{"id":"https://openalex.org/W2127141248","doi":"https://doi.org/10.1186/s12918-014-0104-4","title":"Molecular signatures for obesity and associated disorders identified through partial least square regression models","display_name":"Molecular signatures for obesity and associated disorders identified through partial least square regression models","publication_year":2014,"publication_date":"2014-08-29","ids":{"openalex":"https://openalex.org/W2127141248","doi":"https://doi.org/10.1186/s12918-014-0104-4","mag":"2127141248","pmid":"https://pubmed.ncbi.nlm.nih.gov/25231063"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-014-0104-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-014-0104-4","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-014-0104-4","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-014-0104-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036518137","display_name":"Neeraj Sinha","orcid":"https://orcid.org/0000-0002-0173-9849"},"institutions":[{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Neeraj Sinha","raw_affiliation_strings":["Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna, Asaf Ali Marg, New Delhi, 110067, India. neerajsinha01@gmail.com","Immunology Group; International Centre for Genetic Engineering and Biotechnology; New Delhi India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna, Asaf Ali Marg, New Delhi, 110067, India. neerajsinha01@gmail.com","institution_ids":[]},{"raw_affiliation_string":"Immunology Group; International Centre for Genetic Engineering and Biotechnology; New Delhi India","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101460802","display_name":"Sachin Kumar Sharma","orcid":"https://orcid.org/0000-0003-0627-2392"},"institutions":[{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sachin Sharma","raw_affiliation_strings":["Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna, Asaf Ali Marg, New Delhi, 110067, India. sharmas009@gmail.com","Immunology Group; International Centre for Genetic Engineering and Biotechnology; New Delhi India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna, Asaf Ali Marg, New Delhi, 110067, India. sharmas009@gmail.com","institution_ids":[]},{"raw_affiliation_string":"Immunology Group; International Centre for Genetic Engineering and Biotechnology; New Delhi India","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111458553","display_name":"Parul Tripathi","orcid":null},"institutions":[{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Parul Tripathi","raw_affiliation_strings":["Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna, Asaf Ali Marg, New Delhi, 110067, India. parulvashistha@gmail.com","Immunology Group; International Centre for Genetic Engineering and Biotechnology; New Delhi India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna, Asaf Ali Marg, New Delhi, 110067, India. parulvashistha@gmail.com","institution_ids":[]},{"raw_affiliation_string":"Immunology Group; International Centre for Genetic Engineering and Biotechnology; New Delhi India","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083476228","display_name":"Simarjeet Negi","orcid":null},"institutions":[{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simarjeet Kaur Negi","raw_affiliation_strings":["Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna, Asaf Ali Marg, New Delhi, 110067, India. siminegi2008@gmail.com","Immunology Group; International Centre for Genetic Engineering and Biotechnology; New Delhi India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna, Asaf Ali Marg, New Delhi, 110067, India. siminegi2008@gmail.com","institution_ids":[]},{"raw_affiliation_string":"Immunology Group; International Centre for Genetic Engineering and Biotechnology; New Delhi India","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056111670","display_name":"Kamiya Tikoo","orcid":"https://orcid.org/0000-0002-7043-9073"},"institutions":[{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Kamiya Tikoo","raw_affiliation_strings":["Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna, Asaf Ali Marg, New Delhi, 110067, India. kamiyati@gmail.com","Immunology Group; International Centre for Genetic Engineering and Biotechnology; New Delhi India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna, Asaf Ali Marg, New Delhi, 110067, India. kamiyati@gmail.com","institution_ids":[]},{"raw_affiliation_string":"Immunology Group; International Centre for Genetic Engineering and Biotechnology; New Delhi India","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076624139","display_name":"Dhiraj Kumar","orcid":"https://orcid.org/0000-0001-7578-2930"},"institutions":[{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Dhiraj Kumar","raw_affiliation_strings":["Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna, Asaf Ali Marg, New Delhi, 110067, India. dhirajkrverma@gmail.com","Immunology Group; International Centre for Genetic Engineering and Biotechnology; New Delhi India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna, Asaf Ali Marg, New Delhi, 110067, India. dhirajkrverma@gmail.com","institution_ids":[]},{"raw_affiliation_string":"Immunology Group; International Centre for Genetic Engineering and Biotechnology; New Delhi India","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074134327","display_name":"Kanury V. S. Rao","orcid":"https://orcid.org/0009-0008-7654-0093"},"institutions":[{"id":"https://openalex.org/I91080651","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/043bgf219","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I91080651"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Kanury VS Rao","raw_affiliation_strings":["Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna, Asaf Ali Marg, New Delhi, 110067, India. kanury.rao@gmail.com","Immunology Group; International Centre for Genetic Engineering and Biotechnology; New Delhi India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna, Asaf Ali