{"id":"https://openalex.org/W2105315057","doi":"https://doi.org/10.1186/s12918-014-0138-7","title":"Modelling chemotherapy effects on granulopoiesis","display_name":"Modelling chemotherapy effects on granulopoiesis","publication_year":2014,"publication_date":"2014-12-01","ids":{"openalex":"https://openalex.org/W2105315057","doi":"https://doi.org/10.1186/s12918-014-0138-7","mag":"2105315057","pmid":"https://pubmed.ncbi.nlm.nih.gov/25539928"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-014-0138-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-014-0138-7","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-014-0138-7","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-014-0138-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019934565","display_name":"Sibylle Schirm","orcid":null},"institutions":[{"id":"https://openalex.org/I51923648","display_name":"Life University","ror":"https://ror.org/01c0k9408","country_code":"US","type":"education","lineage":["https://openalex.org/I51923648"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Sibylle Schirm","raw_affiliation_strings":["Institute for Medical Informatics, Statistics and Epidemiology (IMISE) Medical Faculty, University of Leipzig, Haertelstra\u00dfe 16-18, Leipzig, 04107, Germany","LIFE Research Center, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Informatics, Statistics and Epidemiology (IMISE) Medical Faculty, University of Leipzig, Haertelstra\u00dfe 16-18, Leipzig, 04107, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"LIFE Research Center, Leipzig, Germany","institution_ids":["https://openalex.org/I51923648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033292535","display_name":"Christoph Engel","orcid":"https://orcid.org/0000-0002-7247-282X"},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Engel","raw_affiliation_strings":["Institute for Medical Informatics, Statistics and Epidemiology (IMISE) Medical Faculty, University of Leipzig, Haertelstra\u00dfe 16-18, Leipzig, 04107, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Informatics, Statistics and Epidemiology (IMISE) Medical Faculty, University of Leipzig, Haertelstra\u00dfe 16-18, Leipzig, 04107, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025964385","display_name":"Markus Loeffler","orcid":"https://orcid.org/0000-0002-0424-9933"},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Loeffler","raw_affiliation_strings":["Institute for Medical Informatics, Statistics and Epidemiology (IMISE) Medical Faculty, University of Leipzig, Haertelstra\u00dfe 16-18, Leipzig, 04107, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Informatics, Statistics and Epidemiology (IMISE) Medical Faculty, University of Leipzig, Haertelstra\u00dfe 16-18, Leipzig, 04107, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073349248","display_name":"Markus Scholz","orcid":"https://orcid.org/0000-0002-4059-1779"},"institutions":[{"id":"https://openalex.org/I51923648","display_name":"Life University","ror":"https://ror.org/01c0k9408","country_code":"US","type":"education","lineage":["https://openalex.org/I51923648"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Markus Scholz","raw_affiliation_strings":["Institute for Medical Informatics, Statistics and Epidemiology (IMISE) Medical Faculty, University of Leipzig, Haertelstra\u00dfe 16-18, Leipzig, 04107, Germany","LIFE Research Center, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Medical Informatics, Statistics and Epidemiology (IMISE) Medical Faculty, University of Leipzig, Haertelstra\u00dfe 16-18, Leipzig, 04107, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"LIFE Research Center, Leipzig, Germany","institution_ids":["https://openalex.org/I51923648"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5019934565"],"corresponding_institution_ids":["https://openalex.org/I51923648","https://openalex.org/I926574661"],"apc_list":null,"apc_paid":{"value":1594,"currency":"EUR","value_usd":1719},"fwci":0.4475,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.65987382,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"8","issue":"1","first_page":"138","last_page":"138"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.10409999638795853,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12172","display_name":"Neutropenia and Cancer