{"id":"https://openalex.org/W3041924155","doi":"https://doi.org/10.1186/s12911-020-1105-4","title":"Hybrid phenotype mining method for investigating off-target protein and underlying side effects of anti-tumor immunotherapy","display_name":"Hybrid phenotype mining method for investigating off-target protein and underlying side effects of anti-tumor immunotherapy","publication_year":2020,"publication_date":"2020-07-01","ids":{"openalex":"https://openalex.org/W3041924155","doi":"https://doi.org/10.1186/s12911-020-1105-4","mag":"3041924155","pmid":"https://pubmed.ncbi.nlm.nih.gov/32646421"},"language":"en","primary_location":{"id":"doi:10.1186/s12911-020-1105-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-020-1105-4","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-020-1105-4","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-020-1105-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060081349","display_name":"Yuyu Zheng","orcid":null},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuyu Zheng","raw_affiliation_strings":["Hubei Key Lab of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, 430070, China","HZAU - Huazhong Agricultural University [Wuhan] (Wuhan 430070 - Chine)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Key Lab of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, 430070, China","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"HZAU - Huazhong Agricultural University [Wuhan] (Wuhan 430070 - Chine)","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079299290","display_name":"Xiangyu Meng","orcid":"https://orcid.org/0000-0001-5669-3502"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I2746051580","display_name":"Universit\u00e9 Paris Sciences et Lettres","ror":"https://ror.org/013cjyk83","country_code":"FR","type":"education","lineage":["https://openalex.org/I2746051580"]},{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]},{"id":"https://openalex.org/I4210120234","display_name":"Zhongnan Hospital of Wuhan University","ror":"https://ror.org/01v5mqw79","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120234"]},{"id":"https://openalex.org/I4210121573","display_name":"Wuchang University of Technology","ror":"https://ror.org/02mqsna37","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210121573"]},{"id":"https://openalex.org/I4210161403","display_name":"Biologie cellulaire et Cancer","ror":"https://ror.org/04w11tv37","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I2746051580","https://openalex.org/I39804081","https://openalex.org/I4210096427","https://openalex.org/I4210161403","https://openalex.org/I80043"]},{"id":"https://openalex.org/I80043","display_name":"Institut Curie","ror":"https://ror.org/04t0gwh46","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I80043"]}],"countries":["CN","FR"],"is_corresponding":false,"raw_author_name":"Xiangyu Meng","raw_affiliation_strings":["Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China","Institut Curie, CNRS, UMR144, Molecular Oncology Team, PSL Research University, Paris, France","Wuhan University [China] (Wuchang, Wuhan, Hubei, China, 430072 - Chine)","Institut Curie [Paris] ( 26 rue d'Ulm - 75248 Paris - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I4210120234","https://openalex.org/I37461747"]},{"raw_affiliation_string":"Institut Curie, CNRS, UMR144, Molecular Oncology Team, PSL Research University, Paris, France","institution_ids":["https://openalex.org/I2746051580","https://openalex.org/I80043","https://openalex.org/I1294671590","https://openalex.org/I4210161403"]},{"raw_affiliation_string":"Wuhan University [China] (Wuchang, Wuhan, Hubei, China, 430072 - Chine)","institution_ids":["https://openalex.org/I4210121573","https://openalex.org/I37461747"]},{"raw_affiliation_string":"Institut Curie [Paris] ( 26 rue d'Ulm - 75248 Paris - France)","institution_ids":["https://openalex.org/I80043"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090195478","display_name":"Pierre Zweigenbaum","orcid":"https://orcid.org/0000-0001-8410-4808"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I277688954","display_name":"Universit\u00e9 Paris-Saclay","ror":"https://ror.org/03xjwb503","country_code":"FR","type":"education","lineage":["https://openalex.org/I277688954"]},{"id":"https://openalex.org/I4210115485","display_name":"Laboratoire d'Informatique pour la M\u00e9canique et les Sciences de l'Ing\u00e9nieur","ror":"https://ror.org/01raq4x89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I102197404","https://openalex.org/I1294671590","https://openalex.org/I4210115485","https://openalex.org/I4210159245"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pierre Zweigenbaum","raw_affiliation_strings":["Universit\u00e9 Paris-Saclay, CNRS, LIMSI, Orsay, France","ILES - Information, Langue Ecrite et Sign\u00e9e (B\u00e2timent 508, 91405, Orsay cedex - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Paris-Saclay, CNRS, LIMSI, Orsay, France","institution_ids":["https://openalex.org/I277688954","https://openalex.org/I4210115485","https://openalex.org/I1294671590"]},{"raw_affiliation_string":"ILES - Information, Langue Ecrite et Sign\u00e9e (B\u00e2timent 508, 91405, Orsay cedex - France)","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115603233","display_name":"Ling\u2010Ling Chen","orcid":"https://orcid.org/0000-0002-3005-526X"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingling Chen","raw_affiliation_strings":["Hubei Key Lab of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, 430070, China","HZAU - Huazhong Agricultural University [Wuhan] (Wuhan 