{"id":"https://openalex.org/W2967193594","doi":"https://doi.org/10.1186/s12911-019-0888-7","title":"The effect of ICU-tailored drug-drug interaction alerts on medication prescribing and monitoring: protocol for a cluster randomized stepped-wedge trial","display_name":"The effect of ICU-tailored drug-drug interaction alerts on medication prescribing and monitoring: protocol for a cluster randomized stepped-wedge trial","publication_year":2019,"publication_date":"2019-08-13","ids":{"openalex":"https://openalex.org/W2967193594","doi":"https://doi.org/10.1186/s12911-019-0888-7","mag":"2967193594","pmid":"https://pubmed.ncbi.nlm.nih.gov/31409338"},"language":"en","primary_location":{"id":"doi:10.1186/s12911-019-0888-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-019-0888-7","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-019-0888-7","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-019-0888-7","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001267423","display_name":"Tinka Bakker","orcid":"https://orcid.org/0000-0002-7894-6926"},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"T. Bakker","raw_affiliation_strings":["Department of Medical Informatics, Amsterdam UMC (location AMC), Amsterdam, The Netherlands. t.bakker@amc.nl","Department of Medical Informatics, Amsterdam UMC (location AMC), Amsterdam, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-7894-6926","affiliations":[{"raw_affiliation_string":"Department of Medical Informatics, Amsterdam UMC (location AMC), Amsterdam, The Netherlands. t.bakker@amc.nl","institution_ids":["https://openalex.org/I887064364"]},{"raw_affiliation_string":"Department of Medical Informatics, Amsterdam UMC (location AMC), Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006311356","display_name":"Joanna E. Klopotowska","orcid":"https://orcid.org/0000-0002-9707-5740"},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J. E. Klopotowska","raw_affiliation_strings":["Department of Medical Informatics, Amsterdam UMC (location AMC), Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Informatics, Amsterdam UMC (location AMC), Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081689734","display_name":"Saeid Eslami","orcid":"https://orcid.org/0000-0003-3755-1212"},"institutions":[{"id":"https://openalex.org/I165560825","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033","country_code":"IR","type":"education","lineage":["https://openalex.org/I165560825"]},{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["IR","NL"],"is_corresponding":false,"raw_author_name":"S. Eslami","raw_affiliation_strings":["Department of Medical Informatics, Amsterdam UMC (location AMC), Amsterdam, The Netherlands","Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Informatics, Amsterdam UMC (location AMC), Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833"]},{"raw_affiliation_string":"Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran","institution_ids":["https://openalex.org/I165560825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014206473","display_name":"Dylan W. de Lange","orcid":"https://orcid.org/0000-0002-0191-7270"},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"D. W. de Lange","raw_affiliation_strings":["Department of Intensive Care and Dutch Poison Information Center, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care and Dutch Poison Information Center, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042146189","display_name":"Rob J. van Marum","orcid":"https://orcid.org/0000-0003-4292-532X"},"institutions":[{"id":"https://openalex.org/I4210108594","display_name":"Amsterdam Neuroscience","ror":"https://ror.org/01x2d9f70","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210108594"]},{"id":"https://openalex.org/I4210160169","display_name":"Jeroen Bosch Ziekenhuis","ror":"https://ror.org/04rr42t68","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210160169"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R. van Marum","raw_affiliation_strings":["Department of General Practice and Elderly Care Medicine, Amsterdam UMC (location VUmc), Amsterdam, The Netherlands","Department of Geriatrics, Jeroen Bosch Hospital, s-Hertogenbosch, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Practice and Elderly Care Medicine, Amsterdam UMC (location VUmc), Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210108594"]},{"raw_affiliation_string":"Department of Geriatrics, Jeroen Bosch Hospital, s-Hertogenbosch, The Netherlands","institution_ids":["https://openalex.org/I4210160169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049821587","display_name":"Heleen van der Sijs","orcid":"https://orcid.org/0000-0002-1744-0999"},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"H. van der Sijs","raw_affiliation_strings":["Department of Hospital Pharmacy, Erasmus MC, University Medical Center, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hospital Pharmacy, Erasmus MC, University Medical Center, Rotterdam, The Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002897147","display_name":"Evert de Jonge","orcid":"https://orcid.org/0000-0003-1431-8039"},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"E. de Jonge","raw_affiliation_strings":["Department of Intensive Care, Leiden University Medical Center, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care, Leiden University Medical Center, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079156237","display_name":"Dave