{"id":"https://openalex.org/W4414985422","doi":"https://doi.org/10.1186/s12911-025-03207-0","title":"Beyond NT-proBNP and troponin: How machine learning redefines light-chain cardiac amyloidosis risk assessment","display_name":"Beyond NT-proBNP and troponin: How machine learning redefines light-chain cardiac amyloidosis risk assessment","publication_year":2025,"publication_date":"2025-10-09","ids":{"openalex":"https://openalex.org/W4414985422","doi":"https://doi.org/10.1186/s12911-025-03207-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/41068914"},"language":"en","primary_location":{"id":"doi:10.1186/s12911-025-03207-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-025-03207-0","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/counter/pdf/10.1186/s12911-025-03207-0","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedinformdecismak.biomedcentral.com/counter/pdf/10.1186/s12911-025-03207-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101057595","display_name":"Danni Wu","orcid":"https://orcid.org/0000-0002-6989-735X"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801051648","display_name":"China-Japan Friendship Hospital","ror":"https://ror.org/037cjxp13","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801051648"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Danni Wu","raw_affiliation_strings":["Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China","Department of Integrative Medicine Cardiology, China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]},{"raw_affiliation_string":"Department of Integrative Medicine Cardiology, China-Japan Friendship Hospital (Institute of Clinical Medical Sciences), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801051648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101463225","display_name":"Xiaohang Liu","orcid":"https://orcid.org/0000-0002-7661-2949"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohang Liu","raw_affiliation_strings":["Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100611712","display_name":"Xinhao Li","orcid":null},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinhao Li","raw_affiliation_strings":["Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037264322","display_name":"Jia Chen","orcid":"https://orcid.org/0000-0003-3486-7705"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210147887","display_name":"Institute of Hematology & Blood Diseases Hospital","ror":"https://ror.org/04n16t016","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147887"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Chen","raw_affiliation_strings":["Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Hematology & Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210147887"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037864632","display_name":"Xue Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue Lin","raw_affiliation_strings":["Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101984111","display_name":"L Fang","orcid":"https://orcid.org/0009-0000-4898-6014"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ligang Fang","raw_affiliation_strings":["Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101477564","display_name":"Wei Chen","orcid":"https://orcid.org/0000-0001-7522-6897"},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I2801228662","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801228662"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Chen","raw_affiliation_strings":["Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China. chenwei6@medmail.com.cn","Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China. chenwei6@medmail.com.cn","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]},{"raw_affiliation_string":"Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I2801228662"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.17127826,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"1","first_page":"367","last_page":"367"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11305","display_name":"Amyloidosis: Diagnosis, Treatment, Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9878000020980835,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12369","display_name":"Pneumocystis jirovecii pneumonia detection and treatment","score":0.9660000205039978,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-amyloidosis","display_name":"Cardiac amyloidosis","score":0.5623000264167786},{"id":"https://openalex.org/keywords/cohort","display_name":"Cohort","score":0.5037000179290771},{"id":"https://openalex.org/keywords/amyloidosis","display_name":"Amyloidosis","score":0.48590001463890076},{"id":"https://openalex.org/keywords/retrospective-cohort-study","display_name":"Retrospective cohort study","score":0.48260000348091125},{"id":"https://openalex.org/keywords/proportional-hazards-model","display_name":"Proportional hazards model","score":0.4392000138759613},{"id":"https://openalex.org/keywords/brier-score","display_name":"Brier score","score":0.39660000801086426},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.38040000200271606},{"id":"https://openalex.org/keywords/predictive-value-of-tests","display_name":"Predictive value of