{"id":"https://openalex.org/W2136420204","doi":"https://doi.org/10.1186/s12918-015-0226-3","title":"Bayesian modeling suggests that IL-12 (p40), IL-13 and MCP-1 drive murine cytokine networks in vivo","display_name":"Bayesian modeling suggests that IL-12 (p40), IL-13 and MCP-1 drive murine cytokine networks in vivo","publication_year":2015,"publication_date":"2015-11-09","ids":{"openalex":"https://openalex.org/W2136420204","doi":"https://doi.org/10.1186/s12918-015-0226-3","mag":"2136420204","pmid":"https://pubmed.ncbi.nlm.nih.gov/26553024"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-015-0226-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-015-0226-3","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-015-0226-3","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-015-0226-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081268803","display_name":"Sarah Field","orcid":"https://orcid.org/0000-0003-2376-1585"},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sarah L. Field","raw_affiliation_strings":["Women's Health Research Group, Section of Cancer & Pathology, Leeds Institute of Cancer & Pathology, St James's University Hospital, Leeds, LS9 7TF, UK. sarahhonley@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women's Health Research Group, Section of Cancer & Pathology, Leeds Institute of Cancer & Pathology, St James's University Hospital, Leeds, LS9 7TF, UK. sarahhonley@gmail.com","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025897258","display_name":"Tathagata Dasgupta","orcid":"https://orcid.org/0000-0003-3921-0649"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tathagata Dasgupta","raw_affiliation_strings":["Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts, 02115, USA. Tathagata_Dasgupta@hms.harvard.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts, 02115, USA. Tathagata_Dasgupta@hms.harvard.edu","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065892538","display_name":"Michele Cummings","orcid":"https://orcid.org/0000-0001-5663-5548"},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michele Cummings","raw_affiliation_strings":["Women's Health Research Group, Section of Cancer & Pathology, Leeds Institute of Cancer & Pathology, St James's University Hospital, Leeds, LS9 7TF, UK. medmic@leeds.ac.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women's Health Research Group, Section of Cancer & Pathology, Leeds Institute of Cancer & Pathology, St James's University Hospital, Leeds, LS9 7TF, UK. medmic@leeds.ac.uk","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086506904","display_name":"Richard S. Savage","orcid":"https://orcid.org/0000-0001-6025-1571"},"institutions":[{"id":"https://openalex.org/I39555362","display_name":"University of Warwick","ror":"https://ror.org/01a77tt86","country_code":"GB","type":"education","lineage":["https://openalex.org/I39555362"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard S. Savage","raw_affiliation_strings":["Systems Biology Centre, University of Warwick, Coventry, CV4 7AL, UK. r.s.savage@warwick.ac.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology Centre, University of Warwick, Coventry, CV4 7AL, UK. r.s.savage@warwick.ac.uk","institution_ids":["https://openalex.org/I39555362"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037553879","display_name":"Julius Adebayo","orcid":null},"institutions":[{"id":"https://openalex.org/I100005738","display_name":"Brigham Young University","ror":"https://ror.org/047rhhm47","country_code":"US","type":"education","lineage":["https://openalex.org/I100005738"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julius Adebayo","raw_affiliation_strings":["Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts, 02115, USA. julius.adebayo@gmail.com","IDeA Labs, Department of Computer Science, TMCB 1124, Brigham Young University, Provo, UT, 84602, USA. julius.adebayo@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts, 02115, USA. julius.adebayo@gmail.com","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"IDeA Labs, Department of Computer Science, TMCB 1124, Brigham Young University, Provo, UT, 84602, USA. julius.adebayo@gmail.com","institution_ids":["https://openalex.org/I100005738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072511305","display_name":"Hema McSara","orcid":null},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hema McSara","raw_affiliation_strings":["Women's Health Research Group, Section of Cancer & Pathology, Leeds Institute of Cancer & Pathology, St James's University Hospital, Leeds, LS9 7TF, UK. hema.mcsara@leedsth.nhs.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women's Health Research Group, Section of Cancer & Pathology, Leeds Institute of Cancer & Pathology, St James's University Hospital, Leeds, LS9 7TF, UK. hema.mcsara@leedsth.nhs.uk","institution_ids":["https://openalex.org/I2801331674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056777354","display_name":"Jeremy Gunawardena","orcid":"https://orcid.org/0000-0002-7280-1152"},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy Gunawardena","raw_affiliation_strings":["Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts, 02115, USA. jeremy_gunawardena@hms.harvard.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts, 02115, USA. jeremy_gunawardena@hms.harvard.edu","institution_ids":["https://openalex.org/I4210155419","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061253643","display_name":"Nicolas M. Orsi","orcid":"https://orcid.org/0000-0003-0890-0399"},"institutions":[{"id":"https://openalex.org/I2801331674","display_name":"St James's University Hospital","ror":"https://ror.org/013s89d74","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2799390153","https://openalex.org/I2801331674"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nicolas M. Orsi","raw_affiliation_strings":["Women's Health Research Group, Section of Cancer & Pathology, Leeds Institute of Cancer & Pathology, St James's University Hospital, Leeds, LS9 7TF, UK. n.m.orsi@leeds.ac.