Infections","score":0.10409999638795853,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.06989999860525131,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.040300000458955765,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/granulopoiesis","display_name":"Granulopoiesis","score":0.8918266296386719},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"Chemotherapy","score":0.5832740664482117},{"id":"https://openalex.org/keywords/toxicity","display_name":"Toxicity","score":0.5580776929855347},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.5305096507072449},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.5299835205078125},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.47402268648147583},{"id":"https://openalex.org/keywords/dosing","display_name":"Dosing","score":0.46516138315200806},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"Pharmacokinetics","score":0.4625716805458069},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.44459232687950134},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2540853023529053},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2404698133468628},{"id":"https://openalex.org/keywords/haematopoiesis","display_name":"Haematopoiesis","score":0.1229078471660614}],"concepts":[{"id":"https://openalex.org/C2779452902","wikidata":"https://www.wikidata.org/wiki/Q5596845","display_name":"Granulopoiesis","level":4,"score":0.8918266296386719},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5832740664482117},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5580776929855347},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5305096507072449},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5299835205078125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47402268648147583},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.46516138315200806},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.4625716805458069},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44459232687950134},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2540853023529053},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2404698133468628},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.1229078471660614},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003603","descriptor_name":"Cytotoxins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003603","descriptor_name":"Cytotoxins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D003603","descriptor_name":"Cytotoxins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12918-014-0138-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-014-0138-7","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-014-0138-7","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:25539928","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25539928","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:europepmc.org:3282267","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4302124","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:qucosa:de:qucosa:12034","is_oa":true,"landing_page_url":"http://ul.qucosa.de/id/qucosa%3A12034","pdf_url":null,"source":{"id":"https://openalex.org/S4377196312","display_name":"Qucosa (Saxon State and University Library Dresden)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I3132420320","host_organization_name":"SLUB Dresden","host_organization_lineage":["https://openalex.org/I3132420320"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Systems Biology 2014, 8:138 doi:10.1186/s12918-014-0138-7","raw_type":"doc-type:Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-014-0138-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-014-0138-7","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-014-0138-7","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7200000286102295,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320325298","display_name":"Universit\u00e4t Leipzig","ror":"https://ror.org/03s7gtk40"},{"id":"https://openalex.org/F4320328735","display_name":"Freistaat Sachsen","ror":null},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338080","display_name":"European Social Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2105315057.pdf","grobid_xml":"https://content.openalex.org/works/W2105315057.grobid-xml"},"referenced_works_count":94,"referenced_works":["https://openalex.org/W18847791","https://openalex.org/W20604194","https://openalex.org/W109252363","https://openalex.org/W135606421","https://openalex.org/W142403750","https://openalex.org/W172411081","https://openalex.org/W1811037815","https://openalex.org/W1843066912","https://openalex.org/W1905145727","https://openalex.org/W1907938184","https://openalex.org/W1922160368","https://openalex.org/W1924320258","https://openalex.org/W1933587402","https://openalex.org/W1970838504","https://openalex.org/W1975174081","https://openalex.org/W1983192532","https://openalex.org/W1983323548","https://openalex.org/W1986621490","https://openalex.org/W1987694764","https://openalex.org/W1988103510","https://openalex.org/W1989478899","https://openalex.org/W1992123604","https://openalex.org/W2000910321","https://openalex.org/W2002941209","https://openalex.org/W2007083789","https://openalex.org/W2007367046","https://openalex.org/W2024691000","https://openalex.org/W2025834644","https://openalex.org/W2026736608","https://openalex.org/W2027354043","https://openalex.org/W2032414164","https://openalex.org/W2033236068","https://openalex.org/W2033992465","https://openalex.org/W2036067444","https://openalex.org/W2038023916","https://openalex.org/W2039689365","https://openalex.org/W2050846842","https://openalex.org/W2050948710","https://openalex.org/W2051360772","https://openalex.org/W2052223517","https://openalex.org/W2052902941","https://openalex.org/W2054878781","https://openalex.org/W2057167410","https://openalex