{"id":"https://openalex.org/W4408622034","doi":"https://doi.org/10.1186/s12911-025-02963-3","title":"Evaluation and validation of a clinical decision support system for dose optimisation in hospitalized patients with (morbid) obesity \u2013 a retrospective, observational study","display_name":"Evaluation and validation of a clinical decision support system for dose optimisation in hospitalized patients with (morbid) obesity \u2013 a retrospective, observational study","publication_year":2025,"publication_date":"2025-03-19","ids":{"openalex":"https://openalex.org/W4408622034","doi":"https://doi.org/10.1186/s12911-025-02963-3","pmid":"https://pubmed.ncbi.nlm.nih.gov/40108614"},"language":"en","primary_location":{"id":"doi:10.1186/s12911-025-02963-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-025-02963-3","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/counter/pdf/10.1186/s12911-025-02963-3","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedinformdecismak.biomedcentral.com/counter/pdf/10.1186/s12911-025-02963-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048092082","display_name":"Laura Brand","orcid":"https://orcid.org/0009-0009-9829-5647"},"institutions":[{"id":"https://openalex.org/I4210108903","display_name":"Maasstad Ziekenhuis","ror":"https://ror.org/01n0rnc91","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210108903"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Lianne Brand","raw_affiliation_strings":["Department of Clinical Pharmacology and Toxicology, Maasstad Hospital, MaasstadLab, Rotterdam, The Netherlands. l.brand@lumc.nl","Hospital Pharmacy, Maasstad Hospital, Rotterdam, The Netherlands. l.brand@lumc.nl","Department of Clinical Pharmacology and Toxicology, Maasstad Hospital, MaasstadLab, Rotterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0009-0009-9829-5647","affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Toxicology, Maasstad Hospital, MaasstadLab, Rotterdam, The Netherlands. l.brand@lumc.nl","institution_ids":["https://openalex.org/I4210108903"]},{"raw_affiliation_string":"Hospital Pharmacy, Maasstad Hospital, Rotterdam, The Netherlands. l.brand@lumc.nl","institution_ids":["https://openalex.org/I4210108903"]},{"raw_affiliation_string":"Department of Clinical Pharmacology and Toxicology, Maasstad Hospital, MaasstadLab, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I4210108903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010246547","display_name":"Lieke Mitrov\u2010Winkelmolen","orcid":"https://orcid.org/0000-0003-4133-2370"},"institutions":[{"id":"https://openalex.org/I4210108903","display_name":"Maasstad Ziekenhuis","ror":"https://ror.org/01n0rnc91","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210108903"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"L. Mitrov-Winkelmolen","raw_affiliation_strings":["Hospital Pharmacy, Maasstad Hospital, Rotterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-4133-2370","affiliations":[{"raw_affiliation_string":"Hospital Pharmacy, Maasstad Hospital, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I4210108903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055575221","display_name":"T. Martijn Kuijper","orcid":"https://orcid.org/0000-0002-2834-5727"},"institutions":[{"id":"https://openalex.org/I4210108903","display_name":"Maasstad Ziekenhuis","ror":"https://ror.org/01n0rnc91","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210108903"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"T. M. Kuijper","raw_affiliation_strings":["Science Bureau, Maasstad Hospital, Rotterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-2834-5727","affiliations":[{"raw_affiliation_string":"Science Bureau, Maasstad Hospital, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I4210108903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067496521","display_name":"Tessa M. Bosch","orcid":"https://orcid.org/0000-0002-9337-7784"},"institutions":[{"id":"https://openalex.org/I4210108903","display_name":"Maasstad Ziekenhuis","ror":"https://ror.org/01n0rnc91","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210108903"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"T. M. Bosch","raw_affiliation_strings":["Department of Clinical Pharmacology and Toxicology, Maasstad Hospital, MaasstadLab, Rotterdam, The Netherlands","Hospital Pharmacy, Maasstad