{"id":"https://openalex.org/W7116774667","doi":"https://doi.org/10.1186/s12911-025-03312-0","title":"Enhancing TSH-based congenital hypothyroidism screening using machine learning and resampling algorithms","display_name":"Enhancing TSH-based congenital hypothyroidism screening using machine learning and resampling algorithms","publication_year":2025,"publication_date":"2025-12-22","ids":{"openalex":"https://openalex.org/W7116774667","doi":"https://doi.org/10.1186/s12911-025-03312-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/41430694"},"language":"en","primary_location":{"id":"doi:10.1186/s12911-025-03312-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-025-03312-0","pdf_url":null,"source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12911-025-03312-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5118713155","display_name":"Alexander De Furia","orcid":null},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I2799330578","display_name":"Children's Hospital of Eastern Ontario","ror":"https://ror.org/05nsbhw27","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2799330578"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Alexander De Furia","raw_affiliation_strings":["Newborn Screening Ontario, Children's Hospital of Eastern Ontario, 415 Smyth Road, Ottawa, Ontario, K1H 8M8, Canada. adefu020@uottawa.ca","School of Electrical Engineering and Computer Science, University of Ottawa, 800 King Edward Ave., Ottawa, Ontario, K1N 5N6, Canada. adefu020@uottawa.ca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Newborn Screening Ontario, Children's Hospital of Eastern Ontario, 415 Smyth Road, Ottawa, Ontario, K1H 8M8, Canada. adefu020@uottawa.ca","institution_ids":["https://openalex.org/I2799330578"]},{"raw_affiliation_string":"School of Electrical Engineering and Computer Science, University of Ottawa, 800 King Edward Ave., Ottawa, Ontario, K1N 5N6, Canada. adefu020@uottawa.ca","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043554078","display_name":"Paula Branco","orcid":"https://orcid.org/0000-0002-9917-3694"},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Paula Branco","raw_affiliation_strings":["School of Electrical Engineering and Computer Science, University of Ottawa, 800 King Edward Ave., Ottawa, Ontario, K1N 5N6, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electrical Engineering and Computer Science, University of Ottawa, 800 King Edward Ave., Ottawa, Ontario, K1N 5N6, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089748758","display_name":"Matthew Henderson","orcid":"https://orcid.org/0000-0001-5605-1913"},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I2799330578","display_name":"Children's Hospital of Eastern Ontario","ror":"https://ror.org/05nsbhw27","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2799330578"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Matthew Henderson","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada","Newborn Screening Ontario, Children's Hospital of Eastern Ontario, 415 Smyth Road, Ottawa, Ontario, K1H 8M8, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Newborn Screening Ontario, Children's Hospital of Eastern Ontario, 415 Smyth Road, Ottawa, Ontario, K1H 8M8, Canada","institution_ids":["https://openalex.org/I2799330578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5118713155"],"corresponding_institution_ids":["https://openalex.org/I153718931","https://openalex.org/I2799330578"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.58087216,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"1","first_page":"449","last_page":"449"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.4388999938964844,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.4388999938964844,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.12399999797344208,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.0414000004529953,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/health-informatics","display_name":"Health informatics","score":0.5313000082969666},{"id":"https://openalex.org/keywords/resampling","display_name":"Resampling","score":0.5188999772071838},{"id":"https://openalex.org/keywords/congenital-hypothyroidism","display_name":"Congenital hypothyroidism","score":0.38749998807907104},{"id":"https://openalex.org/keywords/statistical-classification","display_name":"Statistical classification","score":0.33489999175071716}],"concepts":[{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.8170999884605408},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6941999793052673},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5669000148773193},{"id":"https://openalex.org/C145642194","wikidata":"https://www.wikidata.org/wiki/Q870895","display_name":"Health informatics","level":3,"score":0.5313000082969666},{"id":"https://openalex.org/C150921843","wikidata":"https://www.wikidata.org/wiki/Q1170431","display_name":"Resampling","level":2,"score":0.5188999772071838},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4943999946117401},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39959999918937683},{"id":"https://openalex.org/C2779258352","wikidata":"https://www.wikidata.org/wiki/Q531012","display_name":"Congenital hypothyroidism","level":3,"score":0.38749998807907104},{"id":"https://openalex.org/C110083411","wikidata":"https://www.wikidata.org/wiki/Q1744628","display_name":"Statistical classification","level":2,"score":0.33489999175071716},{"id":"https://openalex.org/C191630685","wikidata":"https://www.wikidata.org/wiki/Q4027615","display_name":"Informatics","level":2,"score":0.26080000400543213}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003409","descriptor_name":"Congenital Hypothyroidism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003409","descriptor_name":"Congenital Hypothyroidism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003409","descriptor_name":"Congenital Hypothyroidism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003409","descriptor_name":"Congenital Hypothyroidism","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D003409","descriptor_name":"Congenital Hypothyroidism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003409","descriptor_name":"Congenital Hypothyroidism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003409","descriptor_name":"Congenital