{"id":"https://openalex.org/W2144670484","doi":"https://doi.org/10.1186/s12918-014-0086-2","title":"Proteomics-based metabolic modeling and characterization of the cellulolytic bacterium Thermobifida fusca","display_name":"Proteomics-based metabolic modeling and characterization of the cellulolytic bacterium Thermobifida fusca","publication_year":2014,"publication_date":"2014-08-12","ids":{"openalex":"https://openalex.org/W2144670484","doi":"https://doi.org/10.1186/s12918-014-0086-2","mag":"2144670484"},"language":"en","primary_location":{"id":"doi:10.1186/s12918-014-0086-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-014-0086-2","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-014-0086-2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-014-0086-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069498793","display_name":"Niti Vanee","orcid":null},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Niti Vanee","raw_affiliation_strings":["Virginia Commonwealth University, Richmond, USA","Virginia Commonwealth University, Richmond, USA,"],"affiliations":[{"raw_affiliation_string":"Virginia Commonwealth University, Richmond, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Virginia Commonwealth University, Richmond, USA,","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020628068","display_name":"J. Paul Brooks","orcid":"https://orcid.org/0000-0003-0423-8422"},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Paul Brooks","raw_affiliation_strings":["Virginia Commonwealth University, Richmond, USA","Virginia Commonwealth University, Richmond, USA,"],"affiliations":[{"raw_affiliation_string":"Virginia Commonwealth University, Richmond, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Virginia Commonwealth University, Richmond, USA,","institution_ids":["https://openalex.org/I184840846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047961314","display_name":"Victor Spicer","orcid":"https://orcid.org/0000-0002-9097-1913"},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Victor Spicer","raw_affiliation_strings":["University of Manitoba, Winnipeg, Canada","University of Manitoba Winnipeg  Canada"],"affiliations":[{"raw_affiliation_string":"University of Manitoba, Winnipeg, Canada","institution_ids":["https://openalex.org/I46247651"]},{"raw_affiliation_string":"University of Manitoba Winnipeg  Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066590867","display_name":"Dmitriy Shamshurin","orcid":null},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Dmitriy Shamshurin","raw_affiliation_strings":["University of Manitoba, Winnipeg, Canada","University of Manitoba Winnipeg  Canada"],"affiliations":[{"raw_affiliation_string":"University of Manitoba, Winnipeg, Canada","institution_ids":["https://openalex.org/I46247651"]},{"raw_affiliation_string":"University of Manitoba Winnipeg  Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002861890","display_name":"Oleg V. Krokhin","orcid":"https://orcid.org/0000-0002-9989-6593"},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Oleg Krokhin","raw_affiliation_strings":["University of Manitoba, Winnipeg, Canada","University of Manitoba Winnipeg  Canada"],"affiliations":[{"raw_affiliation_string":"University of Manitoba, Winnipeg, Canada","institution_ids":["https://openalex.org/I46247651"]},{"raw_affiliation_string":"University of Manitoba Winnipeg  Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090942754","display_name":"John A. Wilkins","orcid":"https://orcid.org/0000-0002-5465-446X"},"institutions":[{"id":"https://openalex.org/I46247651","display_name":"University of Manitoba","ror":"https://ror.org/02gfys938","country_code":"CA","type":"education","lineage":["https://openalex.org/I46247651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John A Wilkins","raw_affiliation_strings":["University of Manitoba, Winnipeg, Canada","University of Manitoba Winnipeg  Canada"],"affiliations":[{"raw_affiliation_string":"University of Manitoba, Winnipeg, Canada","institution_ids":["https://openalex.org/I46247651"]},{"raw_affiliation_string":"University of Manitoba Winnipeg  Canada","institution_ids":["https://openalex.org/I46247651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049361267","display_name":"Yu Deng","orcid":"https://orcid.org/0000-0002-1909-7223"},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Deng","raw_affiliation_strings":["Kansas State University, Olathe, USA"],"affiliations":[{"raw_affiliation_string":"Kansas State University, Olathe, USA","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047715802","display_name":"Stephen