Hospital, Rotterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-9337-7784","affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacology and Toxicology, Maasstad Hospital, MaasstadLab, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I4210108903"]},{"raw_affiliation_string":"Hospital Pharmacy, Maasstad Hospital, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I4210108903"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060745655","display_name":"L. L. Krens","orcid":"https://orcid.org/0000-0003-3842-9585"},"institutions":[{"id":"https://openalex.org/I4210108903","display_name":"Maasstad Ziekenhuis","ror":"https://ror.org/01n0rnc91","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210108903"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"L. L. Krens","raw_affiliation_strings":["Hospital Pharmacy, Maasstad Hospital, Rotterdam, The Netherlands. KrensL@maasstadziekenhuis.nl","Hospital Pharmacy, Maasstad Hospital, Rotterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-3842-9585","affiliations":[{"raw_affiliation_string":"Hospital Pharmacy, Maasstad Hospital, Rotterdam, The Netherlands. KrensL@maasstadziekenhuis.nl","institution_ids":["https://openalex.org/I4210108903"]},{"raw_affiliation_string":"Hospital Pharmacy, Maasstad Hospital, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I4210108903"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5048092082","https://openalex.org/A5060745655"],"corresponding_institution_ids":["https://openalex.org/I4210108903"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":3.4455,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.92797147,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"25","issue":"1","first_page":"140","last_page":"140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10350","display_name":"Electronic Health Records Systems","score":0.5177000164985657,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10350","display_name":"Electronic Health Records Systems","score":0.5177000164985657,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.10689999908208847,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.06639999896287918,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/observational-study","display_name":"Observational study","score":0.7768089771270752},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.679166853427887},{"id":"https://openalex.org/keywords/health-informatics","display_name":"Health informatics","score":0.5777108073234558},{"id":"https://openalex.org/keywords/morbid-obesity","display_name":"Morbid obesity","score":0.5651227235794067},{"id":"https://openalex.org/keywords/retrospective-cohort-study","display_name":"Retrospective cohort study","score":0.5583465099334717},{"id":"https://openalex.org/keywords/clinical-decision-support-system","display_name":"Clinical decision support system","score":0.48225170373916626},{"id":"https://openalex.org/keywords/emergency-medicine","display_name":"Emergency medicine","score":0.44915854930877686},{"id":"https://openalex.org/keywords/obesity","display_name":"Obesity","score":0.41622069478034973},{"id":"https://openalex.org/keywords/intensive-care-medicine","display_name":"Intensive care medicine","score":0.35642915964126587},{"id":"https://openalex.org/keywords/decision-support-system","display_name":"Decision support system","score":0.3448219299316406},{"id":"https://openalex.org/keywords/medical-emergency","display_name":"Medical emergency","score":0.3275409936904907},{"id":"https://openalex.org/keywords/medical-physics","display_name":"Medical physics","score":0.32142215967178345},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.24996522068977356},{"id":"https://openalex.org/keywords/public-health","display_name":"Public health","score":0.18717879056930542},{"id":"https://openalex.org/keywords/weight-loss","display_name":"Weight loss","score":0.17711785435676575},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.17689314484596252},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.17262795567512512},{"id":"https://openalex.org/keywords/nursing","display_name":"Nursing","score":0.14398208260536194}],"concepts":[{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.7768089771270752},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.679166853427887},{"id":"https://openalex.org/C145642194","wikidata":"https://www.wikidata.org/wiki/Q870895","display_name":"Health