{"id":"https://openalex.org/W2105140815","doi":"https://doi.org/10.1186/s12918-014-0128-9","title":"Photo-sensitive degron variants for tuning protein stability by light","display_name":"Photo-sensitive degron variants for tuning protein stability by light","publication_year":2014,"publication_date":"2014-11-17","ids":{"openalex":"https://openalex.org/W2105140815","doi":"https://doi.org/10.1186/s12918-014-0128-9","mag":"2105140815","pmid":"https://pubmed.ncbi.nlm.nih.gov/25403319"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-014-0128-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-014-0128-9","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-014-0128-9","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-014-0128-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074505162","display_name":"Svetlana Usherenko","orcid":null},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Svetlana Usherenko","raw_affiliation_strings":["Department of Biology/Genetics, Philipps-Universitt Marburg, Karl-von-Frisch-Strasse 8, 35043 Marburg, Germany","Department of Biology/Genetics, Philipps-Universit\u00e4t Marburg, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology/Genetics, Philipps-Universitt Marburg, Karl-von-Frisch-Strasse 8, 35043 Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]},{"raw_affiliation_string":"Department of Biology/Genetics, Philipps-Universit\u00e4t Marburg, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073848026","display_name":"Hilke Stibbe","orcid":null},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hilke Stibbe","raw_affiliation_strings":["Department of Mathematics and Computer Science/Numerical Optimization, Universitt Marburg, Hans-Meerwein-Strae 6, 35032 Marburg, Germany","Department of Mathematics and Computer Science/Numerical Optimization, Universit\u00e4t Marburg, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Computer Science/Numerical Optimization, Universitt Marburg, Hans-Meerwein-Strae 6, 35032 Marburg, Germany","institution_ids":[]},{"raw_affiliation_string":"Department of Mathematics and Computer Science/Numerical Optimization, Universit\u00e4t Marburg, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020193254","display_name":"Massimiliano Musc\u00f3","orcid":null},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Massimiliano Musc\u00f3","raw_affiliation_strings":["Department of Biology/Genetics, Philipps-Universit\u00e4t Marburg, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology/Genetics, Philipps-Universit\u00e4t Marburg, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033695434","display_name":"Lars\u2010Oliver Essen","orcid":"https://orcid.org/0000-0003-4272-4026"},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lars-Oliver Essen","raw_affiliation_strings":["Department of Chemistry/Biomedical Research Center, Philipps-Universitt Marburg, Hans-Meerwein-Strasse 4, 35032 Marburg, Germany","Department of Chemistry/Biomedical Research Center, Philipps-Universit\u00e4t Marburg, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry/Biomedical Research Center, Philipps-Universitt Marburg, Hans-Meerwein-Strasse 4, 35032 Marburg, Germany","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry/Biomedical Research Center, Philipps-Universit\u00e4t Marburg, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012360707","display_name":"Ekaterina Kostina","orcid":"https://orcid.org/0000-0002-1428-7095"},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ekaterina A Kostina","raw_affiliation_strings":["Department of Mathematics and Computer Science/Numerical Optimization, Universitt Marburg, Hans-Meerwein-Strae 6, 35032 Marburg, Germany","Department of Mathematics and Computer Science/Numerical Optimization, Universit\u00e4t Marburg, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Computer Science/Numerical Optimization, Universitt Marburg, Hans-Meerwein-Strae 6, 35032 Marburg, Germany","institution_ids":[]},{"raw_affiliation_string":"Department of Mathematics and Computer Science/Numerical Optimization, Universit\u00e4t Marburg, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049010505","display_name":"Christof Taxis","orcid":"https://orcid.org/0000-0001-5952-7091"},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christof Taxis","raw_affiliation_strings":["Department of Biology/Genetics, Philipps-Universit\u00e4t Marburg, Karl-von-Frisch-Strasse 8, Marburg, 35043, Germany. taxis@staff.uni-marburg.de","Department of Biology/Genetics, Philipps-Universit\u00e4t Marburg, Marburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology/Genetics, Philipps-Universit\u00e4t Marburg, Karl-von-Frisch-Strasse 8, Marburg, 