{"id":"https://openalex.org/W3126948167","doi":"https://doi.org/10.1186/s12911-020-01380-y","title":"Isotypes of autoantibodies against novel differential 4-hydroxy-2-nonenal-modified peptide adducts in serum is associated with rheumatoid arthritis in Taiwanese women","display_name":"Isotypes of autoantibodies against novel differential 4-hydroxy-2-nonenal-modified peptide adducts in serum is associated with rheumatoid arthritis in Taiwanese women","publication_year":2021,"publication_date":"2021-02-10","ids":{"openalex":"https://openalex.org/W3126948167","doi":"https://doi.org/10.1186/s12911-020-01380-y","mag":"3126948167","pmid":"https://pubmed.ncbi.nlm.nih.gov/33568149"},"language":"en","primary_location":{"id":"doi:10.1186/s12911-020-01380-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-020-01380-y","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-020-01380-y","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-020-01380-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033814855","display_name":"Kai-Leun Tsai","orcid":null},"institutions":[{"id":"https://openalex.org/I4210158385","display_name":"Taipei Medical University-Shuang Ho Hospital","ror":"https://ror.org/04k9dce70","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158385"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Kai-Leun Tsai","raw_affiliation_strings":["Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan","Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, 23561, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, 23561, Taiwan","institution_ids":["https://openalex.org/I4210158385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008148261","display_name":"Che\u2010Chang Chang","orcid":"https://orcid.org/0000-0001-8080-2094"},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Che-Chang Chang","raw_affiliation_strings":["Graduate Institute of Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012120635","display_name":"Yu\u2010Sheng Chang","orcid":"https://orcid.org/0000-0002-2622-7524"},"institutions":[{"id":"https://openalex.org/I4210158385","display_name":"Taipei Medical University-Shuang Ho Hospital","ror":"https://ror.org/04k9dce70","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158385"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yu-Sheng Chang","raw_affiliation_strings":["Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan","Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, 23561, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 11031, Taiwan","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, 23561, Taiwan","institution_ids":["https://openalex.org/I4210158385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059688477","display_name":"Yiying Lu","orcid":"https://orcid.org/0000-0002-3180-9991"},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Ying Lu","raw_affiliation_strings":["School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, 250 Wuxing Street, Taipei, 11031, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, 250 Wuxing Street, Taipei, 11031, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076231351","display_name":"I-Jung Tsai","orcid":"https://orcid.org/0000-0002-6251-6091"},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"I-Jung Tsai","raw_affiliation_strings":["School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, 250 Wuxing Street, Taipei, 11031, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, 250 Wuxing Street, Taipei, 11031, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100634404","display_name":"Jinhua Chen","orcid":"https://orcid.org/0000-0002-3130-4125"},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Jin-Hua Chen","raw_affiliation_strings":["Graduate Institute of Data Science, College of Management, Taipei Medical University, Taipei, 11031, Taiwan","Research Center of Biostatistics, College of Management, Taipei Medical University, Taipei, 11031, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Data Science, College of Management, Taipei Medical University, Taipei, 11031, Taiwan","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"Research Center of Biostatistics, College of Management, Taipei Medical University, Taipei, 11031, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078633242","display_name":"Sheng-Hong Lin","orcid":"https://orcid.org/0000-0002-2602-1753"},"institutions":[{"id":"https://openalex.org/I4210158385","display_name":"Taipei Medical University-Shuang Ho Hospital","ror":"https://ror.org/04k9dce70","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158385"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Sheng-Hong Lin","raw_affiliation_strings":["Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, 23561, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, 23561, Taiwan","institution_ids":["https://openalex.org/I4210158385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078435033","display_name":"Chih-Chun Tai","orcid":null},"institutions":[{"id":"https://openalex.org/I4210158385","display_name":"Taipei Medical University-Shuang Ho Hospital","ror":"https://ror.org/04k9dce70","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158385"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Chih-Chun Tai","raw_affiliation_strings":["Department of Laboratory Medicine, Taipei Medical University-Shuang-Ho Hospital, Taipei Medical University, New Taipei City, 23561, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Taipei