{"id":"https://openalex.org/W2125941741","doi":"https://doi.org/10.1186/s12918-014-0136-9","title":"Integrative network analysis of TCGA data for ovarian cancer","display_name":"Integrative network analysis of TCGA data for ovarian cancer","publication_year":2014,"publication_date":"2014-12-01","ids":{"openalex":"https://openalex.org/W2125941741","doi":"https://doi.org/10.1186/s12918-014-0136-9","mag":"2125941741","pmid":"https://pubmed.ncbi.nlm.nih.gov/25551281"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-014-0136-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-014-0136-9","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-014-0136-9","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-014-0136-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025436227","display_name":"Qingyang Zhang","orcid":"https://orcid.org/0000-0002-7965-1927"},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Qingyang Zhang","raw_affiliation_strings":["Department of Statistics, Northwestern University, Evanston, IL60208, USA. qingyangzhang2015@u.northwestern.edu","Northwestern University****"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Northwestern University, Evanston, IL60208, USA. qingyangzhang2015@u.northwestern.edu","institution_ids":[]},{"raw_affiliation_string":"Northwestern University****","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068626380","display_name":"Joanna E. Burdette","orcid":"https://orcid.org/0000-0002-7271-6847"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanna E Burdette","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago, 60607, IL, USA. joannab@uic.edu","Department of Medicinal Chemistry and Pharmacognosy, University of Illinois,Chicago,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, University of Illinois, Chicago, 60607, IL, USA. joannab@uic.edu","institution_ids":[]},{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, University of Illinois,Chicago,USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090013659","display_name":"Ji-Ping Wang","orcid":"https://orcid.org/0000-0002-8398-939X"},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ji-Ping Wang","raw_affiliation_strings":["Department of Statistics, Northwestern University, Evanston, IL60208, USA. jzwang@northwestern.edu","Department of Statistics, Northwestern University, Evanston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Northwestern University, Evanston, IL60208, USA. jzwang@northwestern.edu","institution_ids":[]},{"raw_affiliation_string":"Department of Statistics, Northwestern University, Evanston, USA","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5025436227"],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":null,"apc_paid":null,"fwci":3.1302,"has_fulltext":true,"cited_by_count":80,"citation_normalized_percentile":{"value":0.92329559,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"8","issue":"1","first_page":"1338","last_page":"1338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.5044999718666077,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.5044999718666077,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.11379999667406082,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.09719999879598618,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7396066784858704},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5780748724937439},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.5555131435394287},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5059797167778015},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.49285197257995605},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.46658116579055786},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4376303255558014},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.1596088409423828}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7396066784858704},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5780748724937439},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.5555131435394287},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5059797167778015},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.49285197257995605},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46658116579055786},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4376303255558014},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1596088409423828}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/s12918-014-0136-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-014-0136-9","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-014-0136-9","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:25551281","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25551281","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4331442","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4331442","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-014-0136-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-014-0136-9","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-014-0136-9","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7300000190734863,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G3296431394","display_name":null,"funder_award_id":"U54CA143869","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2125941741.pdf","grobid_xml":"https://content.openalex.org/works/W2125941741.grobid-xml"},"referenced_works_