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Women's Health Research Group, Section of Cancer & Pathology, Leeds Institute of Cancer & Pathology, St James's University Hospital, Leeds, LS9 7TF, UK. n.m.orsi@leeds.ac.uk","institution_ids":["https://openalex.org/I2801331674"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5081268803"],"corresponding_institution_ids":["https://openalex.org/I2801331674"],"apc_list":null,"apc_paid":null,"fwci":1.2047,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.78973429,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"9","issue":"1","first_page":"76","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.21400000154972076,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.21400000154972076,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.13539999723434448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.057100001722574234,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-vivo","display_name":"In vivo","score":0.6918424963951111},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.6452358365058899},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.5832221508026123},{"id":"https://openalex.org/keywords/cytokine","display_name":"Cytokine","score":0.5196653604507446},{"id":"https://openalex.org/keywords/bayesian-network","display_name":"Bayesian network","score":0.5021262168884277},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.499448299407959},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4944431781768799},{"id":"https://openalex.org/keywords/interleukin-10","display_name":"Interleukin 10","score":0.4215153157711029},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4199143946170807},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.34909534454345703},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.34691566228866577},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.14465883374214172},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11626783013343811}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6918424963951111},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.6452358365058899},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.5832221508026123},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5196653604507446},{"id":"https://openalex.org/C33724603","wikidata":"https://www.wikidata.org/wiki/Q812540","display_name":"Bayesian network","level":2,"score":0.5021262168884277},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.499448299407959},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4944431781768799},{"id":"https://openalex.org/C187316574","wikidata":"https://www.wikidata.org/wiki/Q423698","display_name":"Interleukin 10","level":3,"score":0.4215153157711029},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4199143946170807},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.34909534454345703},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34691566228866577},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.14465883374214172},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11626783013343811}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007774","descriptor_name":"Lactation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007774","descriptor_name":"Lactation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007774","descriptor_name":"Lactation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007774","descriptor_name":"Lactation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018664","descriptor_name":"Interleukin-12","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049590","descriptor_name":"Postpartum Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049590","descriptor_name":"Postpartum Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049590","descriptor_name":"Postpartum Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049590","descriptor_name":"Postpartum Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12918-015-0226-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-015-0226-3","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-015-0226-3","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:26553024","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26553024","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:eprints.whiterose.ac.uk:91991","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400854","display_name":"White Rose Research Online (University of Leeds, The University of Sheffield, University of York)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2800616092","host_organization_name":"White Rose University Consortium","host_organization_lineage":["https://openalex.org/I2800616092"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:dash.harvard.edu:1/23845118","is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:23845118","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3613773","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4640223","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-015-0226-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-015-0226-3","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-015-0226-3","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","score":0.6899999976158142,"display_name":"Life in Land"}],"awards":[{"id":"https://openalex.org/G1056052173","display_name":null,"funder_award_id":"06-607","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8604887986","display_name":null,"funder_award_id":"NIH P50 GM068762","funder_id":"https://openalex.org/F4320309369","funder_display_name":"Massachusetts Institute of Technology"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309369","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44"},{"id":"https://openalex.org/F4320320034","display_name":"Wellbeing of