35043, Germany. taxis@staff.uni-marburg.de","institution_ids":[]},{"raw_affiliation_string":"Department of Biology/Genetics, Philipps-Universit\u00e4t Marburg, Marburg, Germany","institution_ids":["https://openalex.org/I161103922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5074505162"],"corresponding_institution_ids":["https://openalex.org/I161103922"],"apc_list":null,"apc_paid":null,"fwci":6.5185,"has_fulltext":true,"cited_by_count":64,"citation_normalized_percentile":{"value":0.96052968,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"128","last_page":"128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11268","display_name":"Light effects on plants","score":0.9217000007629395,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11268","display_name":"Light effects on plants","score":0.9217000007629395,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11708","display_name":"Photochromic and Fluorescence Chemistry","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/degron","display_name":"Degron","score":0.9614959955215454},{"id":"https://openalex.org/keywords/phototropin","display_name":"Phototropin","score":0.855231761932373},{"id":"https://openalex.org/keywords/proteasome","display_name":"Proteasome","score":0.5576258301734924},{"id":"https://openalex.org/keywords/darkness","display_name":"Darkness","score":0.55538010597229},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.547752320766449},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5281503200531006},{"id":"https://openalex.org/keywords/proteolysis","display_name":"Proteolysis","score":0.49340692162513733},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4913620054721832},{"id":"https://openalex.org/keywords/cytoplasm","display_name":"Cytoplasm","score":0.4893738627433777},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"Protein degradation","score":0.48740556836128235},{"id":"https://openalex.org/keywords/mutagenesis","display_name":"Mutagenesis","score":0.4811728894710541},{"id":"https://openalex.org/keywords/wild-type","display_name":"Wild type","score":0.4358152449131012},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.43538594245910645},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.4319971799850464},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.4211300313472748},{"id":"https://openalex.org/keywords/optogenetics","display_name":"Optogenetics","score":0.41726404428482056},{"id":"https://openalex.org/keywords/blue-light","display_name":"Blue light","score":0.41212600469589233},{"id":"https://openalex.org/keywords/ubiquitin","display_name":"Ubiquitin","score":0.40876853466033936},{"id":"https://openalex.org/keywords/yeast","display_name":"Yeast","score":0.40497180819511414},{"id":"https://openalex.org/keywords/arabidopsis-thaliana","display_name":"Arabidopsis thaliana","score":0.3876602351665497},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3781464397907257},{"id":"https://openalex.org/keywords/ubiquitin-ligase","display_name":"Ubiquitin ligase","score":0.2534131407737732},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.15908017754554749},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.1234448254108429},{"id":"https://openalex.org/keywords/botany","display_name":"Botany","score":0.09305021166801453}],"concepts":[{"id":"https://openalex.org/C2775895488","wikidata":"https://www.wikidata.org/wiki/Q5251856","display_name":"Degron","level":5,"score":0.9614959955215454},{"id":"https://openalex.org/C33318195","wikidata":"https://www.wikidata.org/wiki/Q417930","display_name":"Phototropin","level":5,"score":0.855231761932373},{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.5576258301734924},{"id":"https://openalex.org/C2779027399","wikidata":"https://www.wikidata.org/wiki/Q204170","display_name":"Darkness","level":2,"score":0.55538010597229},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.547752320766449},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5281503200531006},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.49340692162513733},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4913620054721832},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.4893738627433777},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.48740556836128235},{"id":"https://openalex.org/C16318435","wikidata":"https://www.wikidata.org/wiki/Q149299","display_name":"Mutagenesis","level":4,"score":0.4811728894710541},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.4358152449131012},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.43538594245910645},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.4319971799850464},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.4211300313472748},{"id":"https://openalex.org/C50738837","wikidata":"https://www.wikidata.org/wiki/Q781492","display_name":"Optogenetics","level":2,"score":0.41726404428482056},{"id":"https://openalex.org/C3017965124","wikidata":"https://www.wikidata.org/wiki/Q4929359","display_name":"Blue