informatics","level":3,"score":0.5777108073234558},{"id":"https://openalex.org/C3020583074","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Morbid obesity","level":4,"score":0.5651227235794067},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.5583465099334717},{"id":"https://openalex.org/C63527458","wikidata":"https://www.wikidata.org/wiki/Q5133829","display_name":"Clinical decision support system","level":3,"score":0.48225170373916626},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.44915854930877686},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.41622069478034973},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.35642915964126587},{"id":"https://openalex.org/C107327155","wikidata":"https://www.wikidata.org/wiki/Q330268","display_name":"Decision support system","level":2,"score":0.3448219299316406},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.3275409936904907},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.32142215967178345},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24996522068977356},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.18717879056930542},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.17711785435676575},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.17689314484596252},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.17262795567512512},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.14398208260536194}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009426","descriptor_name":"Netherlands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009426","descriptor_name":"Netherlands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009426","descriptor_name":"Netherlands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009426","descriptor_name":"Netherlands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009426","descriptor_name":"Netherlands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009767","descriptor_name":"Obesity, Morbid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009767","descriptor_name":"Obesity, Morbid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009767","descriptor_name":"Obesity, Morbid","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12911-025-02963-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-025-02963-3","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/counter/pdf/10.1186/s12911-025-02963-3","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},{"id":"pmid:40108614","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40108614","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical informatics and decision making","raw_type":null},{"id":"pmh:oai:doaj.org/article:f378d6bde2ed431fa19e2f6ef8872423","is_oa":true,"landing_page_url":"https://doaj.org/article/f378d6bde2ed431fa19e2f6ef8872423","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Informatics and Decision Making, Vol 25, Iss 1, Pp 1-11 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:11921672","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11921672","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Med Inform Decis Mak","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12911-025-02963-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-025-02963-3","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/counter/pdf/10.1186/s12911-025-02963-3","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4408622034.pdf"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W1754732328","https://openalex.org/W1837500700","https://openalex.org/W1983798132","https://openalex.org/W2001998560","https://openalex.org/W2005891936","https://openalex.org/W2031333983","https://openalex.org/W2071446117","https://openalex.org/W2084563491","https://openalex.org/W2114840454","https://openalex.org/W2139877139","https://openalex.org/W2141190905","https://openalex.org/W2141496976","https://openalex.org/W2150898197","https://openalex.org/W2312993091","https://openalex.org/W2473659763","https://openalex.org/W2605753964","https://openalex.org/W2776411442","https://openalex.org/W2792364309","https://openalex.org/W2801499037","https://openalex.org/W2889229861","https://openalex.org/W2918348793","https://openalex.org/W2966194224","https://openalex.org/W2982542536","https://openalex.org/W2994936956","https://openalex.org/W3113540706","https://openalex.org/W4315