{"id":"https://openalex.org/W2129048774","doi":"https://doi.org/10.1186/s12918-015-0208-5","title":"Inference of spatiotemporal effects on cellular state transitions from time-lapse microscopy","display_name":"Inference of spatiotemporal effects on cellular state transitions from time-lapse microscopy","publication_year":2015,"publication_date":"2015-09-21","ids":{"openalex":"https://openalex.org/W2129048774","doi":"https://doi.org/10.1186/s12918-015-0208-5","mag":"2129048774","pmid":"https://pubmed.ncbi.nlm.nih.gov/26391569"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-015-0208-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-015-0208-5","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-015-0208-5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-015-0208-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058683692","display_name":"Michael Strasser","orcid":"https://orcid.org/0000-0001-8512-6814"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael K. Strasser","raw_affiliation_strings":["Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Ingolst\u00e4dter Landstr. 1, Neuherberg, 85764, Germany. michael.strasser@helmholtz-muenchen.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Ingolst\u00e4dter Landstr. 1, Neuherberg, 85764, Germany. michael.strasser@helmholtz-muenchen.de","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044515651","display_name":"Justin Feigelman","orcid":"https://orcid.org/0000-0002-6296-7087"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Justin Feigelman","raw_affiliation_strings":["Department of Mathematics, Technische Universit\u00e4t M\u00fcnchen, Boltzmannstr. 3, Garching, 85747, Germany. justin.feigelman@helmholtz-muenchen.de","Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Ingolst\u00e4dter Landstr. 1, Neuherberg, 85764, Germany. justin.feigelman@helmholtz-muenchen.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Technische Universit\u00e4t M\u00fcnchen, Boltzmannstr. 3, Garching, 85747, Germany. justin.feigelman@helmholtz-muenchen.de","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Ingolst\u00e4dter Landstr. 1, Neuherberg, 85764, Germany. justin.feigelman@helmholtz-muenchen.de","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083128670","display_name":"Fabian J. Theis","orcid":"https://orcid.org/0000-0002-2419-1943"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fabian J. Theis","raw_affiliation_strings":["Department of Mathematics, Technische Universit\u00e4t M\u00fcnchen, Boltzmannstr. 3, Garching, 85747, Germany. fabian.theis@helmholtz-muenchen.de","Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Ingolst\u00e4dter Landstr. 1, Neuherberg, 85764, Germany. fabian.theis@helmholtz-muenchen.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Technische Universit\u00e4t M\u00fcnchen, Boltzmannstr. 3, Garching, 85747, Germany. fabian.theis@helmholtz-muenchen.de","institution_ids":["https://openalex.org/I62916508"]},{"raw_affiliation_string":"Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Ingolst\u00e4dter Landstr. 1, Neuherberg, 85764, Germany. fabian.theis@helmholtz-muenchen.de","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046721596","display_name":"Carsten Marr","orcid":"https://orcid.org/0000-0003-2154-4552"},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Zentrum M\u00fcnchen","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Carsten Marr","raw_affiliation_strings":["Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Ingolst\u00e4dter Landstr. 1, Neuherberg, 85764, Germany. carsten.marr@helmholtz-muenchen.de"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Computational Biology, Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Health, Ingolst\u00e4dter Landstr. 1, Neuherberg, 85764, Germany. carsten.marr@helmholtz-muenchen.de","institution_ids":["https://openalex.org/I3018134672"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5046721596"],"corresponding_institution_ids":["https://openalex.org/I3018134672"],"apc_list":{"value":2290,"currency":"USD","value_usd":2290},"apc_paid":{"value":2290,"currency":"USD","value_usd":2290},"fwci":0.2754,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.59188148,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"9","issue":"1","first_page":"61","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.7297999858856201,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.7297999858856201,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.14499999582767487,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.03530000150203705,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6576904058456421},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6300634145736694},{"id":"https://openalex.org/keywords/univariate","display_name":"Univariate","score":0.592995285987854},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.46405401825904846},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4473968744277954},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4258453845977783},{"id":"https://openalex.org/keywords/transition","display_name":"Transition (genetics)","score":0.42102521657943726},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.4185367524623871},{"id":"https://openalex.org/keywords/video-microscopy","display_name":"Video microscopy","score":0.4123552143573761},{"id":"https://openalex.org/keywords/generative-model","display_name":"Generative model","score":0.41031962633132935},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4049382507801056},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.34314805269241333},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.34035906195640564},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.32078951597213745},{"id":"https://openalex.org/keywords/generative-grammar","display_name":"Generative grammar","score":0.2237626314163208},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18412911891937256}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6576904058456421},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6300634145736694},{"id":"https://openalex.org/C199163554","wikidata":"https://www.wikidata.org/wiki/Q1681619","display_name":"Univariate","level":3,"score":0.592995285987854},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.46405401825904846},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4473968744277954},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4258453845977783},{"id":"https://openalex.org/C194232998","wikidata":"https://www.wikidata.org/wiki/Q1606712","display_name":"Transition (genetics)","level":3,"score":0.42102521657943726},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.4185367524623871},{"id":"https://openalex.org/C2993775838","wikidata":"https://www.wikidata.org/wiki/Q14943002","display_name":"Video microscopy","level":2,"score":0.4123552143573761},{"id":"https://openalex.org/C167966045","wikidata":"https://www.wikidata.org/wiki/Q5532625","display_name":"Generative model","level":3,"score":0.41031962633132935},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4049382507801056},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.34314805269241333},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.34035906195640564},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.32078951597213745},{"id":"https://openalex.org/C39890363","wikidata":"https://www.wikidata.org/wiki/Q36108","display_name":"Generative grammar","level":2,"score":0.2237626314163208},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18412911891937256},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002468","descriptor_name":"Cell Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002468","descriptor_name":"Cell Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002468","descriptor_name":"Cell Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059008","descriptor_name":"Time-Lapse Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059008","descriptor_name":"Time-Lapse Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059008","descriptor_name":"Time-Lapse Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12918-015-0208-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-015-0208-5","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-015-0208-5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:26391569","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26391569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:push-zb.helmholtz-munich.de:46815","is_oa":true,"landing_page_url":"https://push-zb.helmholtz-munich.de/frontdoor.php?source_opus=46815","pdf_url":"https://push-zb.helmholtz-munich.de/deliver.php?id=11515","source":{"id":"https://openalex.org/S7407055352","display_name":"PuSH - Publication Server of Helmholtz Zentrum M\u00fcnchen","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst. Biol. 9:61 (2015)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:3552190","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4578671","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:46815","is_oa":true,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=46815","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst. Biol. 9:61 (2015)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12918-015-0208-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-015-0208-5","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-015-0208-5","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2304404308","display_name":null,"funder_award_id":"SPP 1356","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2129048774.pdf","grobid_xml":"https://content.openalex.org/works/W2129048774.