{"id":"https://openalex.org/W2002265556","doi":"https://doi.org/10.1186/s12918-014-0133-z","title":"Hierarchy of non-glucose sugars in Escherichia coli","display_name":"Hierarchy of non-glucose sugars in Escherichia coli","publication_year":2014,"publication_date":"2014-12-01","ids":{"openalex":"https://openalex.org/W2002265556","doi":"https://doi.org/10.1186/s12918-014-0133-z","mag":"2002265556","pmid":"https://pubmed.ncbi.nlm.nih.gov/25539838"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-014-0133-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-014-0133-z","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-014-0133-z","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-014-0133-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024919275","display_name":"Guy Aidelberg","orcid":"https://orcid.org/0000-0002-7521-8851"},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Guy Aidelberg","raw_affiliation_strings":["Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel","Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, , Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, , Israel","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011802262","display_name":"Benjamin D. Towbin","orcid":"https://orcid.org/0000-0001-7046-1257"},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Benjamin D Towbin","raw_affiliation_strings":["Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel","Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, , Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, , Israel","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062898047","display_name":"Daphna Rothschild","orcid":"https://orcid.org/0000-0002-0872-8624"},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Daphna Rothschild","raw_affiliation_strings":["Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel","Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, , Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, , Israel","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111651449","display_name":"E. Dekel","orcid":null},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Erez Dekel","raw_affiliation_strings":["Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel","Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, , Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, , Israel","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102159633","display_name":"Anat Bren","orcid":null},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Anat Bren","raw_affiliation_strings":["Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel","Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, , Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, , Israel","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010209966","display_name":"Uri Alon","orcid":"https://orcid.org/0000-0003-1121-5907"},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Uri Alon","raw_affiliation_strings":["Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel","Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, , Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]},{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, , Israel","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5024919275"],"corresponding_institution_ids":["https://openalex.org/I53964585"],"apc_list":null,"apc_paid":null,"fwci":4.1262,"has_fulltext":true,"cited_by_count":176,"citation_normalized_percentile":{"value":0.94722863,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"8","issue":"1","first_page":"133","last_page":"133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.54830002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.54830002784729,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.24660000205039978,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.13689999282360077,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sugar","display_name":"Sugar","score":0.8301533460617065},{"id":"https://openalex.org/keywords/hierarchy","display_name":"Hierarchy","score":0.773862898349762},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.5313228964805603},{"id":"https://openalex.org/keywords/promoter","display_name":"Promoter","score":0.5164958834648132},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.48572999238967896},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.46021807193756104},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.45537030696868896},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.43320998549461365},{"id":"https://openalex.org/keywords/sucrose","display_name":"Sucrose","score":0.4321445822715759},{"id":"https://openalex.org/keywords/carbon-source","display_name":"Carbon