Marg, New Delhi, 110067, India. kanury.rao@gmail.com","institution_ids":[]},{"raw_affiliation_string":"Immunology Group; International Centre for Genetic Engineering and Biotechnology; New Delhi India","institution_ids":["https://openalex.org/I91080651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082491317","display_name":"Samrat Chatterjee","orcid":"https://orcid.org/0000-0002-5010-2799"},"institutions":[{"id":"https://openalex.org/I2801880299","display_name":"Translational Health Science and Technology Institute","ror":"https://ror.org/01qjqvr92","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I2801880299","https://openalex.org/I4210134808"]},{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Samrat Chatterjee","raw_affiliation_strings":["Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna, Asaf Ali Marg, New Delhi, 110067, India. samrat.ct@gmail.com","Present address: Drug Discovery Research Centre, Translational Health Science & Technology Institute, Gurgaon, 122016, India. samrat.ct@gmail.com","Present address: Drug Discovery Research Centre, Translational Health Science & Technology Institute, Gurgaon, India","Immunology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna, Asaf Ali Marg, New Delhi, 110067, India. samrat.ct@gmail.com","institution_ids":[]},{"raw_affiliation_string":"Present address: Drug Discovery Research Centre, Translational Health Science & Technology Institute, Gurgaon, 122016, India. samrat.ct@gmail.com","institution_ids":[]},{"raw_affiliation_string":"Present address: Drug Discovery Research Centre, Translational Health Science & Technology Institute, Gurgaon, India","institution_ids":["https://openalex.org/I2801880299"]},{"raw_affiliation_string":"Immunology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India","institution_ids":["https://openalex.org/I4210142124"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5036518137"],"corresponding_institution_ids":["https://openalex.org/I91080651"],"apc_list":null,"apc_paid":null,"fwci":0.4313,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.6783925,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8","issue":"1","first_page":"104","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.536300003528595,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.536300003528595,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.04100000113248825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.029500000178813934,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"Obesity","score":0.6938486695289612},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"Diabetes mellitus","score":0.6891540288925171},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"Type 2 diabetes","score":0.5446842908859253},{"id":"https://openalex.org/keywords/microarray","display_name":"Microarray","score":0.5436164736747742},{"id":"https://openalex.org/keywords/microarray-analysis-techniques","display_name":"Microarray analysis techniques","score":0.5012788772583008},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.47964340448379517},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4759804308414459},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4723176658153534},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.45332661271095276},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4268397092819214},{"id":"https://openalex.org/keywords/physiology","display_name":"Physiology","score":0.39962607622146606},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3862985074520111},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.33356809616088867},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.33189114928245544},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.14223551750183105}],"concepts":[{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.6938486695289612},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6891540288925171},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5446842908859253},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.5436164736747742},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5012788772583008},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47964340448379517},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4759804308414459},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4723176658153534},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.45332661271095276},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4268397092819214},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.39962607622146606},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3862985074520111},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.33356809616088867},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33189114928245544},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14223551750183105}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003924","descriptor_name":"Diabetes Mellitus, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008515","descriptor_name":"Medicine, Ayurvedic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008515","descriptor_name":"Medicine, Ayurvedic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008515","descriptor_name":"Medicine, Ayurvedic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013395","descriptor_name":"Sucrose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013395","descriptor_name":"Sucrose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013395","descriptor_name":"Sucrose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016018","descriptor_name":"Least-Squares Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D046228","descriptor_name":"Microarray Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059305","descriptor_name":"Diet, High-Fat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/s12918-014-0104-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-014-0104-4","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-014-0104-4","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"pmid:25231063","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25231063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC systems biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:4363939","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4363939","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Syst Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12918-014-0104-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-014-0104-4","pdf_url":"https://bmcsystbiol.biomedcentral.com/counter/pdf/10.1186/s12918-014-0104-4","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.5799999833106995}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307834","display_name":"PepsiCo","ror":"https://ror.org/00qvqt255"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2127141248.pdf","grobid_xml":"https://content.openalex.org/works/W2127141248.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W74841586","https://openalex.org/W1569114583","https://openalex.org/W1927710737","https://openalex.org/W1964068069","https://openalex.org/W1980217274","https://openalex.org/W1987557377","https://openalex.org/W1995691635","https://openalex.org/W1998628654","https://openalex.org/W2000054651","https://openalex.org/W2007565970","https://openalex.org/W2008620264","https://openalex.org/W2012248291","https://openalex.org/W2018757636","https://openalex.org/W2023833090","https://openalex.org/W2025356299","https://openalex.org/W2037446998","https://openalex.org/W2047691125","https://openalex.org/W2047693963","https://openalex.org/W2057498577","https://openalex.org/W2063407911","https://openalex.org/W2087771881","https://openalex.org/W2112609377","https://openalex.org/W2135326009","https://openalex.org/W2148762636","https://openalex.org/W2151566924","https://openalex.org/W2153321120","https://openalex.org/W2163480486","https://openalex.org/W4211007940"],"related_works":["https://openalex.org/W2796636403","https://openalex.org/W2015700328","https://openalex.org/W2364565895","https://openalex.org/W2767847608","https://openalex.org/W2911678823","https://openalex.org/W2152648570","https://openalex.org/W2037892364","https://openalex.org/W2319154570","https://openalex.org/W3152114242","https://openalex.org/W3028764459"],"abstract_inverted_index":{"BACKGROUND:":[0],"Obesity":[1],"is":[2,66],"now":[3],"a":[4,10,69],"worldwide":[5],"epidemic":[6],"disease":[7],"and":[8,24,54,75,91,96,133,172,208,226,265,293],"poses":[9],"major":[11],"risk":[12],"for":[13,71,182,234,288,314],"diet":[14,89,146],"related":[15],"diseases":[16],"like":[17,166,202],"type":[18,55,294],"2":[19,56,295],"diabetes,":[20],"cardiovascular":[21],"disease,":[22],"stroke":[23],"fatty":[25],"liver":[26],"among":[27],"others.":[28],"In":[29,240],"the":[30,35,43,61,92,120,184,209,231,241,249,254,261,273,284,289],"present":[31],"study":[32],"we":[33,160,194,246],"employed":[34],"murine":[36],"model":[37],"of":[38,84,119,211,263,272,279,291,299,305],"diet-induced":[39,72,221],"obesity":[40,53,76,292],"to":[41,52,152,251],"determine":[42],"early,":[44],"tissue-specific,":[45],"gene":[46],"expression":[47],"signatures":[48,197,257],"that":[49,107,198,258,303],"characterized":[50],"progression":[51,278],"diabetes.":[57,296],"RESULTS:":[58],"We":[59,282],"used":[60,151,310],"C57BL/6":[62],"J":[63],"mouse":[64],"which":[65],"known":[67],"as":[68,311],"counterpart":[70],"human":[73],"diabetes":[74,264],"model.":[77],"Our":[78],"initial":[79],"experiments":[80],"involved":[81,276],"two":[82,243,316],"groups":[83],"mice,":[85],"one":[86],"on":[87,94,144],"normal":[88],"(ND)":[90],"other":[93],"high-fat":[95],"high-sucrose":[97],"(HFHSD).":[98],"The":[99,216],"later":[100],"were":[101,114,138,150],"then":[102],"further":[103,252],"separated":[104],"into":[105],"subgroups":[106],"either":[108],"received":[109],"no":[110],"additional":[111],"treatment,":[112],"or":[113],"treated":[115],"with":[116],"different":[117,125,136,145,163],"doses":[118],"Ayurvedic":[121],"formulation":[122],"KAL-1.":[123],"At":[124],"time":[126,180],"points":[127],"(week3,":[128],"week6,":[129],"week9,":[130],"week12,":[131],"week15":[132],"week18)":[134],"eight":[135],"tissues":[137,149],"isolated":[139],"from":[140],"mice":[141],"being":[142],"fed":[143],"compositions.":[147],"These":[148,267],"extract":[153,253],"gene-expression":[154,196,256,286],"data":[155,301],"through":[156],"microarray":[157],"experiment.":[158],"Simultaneously,":[159],"also":[161],"measured":[162],"body":[164,167,206,224],"parameters":[165,201],"weight,":[168],"blood":[169,203,227],"Glucose":[170],"level":[171],"cytokines":[173,235],"profile":[174],"(anti-inflammatory":[175],"&":[176],"pro-inflammatory)":[177],"at":[178],"each":[179],"point":[181],"all":[183],"groups.":[185],"Using":[186],"partial":[187],"least":[188],"square":[189],"discriminant":[190],"analysis":[191,298],"(PLS-DA)":[192],"method":[193],"identified":[195,283],"predict":[199,260],"physiological":[200],"glucose":[204,228],"levels,":[205,229],"weight":[207,225],"balance":[210],"pro-":[212],"versus":[213],"anti-inflammatory":[214],"cytokines.":[215],"resulting":[217],"models":[218,250],"successfully":[219],"predicted":[220],"changes":[222],"in":[223,277],"although":[230],"predictive":[232],"power":[233],"profiles":[236],"was":[237],"relatively":[238],"poor.":[239],"former":[242],"instances,":[244],"however,":[245],"could":[247,308],"exploit":[248],"early":[255,285],"accurately":[259],"onset":[262,290],"obesity.":[266],"extracted":[268],"genes":[269,307],"allowed":[270],"definition":[271],"regulatory":[274],"network":[275],"disease.":[280],"CONCLUSION:":[281],"signature":[287],"Further":[297],"this":[300],"suggests":[302],"some":[304],"these":[306,315],"be":[309],"potential":[312],"biomarkers":[313],"disease-states.":[317]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-04-29T09:16:38.111599","created_date":"2025-10-10T00:00:00"}