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W229871693","https://openalex.org/W1480376833","https://openalex.org/W1503398984","https://openalex.org/W1528905581","https://openalex.org/W1580788756","https://openalex.org/W1583837637","https://openalex.org/W1865986031","https://openalex.org/W1949099618","https://openalex.org/W1966758700","https://openalex.org/W1967728313","https://openalex.org/W1974683325","https://openalex.org/W1975385846","https://openalex.org/W1980714336","https://openalex.org/W1984477437","https://openalex.org/W1986705681","https://openalex.org/W1994892791","https://openalex.org/W2011287359","https://openalex.org/W2013587414","https://openalex.org/W2030233281","https://openalex.org/W2033687970","https://openalex.org/W2043535514","https://openalex.org/W2063509019","https://openalex.org/W2067683181","https://openalex.org/W2069881735","https://openalex.org/W2072561351","https://openalex.org/W2074401358","https://openalex.org/W2083385452","https://openalex.org/W2084652685","https://openalex.org/W2086335524","https://openalex.org/W2089048280","https://openalex.org/W2101567517","https://openalex.org/W2103706175","https://openalex.org/W2105241495","https://openalex.org/W2111009586","https://openalex.org/W2112669742","https://openalex.org/W2118978333","https://openalex.org/W2119109414","https://openalex.org/W2119843603","https://openalex.org/W2124435756","https://openalex.org/W2125987139","https://openalex.org/W2128940002","https://openalex.org/W2129375080","https://openalex.org/W2135046866","https://openalex.org/W2140514146","https://openalex.org/W2141273399","https://openalex.org/W2142434250","https://openalex.org/W2142756489","https://openalex.org/W2154049504","https://openalex.org/W2154699417","https://openalex.org/W2157699984","https://openalex.org/W2160222246","https://openalex.org/W2161104570","https://openalex.org/W2178225550","https://openalex.org/W2313222308","https://openalex.org/W2420323469","https://openalex.org/W2486999229","https://openalex.org/W2495414240","https://openalex.org/W2787894218","https://openalex.org/W2911964244","https://openalex.org/W2953359837","https://openalex.org/W3101257732","https://openalex.org/W3147894994","https://openalex.org/W4210646479","https://openalex.org/W4236153851","https://openalex.org/W4301861531"],"related_works":["https://openalex.org/W2049578243","https://openalex.org/W1828158523","https://openalex.org/W2122079181","https://openalex.org/W2000145235","https://openalex.org/W3122045730","https://openalex.org/W1985848810","https://openalex.org/W2889939530","https://openalex.org/W2399195672","https://openalex.org/W3121881699","https://openalex.org/W2748838164"],"abstract_inverted_index":{"BACKGROUND:":[0],"Time-lapse":[1],"microscopy":[2,79,244],"allows":[3,120,213],"to":[4,37,66,101,126,168,176,196,214],"monitor":[5],"cell":[6,16,20,46,95,242],"state":[7,21,47,73,202],"transitions":[8,203],"in":[9,77,111],"a":[10,33,64,84,112,122,151],"spatiotemporal":[11,43,68,225],"context.":[12],"Combined":[13],"with":[14,51],"single":[15,241],"tracking":[17],"and":[18,45,98,125,144,204,228],"appropriate":[19],"markers,":[22],"transition":[23,74,104,179],"events":[24,75,180],"can":[25,138],"be":[26],"observed":[27,76],"within":[28],"the":[29,39,42,72,109,141,146,162,166,171,208,216,223,236],"genealogical":[30],"relationship":[31],"of":[32,56,71,154,165,181,201,218,239],"proliferating":[34],"population.":[35],"However,":[36],"infer":[38,67],"correlations":[40],"between":[41],"context":[44],"transitions,":[48,97],"statistical":[49,226],"analysis":[50,124],"an":[52,232],"appropriately":[53],"large":[54],"number":[55,153,217],"samples":[57,155],"is":[58,156,174,194],"required.":[59],"RESULTS:":[60],"Here,":[61],"we":[62,107,159,189,205,229],"present":[63],"method":[65,137,193],"features":[69,143,199],"predictive":[70,200],"time-lapse":[78,243],"data.":[80],"We":[81,133],"first":[82],"formulate":[83,108],"generative":[85],"model,":[86],"simulate":[87],"different":[88],"scenarios,":[89],"such":[90],"as":[91],"time-dependent":[92],"or":[93],"local":[94],"density-dependent":[96],"illustrate":[99],"how":[100],"estimate":[102,215],"univariate":[103],"rates.":[105],"Second,":[106],"problem":[110],"machine-learning":[113],"language":[114],"using":[115],"regularized":[116],"linear":[117],"models.":[118],"This":[119],"for":[121,222,235],"multivariate":[123],"disentangle":[127],"indirect":[128],"dependencies":[129],"via":[130],"feature":[131],"selection.":[132],"find":[134],"that":[135,191],"our":[136,192],"accurately":[139],"recover":[140],"relevant":[142],"reconstruct":[145],"underlying":[147],"interaction":[148],"kernels":[149],"if":[150,170],"critical":[152],"available.":[157],"Finally,":[158],"explicitly":[160],"use":[161],"tree":[163],"structure":[164],"data":[167],"validate":[169,207],"estimated":[172],"model":[173],"sufficient":[175],"explain":[177],"correlated":[178],"sister":[182],"cells.":[183],"CONCLUSIONS:":[184],"Using":[185],"synthetic":[186],"cellular":[187,219],"genealogies,":[188],"prove":[190],"able":[195],"correctly":[197],"identify":[198],"moreover":[206],"chosen":[209],"model.":[210],"Our":[211],"approach":[212],"genealogies":[220],"required":[221],"proposed":[224],"analysis,":[227],"thus":[230],"provide":[231],"important":[233],"tool":[234],"experimental":[237],"design":[238],"challenging":[240],"assays.":[245]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}