source","score":0.42440757155418396},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3653425872325897},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3419116139411926},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.20066305994987488},{"id":"https://openalex.org/keywords/economics","display_name":"Economics","score":0.08820956945419312}],"concepts":[{"id":"https://openalex.org/C2777108408","wikidata":"https://www.wikidata.org/wiki/Q11002","display_name":"Sugar","level":2,"score":0.8301533460617065},{"id":"https://openalex.org/C31170391","wikidata":"https://www.wikidata.org/wiki/Q188619","display_name":"Hierarchy","level":2,"score":0.773862898349762},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.5313228964805603},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.5164958834648132},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.48572999238967896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46021807193756104},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.45537030696868896},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43320998549461365},{"id":"https://openalex.org/C2778597767","wikidata":"https://www.wikidata.org/wiki/Q4027534","display_name":"Sucrose","level":2,"score":0.4321445822715759},{"id":"https://openalex.org/C2982740256","wikidata":"https://www.wikidata.org/wiki/Q56064425","display_name":"Carbon source","level":2,"score":0.42440757155418396},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3653425872325897},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3419116139411926},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20066305994987488},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.08820956945419312},{"id":"https://openalex.org/C34447519","wikidata":"https://www.wikidata.org/wiki/Q179522","display_name":"Market economy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002241","descriptor_name":"Carbohydrates","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002241","descriptor_name":"Carbohydrates","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002241","descriptor_name":"Carbohydrates","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002241","descriptor_name":"Carbohydrates","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002241","descriptor_name":"Carbohydrates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002241","descriptor_name":"Carbohydrates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002241","descriptor_name":"Carbohydrates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002241","descriptor_name":"Carbohydrates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12918-014-0133-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-014-0133-z","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-014-0133-z","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:25539838","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25539838","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:boris.unibe.ch:130605","is_oa":true,"landing_page_url":"https://boris.unibe.ch/130605/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401086","display_name":"Bern Open Repository and Information System (University of Bern)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I118564535","host_organization_name":"University of Bern","host_organization_lineage":["https://openalex.org/I118564535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Aidelberg, Guy; Towbin, Benjamin D; Rothschild, Daphna; Dekel, Erez; Bren, Anat; Alon, Uri (2014). Hierarchy of non-glucose sugars in Escherichia coli. BMC systems biology, 8(133), p. 133. BioMed Central 10.1186/s12918-014-0133-z <http://dx.doi.org/10.1186/s12918-014-0133-z>","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4304618","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4304618","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-014-0133-z","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-014-0133-z","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-014-0133-z","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"No poverty","id":"https://metadata.un.org/sdg/1","score":0.5}],"awards":[{"id":"https://openalex.org/G1323383031","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G2488755638","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320322252","funder_display_name":"Israel Science Foundation"},{"id":"https://openalex.org/G2917205702","display_name":"Design principles and controllability of protein circuits","funder_award_id":"249919","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3829048491","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4104599821","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5593277320","display_name":null,"funder_award_id":"2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5702163051","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002265556.pdf","grobid_xml":"https://content.openalex.org/works/W2002265556.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1871441147","https://openalex.org/W1966054814","https://openalex.org/W1971866274","https://openalex.org/W1972074342","https://openalex.org/W1996264210","https://openalex.org/W1996983929","https://openalex.org/W2004801113","https://openalex.org/W2009163705","https://openalex.org/W2010025771","https://openalex.org/W2012757382","https://openalex.org/W2015369732","https://openalex.org/W2016377588","https://openalex.org/W2018073151","https://openalex.org/W2023272532","https://openalex.org/W2029836638","https://openalex.org/W2032867950","https://openalex.org/W2036449301","https://openalex.org/W2037462150","https://openalex.org/W2038186289","https://openalex.org/W2042231801","https://openalex.org/W2042859590","https://openalex.org/W2044463066","https://openalex.org/W2056756011","https://openalex.org/W2063855430","https://openalex.org/W2067252347","https://openalex.org/W2068872