A. Dongelmans","orcid":"https://orcid.org/0000-0001-8477-6671"},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"D. A. Dongelmans","raw_affiliation_strings":["Department of Intensive Care Medicine, Amsterdam UMC (location AMC), Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intensive Care Medicine, Amsterdam UMC (location AMC), Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108109798","display_name":"N. F. de Keizer","orcid":null},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"N. F. de Keizer","raw_affiliation_strings":["Department of Medical Informatics, Amsterdam UMC (location AMC), Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Informatics, Amsterdam UMC (location AMC), Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075388940","display_name":"Ameen Abu\u2013Hanna","orcid":"https://orcid.org/0000-0003-4324-7954"},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A. Abu-Hanna","raw_affiliation_strings":["Department of Medical Informatics, Amsterdam UMC (location AMC), Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Informatics, Amsterdam UMC (location AMC), Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I4210151833"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5001267423"],"corresponding_institution_ids":["https://openalex.org/I4210151833","https://openalex.org/I887064364"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":2.8356,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.92134831,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"19","issue":"1","first_page":"159","last_page":"159"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10350","display_name":"Electronic Health Records Systems","score":0.38339999318122864,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10350","display_name":"Electronic Health Records Systems","score":0.38339999318122864,"subfield":{"id":"https://openalex.org/subfields/3605","display_name":"Health Information Management"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.1964000016450882,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10508","display_name":"Patient Safety and Medication Errors","score":0.16660000383853912,"subfield":{"id":"https://openalex.org/subfields/3604","display_name":"Emergency Medical Services"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.8751993179321289},{"id":"https://openalex.org/keywords/clinical-decision-support-system","display_name":"Clinical decision support system","score":0.6187556982040405},{"id":"https://openalex.org/keywords/intensive-care-unit","display_name":"Intensive care unit","score":0.5564621686935425},{"id":"https://openalex.org/keywords/polypharmacy","display_name":"Polypharmacy","score":0.5267414450645447},{"id":"https://openalex.org/keywords/randomized-controlled-trial","display_name":"Randomized controlled trial","score":0.5187966227531433},{"id":"https://openalex.org/keywords/emergency-medicine","display_name":"Emergency medicine","score":0.48895204067230225},{"id":"https://openalex.org/keywords/protocol","display_name":"Protocol (science)","score":0.44121071696281433},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.4403853714466095},{"id":"https://openalex.org/keywords/patient-safety","display_name":"Patient safety","score":0.43925753235816956},{"id":"https://openalex.org/keywords/intensive-care-medicine","display_name":"Intensive care medicine","score":0.41391319036483765},{"id":"https://openalex.org/keywords/medical-emergency","display_name":"Medical emergency","score":0.35042768716812134},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.21959039568901062},{"id":"https://openalex.org/keywords/decision-support-system","display_name":"Decision support system","score":0.19198822975158691},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.14473789930343628},{"id":"https://openalex.org/keywords/health-care","display_name":"Health care","score":0.14371219277381897},{"id":"https://openalex.org/keywords/alternative-medicine","display_name":"Alternative medicine","score":0.09857037663459778}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8751993179321289},{"id":"https://openalex.org/C63527458","wikidata":"https://www.wikidata.org/wiki/Q5133829","display_name":"Clinical decision support system","level":3,"score":0.6187556982040405},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.5564621686935425},{"id":"https://openalex.org/C36434225","wikidata":"https://www.wikidata.org/wiki/Q1895998","display_name":"Polypharmacy","level":2,"score":0.5267414450645447},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5187966227531433},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.48895204067230225},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.44121071696281433},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4403853714466095},{"id":"https://openalex.org/C2779328685","wikidata":"https://www.wikidata.org/wiki/Q1475557","display_name":"Patient safety","level":3,"score":0.43925753235816956},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.41391319036483765},{"id":"https://openalex.org/C545542383","wikidata":"https://www.wikidata.org/wiki/Q2751242","display_name":"Medical emergency","level":1,"score":0.35042768716812134},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21959039568901062},{"id":"https://openalex.org/C107327155","wikidata":"https://www.wikidata.org/wiki/Q330268","display_name":"Decision support