S. Fong","orcid":"https://orcid.org/0000-0003-2171-7783"},"institutions":[{"id":"https://openalex.org/I184840846","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79","country_code":"US","type":"education","lineage":["https://openalex.org/I184840846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen S Fong","raw_affiliation_strings":["Virginia Commonwealth University, Richmond, USA","Virginia Commonwealth University, Richmond, USA,"],"affiliations":[{"raw_affiliation_string":"Virginia Commonwealth University, Richmond, USA","institution_ids":["https://openalex.org/I184840846"]},{"raw_affiliation_string":"Virginia Commonwealth University, Richmond, USA,","institution_ids":["https://openalex.org/I184840846"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5069498793"],"corresponding_institution_ids":["https://openalex.org/I184840846"],"apc_list":null,"apc_paid":null,"fwci":1.4233,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.81505485,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"8","issue":"1","first_page":"7","last_page":"86"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9886000156402588,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bioprocess","display_name":"Bioprocess","score":0.8549362421035767},{"id":"https://openalex.org/keywords/cellobiose","display_name":"Cellobiose","score":0.7522897720336914},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.7008172273635864},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.6654538512229919},{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"Metabolic engineering","score":0.6477529406547546},{"id":"https://openalex.org/keywords/metabolic-flux-analysis","display_name":"Metabolic flux analysis","score":0.6283524036407471},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6164103150367737},{"id":"https://openalex.org/keywords/organism","display_name":"Organism","score":0.582834005355835},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.5565913915634155},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5211682319641113},{"id":"https://openalex.org/keywords/bioconversion","display_name":"Bioconversion","score":0.5145530104637146},{"id":"https://openalex.org/keywords/metabolomics","display_name":"Metabolomics","score":0.511823832988739},{"id":"https://openalex.org/keywords/biomass","display_name":"Biomass (ecology)","score":0.4441757798194885},{"id":"https://openalex.org/keywords/biofuel","display_name":"Biofuel","score":0.44326597452163696},{"id":"https://openalex.org/keywords/biotechnology","display_name":"Biotechnology","score":0.44106775522232056},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4185864329338074},{"id":"https://openalex.org/keywords/model-organism","display_name":"Model organism","score":0.41253432631492615},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.408537358045578},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3275992274284363},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.17280852794647217},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.1724453866481781},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.14830142259597778},{"id":"https://openalex.org/keywords/fermentation","display_name":"Fermentation","score":0.14365246891975403},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.14298537373542786},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10726600885391235},{"id":"https://openalex.org/keywords/ecology","display_name":"Ecology","score":0.08528760075569153},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.0716683566570282}],"concepts":[{"id":"https://openalex.org/C4916135","wikidata":"https://www.wikidata.org/wiki/Q4119055","display_name":"Bioprocess","level":2,"score":0.8549362421035767},{"id":"https://openalex.org/C2780412358","wikidata":"https://www.wikidata.org/wiki/Q409017","display_name":"Cellobiose","level":4,"score":0.7522897720336914},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.7008172273635864},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.6654538512229919},{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.6477529406547546},{"id":"https://openalex.org/C160941953","wikidata":"https://www.wikidata.org/wiki/Q6822342","display_name":"Metabolic flux