{"id":"https://openalex.org/W4380482751","doi":"https://doi.org/10.1186/s12911-023-02171-x","title":"Construction of the XGBoost model for early lung cancer prediction based on metabolic indices","display_name":"Construction of the XGBoost model for early lung cancer prediction based on metabolic indices","publication_year":2023,"publication_date":"2023-06-13","ids":{"openalex":"https://openalex.org/W4380482751","doi":"https://doi.org/10.1186/s12911-023-02171-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/37312179"},"language":"en","primary_location":{"id":"doi:10.1186/s12911-023-02171-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-023-02171-x","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/counter/pdf/10.1186/s12911-023-02171-x","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedinformdecismak.biomedcentral.com/counter/pdf/10.1186/s12911-023-02171-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049793210","display_name":"Xiuliang Guan","orcid":"https://orcid.org/0000-0002-2291-0748"},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiuliang Guan","raw_affiliation_strings":["School of Public Health, Dalian Medical University, Dalian, 116000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Dalian Medical University, Dalian, 116000, China","institution_ids":["https://openalex.org/I191996457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054116837","display_name":"Yue Du","orcid":"https://orcid.org/0009-0009-6470-6436"},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Du","raw_affiliation_strings":["School of Public Health, Dalian Medical University, Dalian, 116000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Dalian Medical University, Dalian, 116000, China","institution_ids":["https://openalex.org/I191996457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049434338","display_name":"Rufei Ma","orcid":"https://orcid.org/0009-0004-1008-1868"},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rufei Ma","raw_affiliation_strings":["School of Public Health, Dalian Medical University, Dalian, 116000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Dalian Medical University, Dalian, 116000, China","institution_ids":["https://openalex.org/I191996457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080957101","display_name":"Nan Teng","orcid":null},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Teng","raw_affiliation_strings":["School of Public Health, Dalian Medical University, Dalian, 116000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Dalian Medical University, Dalian, 116000, China","institution_ids":["https://openalex.org/I191996457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015897455","display_name":"Shu Ou","orcid":null},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shu Ou","raw_affiliation_strings":["School of Public Health, Dalian Medical University, Dalian, 116000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health, Dalian Medical University, Dalian, 116000, China","institution_ids":["https://openalex.org/I191996457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101461477","display_name":"Hui Zhao","orcid":"https://orcid.org/0000-0003-1614-1994"},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210100868","display_name":"Second Affiliated Hospital of Dalian Medical University","ror":"https://ror.org/012f2cn18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210100868"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hui Zhao","raw_affiliation_strings":["Department of Health Examination Center, The Second Affiliated Hospital of Dalian Medical University, Dalian, China. zhaohui@dmu.edu.cn","Department of Health Examination Center, The Second Affiliated Hospital of Dalian Medical University, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Health Examination Center, The Second Affiliated Hospital of Dalian Medical University, Dalian, China. zhaohui@dmu.edu.cn","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210100868"]},{"raw_affiliation_string":"Department of Health Examination Center, The Second Affiliated Hospital of Dalian Medical University, Dalian, China","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210100868"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000403795","display_name":"Xiaofeng Li","orcid":"https://orcid.org/0000-0002-1786-9154"},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaofeng Li","raw_affiliation_strings":["School of Public Health, Dalian Medical University, Dalian, 116000, China. lxf_chen@dmu.edu.cn","School of Public Health, Dalian Medical University, Dalian, 116000, China"],"raw_orcid":"https://orcid.org/0000-0002-1786-9154","affiliations":[{"raw_affiliation_string":"School of Public Health, Dalian Medical University, Dalian, 116000, China. lxf_chen@dmu.edu.cn","institution_ids":["https://openalex.org/I191996457"]},{"raw_affiliation_string":"School