light","level":2,"score":0.41212600469589233},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.40876853466033936},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.40497180819511414},{"id":"https://openalex.org/C2775988993","wikidata":"https://www.wikidata.org/wiki/Q158695","display_name":"Arabidopsis thaliana","level":4,"score":0.3876602351665497},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3781464397907257},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.2534131407737732},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15908017754554749},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.1234448254108429},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.09305021166801453},{"id":"https://openalex.org/C49040817","wikidata":"https://www.wikidata.org/wiki/Q193091","display_name":"Optoelectronics","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D056949","descriptor_name":"Phototropins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056949","descriptor_name":"Phototropins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056949","descriptor_name":"Phototropins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056949","descriptor_name":"Phototropins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056949","descriptor_name":"Phototropins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056949","descriptor_name":"Phototropins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056949","descriptor_name":"Phototropins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056949","descriptor_name":"Phototropins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056949","descriptor_name":"Phototropins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D062308","descriptor_name":"Optogenetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D062308","descriptor_name":"Optogenetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D062308","descriptor_name":"Optogenetics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/s12918-014-0128-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-014-0128-9","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-014-0128-9","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:25403319","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25403319","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:europepmc.org:3208126","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4236813","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-014-0128-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-014-0128-9","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-014-0128-9","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6414157565","display_name":null,"funder_award_id":"GRK1216","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G7540042340","display_name":null,"funder_award_id":"TA320/3-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320330692","display_name":"Zentrum f\u00fcr Synthetische Mikrobiologie","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2105140815.pdf","grobid_xml":"https://content.openalex.org/works/W2105140815.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W276882634","https://openalex.org/W317852650","https://openalex.org/W1497947649","https://openalex.org/W1965813899","https://openalex.org/W1968177771","https://openalex.org/W1968955608","https://openalex.org/W1970797483","https://openalex.org/W1973385463","https://openalex.org/W1974338734","https://openalex.org/W1980552600","https://openalex.org/W1984175146","https://openalex.org/W1985001103","https://openalex.org/W1985542063","https://openalex.org/W1987423687","https://openalex.org/W1988840491","https://openalex.org/W1991383594","https://openalex.org/W1993724093","https://openalex.org/W1999743462","https://openalex.org/W2001831734","https://openalex.org/W2003001669","https://openalex.org/W2003185017","https://openalex.org/W2003885556","https://openalex.org/W2011721474","https://openalex.org/W2020470870","https://openalex.org/W2022268945","https://openalex.org/W2023100445","https://openalex.org/W2026993081","https://openalex.org/W2027387232","https://openalex.org/W2032470286","https://openalex.org/W2035216850","https://openalex.org/W2040078255","https://openalex.org/W2040444669","https://openalex.org/W2048599311","https://openalex.org/W2050140768","https://openalex.org/W2064199906","https://openalex.org/W2064202875","https://openalex.org/W2064547968","https://openalex.org/W2065350448","https://openalex.org/W2066065623","https://openalex.org/W2071056869","https://openalex.org/W2075240236","https://openalex.org/W2079042867","https://openalex.org/W2082001960","https://openalex.org/W2092533253","https://openalex.org/W2093372995","https://openalex.org/W2096165020","https://openalex.org/W2097382368","https://openalex.org/W2101506009","https://openalex.org/W2109281577","https://openalex.org/W2111648798","https://openalex.org/W2112940322","https://openalex.org/W2118820287","https://openalex.org/W2124990349","https://openalex.org/W2128017468","https://openalex.org/W2139092386","https://openalex.org/W2144193855","https://openalex.org/W2151457629","https://openalex.org/W2166771618","https://openalex.org/W2171342914","https://openalex.org/W2317286799","https://openalex.org/W2323109000","https://openalex.org/W2786774014"],"related_works":["https://openalex.org/W2606555802","https://openalex.org/W2717506135","https://openalex.org/W2023263282","https://openalex.org/W2105140815","https://openalex.org/W1874624348","https://openalex.org/W2969787671","https://openalex.org/W2379356908","https://openalex.org/W2802710766","https://openalex.org/W4256402221","https://openalex.org/W3176524212"],"abstract_inverted_index":{"BACKGROUND:":[0],"Regulated":[1],"proteolysis":[2],"by":[3,101,242,272],"the":[4,9,46,56,81,95,105,111,114,119,193,198,220,245,248,254,285,292,299,302,305],"proteasome":[5],"is":[6,108],"one":[7],"of":[8,39,55,84,90,201,228,247,265,291,301,307],"fundamental":[10],"mechanisms":[11],"used":[12,118],"in":[13,134,165,176,204,219,238,244,258,295,304,310],"eukaryotic":[14],"cells":[15,166,206],"to":[16,22,69,110,124,139,153,168,173,192,284],"control":[17,38],"cellular":[18],"behavior.":[19],"Efficient":[20],"tools":[21,297],"regulate":[23],"protein":[24,40,266],"stability":[25,41,190,267],"offer":[26],"synthetic":[27,311],"influence":[28],"on":[29,32],"molecular":[30],"level":[31],"a":[33,70,269],"selected":[34,202],"biological":[35],"process.":[36],"Optogenetic":[37],"has":[42],"been":[43],"achieved":[44],"with":[45,94,129,213],"photo-sensitive":[47],"degron":[48,83],"(psd)":[49],"module.":[50,196,224],"This":[51],"engineered":[52],"tool":[53],"consists":[54],"photoreceptor":[57,229],"domain":[58,294],"light":[59,103,141,170],"oxygen":[60],"voltage":[61],"2":[62],"(LOV2)":[63],"from":[64,80],"Arabidopsis":[65],"thaliana":[66],"phototropin1":[67],"fused":[68],"sequence":[71],"that":[72,208,233,279],"induces":[73],"direct":[74],"proteasomal":[75],"degradation,":[76],"which":[77,262],"was":[78],"derived":[79],"carboxy-terminal":[82],"murine":[85],"ornithine":[86],"decarboxylase.":[87],"The":[88,147,288],"abundance":[89],"target":[91],"proteins":[92,156],"tagged":[93],"psd":[96,126,195,223,259],"module":[97,127,260],"can":[98],"be":[99],"regulated":[100],"blue":[102,140,169,179,273],"if":[104],"degradation":[106,185],"tag":[107],"exposed":[109,138,167],"cytoplasm":[112],"or":[113,136],"nucleus.":[115],"RESULTS:":[116],"We":[117],"model":[120],"organism":[121],"Saccharomyces":[122],"cerevisiae":[123],"generate":[125],"variants":[128,148,182,188,210,276],"increased":[130,189],"and":[131,144,157,162,171,186,312],"decreased":[132],"stabilities":[133],"darkness":[135],"when":[137],"using":[142],"site-specific":[143],"random":[145],"mutagenesis.":[146],"were":[149,211,240],"characterized":[150],"as":[151,216,218,315],"fusions":[152],"fluorescent":[154],"reporter":[155],"showed":[158,183,207,277],"half-lives":[159],"between":[160],"6":[161],"75":[163],"minutes":[164,175],"14":[172],"187":[174],"darkness.":[177],"In":[178,225,252],"light,":[180],"ten":[181],"accelerated":[184],"four":[187],"compared":[191,283],"original":[194,286],"Measuring":[197],"dark/light":[199],"ratio":[200],"constructs":[203],"yeast":[205],"two":[209],"obtained":[212],"ratios":[214],"twice":[215],"high":[217],"wild":[221],"type":[222],"silico":[226],"modeling":[227],"variant":[230],"characteristics":[231,278],"suggested":[232],"for":[234],"most":[235],"cases":[236],"alterations":[237],"behavior":[239],"induced":[241],"changes":[243],"light-response":[246],"LOV2":[249,293],"domain.":[250],"CONCLUSIONS:":[251],"total,":[253],"mutational":[255],"analysis":[256],"resulted":[257],"variants,":[261],"provide":[263],"tuning":[264],"over":[268],"broad":[270],"range":[271],"light.":[274],"Two":[275],"are":[280],"profoundly":[281],"improved":[282],"construct.":[287],"modular":[289],"usage":[290,300],"optogenetic":[296],"allows":[298],"mutants":[303],"context":[306],"other":[308],"applications":[309],"systems":[313],"biology":[314],"well.":[316]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}