analysis","level":3,"score":0.6283524036407471},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6164103150367737},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.582834005355835},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.5565913915634155},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5211682319641113},{"id":"https://openalex.org/C2780074830","wikidata":"https://www.wikidata.org/wiki/Q864423","display_name":"Bioconversion","level":3,"score":0.5145530104637146},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.511823832988739},{"id":"https://openalex.org/C115540264","wikidata":"https://www.wikidata.org/wiki/Q2945560","display_name":"Biomass (ecology)","level":2,"score":0.4441757798194885},{"id":"https://openalex.org/C53991642","wikidata":"https://www.wikidata.org/wiki/Q128991","display_name":"Biofuel","level":2,"score":0.44326597452163696},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.44106775522232056},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4185864329338074},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.41253432631492615},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.408537358045578},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3275992274284363},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.17280852794647217},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.1724453866481781},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14830142259597778},{"id":"https://openalex.org/C100544194","wikidata":"https://www.wikidata.org/wiki/Q41760","display_name":"Fermentation","level":2,"score":0.14365246891975403},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.14298537373542786},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10726600885391235},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.08528760075569153},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0716683566570282},{"id":"https://openalex.org/C141603559","wikidata":"https://www.wikidata.org/wiki/Q410324","display_name":"Cellulase","level":3,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s12918-014-0086-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-014-0086-2","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-014-0086-2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},{"id":"mag:25115351","is_oa":false,"landing_page_url":"https://dialnet.unirioja.es/servlet/articulo?codigo=435344","pdf_url":null,"source":{"id":"https://openalex.org/S165893625","display_name":"\u0098The \u009cNew York times book review","issn_l":"0028-7806","issn":["0028-7806"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/P4310311721","host_organization_name":"Cambridge University Press","host_organization_lineage":["https://openalex.org/P4310311721","https://openalex.org/P4310311702"],"host_organization_lineage_names":["Cambridge University Press","University of Cambridge"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"\u0098The \u009cNew York times book review","raw_type":null},{"id":"pmh:oai:europepmc.org:3208116","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4236713","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:mspace.lib.umanitoba.ca:1993/23881","is_oa":false,"landing_page_url":"http://hdl.handle.net/1993/23881","pdf_url":null,"source":{"id":"https://openalex.org/S4306400554","display_name":"Mspace (University of Manitoba)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I46247651","host_organization_name":"University of Manitoba","host_organization_lineage":["https://openalex.org/I46247651"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/s12918-014-0086-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12918-014-0086-2","pdf_url":"https://bmcsystbiol.biomedcentral.com/track/pdf/10.1186/s12918-014-0086-2","source":{"id":"https://openalex.org/S92363890","display_name":"BMC Systems Biology","issn_l":"1752-0509","issn":["1752-0509"],"is_oa":true,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Systems Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Industry, innovation and infrastructure","score":0.6000000238418579,"id":"https://metadata.un.org/sdg/9"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320310787","display_name":"Genome Canada","ror":"https://ror.org/029s29983"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2144670484.pdf","grobid_xml":"https://content.openalex.org/works/W2144670484.