007","https://openalex.org/W2077055700","https://openalex.org/W2081007384","https://openalex.org/W2086440427","https://openalex.org/W2087279790","https://openalex.org/W2089857658","https://openalex.org/W2090806625","https://openalex.org/W2093548226","https://openalex.org/W2096666146","https://openalex.org/W2101762601","https://openalex.org/W2102451723","https://openalex.org/W2102469838","https://openalex.org/W2110014577","https://openalex.org/W2110401991","https://openalex.org/W2121365413","https://openalex.org/W2123425265","https://openalex.org/W2123569104","https://openalex.org/W2129282478","https://openalex.org/W2130665506","https://openalex.org/W2137753831","https://openalex.org/W2139833543","https://openalex.org/W2143377380","https://openalex.org/W2145744900","https://openalex.org/W2147303597","https://openalex.org/W2148334858","https://openalex.org/W2148581822","https://openalex.org/W2150473143","https://openalex.org/W2152146387","https://openalex.org/W2152808252","https://openalex.org/W2153685804","https://openalex.org/W2154345459","https://openalex.org/W2155408323","https://openalex.org/W2161446862","https://openalex.org/W2161589208","https://openalex.org/W2162530194","https://openalex.org/W2165081628","https://openalex.org/W2170806980","https://openalex.org/W2182611834","https://openalex.org/W4205349122","https://openalex.org/W4235608950","https://openalex.org/W4249758294"],"related_works":["https://openalex.org/W2015979974","https://openalex.org/W1969771092","https://openalex.org/W4238210670","https://openalex.org/W2795723184","https://openalex.org/W2315333440","https://openalex.org/W2007182162","https://openalex.org/W2025529750","https://openalex.org/W2381156367","https://openalex.org/W2891858816","https://openalex.org/W203553246"],"abstract_inverted_index":{"BACKGROUND:":[0],"Understanding":[1],"how":[2],"cells":[3],"make":[4,9,119],"decisions,":[5],"and":[6,63,87,95,114,125,151,250,290],"why":[7],"they":[8,12],"the":[10,26,54,71,81,99,137,155,167,174,176,179,181,184,191,194,204,207,213,224,292,298,319],"decisions":[11,27,332],"make,":[13],"is":[14,44,68,188,262],"of":[15,56,61,73,84,101,122,131,148,203,206,223,235,247,253,256,268,307,337],"fundamental":[16],"interest":[17],"in":[18,80,88,128,142,145,190,237],"systems":[19],"biology.":[20],"To":[21],"address":[22],"this,":[23],"we":[24,92,244],"study":[25],"made":[28],"by":[29,59,171,226,265,281,315,318],"E.":[30,48,85,102],"coli":[31,86,103],"on":[32,183,220,297],"which":[33,77,272,310],"genes":[34],"to":[35,97,118,166,329],"express":[36],"when":[37,333],"presented":[38,334],"with":[39,335],"two":[40],"different":[41,106],"sugars.":[42,133],"It":[43],"well-known":[45],"that":[46,136,193,212],"glucose,":[47],"coli's":[49],"preferred":[50],"carbon":[51,108],"source,":[52],"represses":[53],"uptake":[55],"other":[57],"sugars":[58,138],"means":[60],"global":[62],"gene-specific":[64],"mechanisms.":[65],"However,":[66],"less":[67],"known":[69],"about":[70],"utilization":[72],"glucose-free":[74],"sugar":[75,157,182,196,229,238,308],"mixtures":[76,240,336],"are":[78,198],"found":[79],"natural":[82],"environment":[83],"biotechnology.":[89],"RESULTS:":[90],"Here,":[91],"combine":[93],"experiment":[94],"theory":[96],"map":[98],"choices":[100],"among":[104],"6":[105],"non-glucose":[107],"sources.":[109],"We":[110,134,277,302],"used":[111,328],"robotic":[112],"assays":[113],"fluorescence":[115],"reporter":[116],"strains":[117],"precise":[120],"measurements":[121],"promoter":[123,161],"activity":[124,205],"growth":[126,168,177,269,296],"rate":[127,169,270],"all":[129],"pairs":[130],"these":[132,279],"find":[135,245,303],"can":[139,215,311,326],"be":[140,216,312,327],"ranked":[141],"a":[143,146,149,152,233,304],"hierarchy:":[144],"mixture":[147],"higher":[150,180],"lower":[153,156,195],"sugar,":[154],"system":[158,230],"shows":[159,211],"reduced":[160],"activity.":[162],"The":[163,186,323],"hierarchy":[164,187,214,306],"corresponds":[165],"supported":[170],"each":[172],"sugar-":[173],"faster":[175],"rate,":[178],"hierarchy.":[185],"'soft'":[189],"sense":[192],"promoters":[197,225],"not":[199,263],"completely":[200],"repressed.":[201],"Measurement":[202],"master":[208,320],"regulator":[209,321],"CRP-cAMP":[210],"quantitatively":[217,313],"explained":[218,314],"based":[219],"differential":[221,316],"activation":[222,231,317],"CRP-cAMP.":[227],"Comparing":[228],"as":[232],"function":[234],"time":[236],"pair":[239],"at":[241],"sub-saturating":[242],"concentrations,":[243],"cases":[246,252],"sequential":[248,275],"activation,":[249],"also":[251],"simultaneous":[254,260],"expression":[255,261],"both":[257,286],"systems.":[258],"Such":[259],"predicted":[264],"simple":[266],"models":[267,280],"optimization,":[271],"predict":[273],"only":[274],"activation.":[276],"extend":[278],"suggesting":[282],"multi-objective":[283],"optimization":[284],"for":[285,294],"growing":[287],"rapidly":[288],"now":[289],"preparing":[291],"cell":[293,331],"future":[295],"poorer":[299],"sugar.":[300],"CONCLUSION:":[301],"defined":[305],"utilization,":[309],"cAMP-CRP.":[322],"present":[324],"approach":[325],"understand":[330],"conditions.":[338]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":16},{"year":2018,"cited_by_count":25},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}