Medical University-Shuang-Ho Hospital, Taipei Medical University, New Taipei City, 23561, Taiwan","institution_ids":["https://openalex.org/I4210158385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077624827","display_name":"Yi-Fang Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I4210158385","display_name":"Taipei Medical University-Shuang Ho Hospital","ror":"https://ror.org/04k9dce70","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210158385"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yi-Fang Lin","raw_affiliation_strings":["Department of Laboratory Medicine, Taipei Medical University-Shuang-Ho Hospital, Taipei Medical University, New Taipei City, 23561, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Taipei Medical University-Shuang-Ho Hospital, Taipei Medical University, New Taipei City, 23561, Taiwan","institution_ids":["https://openalex.org/I4210158385"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067538672","display_name":"Hui\u2010Wen Chang","orcid":"https://orcid.org/0000-0001-8877-1886"},"institutions":[{"id":"https://openalex.org/I2802331550","display_name":"Taipei Medical University Hospital","ror":"https://ror.org/03k0md330","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802331550"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Hui-Wen Chang","raw_affiliation_strings":["Department of Medical Laboratory, Taipei Medical University Hospital, Taipei, 11031, Taiwan","PhD Program in Medical Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Laboratory, Taipei Medical University Hospital, Taipei, 11031, Taiwan","institution_ids":["https://openalex.org/I2802331550"]},{"raw_affiliation_string":"PhD Program in Medical Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066665226","display_name":"Ching\u2010Yu Lin","orcid":"https://orcid.org/0000-0001-8269-797X"},"institutions":[{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]},{"id":"https://openalex.org/I75430998","display_name":"National Ilan University","ror":"https://ror.org/01npf0s58","country_code":"TW","type":"education","lineage":["https://openalex.org/I75430998"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Ching-Yu Lin","raw_affiliation_strings":["Department of Biotechnology and Animal Science, National Ilan University, Ilan, 26047, Taiwan. cylin@tmu.edu.tw","PhD Program in Medical Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan. cylin@tmu.edu.tw","School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, 250 Wuxing Street, Taipei, 11031, Taiwan. cylin@tmu.edu.tw","School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, 250 Wuxing Street, Taipei, 11031, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Animal Science, National Ilan University, Ilan, 26047, Taiwan. cylin@tmu.edu.tw","institution_ids":["https://openalex.org/I75430998"]},{"raw_affiliation_string":"PhD Program in Medical Biotechnology, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan. cylin@tmu.edu.tw","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, 250 Wuxing Street, Taipei, 11031, Taiwan. cylin@tmu.edu.tw","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology, Taipei Medical University, 250 Wuxing Street, Taipei, 11031, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081102186","display_name":"Emily Chia\u2010Yu Su","orcid":"https://orcid.org/0000-0003-4801-5159"},"institutions":[{"id":"https://openalex.org/I2802331550","display_name":"Taipei Medical University Hospital","ror":"https://ror.org/03k0md330","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I2802331550"]},{"id":"https://openalex.org/I47519274","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94","country_code":"TW","type":"education","lineage":["https://openalex.org/I47519274"]}],"countries":["TW"],"is_corresponding":true,"raw_author_name":"Emily Chia-Yu Su","raw_affiliation_strings":["Clinical Big Data Research Center, Taipei Medical University Hospital, Taipei, 11031, Taiwan. emilysu@tmu.edu.tw","Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan. emilysu@tmu.edu.tw","Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan"],"raw_orcid":"https://orcid.org/0000-0003-4801-5159","affiliations":[{"raw_affiliation_string":"Clinical Big Data Research Center, Taipei Medical University Hospital, Taipei, 11031, Taiwan. emilysu@tmu.edu.tw","institution_ids":["https://openalex.org/I2802331550"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan. emilysu@tmu.edu.tw","institution_ids":["https://openalex.org/I47519274"]},{"raw_affiliation_string":"Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, 11031, Taiwan","institution_ids":["https://openalex.org/I47519274"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5081102186"],"corresponding_institution_ids":["https://openalex.org/I2802331550","https://openalex.org/I47519274"],"apc_list":{"value":1570,"currency":"GBP","value_usd":1925},"apc_paid":{"value":1570,"currency":"GBP","value_usd":1925},"fwci":1.478,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.81136425,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"21","issue":"1","first_page":"49","last_page":"49"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.7031999826431274,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.7031999826431274,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.036400001496076584,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.03420000150799751,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoantibody","display_name":"Autoantibody","score":0.8450310230255127},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6798198223114014},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"Rheumatoid