Women","ror":"https://ror.org/01etdvs72"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2136420204.pdf","grobid_xml":"https://content.openalex.org/works/W2136420204.grobid-xml"},"referenced_works_count":90,"referenced_works":["https://openalex.org/W2316772","https://openalex.org/W85516301","https://openalex.org/W135576246","https://openalex.org/W196697298","https://openalex.org/W1255171879","https://openalex.org/W1514861465","https://openalex.org/W1541257670","https://openalex.org/W1592076897","https://openalex.org/W1626295059","https://openalex.org/W1663973292","https://openalex.org/W1964334230","https://openalex.org/W1964508470","https://openalex.org/W1966524332","https://openalex.org/W1968034889","https://openalex.org/W1970244022","https://openalex.org/W1970847065","https://openalex.org/W1975385846","https://openalex.org/W1976677638","https://openalex.org/W1977341142","https://openalex.org/W1982063012","https://openalex.org/W1983390546","https://openalex.org/W1983989471","https://openalex.org/W1986110934","https://openalex.org/W1986814434","https://openalex.org/W1986924155","https://openalex.org/W1993449521","https://openalex.org/W2003642939","https://openalex.org/W2006239951","https://openalex.org/W2008395997","https://openalex.org/W2009393272","https://openalex.org/W2016385245","https://openalex.org/W2023608933","https://openalex.org/W2024403544","https://openalex.org/W2027364786","https://openalex.org/W2033636363","https://openalex.org/W2034420655","https://openalex.org/W2041102049","https://openalex.org/W2042087846","https://openalex.org/W2043977568","https://openalex.org/W2045019335","https://openalex.org/W2046202910","https://openalex.org/W2051385705","https://openalex.org/W2051808553","https://openalex.org/W2055404539","https://openalex.org/W2056058997","https://openalex.org/W2056860999","https://openalex.org/W2058688700","https://openalex.org/W2062533676","https://openalex.org/W2071961667","https://openalex.org/W2073307618","https://openalex.org/W2075111288","https://openalex.org/W2077154148","https://openalex.org/W2077495741","https://openalex.org/W2078344286","https://openalex.org/W2083667678","https://openalex.org/W2089360326","https://openalex.org/W2090184738","https://openalex.org/W2100784279","https://openalex.org/W2101420429","https://openalex.org/W2108986329","https://openalex.org/W2110065044","https://openalex.org/W2116276051","https://openalex.org/W2118037512","https://openalex.org/W2119231821","https://openalex.org/W2121754708","https://openalex.org/W2122410182","https://openalex.org/W2133990480","https://openalex.org/W2134092975","https://openalex.org/W2137584815","https://openalex.org/W2137739362","https://openalex.org/W2138591706","https://openalex.org/W2139648300","https://openalex.org/W2145185533","https://openalex.org/W2150627960","https://openalex.org/W2151808499","https://openalex.org/W2159203162","https://openalex.org/W2159675211","https://openalex.org/W2161937009","https://openalex.org/W2162592262","https://openalex.org/W2165736537","https://openalex.org/W2170112109","https://openalex.org/W2170797914","https://openalex.org/W2175728753","https://openalex.org/W2338828196","https://openalex.org/W2464600404","https://openalex.org/W2611370172","https://openalex.org/W2623293810","https://openalex.org/W3114911410","https://openalex.org/W3191596906","https://openalex.org/W4240689716"],"related_works":["https://openalex.org/W2972991241","https://openalex.org/W2381390841","https://openalex.org/W2955463503","https://openalex.org/W3207148653","https://openalex.org/W2057769265","https://openalex.org/W2371925260","https://openalex.org/W2094776015","https://openalex.org/W2029380307","https://openalex.org/W837124458","https://openalex.org/W2108323291"],"abstract_inverted_index":{"BACKGROUND:":[0],"Cytokine-hormone":[1],"network":[2,88,109,121],"deregulations":[3],"underpin":[4],"pathologies":[5],"ranging":[6],"from":[7],"autoimmune":[8],"disorders":[9],"to":[10,27],"cancer,":[11],"but":[12],"our":[13,103],"understanding":[14],"of":[15,45,87,102,120,127,139,153],"these":[16],"networks":[17,26,62],"in":[18,31,54,107,113,142,149,157],"physiological/pathophysiological":[19],"states":[20],"remains":[21],"patchy.":[22],"We":[23],"employed":[24],"Bayesian":[25],"analyze":[28],"cytokine-hormone":[29],"interactions":[30,129],"vivo":[32,114],"using":[33],"murine":[34],"lactation":[35],"as":[36],"a":[37],"dynamic,":[38],"physiological":[39,94],"model":[40],"system.":[41],"RESULTS:":[42],"Circulatory":[43],"levels":[44],"estrogen,":[46],"progesterone,":[47],"prolactin":[48],"and":[49,66,78,148],"twenty-three":[50],"cytokines":[51],"were":[52,63,83],"profiled":[53],"post":[55],"partum":[56],"mice":[57],"with/without":[58],"pups.":[59],"The":[60],"resultant":[61],"very":[64],"robust":[65],"assembled":[67],"about":[68],"structural":[69,91],"hubs,":[70],"with":[71,97],"evidence":[72],"that":[73,106],"interleukin":[74],"(IL)-12":[75],"(p40),":[76],"IL-13":[77],"monocyte":[79],"chemoattractant":[80],"protein":[81],"(MCP)-1":[82],"the":[84,98,137,151],"primary":[85],"drivers":[86],"behavior.":[89],"Network":[90],"conservation":[92],"across":[93],"scenarios":[95],"coupled":[96],"successful":[99],"empirical":[100],"validation":[101],"approach":[104],"suggested":[105],"silico":[108,118],"perturbations":[110],"can":[111],"predict":[112],"qualitative":[115],"responses.":[116],"In":[117],"perturbation":[119],"components":[122],"also":[123],"captured":[124],"biological":[125],"features":[126],"cytokine":[128,145],"(antagonism,":[130],"synergy,":[131],"redundancy).":[132],"CONCLUSION:":[133],"These":[134],"findings":[135],"highlight":[136],"potential":[138],"network-based":[140],"approaches":[141],"identifying":[143],"novel":[144],"pharmacological":[146],"targets":[147],"predicting":[150],"effects":[152],"their":[154],"exogenous":[155],"manipulation":[156],"inflammatory/immune":[158],"disorders.":[159]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}
