya@jaea.go.jp","Research Group for Radiation Effect Analysis, Japan Atomic Energy Agency, 2-4, Shirakata Shirane, Tokai, Ibaraki, 319-1195, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Group for Radiation Effect Analysis, Japan Atomic Energy Agency, 2-4, Shirakata Shirane, Tokai, Ibaraki, 319-1195, Japan. hattori.yuya@jaea.go.jp","institution_ids":["https://openalex.org/I117197279"]},{"raw_affiliation_string":"Research Group for Radiation Effect Analysis, Japan Atomic Energy Agency, 2-4, Shirakata Shirane, Tokai, Ibaraki, 319-1195, Japan","institution_ids":["https://openalex.org/I117197279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021551545","display_name":"Akinari Yokoya","orcid":"https://orcid.org/0000-0002-3248-1449"},"institutions":[{"id":"https://openalex.org/I117197279","display_name":"Japan Atomic Energy Agency","ror":"https://ror.org/05nf86y53","country_code":"JP","type":"funder","lineage":["https://openalex.org/I117197279"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akinari Yokoya","raw_affiliation_strings":["Research Group for Radiation and Biomolecular Science, Japan Atomic Energy Agency, Ibaraki, 319-1195, Japan. yokoya.akinari@jaea.go.jp","Research Group for Radiation and Biomolecular Science, Japan Atomic Energy Agency, Ibaraki, 319-1195, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Group for Radiation and Biomolecular Science, Japan Atomic Energy Agency, Ibaraki, 319-1195, Japan. yokoya.akinari@jaea.go.jp","institution_ids":["https://openalex.org/I117197279"]},{"raw_affiliation_string":"Research Group for Radiation and Biomolecular Science, Japan Atomic Energy Agency, Ibaraki, 319-1195, Japan","institution_ids":["https://openalex.org/I117197279"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112216480","display_name":"Ritsuko Watanabe","orcid":null},"institutions":[{"id":"https://openalex.org/I117197279","display_name":"Japan Atomic Energy Agency","ror":"https://ror.org/05nf86y53","country_code":"JP","type":"funder","lineage":["https://openalex.org/I117197279"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ritsuko Watanabe","raw_affiliation_strings":["Research Group for Radiation Effect Analysis, Japan Atomic Energy Agency, 2-4, Shirakata Shirane, Tokai, Ibaraki, 319-1195, Japan. watanabe.ritsuko@jaea.go.jp","Research Group for Radiation Effect Analysis, Japan Atomic Energy Agency, 2-4, Shirakata Shirane, Tokai, Ibaraki, 319-1195, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Group for Radiation Effect Analysis, Japan Atomic Energy Agency, 2-4, Shirakata Shirane, Tokai, Ibaraki, 319-1195, Japan. watanabe.ritsuko@jaea.go.jp","institution_ids":["https://openalex.org/I117197279"]},{"raw_affiliation_string":"Research Group for Radiation Effect Analysis, Japan Atomic Energy Agency, 2-4, Shirakata Shirane, Tokai, Ibaraki, 319-1195, Japan","institution_ids":["https://openalex.org/I117197279"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5075344540"],"corresponding_institution_ids":["https://openalex.org/I117197279"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":1.9575,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.85561313,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"9","issue":"1","first_page":"90","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10874","display_name":"Electromagnetic Fields and Biological Effects","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bystander-effect","display_name":"Bystander effect","score":0.9542667865753174},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.7628989219665527},{"id":"https://openalex.org/keywords/cell-cycle","display_name":"Cell cycle","score":0.67203688621521},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6597445607185364},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"Programmed cell death","score":0.5583942532539368},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.5363074541091919},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.4868404269218445},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4769010543823242},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.4613262712955475},{"id":"https://openalex.org/keywords/cell-growth","display_name":"Cell growth","score":0.4151366353034973},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3225722312927246},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.22204098105430603},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.186009019613266},{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.17950484156608582},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.16571438312530518}],"concepts":[{"id":"https://openalex.org/C19106626","wikidata":"https://www.wikidata.org/wiki/Q230749","display_name":"Bystander effect","level":2,"score":0.9542667865753174},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.7628989219665527},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.67203688621521},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6597445607185364},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5583942532539368},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.5363074541091919},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4868404269218445},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4769010543823242},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.4613262712955475},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4151366353034973},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3225722312927246},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.22204098105430603},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.186009019613266},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.17950484156608582},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16571438312530518}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D024201","descriptor_name":"Bystander Effect","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D024201","descriptor_name":"Bystander Effect","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D024201","descriptor_name":"Bystander Effect","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D053903","descriptor_name":"DNA