430070 - Chine)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Key Lab of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, 430070, China","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"HZAU - Huazhong Agricultural University [Wuhan] (Wuhan 430070 - Chine)","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039800976","display_name":"Jingbo Xia","orcid":"https://orcid.org/0000-0002-7285-588X"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingbo Xia","raw_affiliation_strings":["Hubei Key Lab of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, 430070, China. xiajingbo.math@gmail.com","HZAU - Huazhong Agricultural University [Wuhan] (Wuhan 430070 - Chine)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Key Lab of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan, 430070, China. xiajingbo.math@gmail.com","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"HZAU - Huazhong Agricultural University [Wuhan] (Wuhan 430070 - Chine)","institution_ids":["https://openalex.org/I204823248"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5060081349"],"corresponding_institution_ids":["https://openalex.org/I204823248"],"apc_list":{"value":1570,"currency":"GBP","value_usd":1925},"apc_paid":{"value":1570,"currency":"GBP","value_usd":1925},"fwci":0.2501,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.53892129,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"20","issue":"S3","first_page":"133","last_page":"133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.756600022315979,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.756600022315979,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.06449999660253525,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.02969999983906746,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.5927786827087402},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5327669978141785},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.4713895916938782},{"id":"https://openalex.org/keywords/side-effect","display_name":"Side effect (computer science)","score":0.43407657742500305},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4070010185241699},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3955652713775635},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3861043155193329},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.37580108642578125},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.3439924418926239},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.254921555519104},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24672383069992065},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12504106760025024},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.08467477560043335}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5927786827087402},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5327669978141785},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4713895916938782},{"id":"https://openalex.org/C3454156","wikidata":"https://www.wikidata.org/wiki/Q1144241","display_name":"Side effect (computer science)","level":2,"score":0.43407657742500305},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4070010185241699},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3955652713775635},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3861043155193329},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.37580108642578125},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.3439924418926239},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.254921555519104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24672383069992065},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12504106760025024},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08467477560043335},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12911-020-1105-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-020-1105-4","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-020-1105-4","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},{"id":"pmid:32646421","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32646421","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical informatics and decision making","raw_type":null},{"id":"pmh:oai:HAL:hal-03100540v1","is_oa":true,"landing_page_url":"https://hal.science/hal-03100540","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Informatics and Decision Making, 2020, 20 (S3), pp.133. &#x27E8;10.1186/s12911-020-1105-4&#x27E9;","raw_type":"Journal articles"},{"id":"pmh:oai:doaj.org/article:0f4a6bf34bc44f5b83a14a14e830021c","is_oa":true,"landing_page_url":"https://doaj.org/article/0f4a6bf34bc44f5b83a14a14e830021c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Informatics and Decision Making, Vol 20, Iss S3, Pp 1-11 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7346346","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7346346","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Med Inform Decis Mak","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12911-020-1105-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-020-1105-4","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-020-1105-4","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6299999952316284}],"awards":[{"id":"https://openalex.org/G5328452302","display_name":null,"funder_award_id":"2662018PY096","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"},{"id":"https://openalex.org/G6884668218","display_name":null,"funder_award_id":"31871269","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320319344","display_name":"Alliance Nationale pour les Sciences de la Vie et de la Sant\u00e9","ror":"https://ror.org/05g3p2p60"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324775","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294"},{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3041924155.pdf","grobid_xml":"https://content.openalex.org/works/W3041924155.