tests","score":0.3693999946117401},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"Risk stratification","score":0.36039999127388}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8215000033378601},{"id":"https://openalex.org/C2777607188","wikidata":"https://www.wikidata.org/wiki/Q5038315","display_name":"Cardiac amyloidosis","level":3,"score":0.5623000264167786},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5228000283241272},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5062999725341797},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5037000179290771},{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.48590001463890076},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.48260000348091125},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.4392000138759613},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4120999872684479},{"id":"https://openalex.org/C35405484","wikidata":"https://www.wikidata.org/wiki/Q4967066","display_name":"Brier score","level":2,"score":0.39660000801086426},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3921000063419342},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.38040000200271606},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.3693999946117401},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.36039999127388},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.35010001063346863},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.3474999964237213},{"id":"https://openalex.org/C2776127602","wikidata":"https://www.wikidata.org/wiki/Q5038319","display_name":"Cardiac imaging","level":2,"score":0.328900009393692},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.32659998536109924},{"id":"https://openalex.org/C2778789114","wikidata":"https://www.wikidata.org/wiki/Q235007","display_name":"Cardiac surgery","level":2,"score":0.3181999921798706},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.3098999857902527},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.30320000648498535},{"id":"https://openalex.org/C2776034619","wikidata":"https://www.wikidata.org/wiki/Q3428020","display_name":"Cardiac resynchronization therapy","level":4,"score":0.28870001435279846},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.2867000102996826},{"id":"https://openalex.org/C37616216","wikidata":"https://www.wikidata.org/wiki/Q3218363","display_name":"Lasso (programming language)","level":2,"score":0.2849999964237213},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.28220000863075256},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.28029999136924744},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2750000059604645},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.274399995803833},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.26910001039505005},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.25519999861717224},{"id":"https://openalex.org/C2780040984","wikidata":"https://www.wikidata.org/wiki/Q79785","display_name":"Electrocardiography","level":2,"score":0.25189998745918274}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000075363","descriptor_name":"Immunoglobulin Light-chain Amyloidosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000075363","descriptor_name":"Immunoglobulin Light-chain Amyloidosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000075363","descriptor_name":"Immunoglobulin Light-chain Amyloidosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000075363","descriptor_name":"Immunoglobulin Light-chain Amyloidosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000075363","descriptor_name":"Immunoglobulin Light-chain Amyloidosis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D000075363","descriptor_name":"Immunoglobulin Light-chain Amyloidosis","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D000098412","descriptor_name":"Predictive Learning Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098412","descriptor_name":"Predictive Learning Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098429","descriptor_name":"Classification Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098429","descriptor_name":"Classification Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014336","descriptor_name":"Troponin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014336","descriptor_name":"Troponin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D020097","descriptor_name":"Natriuretic Peptide, Brain","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12911-025-03207-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-025-03207-0","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/counter/pdf/10.1186/s12911-025-03207-0","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},{"id":"pmid:41068914","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41068914","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical informatics and decision making","raw_type":null},{"id":"pmh:oai:doaj.org/article:567e4ea145654c68ad36a8c02bf7ffbb","is_oa":true,"landing_page_url":"https://doaj.org/article/567e4ea145654c68ad36a8c02bf7ffbb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Informatics and Decision Making, Vol 25, Iss 1, Pp 1-13 (2025)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:11320609","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12512860","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12911-025-03207-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-025-03207-0","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/counter/pdf/10.1186/s12911-025-03207-0","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324962","display_name":"Peking Union Medical College Hospital","ror":"https://ror.org/04jztag35"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4414985422.pdf","grobid_xml":"https://content.openalex.org/works/W4414985422.