.org/W2058892595","https://openalex.org/W2059070026","https://openalex.org/W2060725286","https://openalex.org/W2063382772","https://openalex.org/W2070241398","https://openalex.org/W2071813692","https://openalex.org/W2072517403","https://openalex.org/W2075259252","https://openalex.org/W2089344492","https://openalex.org/W2096104385","https://openalex.org/W2096885361","https://openalex.org/W2098506106","https://openalex.org/W2102773208","https://openalex.org/W2104009100","https://openalex.org/W2105288765","https://openalex.org/W2106833866","https://openalex.org/W2106928992","https://openalex.org/W2108465006","https://openalex.org/W2118935462","https://openalex.org/W2119342289","https://openalex.org/W2119481331","https://openalex.org/W2119584141","https://openalex.org/W2119897082","https://openalex.org/W2121254130","https://openalex.org/W2121934166","https://openalex.org/W2135826545","https://openalex.org/W2136802843","https://openalex.org/W2136962826","https://openalex.org/W2142195688","https://openalex.org/W2146457764","https://openalex.org/W2148343095","https://openalex.org/W2149428548","https://openalex.org/W2149759073","https://openalex.org/W2152474929","https://openalex.org/W2152978265","https://openalex.org/W2157801924","https://openalex.org/W2163679408","https://openalex.org/W2164788594","https://openalex.org/W2166572860","https://openalex.org/W2167517071","https://openalex.org/W2169256688","https://openalex.org/W2169372049","https://openalex.org/W2171588044","https://openalex.org/W2235063564","https://openalex.org/W2269955197","https://openalex.org/W2341719812","https://openalex.org/W2400090911","https://openalex.org/W2412177838","https://openalex.org/W2418657325","https://openalex.org/W4232293309","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W120951549","https://openalex.org/W2281745172","https://openalex.org/W1985680363","https://openalex.org/W79606884","https://openalex.org/W2568259120","https://openalex.org/W1986296864","https://openalex.org/W196519228","https://openalex.org/W1986957385","https://openalex.org/W2409390381","https://openalex.org/W2418396433"],"abstract_inverted_index":{"Although":[0],"the":[1,47,65,82,134,156,175,242,252],"growth-factor":[2],"G-CSF":[3,38,56,70,229,246,262],"is":[4,18],"widely":[5],"used":[6,39,62],"to":[7,63,161,188,217,238,250,258],"prevent":[8],"granulotoxic":[9],"side":[10],"effects":[11],"of":[12,33,37,55,67,90,101,107,115,126,131,137,147,158,166,194,212,227,244],"cytotoxic":[13],"chemotherapies,":[14,34],"its":[15],"optimal":[16],"use":[17],"still":[19],"unknown":[20],"since":[21],"treatment":[22],"outcome":[23,243],"depends":[24],"on":[25],"many":[26],"parameters":[27,149],"such":[28],"as":[29],"dosing":[30],"and":[31,40,52,57,93,110,119,128,207,230,240,260],"timing":[32],"pharmaceutical":[35],"derivative":[36],"individual":[41],"risk":[42],"factors.":[43],"We":[44,222,248],"showed":[45],"in":[46,191,202,219,233,254],"past":[48],"that":[49],"a":[50,74,87,145,224],"pharmacokinetic":[51],"\u2013dynamic":[53],"model":[54,89,100,160,226,253],"human":[58],"granulopoiesis":[59],"can":[60,141,151],"be":[61,142,152,189],"predict":[64,239],"performance":[66],"yet":[68],"untested":[69],"schedules.":[71,247],"However,":[72],"only":[73],"single":[75],"chemotherapy":[76,91,231],"was":[77],"considered":[78],"so":[79],"far.":[80],"In":[81],"present":[83],"paper,":[84],"we":[85],"propose":[86],"comprehensive":[88,225],"toxicity":[92,130,148,220],"combine":[94],"it":[95],"with":[96,206],"our":[97,159],"cell":[98,108,111,120],"kinetic":[99],"granulopoiesis.":[102],"Major":[103],"assumptions":[104,186],"are:":[105],"proportionality":[106],"numbers":[109],"loss,":[112],"delayed":[113],"action":[114,232],"chemotherapy,":[116],"drug,":[117],"drug-dose":[118],"stage":[121],"specific":[122],"toxicities,":[123],"no":[124],"interaction":[125],"drugs":[127,132,198],"higher":[129],"at":[133],"first":[135],"time":[136,163],"application.":[138],"Correspondingly,":[139],"chemotherapies":[140],"characterized":[143],"by":[144,154],"set":[146],"which":[150,235],"estimated":[153],"fitting":[155],"predictions":[157],"clinical":[162,182,256],"series":[164],"data":[165],"patients":[167],"under":[168],"therapy.":[169],"Data":[170],"were":[171,178,214],"either":[172],"extracted":[173],"from":[174,180],"literature":[176],"or":[177,199],"received":[179],"cooperating":[181],"study":[183],"groups.":[184],"Model":[185],"proved":[187],"feasible":[190],"explaining":[192],"granulotoxicity":[193,213],"10":[195],"different":[196,204,255],"chemotherapeutic":[197],"drug-combinations":[200],"applied":[201],"33":[203],"schedules":[205],"without":[208],"G-CSF.":[209],"Risk":[210],"groups":[211],"traced":[215],"back":[216],"differences":[218],"parameters.":[221],"established":[223],"combined":[228],"humans":[234],"allows":[236],"us":[237],"compare":[241],"alternative":[245],"aim":[249],"apply":[251],"contexts":[257],"optimize":[259],"individualize":[261],"treatment.":[263]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-05-16T08:24:45.110214","created_date":"2025-10-10T00:00:00"}