count":45,"referenced_works":["https://openalex.org/W50240922","https://openalex.org/W75929868","https://openalex.org/W97652101","https://openalex.org/W304933894","https://openalex.org/W602985745","https://openalex.org/W1485321296","https://openalex.org/W1524326598","https://openalex.org/W1573465223","https://openalex.org/W1661871015","https://openalex.org/W1969545721","https://openalex.org/W1973691578","https://openalex.org/W1996278079","https://openalex.org/W1996989652","https://openalex.org/W2017337590","https://openalex.org/W2031514765","https://openalex.org/W2039189450","https://openalex.org/W2044702943","https://openalex.org/W2049409526","https://openalex.org/W2053775054","https://openalex.org/W2056636001","https://openalex.org/W2058785803","https://openalex.org/W2067082610","https://openalex.org/W2073307618","https://openalex.org/W2074264162","https://openalex.org/W2081225729","https://openalex.org/W2081746825","https://openalex.org/W2087539641","https://openalex.org/W2090287261","https://openalex.org/W2090968329","https://openalex.org/W2091998086","https://openalex.org/W2096283457","https://openalex.org/W2104989537","https://openalex.org/W2105800735","https://openalex.org/W2116236561","https://openalex.org/W2123696077","https://openalex.org/W2125072260","https://openalex.org/W2128088446","https://openalex.org/W2160915478","https://openalex.org/W2171265988","https://openalex.org/W2185572869","https://openalex.org/W2330192890","https://openalex.org/W2397866408","https://openalex.org/W2560367415","https://openalex.org/W3098745759","https://openalex.org/W6610966482"],"related_works":["https://openalex.org/W5284979","https://openalex.org/W2949927938","https://openalex.org/W2029387041","https://openalex.org/W2135896045","https://openalex.org/W2032799661","https://openalex.org/W4245853730","https://openalex.org/W2884256268","https://openalex.org/W2131025197","https://openalex.org/W2799842390","https://openalex.org/W2171763327"],"abstract_inverted_index":{"BACKGROUND:":[0],"Over":[1],"the":[2,12,16,42,46,54,81,94,101,130,179,211,215,256,301],"past":[3],"years,":[4],"tremendous":[5],"efforts":[6],"have":[7,27],"been":[8,28],"made":[9],"to":[10,44,68,75,79,143,177,228,245,281],"elucidate":[11],"molecular":[13,302],"basis":[14],"of":[15,20,37,49,56,109,189,208,225,260,304],"initiation":[17],"and":[18,59,71,78,120,159,185,197,237,249,275],"progression":[19],"ovarian":[21,76,124,261,305],"cancer.":[22,306],"However,":[23],"most":[24],"existing":[25,212],"studies":[26],"focused":[29],"on":[30,93],"individual":[31],"genes":[32,111,127,134,192,243],"or":[33,118],"a":[34,88,107,139,168,173,187],"single":[35],"type":[36],"data,":[38],"which":[39,209,226,295],"may":[40,296],"lack":[41],"power":[43],"detect":[45],"complex":[47,282],"mechanisms":[48,303],"cancer":[50,77,125,262,283],"formation":[51],"by":[52,112],"overlooking":[53],"interactions":[55],"different":[57],"genetic":[58,70,205,274],"epigenetic":[60,72,276],"factors.":[61],"RESULTS:":[62],"We":[63,166],"propose":[64],"an":[65,121],"integrative":[66],"framework":[67,267],"identify":[69,144],"features":[73,86,147,184,277],"related":[74,126,244,280],"quantify":[80,178],"causal":[82,180],"relationships":[83,181],"among":[84,182],"these":[85,183],"using":[87],"probabilistic":[89],"graphical":[90],"model":[91,171],"based":[92],"Cancer":[95],"Genome":[96],"Atlas":[97],"(TCGA)":[98],"data.":[99],"In":[100,240],"feature":[102],"selection,":[103],"we":[104],"first":[105],"defined":[106],"set":[108,188],"seed":[110,133],"including":[113,148,193,232],"48":[114],"candidate":[115],"tumor":[116,235],"suppressors":[117],"oncogenes":[119],"additional":[122,146],"20":[123],"reported":[128],"in":[129,214,270],"literature.":[131,216],"The":[132,199,265,285],"were":[135,251],"then":[136],"fed":[137],"into":[138,300],"stepwise":[140],"correlation-based":[141],"selector":[142],"271":[145],"177":[149],"genes,":[150],"82":[151],"copy":[152],"number":[153],"variation":[154],"sites,":[155],"11":[156],"methylation":[157],"sites":[158],"1":[160],"somatic":[161],"mutation":[162],"(at":[163],"gene":[164,222],"TP53).":[165],"built":[167],"Bayesian":[169,287],"network":[170,288],"with":[172],"logit":[174],"link":[175],"function":[176],"discovered":[186],"13":[190],"hub":[191],"ARID1A,":[194],"C19orf53,":[195],"CSKN2A1":[196],"COL5A2.":[198],"directed":[200],"graph":[201],"revealed":[202],"many":[203],"potential":[204],"pathways,":[206,294],"some":[207,291],"confirmed":[210],"results":[213],"Clustering":[217],"analysis":[218],"further":[219],"suggested":[220],"four":[221],"clusters,":[223],"three":[224],"correspond":[227],"well-defined":[229],"cellular":[230],"processes":[231],"cell":[233],"division,":[234],"invasion":[236],"mitochondrial":[238],"system.":[239],"addition,":[241],"two":[242],"glycoprotein":[246],"synthesis,":[247],"PSG11":[248],"GALNT10,":[250],"found":[252],"highly":[253],"predictive":[254],"for":[255],"overall":[257],"survival":[258],"time":[259],"patients.":[263],"CONCLUSIONS:":[264],"proposed":[266],"is":[268],"effective":[269],"identifying":[271],"possible":[272],"important":[273],"that":[278],"are":[279],"diseases.":[284],"constructed":[286],"has":[289],"identified":[290],"new":[292,298],"genetic/epigenetic":[293],"shed":[297],"light":[299]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":16},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}