arthritis","score":0.6020912528038025},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.597777783870697},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.5100139379501343},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.48343953490257263},{"id":"https://openalex.org/keywords/haptoglobin","display_name":"Haptoglobin","score":0.4740994870662689},{"id":"https://openalex.org/keywords/rheumatoid-factor","display_name":"Rheumatoid factor","score":0.461141437292099},{"id":"https://openalex.org/keywords/arthritis","display_name":"Arthritis","score":0.4489797055721283},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.4072231352329254}],"concepts":[{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.8450310230255127},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6798198223114014},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.6020912528038025},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.597777783870697},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5100139379501343},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.48343953490257263},{"id":"https://openalex.org/C206396517","wikidata":"https://www.wikidata.org/wiki/Q422025","display_name":"Haptoglobin","level":2,"score":0.4740994870662689},{"id":"https://openalex.org/C2776232647","wikidata":"https://www.wikidata.org/wiki/Q702883","display_name":"Rheumatoid factor","level":3,"score":0.461141437292099},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4489797055721283},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4072231352329254}],"mesh":[{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000447","descriptor_name":"Aldehydes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12911-020-01380-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-020-01380-y","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-020-01380-y","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},{"id":"pmid:33568149","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33568149","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical informatics and decision making","raw_type":null},{"id":"pmh:oai:doaj.org/article:eeb417a13f50450d949fa0c1d45d2f8e","is_oa":true,"landing_page_url":"https://doaj.org/article/eeb417a13f50450d949fa0c1d45d2f8e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Informatics and Decision Making, Vol 21, Iss 1, Pp 1-19 (2021)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7874460","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7874460","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Med Inform Decis Mak","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12911-020-01380-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-020-01380-y","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-020-01380-y","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7400000095367432,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G8368993781","display_name":null,"funder_award_id":"MOST104-2314-B-038-026","funder_id":"https://openalex.org/F4320322795","funder_display_name":"Ministry of Science and Technology, Taiwan"}],"funders":[{"id":"https://openalex.org/F4320322795","display_name":"Ministry of Science and Technology, Taiwan","ror":"https://ror.org/02kv4zf79"},{"id":"https://openalex.org/F4320322814","display_name":"Taipei Medical University","ror":"https://ror.org/05031qk94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3126948167.pdf","grobid_xml":"https://content.openalex.org/works/W3126948167.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W246691693","https://openalex.org/W982076325","https://openalex.org/W1510770161","https://openalex.org/W1524682237","https://openalex.org/W1573250191","https://openalex.org/W1575509548","https://openalex.org/W1744757207","https://openalex.org/W1880884681","https://openalex.org/W1958009759","https://openalex.org/W1964750380","https://openalex.org/W1966854142","https://openalex.org/W1968753290","https://openalex.org/W1970816245","https://openalex.org/W1975230923","https://openalex.org/W1980811192","https://openalex.org/W1981288431","https://openalex.org/W1984601987","https://openalex.org/W1987322894","https://openalex.org/W1991480450","https://openalex.org/W1996535196","https://openalex.org/W1996584569","https://openalex.org/W1999047083","https://openalex.org/W1999917690","https://openalex.org/W2000518375","https://openalex.org/W2002261915","https://openalex.org/W2020851102","https://openalex.org/W2028244560","https://openalex.org/W2033890835","https://openalex.org/W2039021289","https://openalex.org/W2042851093","https://openalex.org/W2045642603","https://openalex.org/W2052182132","https://openalex.org/W2053921780","https://openalex.org/W2058147305","https://openalex.org/W2058366423","https://openalex.org/W2062097745","https://openalex.org/W2069219703","https://openalex.org/W2073238101","https://openalex.org/W2080145370","https://openalex.org/W2082323986","https://openalex.org/W2096388167","https://openalex.org/W2096816771","https://openalex.org/W2101234009","https://openalex.org/W2101467420","https://openalex.org/W2106176385","https://openalex.org/W2111649022","https://openalex.org/W2125661827","https://openalex.org/W2128952811","https://openalex.org/W2129852694","https://openalex.org/W2133876