{"id":"https://openalex.org/W1457711407","doi":"https://doi.org/10.1186/s12918-015-0230-7","title":"Tip cell overtaking occurs as a side effect of sprouting in computational models of angiogenesis","display_name":"Tip cell overtaking occurs as a side effect of sprouting in computational models of angiogenesis","publication_year":2015,"publication_date":"2015-11-21","ids":{"openalex":"https://openalex.org/W1457711407","doi":"https://doi.org/10.1186/s12918-015-0230-7","mag":"1457711407","pmid":"https://pubmed.ncbi.nlm.nih.gov/26589386"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-015-0230-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-015-0230-7","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-015-0230-7","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-015-0230-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024147405","display_name":"Sonja E. M. Boas","orcid":"https://orcid.org/0000-0001-9413-7013"},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I1341640284","display_name":"Centrum Wiskunde & Informatica","ror":"https://ror.org/00x7ekv49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1341640284","https://openalex.org/I2800991832"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Sonja E. M. Boas","raw_affiliation_strings":["Life Sciences, Centrum Wiskunde & Informatica (CWI), Science Park 123, 1098 XG, Amsterdam, The Netherlands. boas@cwi.nl","Mathematical Institute, Leiden University, Niels Bohrweg 1, 2333 CA, Leiden, The Netherlands. boas@cwi.nl"],"affiliations":[{"raw_affiliation_string":"Life Sciences, Centrum Wiskunde & Informatica (CWI), Science Park 123, 1098 XG, Amsterdam, The Netherlands. boas@cwi.nl","institution_ids":["https://openalex.org/I1341640284"]},{"raw_affiliation_string":"Mathematical Institute, Leiden University, Niels Bohrweg 1, 2333 CA, Leiden, The Netherlands. boas@cwi.nl","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049980767","display_name":"Roeland M. H. Merks","orcid":"https://orcid.org/0000-0002-6152-687X"},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]},{"id":"https://openalex.org/I1341640284","display_name":"Centrum Wiskunde & Informatica","ror":"https://ror.org/00x7ekv49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I1341640284","https://openalex.org/I2800991832"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Roeland M. H. Merks","raw_affiliation_strings":["Life Sciences, Centrum Wiskunde & Informatica (CWI), Science Park 123, 1098 XG, Amsterdam, The Netherlands. Roeland.merks@cwi.nl","Mathematical Institute, Leiden University, Niels Bohrweg 1, 2333 CA, Leiden, The Netherlands. Roeland.merks@cwi.nl"],"affiliations":[{"raw_affiliation_string":"Life Sciences, Centrum Wiskunde & Informatica (CWI), Science Park 123, 1098 XG, Amsterdam, The Netherlands. Roeland.merks@cwi.nl","institution_ids":["https://openalex.org/I1341640284"]},{"raw_affiliation_string":"Mathematical Institute, Leiden University, Niels Bohrweg 1, 2333 CA, Leiden, The Netherlands. Roeland.merks@cwi.nl","institution_ids":["https://openalex.org/I121797337"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024147405"],"corresponding_institution_ids":["https://openalex.org/I121797337","https://openalex.org/I1341640284"],"apc_list":null,"apc_paid":null,"fwci":2.5654,"has_fulltext":true,"cited_by_count":47,"citation_normalized_percentile":{"value":0.89504409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"9","issue":"1","first_page":"86","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sprouting-angiogenesis","display_name":"Sprouting angiogenesis","score":0.8276047110557556},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"Angiogenesis","score":0.8008780479431152},{"id":"https://openalex.org/keywords/sprouting","display_name":"Sprouting","score":0.7417739033699036},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6873502731323242},{"id":"https://openalex.org/keywords/overtaking","display_name":"Overtaking","score":0.653753399848938},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"Chemotaxis","score":0.6177736520767212},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.4648436903953552},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.44417625665664673},{"id":"https://openalex.org/keywords/endothelial-stem-cell","display_name":"Endothelial stem cell","score":0.44321584701538086},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4097161293029785},{"id":"https://openalex.org/keywords/neovascularization","display_name":"Neovascularization","score":0.23966827988624573},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.1516541838645935},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.13069170713424683},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.09948167204856873},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.07754257321357727},{"id":"https://openalex.org/keywords/botany","display_name":"Botany","score":0.0638088583946228}],"concepts":[{"id":"https://openalex.org/C2910429298","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Sprouting angiogenesis","level":4,"score":0.8276047110557556},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8008780479431152},{"id":"https://openalex.org/C2778241760","wikidata":"https://www.wikidata.org/wiki/Q1057052","display_name":"Sprouting","level":2,"score":0.7417739033699036},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6873502731323242},{"id":"https://openalex.org/C2778448659","wikidata":"https://www.wikidata.org/wiki/Q1931051","display_name":"Overtaking","level":2,"score":0.653753399848938},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.6177736520767212},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4648436903953552},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44417625665664673},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.44321584701538086},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4097161293029785},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.23966827988624573},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1516541838645935},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13069170713424683},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.09948167204856873},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07754257321357727},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0638088583946228},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C147176958","wikidata":"https://www.wikidata.org/wiki/Q77590","display_name":"Civil engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D042783","descriptor_name":"Endothelial Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051880","descriptor_name":"Receptors, Notch","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/s12918-015-0230-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-015-0230-7","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-015-0230-7","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:26589386","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26589386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:arXiv.org:1507.06230","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1507.06230","pdf_url":"https://arxiv.org/pdf/1507.06230","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:cwi:oai:cwi.nl:23976","is_oa":true,"landing_page_url":"https://ir.cwi.nl/pub/23976","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology, 9","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:openaccess.leidenuniv.nl:1887/51279","is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/51279","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"9","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:pubmedcentral.nih.gov:4654812","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4654812","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_2865280","is_oa":false,"landing_page_url":"https://hdl.handle.net/1887/51279","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology","raw_type":"Article / Letter to editor"}],"best_oa_location":{"id":"doi:10.1186/s12918-015-0230-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-015-0230-7","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-015-0230-7","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G629491556","display_name":null,"funder_award_id":"(NWO)","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G7353793226","display_name":null,"funder_award_id":"SURFsara","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1457711407.pdf","grobid_xml":"https://content.openalex.org/works/W1457711407.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1487517758","https://openalex.org/W1505353324","https://openalex.org/W1513770217","https://openalex.org/W1574424832","https://openalex.org/W1628893367","https://openalex.org/W1679229092","https://openalex.org/W1966571267","https://openalex.org/W1969732580","https://openalex.org/W1971324461","https://openalex.org/W1971868761","https://openalex.org/W1973027889","https://openalex.org/W1974673184","https://openalex.org/W1980122996","https://openalex.org/W1991797784","https://openalex.org/W1993321285","https://openalex.org/W1993523135","https://openalex.org/W2001657041","https://openalex.org/W2002785668","https://openalex.org/W2003933044","https://openalex.org/W2009702490","https://openalex.org/W2011269103","https://openalex.org/W2020644315","https://openalex.org/W2026774353","https://openalex.org/W2028817453","https://openalex.org/W2037943855","https://openalex.org/W2041619208","https://openalex.org/W2042892258","https://openalex.org/W2043854809","https://openalex.org/W2073281753","https://openalex.org/W2073465941","https://openalex.org/W2103067868","https://openalex.org/W2106199085","https://openalex.org/W2110287546","https://openalex.org/W2112251383","https://openalex.org/W2112479189","https://openalex.org/W2120474091","https://openalex.org/W2125862744","https://openalex.org/W2132729583","https://openalex.org/W2137297789","https://openalex.org/W2144970171","https://openalex.org/W2151128289","https://openalex.org/W2154474869","https://openalex.org/W2157930949","https://openalex.org/W2159067958","https://openalex.org/W2159084624","https://openalex.org/W2161590805","https://openalex.org/W2563912725","https://openalex.org/W2944782266","https://openalex.org/W3099680082","https://openalex.org/W4290935769"],"related_works":["https://openalex.org/W3084163143","https://openalex.org/W3198453306","https://openalex.org/W3081587374","https://openalex.org/W2085294619","https://openalex.org/W73525567","https://openalex.org/W4224950200","https://openalex.org/W1022629199","https://openalex.org/W1799814938","https://openalex.org/W2416058516","https://openalex.org/W2053123759"],"abstract_inverted_index":{"Our":[0],"modeling":[1],"results":[2],"suggest":[3],"that":[4,56,77,80],"tip":[5,21,48,86,90],"cell":[6,22,49,68,79,91],"overtaking":[7,23],"can":[8,39],"occur":[9],"spontaneously":[10],"due":[11],"to":[12,45,65,75],"the":[13,41,47,57,72,78,85,89],"stochastic":[14],"motion":[15],"of":[16,43,59],"cells":[17,44],"during":[18],"sprouting.":[19],"Thus,":[20],"and":[24,30,34],"sprouting":[25],"dynamics":[26],"may":[27],"be":[28,32,64],"interdependent":[29],"should":[31],"studied":[33],"interpreted":[35],"in":[36,51],"combination.":[37],"VEGF-Dll4-Notch":[38,60],"regulate":[40,66],"ability":[42],"occupy":[46],"position":[50,87],"our":[52],"simulations.":[53],"We":[54],"propose":[55],"function":[58],"signaling":[61],"might":[62],"not":[63],"which":[67],"ends":[69,82],"up":[70,83],"at":[71,84],"tip,":[73],"but":[74],"assure":[76],"randomly":[81],"acquires":[88],"phenotype.":[92]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":2}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}