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W56055795","https://openalex.org/W1529898704","https://openalex.org/W1564500812","https://openalex.org/W1568630772","https://openalex.org/W1588999135","https://openalex.org/W1971165155","https://openalex.org/W1979898078","https://openalex.org/W1987607959","https://openalex.org/W1992306474","https://openalex.org/W1996988499","https://openalex.org/W1997417034","https://openalex.org/W1998633945","https://openalex.org/W2006672203","https://openalex.org/W2010738300","https://openalex.org/W2037443039","https://openalex.org/W2041354102","https://openalex.org/W2054014756","https://openalex.org/W2054016284","https://openalex.org/W2062245653","https://openalex.org/W2062382569","https://openalex.org/W2075283200","https://openalex.org/W2078355959","https://openalex.org/W2079733254","https://openalex.org/W2091564145","https://openalex.org/W2097107919","https://openalex.org/W2100084634","https://openalex.org/W2102164505","https://openalex.org/W2113365252","https://openalex.org/W2114034054","https://openalex.org/W2115326165","https://openalex.org/W2117931838","https://openalex.org/W2124737787","https://openalex.org/W2126175129","https://openalex.org/W2130364940","https://openalex.org/W2130706354","https://openalex.org/W2132485204","https://openalex.org/W2138767597","https://openalex.org/W2141360045","https://openalex.org/W2147598079","https://openalex.org/W2151023149","https://openalex.org/W2152549251","https://openalex.org/W2154061034","https://openalex.org/W2158423480","https://openalex.org/W2159482845","https://openalex.org/W2165674132","https://openalex.org/W2170298003","https://openalex.org/W2171769617","https://openalex.org/W2605068739","https://openalex.org/W2766937192","https://openalex.org/W4212920271","https://openalex.org/W4231558555","https://openalex.org/W4240016871","https://openalex.org/W4294216483"],"related_works":["https://openalex.org/W4200255649","https://openalex.org/W2334199047","https://openalex.org/W2008812255","https://openalex.org/W1579192815","https://openalex.org/W3195294259","https://openalex.org/W205850151","https://openalex.org/W2353873485","https://openalex.org/W1990712597","https://openalex.org/W1995173266","https://openalex.org/W2350881169"],"abstract_inverted_index":{"Thermobifida":[0,123],"fusca":[1,43,68,108,124,223],"is":[2,49],"a":[3,12,45,72,102,119,184,210,252],"cellulolytic":[4],"bacterium":[5],"with":[6,170,183],"potential":[7,31,226],"to":[8,27,32,36,51,86,97,100,139,212,256,261],"be":[9,257],"used":[10],"as":[11,44,251],"platform":[13,211],"organism":[14],"for":[15,157,167,198,224,231],"sustainable":[16],"industrial":[17],"production":[18,169,233],"of":[19,30,66,71,82,105,115,118,122,149,174,188,194,219,234,247],"biofuels,":[20],"pharmaceutical":[21,237],"ingredients":[22],"and":[23,76,95,134,155,214,236],"other":[24],"bioprocesses":[25],"due":[26],"its":[28,53],"capability":[29],"convert":[33],"plant":[34],"biomass":[35,168],"value-added":[37],"chemicals.":[38],"To":[39],"best":[40],"develop":[41],"T.":[42,67,107,222],"bioprocess":[46,229],"organism,":[47],"it":[48],"important":[50],"understand":[52,213],"native":[54],"cellular":[55],"processes.":[56],"In":[57,191],"the":[58,63,106,113,144,171,195,216,220,225,232,245,258],"current":[59],"study,":[60],"we":[61],"characterize":[62],"metabolic":[64,74,89,109,120,217],"network":[65],"through":[69],"reconstruction":[70,243],"genome-scale":[73],"model":[75,121,137,146,164,242],"proteomics":[77,249],"data.":[78],"The":[79,136,163],"overall":[80],"goal":[81],"this":[83],"study":[84],"was":[85,143,165,201],"use":[87,227,246],"multiple":[88],"models":[90],"generated":[91],"by":[92],"different":[93,130,241],"methods":[94],"comparison":[96],"experimental":[98],"data":[99,250],"gain":[101],"high-confidence":[103],"understanding":[104],"network.":[110],"We":[111],"report":[112],"generation":[114],"three":[116,129],"versions":[117],"sp.":[125],"XY":[126],"developed":[127],"using":[128,204],"approaches":[131],"(automated,":[132],"semi-automated,":[133],"proteomics-derived).":[135],"closest":[138],"in":[140,228,262],"vivo":[141,192,263],"growth":[142],"proteomics-derived":[145],"that":[147],"consists":[148],"975":[150],"reactions":[151],"involving":[152],"1382":[153],"metabolites":[154],"account":[156],"316":[158],"EC":[159],"numbers":[160],"(296":[161],"genes).":[162],"optimized":[166],"optimal":[172],"flux":[173],"0.48":[175],"doublings":[176],"per":[177],"hour":[178],"when":[179],"grown":[180],"on":[181],"cellobiose":[182],"substrate":[185],"uptake":[186],"rate":[187],"0.25":[189],"mmole/h.":[190],"activity":[193],"DXP":[196],"pathway":[197],"terpenoid":[199],"biosynthesis":[200],"also":[202],"confirmed":[203],"real-time":[205],"PCR.":[206],"i":[207],"Tfu296":[208],"provides":[209],"explore":[215],"capabilities":[218],"actinomycete":[221],"industries":[230],"biofuel":[235],"ingredients.":[238],"By":[239],"comparing":[240],"methods,":[244],"high-throughput":[248],"starting":[253],"point":[254],"proved":[255],"most":[259],"accurate":[260],"growth.":[264]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2016-06-24T00:00:00"}