system","level":2,"score":0.19198822975158691},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.14473789930343628},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.14371219277381897},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.09857037663459778},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002985","descriptor_name":"Clinical Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002985","descriptor_name":"Clinical Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002985","descriptor_name":"Clinical Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006760","descriptor_name":"Hospitalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007362","descriptor_name":"Intensive Care Units","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007362","descriptor_name":"Intensive Care Units","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007362","descriptor_name":"Intensive Care Units","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007362","descriptor_name":"Intensive Care Units","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007362","descriptor_name":"Intensive Care Units","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020000","descriptor_name":"Decision Support Systems, Clinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":13,"locations":[{"id":"doi:10.1186/s12911-019-0888-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-019-0888-7","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-019-0888-7","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},{"id":"pmid:31409338","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31409338","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical informatics and decision making","raw_type":null},{"id":"pmh:oai:pure.eur.nl:openaire/22785716-49fe-4792-89c9-47ad5140880a","is_oa":true,"landing_page_url":"https://pure.eur.nl/en/publications/22785716-49fe-4792-89c9-47ad5140880a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bakker, T, Klopotowska, JE, Eslami, S, de Lange, DW, van Marum, R, van der Sijs, H, Jonge, E, Dongelmans, DA, de Keizer, NF & Abu-Hanna, A 2019, 'The effect of ICU-tailored drug-drug interaction alerts on medication prescribing and monitoring: protocol for a cluster randomized stepped-wedge trial', BMC Medical Informatics and Decision Making, vol. 19, no. 1, 159. https://doi.org/10.1186/s12911-019-0888-7","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/2fecd142-b0b7-4e28-8856-929797124269","is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/2fecd142-b0b7-4e28-8856-929797124269","pdf_url":"https://pure.amsterdamumc.nl/ws/files/157473483/The-effect-of-icu-tailored-drug-drug-interaction-alerts-on-medication-prescribing-and-monitoring-protocol-for-a-cluster.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Bakker, T, Klopotowska, J E, Eslami, S, de Lange, D W, van Marum, R, van der Sijs, H, de Jonge, E, Dongelmans, D A, de Keizer, N F & Abu-Hanna, A 2019, 'The effect of ICU-tailored drug-drug interaction alerts on medication prescribing and monitoring: Protocol for a cluster randomized stepped-wedge trial', BMC medical informatics and decision making, vol. 19, no. 1, 159, pp. 159. https://doi.org/10.1186/s12911-019-0888-7","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/0b0852de-60ef-4862-aaee-a92d31cad0f7","is_oa":true,"landing_page_url":"https://pure.amc.nl/en/publications/the-effect-of-icutailored-drugdrug-interaction-alerts-on-medication-prescribing-and-monitoring-protocol-for-a-cluster-randomized-steppedwedge-trial(0b0852de-60ef-4862-aaee-a92d31cad0f7).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC medical informatics and decision making, 19(1):159. BioMed Central","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:repub.eur.nl:119058","is_oa":true,"landing_page_url":"http://hdl.handle.net/1765/119058","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"B M C Medical Informatics and Decision Making, 19(1)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:lumc:oai:openaccess.leidenuniv.nl:1887/120921","is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/120921","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"VOLUME=19;ISSUE=1;TITLE=None","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:84f615f1c9f94f9baac601f89162e325","is_oa":true,"landing_page_url":"https://doaj.org/article/84f615f1c9f94f9baac601f89162e325","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Informatics and Decision Making, Vol 19, Iss 1, Pp 1-10 (2019)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5644710","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6692933","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:repub.eur.nl:119058","is_oa":true,"landing_page_url":"http://repub.eur.nl/pub/119058","pdf_url":null,"source":{"id":"https://openalex.org/S4377196287","display_name":"RePub (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"B M C Medical Informatics and Decision Making vol. 19 no. 1","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_2986290","is_oa":false,"landing_page_url":"https://hdl.handle.net/1887/120921","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"Article / Letter to editor"},{"id":"pmh:umcu:oai:dspace.library.uu.nl:1874/388732","is_oa":true,"landing_page_url":"https://dspace.library.uu.nl/handle/1874/388732","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Informatics and Decision Making, 19(1). BioMed Central","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:vumc:oai:pure.atira.dk:publications/0391de09-8456-4ef3-a196-0c5e65fb9e88","is_oa":true,"landing_page_url":"https://research.vumc.nl/en/publications/0391de09-8456-4ef3-a196-0c5e65fb9e88","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Informatics and Decision Making, 19(1):159. BioMed Central","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1186/s12911-019-0888-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-019-0888-7","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-019-0888-7","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4699999988079071,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G2210021695","display_name":null,"funder_award_id":"80\u201383600\u201398\u201340140","funder_id":"https://openalex.org/F4320321007","funder_display_name":"ZonMw"}],"funders":[{"id":"https://openalex.org/F4320321007","display_name":"ZonMw","ror":"https://ror.org/01yaj9a77"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2967193594.pdf","grobid_xml":"https://content.openalex.org/works/W2967193594.