of Public Health, Dalian Medical University, Dalian, 116000, China","institution_ids":["https://openalex.org/I191996457"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101461477"],"corresponding_institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210100868"],"apc_list":{"value":1570,"currency":"GBP","value_usd":2690},"apc_paid":{"value":1570,"currency":"GBP","value_usd":2690},"fwci":7.4995,"has_fulltext":true,"cited_by_count":80,"citation_normalized_percentile":{"value":0.98386558,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"23","issue":"1","first_page":"107","last_page":"107"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9552000164985657,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9552000164985657,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/health-informatics","display_name":"Health informatics","score":0.7539810538291931},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.603779673576355},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4561554193496704},{"id":"https://openalex.org/keywords/predictive-modelling","display_name":"Predictive modelling","score":0.42386576533317566},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.36055678129196167},{"id":"https://openalex.org/keywords/public-health","display_name":"Public health","score":0.307020902633667},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.23814332485198975},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.22006899118423462},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.14269894361495972}],"concepts":[{"id":"https://openalex.org/C145642194","wikidata":"https://www.wikidata.org/wiki/Q870895","display_name":"Health informatics","level":3,"score":0.7539810538291931},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.603779673576355},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4561554193496704},{"id":"https://openalex.org/C45804977","wikidata":"https://www.wikidata.org/wiki/Q7239673","display_name":"Predictive modelling","level":2,"score":0.42386576533317566},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36055678129196167},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.307020902633667},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.23814332485198975},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.22006899118423462},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14269894361495972}],"mesh":[{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009952","descriptor_name":"Ornithine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009952","descriptor_name":"Ornithine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009952","descriptor_name":"Ornithine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010172","descriptor_name":"Palmitoylcarnitine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010172","descriptor_name":"Palmitoylcarnitine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010172","descriptor_name":"Palmitoylcarnitine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12911-023-02171-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-023-02171-x","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/counter/pdf/10.1186/s12911-023-02171-x","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},{"id":"pmid:37312179","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37312179","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical informatics and decision making","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:10262551","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10262551","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10262551/pdf/12911_2023_Article_2171.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Med Inform Decis Mak","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:deb890739a59464a82bdc73e6e1435dc","is_oa":true,"landing_page_url":"https://doaj.org/article/deb890739a59464a82bdc73e6e1435dc","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Informatics and Decision Making, Vol 23, Iss 1, Pp 1-16 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12911-023-02171-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-023-02171-x","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/counter/pdf/10.1186/s12911-023-02171-x","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7900000214576721,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1848697959","display_name":null,"funder_award_id":"No. LJKZ0849","funder_id":"https://openalex.org/F4320326218","funder_display_name":"Foundation of Liaoning Province Education Administration"},{"id":"https://openalex.org/G6289929424","display_name":null,"funder_award_id":"LJKZ0849","funder_id":"https://openalex.org/F4320326218","funder_display_name":"Foundation of Liaoning Province Education