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1567835982","https://openalex.org/W1840249871","https://openalex.org/W1976601231","https://openalex.org/W2011865037","https://openalex.org/W2041437149","https://openalex.org/W2063745696","https://openalex.org/W2098093182","https://openalex.org/W2111080788","https://openalex.org/W2129528847","https://openalex.org/W2171033052","https://openalex.org/W2313186535","https://openalex.org/W2522056109","https://openalex.org/W2809949684","https://openalex.org/W2897804486","https://openalex.org/W3034845896","https://openalex.org/W3044693287","https://openalex.org/W3046046238","https://openalex.org/W3048889268","https://openalex.org/W3083404665","https://openalex.org/W3123330152","https://openalex.org/W3206998179","https://openalex.org/W4285798676","https://openalex.org/W4296798895","https://openalex.org/W4317477481","https://openalex.org/W4322757994","https://openalex.org/W4390236677","https://openalex.org/W4392665791","https://openalex.org/W4395009856","https://openalex.org/W4405401219"],"related_works":[],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"develop":[2],"and":[3,44,91,94,188,205,228,243],"validate":[4],"a":[5,27,95,229,256],"machine":[6,79],"learning-based":[7],"prognostic":[8],"model":[9,98,199],"that":[10],"provides":[11,247],"enhanced":[12],"risk":[13,261],"stratification":[14,262],"for":[15],"AL":[16,34,264],"cardiac":[17,35,53,131,265],"amyloidosis":[18,36],"patients":[19,37,110],"beyond":[20],"existing":[21],"staging":[22,104,219],"system.":[23,105],"METHODS:":[24],"We":[25],"conducted":[26],"retrospective":[28],"cohort":[29],"study":[30],"of":[31,214,226,232,259],"newly":[32],"diagnosed":[33],"(2006\u20132024),":[38],"randomly":[39],"allocating":[40],"participants":[41],"into":[42],"training":[43],"test":[45],"sets":[46],"(8:2":[47],"ratio).":[48],"Cardiac":[49],"involvement":[50],"required":[51],"elevated":[52],"biomarkers":[54],"(NT-proBNP":[55],">":[56,66],"332":[57],"ng/L)":[58],"or":[59],"increased":[60],"wall":[61,64],"thickness":[62,65],"(mean":[63],"12":[67],"mm).":[68],"Using":[69],"all-cause":[70],"mortality":[71],"as":[72],"the":[73,100,211,215],"primary":[74],"endpoint,":[75],"we":[76],"compared":[77],"five":[78],"learning":[80,236],"algorithms":[81],"(support":[82],"vector":[83],"machine,":[84],"CoxBoost,":[85],"random":[86],"survival":[87],"forest,":[88],"multi-layer":[89],"perceptron,":[90],"k-neighbors":[92],"classifier)":[93],"traditional":[96],"Cox":[97],"against":[99],"2015":[101],"European-modified":[102],"Mayo":[103,217],"RESULTS:":[106],"Among":[107],"132":[108],"enrolled":[109],"(median":[111],"age":[112],"60":[113],"years;":[114],"56.8%":[115],"male),":[116],"83":[117],"deaths":[118],"(62.8%)":[119],"occurred":[120],"during":[121],"median":[122],"14.5-month":[123],"follow-up.":[124],"Feature":[125],"selection":[126],"identified":[127],"six":[128],"key":[129],"predictors:":[130],"response":[132,141],"(36%":[133],"vs.":[134,143,153,169,182,192],"15%,":[135],"P":[136,145,157,174,185,194],"<":[137,146,195],"0.001),":[138,147],"complete":[139],"hematological":[140],"(35%":[142],"20%,":[144],"E/e\u2019":[148],"ratio":[149],"(15.0":[150],"[12.0,":[151],"20.0]":[152],"19.0":[154],"[15.0,":[155],"25.0],":[156],"=":[158,175,186],"0.009),":[159],"left":[160],"ventricular":[161],"global":[162],"longitudinal":[163],"strain":[164,242],"(-14.1":[165],"[-11.2":[166],"\u2013":[167,172],"-16.1]":[168],"-10.7":[170],"[-8.8":[171],"-13.6],":[173],"0.003),":[176],"serum":[177],"uric":[178],"acid":[179],"(341.0":[180],"[292.0\u2013439.0]":[181],"429.0":[183],"[345.5\u2013518.0],":[184],"0.002),":[187],"weight":[189],"loss":[190],"(30.6%":[191],"65.1%,":[193],"0.001).":[196],"The":[197],"CoxBoost":[198],"demonstrated":[200],"superior":[201],"discrimination":[202],"(AUC":[203],"92%)":[204],"calibration":[206],"(brier":[207],"score":[208,231],"0.11).":[209],"Conversely,":[210],"predictive":[212],"value":[213],"revised":[216],"2004":[218],"system":[220],"was":[221],"unsatisfactory,":[222],"with":[223],"an":[224],"AUC":[225],"74%":[227],"brier":[230],"0.19.":[233],"CONCLUSIONS:":[234],"Machine":[235],"incorporating":[237],"multi-dimensional":[238],"parameters":[239],"(including":[240],"myocardial":[241],"dynamic":[244],"clinical":[245],"variables)":[246],"significantly":[248],"more":[249],"accurate":[250],"prognostication":[251],"than":[252],"NT-proBNP/troponin-dependent":[253],"staging,":[254],"enabling":[255],"new":[257],"era":[258],"personalized":[260],"in":[263],"amyloidosis.":[266]},"counts_by_year":[],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}