Breaks, Double-Stranded","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/s12918-015-0235-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-015-0235-2","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-015-0235-2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:26642882","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26642882","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4672575","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4672575","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-015-0235-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-015-0235-2","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-015-0235-2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7300000190734863}],"awards":[{"id":"https://openalex.org/G5006975689","display_name":"Computational analysis of low-dose radiation responses based on artificial neural network","funder_award_id":"15K16088","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2191528140.pdf","grobid_xml":"https://content.openalex.org/works/W2191528140.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1491153233","https://openalex.org/W1968029748","https://openalex.org/W1968313826","https://openalex.org/W1986965946","https://openalex.org/W1987391644","https://openalex.org/W1990942802","https://openalex.org/W1995372825","https://openalex.org/W1996435746","https://openalex.org/W2000223014","https://openalex.org/W2005993590","https://openalex.org/W2011380984","https://openalex.org/W2019963243","https://openalex.org/W2022713897","https://openalex.org/W2039341350","https://openalex.org/W2040004060","https://openalex.org/W2040646847","https://openalex.org/W2042072258","https://openalex.org/W2055011117","https://openalex.org/W2068634088","https://openalex.org/W2070548474","https://openalex.org/W2075497030","https://openalex.org/W2081130403","https://openalex.org/W2087524408","https://openalex.org/W2090513228","https://openalex.org/W2096775962","https://openalex.org/W2100284834","https://openalex.org/W2101331356","https://openalex.org/W2105776175","https://openalex.org/W2109126550","https://openalex.org/W2112001893","https://openalex.org/W2113603158","https://openalex.org/W2114101456","https://openalex.org/W2117826016","https://openalex.org/W2122832395","https://openalex.org/W2123929920","https://openalex.org/W2127353430","https://openalex.org/W2128943897","https://openalex.org/W2131708870","https://openalex.org/W2144318283","https://openalex.org/W2164846304","https://openalex.org/W2168241051","https://openalex.org/W2173782486","https://openalex.org/W2178785249","https://openalex.org/W2417650233","https://openalex.org/W2586952664","https://openalex.org/W2626425857","https://openalex.org/W4214917868"],"related_works":["https://openalex.org/W2053004761","https://openalex.org/W2060232277","https://openalex.org/W2372296322","https://openalex.org/W2370719635","https://openalex.org/W2359636035","https://openalex.org/W2083162155","https://openalex.org/W2015481726","https://openalex.org/W2886313449","https://openalex.org/W2033577131","https://openalex.org/W2808663575"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,17,71,107,118,133,188],"radiation-induced":[2],"bystander":[3,18,195,233],"effect":[4,19],"is":[5,20,73],"a":[6,52,64,76,227,264,273],"biological":[7],"response":[8,58],"observed":[9],"in":[10,112,276],"non-irradiated":[11,280],"cells":[12,196,203,211,281],"surrounding":[13],"an":[14],"irradiated":[15,116,278],"cell.":[16],"known":[21],"to":[22,267],"be":[23,263],"induced":[24],"by":[25,216,220],"two":[26,61],"intercellular":[27,91,108,181],"signaling":[28,47,182],"pathways,":[29,62],"the":[30,35,42,56,121,124,139,167,185,194,199,217,221],"medium-mediated":[31],"pathway":[32,38],"(MDP)":[33],"and":[34,79,88,100,113,123,135,171,180,238,245,252,257,279],"gap":[36],"junctional":[37],"(GJP).":[39],"To":[40],"investigate":[41],"relative":[43],"contribution":[44],"of":[45,55,81,90,95,141,146,169,190,201,255,272],"each":[46],"pathway,":[48],"we":[49],"have":[50],"developed":[51],"mathematical":[53,228],"model":[54,72,158,191,229,261],"cellular":[57,77,147,258,274],"through":[59,120],"these":[60],"with":[63,208],"particular":[65],"focus":[66],"on":[67,75,130,166],"cell-cycle":[68,102,151,243],"modification.":[69],"METHODS:":[70],"based":[74,129],"automaton":[78],"consists":[80],"four":[82],"components:":[83],"(1)":[84],"irradiation,":[85],"(2)":[86],"generation":[87],"diffusion":[89,131],"signals,":[92],"(3)":[93],"induction":[94],"DNA":[96],"double-strand":[97],"breaks":[98],"(DSBs),":[99],"(4)":[101],"modification":[103],"or":[104,153],"cell":[105,154,172,186,246],"death.":[106,155,247],"signals":[109,119,137],"are":[110,126],"generated":[111],"released":[114],"from":[115],"cells.":[117],"MDP":[122,237],"GJP":[125,218,239],"modeled":[127],"independently":[128],"equations.":[132],"irradiation":[134,256],"both":[136],"raise":[138],"number":[140,168,200],"DSBs,":[142],"which":[143,277],"determines":[144],"transitions":[145],"states,":[148],"such":[149,235],"as":[150,236],"arrest":[152],"RESULTS:":[156],"Our":[157],"reproduced":[159],"fairly":[160],"well":[161],"previously":[162],"reported":[163],"experimental":[164],"data":[165],"DSBs":[170],"survival":[173],"curves.":[174],"We":[175,224],"examined":[176],"how":[177],"radiation":[178],"dose":[179],"dynamically":[183],"affect":[184],"cycle.":[187],"analysis":[189],"dynamics":[192],"for":[193],"revealed":[197],"that":[198,230],"arrested":[202],"did":[204],"not":[205],"increase":[206],"linearly":[207],"dose.":[209],"Arrested":[210],"were":[212],"more":[213],"efficiently":[214],"accumulated":[215],"than":[219],"MDP.":[222],"CONCLUSIONS:":[223],"present":[225],"here":[226],"integrates":[231],"various":[232],"responses,":[234],"signaling,":[240],"DSB":[241],"induction,":[242],"arrest,":[244],"Because":[248],"it":[249],"simulates":[250],"spatial":[251],"temporal":[253],"conditions":[254],"characteristics,":[259],"our":[260],"will":[262],"powerful":[265],"tool":[266],"predict":[268],"dynamical":[269],"radiobiological":[270],"responses":[271],"population":[275],"co-exist.":[282]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}