Administration"}],"funders":[{"id":"https://openalex.org/F4320326218","display_name":"Foundation of Liaoning Province Education Administration","ror":null}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4380482751.pdf"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1579311705","https://openalex.org/W1978004240","https://openalex.org/W1980181091","https://openalex.org/W1987789641","https://openalex.org/W2002583208","https://openalex.org/W2071810261","https://openalex.org/W2082541697","https://openalex.org/W2094223456","https://openalex.org/W2106447813","https://openalex.org/W2138575767","https://openalex.org/W2152943013","https://openalex.org/W2159571285","https://openalex.org/W2163351155","https://openalex.org/W2190934640","https://openalex.org/W2265836483","https://openalex.org/W2469060315","https://openalex.org/W2519435458","https://openalex.org/W2530067632","https://openalex.org/W2563427432","https://openalex.org/W2593540640","https://openalex.org/W2886153933","https://openalex.org/W2915999106","https://openalex.org/W2917330976","https://openalex.org/W2923046924","https://openalex.org/W2950457484","https://openalex.org/W2961259995","https://openalex.org/W2967852385","https://openalex.org/W2972884213","https://openalex.org/W2973871066","https://openalex.org/W2979026278","https://openalex.org/W2981000855","https://openalex.org/W2982414086","https://openalex.org/W2995996162","https://openalex.org/W2998732610","https://openalex.org/W3023612051","https://openalex.org/W3040813705","https://openalex.org/W3045677677","https://openalex.org/W3092693700","https://openalex.org/W3094511086","https://openalex.org/W3095709044","https://openalex.org/W3162737041","https://openalex.org/W3169360108","https://openalex.org/W4206964597","https://openalex.org/W4207022089","https://openalex.org/W4210992155","https://openalex.org/W4212962929","https://openalex.org/W4224046409","https://openalex.org/W4225263025","https://openalex.org/W4226277510","https://openalex.org/W4281635832"],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4380684963","https://openalex.org/W4387964980","https://openalex.org/W4399928006","https://openalex.org/W4248671430","https://openalex.org/W2073564825","https://openalex.org/W2046591752","https://openalex.org/W3171719212"],"abstract_inverted_index":{"BACKGROUND:":[0],"Lung":[1],"cancer":[2,20,36,61,75,177,242],"is":[3,169],"a":[4,43,87,120,194,217],"malignant":[5],"tumour,":[6],"and":[7,66,77,99,108,110,154,192,197,234],"early":[8,59,175,202,224,240],"diagnosis":[9,62,203],"has":[10],"been":[11],"shown":[12],"to":[13,52,55,159,222],"improve":[14],"the":[15,27,49,115,132,150,185,225],"survival":[16],"rate":[17],"of":[18,29,114,187,204,227],"lung":[19,35,53,60,74,82,162,176,205,228,241],"patients.":[21],"In":[22,38,71],"this":[23,39],"study,":[24],"we":[25,41],"assessed":[26],"use":[28],"plasma":[30],"metabolites":[31,191],"as":[32,171],"biomarkers":[33,57,152,158,232],"for":[34,48,58,161,174,184,190,201,239],"diagnosis.":[37,243],"work,":[40],"used":[42],"novel":[44],"interdisciplinary":[45,212],"mechanism,":[46],"applied":[47],"first":[50],"time":[51],"cancer,":[54],"detect":[56],"by":[63,119],"combining":[64,214],"metabolomics":[65,104,215],"machine":[67,133,165,218],"learning":[68,134,166,219],"approaches.":[69],"RESULTS:":[70],"total,":[72],"478":[73],"patients":[76],"370":[78],"subjects":[79],"with":[80,149,216],"benign":[81],"nodules":[83],"were":[84,126],"enrolled":[85],"from":[86,102],"hospital":[88],"in":[89,131],"Dalian,":[90],"Liaoning":[91],"Province.":[92],"We":[93],"selected":[94],"47":[95],"serum":[96],"amino":[97],"acid":[98],"carnitine":[100],"indicators":[101,113],"targeted":[103],"studies":[105],"using":[106],"LC\u2012MS/MS":[107],"age":[109],"sex":[111],"demographic":[112],"subjects.":[116],"After":[117],"screening":[118,189],"stepwise":[121],"regression":[122],"algorithm,":[123],"16":[124],"metrics":[125],"included.":[127],"The":[128,164,230],"XGBoost":[129,168],"model":[130,167,220],"algorithm":[135],"showed":[136,236],"superior":[137],"predictive":[138],"power":[139,238],"(AUC":[140],"=":[141,144,147],"0.81,":[142],"accuracy":[143],"75.29%,":[145],"sensitivity":[146],"74%),":[148],"metabolic":[151,231],"ornithine":[153,233],"palmitoylcarnitine":[155,235],"being":[156],"potential":[157],"screen":[160],"cancer.":[163,206,229],"proposed":[170],"an":[172,211],"tool":[173,200],"prediction.":[178],"This":[179,208],"study":[180,209],"provides":[181],"strong":[182],"support":[183],"feasibility":[186],"blood-based":[188],"provide":[193],"safer,":[195],"faster":[196],"more":[198],"accurate":[199],"CONCLUSIONS:":[207],"proposes":[210],"approach":[213],"(XGBoost)":[221],"predict":[223],"occurrence":[226],"significant":[237]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":36},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":7}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}