650218"],"related_works":["https://openalex.org/W4245848028","https://openalex.org/W2743915337","https://openalex.org/W2046929026","https://openalex.org/W2779278343","https://openalex.org/W1996434451","https://openalex.org/W1569026615","https://openalex.org/W2791725133","https://openalex.org/W2338117633","https://openalex.org/W2112831187","https://openalex.org/W2122149485"],"abstract_inverted_index":{"BACKGROUND:":[0],"Obesity":[1],"changes":[2],"a":[3,40,114,225,269,277,285],"patient's":[4,160],"pharmacokinetics":[5],"and":[6,26,28,81,102,130,143,149,184,204,241,284,322,335,342],"pharmacotherapeutic":[7,226],"advices":[8,19,56,101,305],"should":[9],"be":[10],"personalized":[11],"to":[12,53,82,93,103,167,206,231,298],"ensure":[13],"proper":[14],"treatment.":[15],"Currently,":[16],"implementations":[17],"of":[18,199,201,262,273,279,287,333],"regarding":[20],"the":[21,99,120,125,159,171,197,202,207,229,232,237,257,265,302,304,324,336],"obese":[22,59,326],"population":[23],"are":[24,33,75,87],"lacking":[25],"weight":[27,161],"body":[29],"mass":[30],"index":[31],"(BMI)":[32],"rarely":[34],"monitored.":[35],"The":[36,111,133,173,315,331],"Maasstad":[37,121],"Hospital":[38,122],"built":[39],"clinical":[41],"decision":[42],"support":[43],"system":[44],"(CDSS)":[45],"for":[46,57,177],"pharmacists,":[47],"based":[48,61],"on":[49,62,98,196,301],"current":[50],"Dutch":[51],"guidelines,":[52],"supply":[54],"therapeutic":[55],"(morbidly)":[58,325],"patients":[60,71,327],"patient":[63,147],"characteristics.":[64],"In":[65,234],"this":[66,79],"study":[67,117],"we":[68],"evaluated":[69,176],"whether":[70],"receiving":[72],"inadequate":[73,329],"pharmacotherapy":[74,310],"indeed":[76],"identified":[77],"via":[78,170],"CDSS":[80,150,174,203,208,318],"which":[83,94,104],"extent":[84,95,105],"irrelevant":[85,194],"alerts":[86,195,213,221,272,294],"generated.":[88,219],"Moreover,":[89],"it":[90],"is":[91],"investigated":[92],"pharmacists":[96],"carry":[97],"generated":[100],"physicians":[106,334],"act":[107],"upon":[108],"these.":[109],"METHODS:":[110],"research":[112,349],"concerned":[113],"retrospective":[115],"observational":[116],"performed":[118],"at":[119],"in":[123,224,268,307,312,338],"Rotterdam,":[124],"Netherlands":[126],"between":[127],"January":[128],"2021":[129],"august":[131],"2021.":[132],"drugs":[134,251],"included":[135,157],"were":[136,152,209,218,243,254],"dalteparin,":[137],"apixaban,":[138],"dabigatran,":[139],"edoxaban,":[140],"rivaroxaban,":[141],"vancomycin":[142,263],"ciprofloxacin.":[144],"Dispensing":[145,154],"data,":[146],"characteristics":[148],"processing":[151],"collected.":[153],"data":[155],"was":[156,175],"when":[158],"or":[162],"BMI":[163,260],"could":[164],"potentially":[165],"lead":[166],"dose":[168],"adjustments":[169,253,311],"CDSS.":[172],"sensitivity,":[178,238],"specificity,":[179,239],"positive":[180],"predictive":[181,186],"value":[182,187],"(PPV)":[183],"negative":[185],"(NPV).":[188],"Additionally,":[189],"excess":[190,271,293],"alerts,":[191],"defined":[192],"as":[193,320],"moment":[198],"assessment,":[200],"adherence":[205,332],"investigated.":[210],"RESULTS:":[211],"1218":[212],"over":[214],"3735":[215],"drug":[216],"dispenses":[217],"568":[220],"(46.6%)":[222],"resulted":[223,306],"advice":[227],"by":[228],"pharmacist":[230],"physician.":[233],"most":[235],"cases,":[236],"PPV":[240],"NPV":[242,278],"100.0%":[244],"with":[245,328],"varying":[246],"95%":[247,281,289],"CIs.":[248],"For":[249],"some":[250],"technical":[252],"needed,":[255],"including":[256],"initially":[258],"incorrect":[259],"setting":[261],"within":[264],"CDSS,":[266],"resulting":[267],"high":[270],"56.9%.":[274,299],"Dabigatran":[275],"had":[276],"22.2%":[280,297],"CI":[282,290],"[6.3-54.7]":[283],"sensitivity":[286],"56.3%":[288],"[33.2-76.9].":[291],"Overall":[292],"varied":[295],"from":[296],"Depending":[300],"drug,":[303],"6.9-100.0%":[308],"real":[309],"practise.":[313],"CONCLUSION:":[314],"(morbid)":[316],"obesity":[317],"functions":[319],"expected":[321],"identifies":[323],"pharmacotherapy.":[330],"follow-up":[337],"practise":[339],"varies":[340],"widely":[341],"requires":[343],"further":[344],"investigation.":[345],"TRIAL":[346],"REGISTRATION:":[347],"Non-WMO":[348],"W21.218.":[350]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-07-29T09:40:50.615796","created_date":"2025-10-10T00:00:00"}