809","https://openalex.org/W2134685432","https://openalex.org/W2137304121","https://openalex.org/W2138443291","https://openalex.org/W2139212933","https://openalex.org/W2139632945","https://openalex.org/W2148512898","https://openalex.org/W2148759288","https://openalex.org/W2149706766","https://openalex.org/W2152348310","https://openalex.org/W2168243241","https://openalex.org/W2284471954","https://openalex.org/W2321578212","https://openalex.org/W2344233596","https://openalex.org/W2405726538","https://openalex.org/W2413314876","https://openalex.org/W2414591521","https://openalex.org/W2424628474","https://openalex.org/W2468517437","https://openalex.org/W2566931670","https://openalex.org/W2567820440","https://openalex.org/W2600057717","https://openalex.org/W2751417367","https://openalex.org/W2755526779","https://openalex.org/W2793343947","https://openalex.org/W2911964244","https://openalex.org/W2973329262","https://openalex.org/W4236137412","https://openalex.org/W4237427043","https://openalex.org/W4253900403","https://openalex.org/W6675354045","https://openalex.org/W6731027119"],"related_works":["https://openalex.org/W2991075454","https://openalex.org/W2414842819","https://openalex.org/W3085118099","https://openalex.org/W2183216315","https://openalex.org/W2377398046","https://openalex.org/W2320290032","https://openalex.org/W4390727822","https://openalex.org/W2473993907","https://openalex.org/W2107560119","https://openalex.org/W2041632454"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Rheumatoid":[2],"arthritis":[3],"(RA)":[4],"is":[5],"an":[6,21,262,295],"autoimmune":[7],"disorder":[8],"with":[9,41,57,60,216,312,334],"systemic":[10],"inflammation":[11,335],"and":[12,38,63,95,126,130,134,139,164,184,209,252,277,279,326,328,336,354],"may":[13,189,331,358],"be":[14,190,332],"induced":[15],"by":[16],"oxidative":[17],"stress":[18],"that":[19,290,307,323,345],"affects":[20],"inflamed":[22],"joint.":[23],"Our":[24],"objectives":[25],"were":[26,68,100,143,152,169,213],"to":[27,272,283],"examine":[28],"isotypes":[29],"of":[30,44,122,147,161,174,200,231,303],"autoantibodies":[31,45,131,165,310],"against":[32,132],"4-hydroxy-2-nonenal":[33],"(HNE)":[34],"modifications":[35],"in":[36,46,149,158,166,221,339,362],"RA":[37,47,111,150,167,232,274,363],"associate":[39],"them":[40],"increased":[42,263],"levels":[43,121,157,199],"patients.":[48],"Methods":[49],"Serum":[50],"samples":[51],"from":[52,110,275],"155":[53],"female":[54],"patients":[55,112,151,168],"[60":[56],"RA,":[58],"35":[59],"osteoarthritis":[61],"(OA),":[62],"60":[64],"healthy":[65],"controls":[66],"(HCs)]":[67],"obtained.":[69],"Four":[70],"novel":[71],"differential":[72],"HNE-modified":[73,135],"peptide":[74],"adducts,":[75,129],"complement":[76],"factor":[77],"H":[78],"(CFAH)":[79],"1211\u20131230":[80],",":[81,85,94,99,183,208,353],"haptoglobin":[82],"(HPT)":[83],"78\u2013108":[84],"immunoglobulin":[86],"(Ig)":[87],"kappa":[88],"chain":[89],"C":[90],"region":[91],"(IGKC)":[92],"2\u201319":[93],"prothrombin":[96],"(THRB)":[97],"328\u2013345":[98],"re-analyzed":[101],"using":[102],"tandem":[103],"mass":[104],"spectrometric":[105],"(MS/MS)":[106],"spectra":[107],"(ProteomeXchange:":[108],"PXD004546)":[109],"vs":[113],".":[114],"HCs.":[115,159,175],"Further,":[116,228],"we":[117,266],"determined":[118],"serum":[119],"protein":[120,226],"CFAH,":[123],"HPT,":[124],"IGKC":[125],"THRB,":[127],"HNE-protein":[128,162],"unmodified":[133],"peptides.":[136],"Significant":[137],"correlations":[138],"odds":[140],"ratios":[141],"(ORs)":[142],"calculated.":[144],"Results":[145],"Levels":[146,160],"HPT":[148],"greatly":[153],"higher":[154],"than":[155,172],"the":[156,217,229,298],"adducts":[163],"significantly":[170],"greater":[171],"those":[173],"IgM":[176,180,185,201,205,235,244,346,350],"anti-HPT":[177,202,236,347],"78\u2212108":[178,203,237,348],"HNE,":[179,204,349],"anti-IGKC":[181,186,206,245,351],"2\u221219":[182,187,207,246,352],"HNE":[188,238],"considered":[191],"as":[192],"diagnostic":[193],"biomarkers":[194],"for":[195,224],"RA.":[196,318,340],"Importantly,":[197],"elevated":[198],"IgG":[210,253,355],"anti-THRB":[211,254,356],"328\u2212345":[212,255,357],"positively":[214],"correlated":[215,333],"disease":[218,337],"activity":[219,338],"score":[220],"28":[222],"joints":[223],"C-reactive":[225],"(DAS28-CRP).":[227],"ORs":[230],"development":[233],"through":[234],"(OR":[239,247,256],"5.235,":[240],"p":[241,249,258],"&lt;":[242,250,259],"0.001),":[243,251],"12.655,":[248],"5.761,":[257],"0.001)":[260],"showed":[261,289],"risk.":[264],"Lastly,":[265],"incorporated":[267],"three":[268],"machine":[269,313],"learning":[270,314],"models":[271],"differentiate":[273],"HC":[276],"OA,":[278],"performed":[280],"feature":[281],"selection":[282],"determine":[284],"discriminative":[285],"features.":[286],"Experimental":[287],"results":[288],"our":[291,308,342],"proposed":[292],"method":[293],"achieved":[294],"area":[296],"under":[297],"receiver":[299],"operating":[300],"characteristic":[301],"curve":[302],"0.92,":[304],"which":[305],"demonstrated":[306],"selected":[309],"combined":[311],"can":[315],"efficiently":[316],"detect":[317],"Conclusions":[319],"This":[320],"study":[321],"discovered":[322],"some":[324],"IgG-":[325],"IgM-NAAs":[327],"anti-HNE":[329],"M-NAAs":[330],"Moreover,":[341],"findings":[343],"suggested":[344],"play":[359],"heavy":[360],"roles":[361],"development.":[364]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