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W50282668","https://openalex.org/W1437651867","https://openalex.org/W1512542755","https://openalex.org/W1514832654","https://openalex.org/W1951965559","https://openalex.org/W1977226999","https://openalex.org/W2002486484","https://openalex.org/W2030775318","https://openalex.org/W2060447171","https://openalex.org/W2078247782","https://openalex.org/W2079215577","https://openalex.org/W2089218471","https://openalex.org/W2101754128","https://openalex.org/W2107318542","https://openalex.org/W2109587213","https://openalex.org/W2110922423","https://openalex.org/W2112215637","https://openalex.org/W2118734816","https://openalex.org/W2164590486","https://openalex.org/W2166023752","https://openalex.org/W2167601673","https://openalex.org/W2177518629","https://openalex.org/W2177849715","https://openalex.org/W2257208207","https://openalex.org/W2529453173","https://openalex.org/W2550283493","https://openalex.org/W2560280054","https://openalex.org/W2589497695","https://openalex.org/W2590778886","https://openalex.org/W2749694042","https://openalex.org/W2766129742","https://openalex.org/W2789073150","https://openalex.org/W2789922031","https://openalex.org/W2885961185","https://openalex.org/W4304182209"],"related_works":["https://openalex.org/W4310739378","https://openalex.org/W2594890405","https://openalex.org/W2103640491","https://openalex.org/W2398672653","https://openalex.org/W3028382539","https://openalex.org/W2171692026","https://openalex.org/W2269921241","https://openalex.org/W2983667031","https://openalex.org/W1997275959","https://openalex.org/W2998462387"],"abstract_inverted_index":{"BACKGROUND:":[0],"Drug-drug":[1],"interactions":[2,113],"(DDIs)":[3],"can":[4,271],"cause":[5],"patient":[6,193],"harm.":[7],"Between":[8],"46":[9],"and":[10,76,218,281],"90%":[11],"of":[12,61,70,98,106,121,185,232,257,260,268,276],"patients":[13,34],"admitted":[14],"to":[15,23,47,102,205,216,263],"the":[16,51,67,71,90,104,115,119,129,156,163,170,191,199,208,211,223,230,248,258,273,279],"Intensive":[17],"Care":[18],"Unit":[19],"(ICU)":[20],"are":[21,86,151],"exposed":[22],"potential":[24,46],"DDIs":[25],"(pDDIs).":[26],"This":[27,241],"rate":[28],"is":[29,56,93,101,162,229],"twice":[30],"as":[31,33,285],"high":[32],"on":[35,83,109,118,169],"general":[36],"wards.":[37],"Clinical":[38],"decision":[39],"support":[40],"systems":[41],"(CDSSs)":[42],"have":[43],"shown":[44],"their":[45],"prevent":[48],"pDDIs.":[49,173,266],"However,":[50,81],"literature":[52],"shows":[53],"that":[54,165],"there":[55],"considerable":[57],"room":[58],"for":[59,114,155,247],"improvement":[60],"CDSSs,":[62],"in":[63,89,141,179,197,207,222,278,282],"particular":[64],"by":[65],"increasing":[66],"clinical":[68],"relevance":[69],"pDDI":[72],"alerts":[73,107,167,261],"they":[74],"generate":[75],"thereby":[77],"reducing":[78],"alert":[79],"fatigue.":[80],"consensus":[82],"which":[84,142,149,198],"pDDIs":[85,122,150,235,245],"clinically":[87,111,130,153,171,233,264],"relevant":[88,112,131,154,172,234,246,265],"ICU":[91,116,158,249,280],"setting":[92,117],"lacking.":[94],"The":[95,160,174],"primary":[96,226],"aim":[97],"this":[99],"study":[100,242],"evaluate":[103],"effect":[105],"based":[108,168],"only":[110],"prevention":[120],"among":[123],"Dutch":[124,157,187],"ICUs.":[125],"METHODS:":[126],"To":[127],"define":[128],"pDDIs,":[132],"we":[133],"will":[134,147,176,201,219,243,252],"follow":[135],"a":[136,143,180],"rigorous":[137],"two-step":[138],"Delphi":[139],"procedure":[140],"national":[144],"expert":[145],"panel":[146],"assess":[148],"perceived":[152],"setting.":[159,250],"intervention":[161,175],"CDSS":[164,200],"generates":[166],"be":[177,220],"evaluated":[178],"stepped-wedge":[181],"trial.":[182,209,224],"A":[183],"total":[184],"12":[186,212],"adult":[188],"ICUs":[189],"using":[190],"same":[192],"data":[194],"management":[195],"system,":[196],"operate,":[202],"were":[203],"invited":[204],"participate":[206,217],"Of":[210],"ICUs,":[213],"9":[214],"agreed":[215],"enrolled":[221],"Our":[225],"outcome":[227],"measure":[228],"incidence":[231],"per":[236],"1000":[237],"medication":[238],"administrations.":[239],"DISCUSSION:":[240],"identify":[244],"It":[251],"also":[253],"enhance":[254],"our":[255],"understanding":[256],"effectiveness":[259],"confined":[262],"Both":[267],"these":[269],"contributions":[270],"facilitate":[272],"successful":[274],"implementation":[275],"CDSSs":[277],"other":[283],"domains":[284],"well.":[286],"TRIAL":[287],"REGISTRATION:":[288],"Nederlands":[289],"Trial":[290],"register":[291],"Identifier:":[292],"NL6762":[293],".":[294],"Registered":[295],"November":[296],"26,":[297],"2018.":[298]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5}],"updated_date":"2026-08-02T14:50:37.381335","created_date":"2025-10-10T00:00:00"}