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W24553703","https://openalex.org/W55204438","https://openalex.org/W1605630196","https://openalex.org/W2057499380","https://openalex.org/W2066671159","https://openalex.org/W2070829838","https://openalex.org/W2071383132","https://openalex.org/W2111217091","https://openalex.org/W2115871101","https://openalex.org/W2138512826","https://openalex.org/W2154896031","https://openalex.org/W2159583324","https://openalex.org/W2160986985","https://openalex.org/W2170146596","https://openalex.org/W2209812019","https://openalex.org/W2277326116","https://openalex.org/W2473872168","https://openalex.org/W2516527638","https://openalex.org/W2533179929","https://openalex.org/W2557385283","https://openalex.org/W2560367415","https://openalex.org/W2570190993","https://openalex.org/W2572174216","https://openalex.org/W2586232813","https://openalex.org/W2595182131","https://openalex.org/W2606764737","https://openalex.org/W2607144338","https://openalex.org/W2614467908","https://openalex.org/W2726507447","https://openalex.org/W2733628661","https://openalex.org/W2734670400","https://openalex.org/W2767891136","https://openalex.org/W2768185458","https://openalex.org/W2768260478","https://openalex.org/W2769764904","https://openalex.org/W2769936894","https://openalex.org/W2782676239","https://openalex.org/W2783246934","https://openalex.org/W2805112892","https://openalex.org/W2807245675","https://openalex.org/W2887052906","https://openalex.org/W2902848175","https://openalex.org/W2914969394","https://openalex.org/W2946690328","https://openalex.org/W2953846371","https://openalex.org/W3024839386"],"related_works":["https://openalex.org/W2411788938","https://openalex.org/W1840542775","https://openalex.org/W2416830231","https://openalex.org/W2003932708","https://openalex.org/W3003578468","https://openalex.org/W3029386772","https://openalex.org/W1967424056","https://openalex.org/W3159716479","https://openalex.org/W2336657400","https://openalex.org/W1483913375"],"abstract_inverted_index":{"BACKGROUND:":[0],"It":[1],"is":[2,14],"of":[3,18,61,84,142,162,194,206,220,240,252,264],"utmost":[4],"importance":[5],"to":[6,79,128,150,187,247,267],"investigate":[7,188,248],"novel":[8],"therapies":[9],"for":[10,107,133,261],"cancer,":[11],"as":[12],"it":[13,127],"a":[15,92,113,182,237],"major":[16],"cause":[17,52,60],"death.":[19],"In":[20,87],"recent":[21],"years,":[22],"immunotherapies,":[23],"especially":[24],"those":[25],"against":[26],"immune":[27,44],"checkpoints,":[28],"have":[29],"been":[30],"developed":[31],"and":[32,54,102,158,198,209,225,245],"brought":[33],"significant":[34],"improvement":[35],"in":[36],"cancer":[37],"management.":[38],"However,":[39],"on":[40,118],"the":[41,59,80,119,134,139,143,151,159,167,176,204,207,213,218,226,249,262],"other":[42,268],"hand,":[43],"checkpoints":[45],"blockade":[46],"(ICB)":[47],"by":[48,155,191,217],"monoclonal":[49],"antiboties":[50],"may":[51,70],"common":[53],"severe":[55],"adverse":[56,72],"reactions":[57,73],"(ADRs),":[58],"which":[62,97],"remains":[63],"largely":[64],"undetermined.":[65],"We":[66,111],"hypothesize":[67],"that":[68],"ICB-agents":[69],"induce":[71],"through":[74,203],"off-target":[75,82,189,214,229],"protein":[76],"interactions,":[77],"similar":[78,149],"ADR-causing":[81],"effects":[83],"small":[85],"molecules.":[86],"this":[88],"study,":[89],"we":[90],"propose":[91],"hybrid":[93,238],"phenotype":[94,178],"mining":[95],"approach":[96],"integrates":[98],"molecular":[99],"level":[100],"information":[101],"provides":[103],"new":[104],"mechanistic":[105],"insights":[106],"ICB-associated":[108],"ADRs.":[109],"METHODS:":[110],"trained":[112],"conditional":[114],"random":[115],"fields":[116],"model":[117],"TAC":[120],"2017":[121],"benchmark":[122],"training":[123],"data,":[124],"then":[125],"used":[126],"extract":[129],"all":[130],"drug-centric":[131],"phenotypes":[132,172],"five":[135],"anti-PD-1/PD-L1":[136],"drugs":[137,152,163],"from":[138,166,175],"drug":[140,208],"labels":[141],"DailyMed":[144],"database.":[145,169,180],"Proteins":[146],"with":[147],"structure":[148],"were":[153,164,173],"obtained":[154,165],"using":[156],"BlastP,":[157],"gene":[160,195,211,221],"targets":[161],"STRING":[168],"The":[170,255],"target-centric":[171],"extracted":[174],"human":[177],"ontology":[179,196],"Finally,":[181],"screening":[183],"module":[184],"was":[185,223,231],"designed":[186],"proteins,":[190],"making":[192],"use":[193],"analysis":[197],"pathway":[199],"analysis.":[200],"RESULTS:":[201],"Eventually,":[202],"cross-analysis":[205],"target":[210],"phenotypes,":[212],"effect":[215],"caused":[216],"mutation":[219],"BTK":[222],"found,":[224],"candidate":[227],"side-effect":[228],"site":[230],"analyzed.":[232],"CONCLUSIONS:":[233],"This":[234],"research":[235],"provided":[236],"method":[239,256],"biomedical":[241],"natural":[242],"language":[243],"processing":[244],"bioinformatics":[246],"off-target-based":[250],"mechanism":[251],"ICB":[253],"treatment.":[254],"can":[257],"also":[258],"be":[259],"applied":[260],"investigation":[263],"ADRs":[265],"related":[266],"large":[269],"molecule":[270],"drugs.":[271]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-06-03T09:05:47.796612","created_date":"2025-10-10T00:00:00"}