Hypothyroidism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003409","descriptor_name":"Congenital Hypothyroidism","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015997","descriptor_name":"Neonatal Screening","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015997","descriptor_name":"Neonatal Screening","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015997","descriptor_name":"Neonatal Screening","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015997","descriptor_name":"Neonatal Screening","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D015997","descriptor_name":"Neonatal Screening","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D015997","descriptor_name":"Neonatal Screening","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D015997","descriptor_name":"Neonatal Screening","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D015997","descriptor_name":"Neonatal Screening","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12911-025-03312-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-025-03312-0","pdf_url":null,"source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},{"id":"pmid:41430694","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41430694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical informatics and decision making","raw_type":null},{"id":"pmh:oai:doaj.org/article:23b80951df09498f9b8feb57c43a2d41","is_oa":true,"landing_page_url":"https://doaj.org/article/23b80951df09498f9b8feb57c43a2d41","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Informatics and Decision Making, Vol 25, Iss 1, Pp 1-17 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12751215","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12751215/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Med Inform Decis Mak","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12911-025-03312-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-025-03312-0","pdf_url":null,"source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/4","score":0.7468858361244202,"display_name":"Quality Education"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W478671","https://openalex.org/W571200655","https://openalex.org/W1977060944","https://openalex.org/W2047227162","https://openalex.org/W2086610967","https://openalex.org/W2175937775","https://openalex.org/W2265317218","https://openalex.org/W2674154446","https://openalex.org/W2761578961","https://openalex.org/W2887516490","https://openalex.org/W2911964244","https://openalex.org/W2995098893","https://openalex.org/W2996025931","https://openalex.org/W3037352346","https://openalex.org/W3042129837","https://openalex.org/W3109650690","https://openalex.org/W4221003946","https://openalex.org/W4323075498","https://openalex.org/W4378417908","https://openalex.org/W4380872583","https://openalex.org/W4385732922","https://openalex.org/W4387524805"],"related_works":[],"abstract_inverted_index":{"PURPOSE:":[0],"Congenital":[1,52],"hypothyroidism":[2,24,53,90],"(CH)":[3],"is":[4],"a":[5,28,69,123,166,176,185,251],"common":[6],"cause":[7],"of":[8,30,85,125,214,232,277],"severe":[9],"intellectual":[10],"disability,":[11],"affecting":[12],"approximately":[13],"1":[14],"in":[15,48,188,202],"2,000":[16],"newborns":[17],"globally.":[18,281],"Treatable":[19],"with":[20,270],"early":[21],"intervention,":[22],"congenital":[23,89],"has":[25,55],"long":[26],"been":[27],"target":[29],"newborn":[31,278],"screening":[32,54,76,91,258,279],"programs.":[33],"Current":[34],"thyroid":[35],"stimulating":[36],"hormone":[37],"(TSH)":[38],"based":[39],"programs":[40,280],"suffer":[41],"from":[42,97,217],"low":[43],"positive":[44,144,189],"predictive":[45,145,190],"value,":[46],"resulting":[47],"unnecessary":[49,265],"diagnostic":[50],"investigations.":[51],"proven":[56],"challenging":[57],"for":[58,88,122,140,254],"machine":[59,86,225,248],"learning":[60,87,226,249],"previously":[61],"due":[62],"to":[63,92,134,164,210,220,237],"massive":[64],"class":[65],"imbalance":[66],"and":[67,107,111,142,157,179,234,263,267],"having":[68],"single":[70],"well":[71],"known":[72],"predictor,":[73],"preventing":[74],"acceptable":[75],"sensitivity.":[77],"This":[78,183],"study":[79],"represents":[80,184],"the":[81,193,198,275],"most":[82],"comprehensive":[83],"evaluation":[84],"date.":[93],"METHODS:":[94],"Analyzing":[95],"data":[96],"616,910":[98],"infants":[99],"screened":[100],"by":[101,274],"Newborn":[102],"Screening":[103],"Ontario":[104],"between":[105],"2019":[106],"2024.":[108],"12":[109,112],"classification":[110],"resampling":[113],"algorithms":[114,227],"were":[115,138,162],"trained":[116],"using":[117,130,147,154,175],"4":[118],"different":[119],"optimization":[120],"metrics,":[121],"total":[124],"576":[126],"distinct":[127],"models":[128],"evaluated":[129],"stratified":[131],"5-fold":[132],"cross-validation":[133],"ensure":[135],"robustness.":[136],"Models":[137],"optimized":[139],"sensitivity":[141,174],"then":[143],"value":[146,191],"various":[148],"metrics.":[149],"Model":[150],"explainability":[151],"was":[152,208],"assessed":[153],"SHAP":[155],"values":[156],"feature":[158],"importances.":[159],"RESULTS:":[160],"We":[161],"able":[163,209,236],"create":[165],"model":[167,207],"achieving":[168],"16.8%":[169],"PPV":[170],"while":[171],"maintaining":[172],"100%":[173],"RUSBoost":[177],"classifier":[178],"Gaussian":[180],"Noise":[181],"resampling.":[182],"60%":[186],"improvement":[187],"over":[192],"current":[194,203,271],"approach.":[195],"TSH":[196],"remained":[197],"dominant":[199],"predictor":[200],"as":[201],"screening,":[204],"but":[205],"our":[206],"include":[211],"minor":[212],"amounts":[213],"additional":[215],"information":[216],"other":[218],"features":[219],"improve":[221,239],"performance.":[222],"CONCLUSION:":[223],"These":[224],"show":[228],"no":[229],"missed":[230],"cases":[231],"CH":[233,257],"are":[235],"significantly":[238],"performance":[240],"across":[241],"robust":[242],"testing.":[243],"The":[244],"findings":[245],"suggest":[246],"that":[247],"offers":[250],"promising":[252],"avenue":[253],"refining":[255],"TSH-based":[256],"processes,":[259],"reducing":[260],"false":[261],"positives,":[262],"alleviating":[264],"stress":[266],"costs":[268],"associated":[269],"methods":[272],"used":[273],"majority":[276]},"counts_by_year":[],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-12-22T00:00:00"}