{"id":"https://openalex.org/W2911876118","doi":"https://doi.org/10.1186/s12911-019-0743-x","title":"Treatment recommendations to cancer patients in the context of FDA guidance for next generation sequencing","display_name":"Treatment recommendations to cancer patients in the context of FDA guidance for next generation sequencing","publication_year":2019,"publication_date":"2019-01-18","ids":{"openalex":"https://openalex.org/W2911876118","doi":"https://doi.org/10.1186/s12911-019-0743-x","mag":"2911876118","pmid":"https://pubmed.ncbi.nlm.nih.gov/30658646"},"language":"en","primary_location":{"id":"doi:10.1186/s12911-019-0743-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-019-0743-x","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-019-0743-x","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-019-0743-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025646273","display_name":"Grace K. Dy","orcid":"https://orcid.org/0000-0002-5061-0072"},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Grace K. Dy","raw_affiliation_strings":["Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071349192","display_name":"Mary Nesline","orcid":"https://orcid.org/0000-0003-0523-4597"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary K. Nesline","raw_affiliation_strings":["OmniSeq, Inc., Buffalo, NY, 14203, USA"],"affiliations":[{"raw_affiliation_string":"OmniSeq, Inc., Buffalo, NY, 14203, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049142712","display_name":"Antonios Papanicolau\u2010Sengos","orcid":"https://orcid.org/0009-0008-9276-7052"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonios Papanicolau-Sengos","raw_affiliation_strings":["OmniSeq, Inc., Buffalo, NY, 14203, USA"],"affiliations":[{"raw_affiliation_string":"OmniSeq, Inc., Buffalo, NY, 14203, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028036101","display_name":"Paul DePietro","orcid":"https://orcid.org/0000-0001-9072-0631"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul DePietro","raw_affiliation_strings":["OmniSeq, Inc., Buffalo, NY, 14203, USA"],"affiliations":[{"raw_affiliation_string":"OmniSeq, Inc., Buffalo, NY, 14203, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035002650","display_name":"Charles LeVea","orcid":"https://orcid.org/0000-0001-7443-0968"},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles M. LeVea","raw_affiliation_strings":["Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111187382","display_name":"Amy Early","orcid":null},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Early","raw_affiliation_strings":["Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104193303","display_name":"Hongbin Chen","orcid":"https://orcid.org/0009-0008-1649-8620"},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongbin Chen","raw_affiliation_strings":["Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112566920","display_name":"Anne Grand\u2019Maison","orcid":null},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne Grand\u2019Maison","raw_affiliation_strings":["Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069585958","display_name":"Patrick M. Boland","orcid":"https://orcid.org/0000-0002-4213-8847"},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Boland","raw_affiliation_strings":["Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089516753","display_name":"Marc S. Ernstoff","orcid":"https://orcid.org/0000-0002-8132-7069"},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc S. Ernstoff","raw_affiliation_strings":["Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019007552","display_name":"Stephen B. Edge","orcid":"https://orcid.org/0000-0002-3285-6191"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen Edge","raw_affiliation_strings":["Sandra and Edward Meyer Cancer Center, New York, NY, 10065, USA"],"affiliations":[{"raw_affiliation_string":"Sandra and Edward Meyer Cancer Center, New York, NY, 10065, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061166200","display_name":"Stacey N. Akers","orcid":null},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stacey Akers","raw_affiliation_strings":["Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079022151","display_name":"Mateusz Opyrchal","orcid":"https://orcid.org/0000-0003-2454-7441"},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mateusz Opyrchal","raw_affiliation_strings":["Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089256383","display_name":"Gurkamal Chatta","orcid":"https://orcid.org/0000-0002-3154-9042"},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gurkamal Chatta","raw_affiliation_strings":["Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009400324","display_name":"Kunle Odunsi","orcid":"https://orcid.org/0000-0002-4444-7651"},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kunle Odunsi","raw_affiliation_strings":["Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067217729","display_name":"Sarabjot Pabla","orcid":"https://orcid.org/0000-0002-7746-9144"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarabjot Pabla","raw_affiliation_strings":["OmniSeq, Inc., Buffalo, NY, 14203, USA"],"affiliations":[{"raw_affiliation_string":"OmniSeq, Inc., Buffalo, NY, 14203, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027499943","display_name":"Jeffrey M. Conroy","orcid":"https://orcid.org/0000-0003-1764-9706"},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey M. Conroy","raw_affiliation_strings":["Center for Personalized Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA","OmniSeq, Inc., Buffalo, NY, 14203, USA"],"affiliations":[{"raw_affiliation_string":"Center for Personalized Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"OmniSeq, Inc., Buffalo, NY, 14203, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104275868","display_name":"Sean T. Glenn","orcid":null},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I4210145812","display_name":"Cancer Genetics (United States)","ror":"https://ror.org/05feyya22","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean T. Glenn","raw_affiliation_strings":["Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA","OmniSeq, Inc., Buffalo, NY, 14203, USA"],"affiliations":[{"raw_affiliation_string":"Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I4210145812"]},{"raw_affiliation_string":"OmniSeq, Inc., Buffalo, NY, 14203, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003971102","display_name":"Hanchun T. DeFedericis","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hanchun T. DeFedericis","raw_affiliation_strings":["OmniSeq, Inc., Buffalo, NY, 14203, USA"],"affiliations":[{"raw_affiliation_string":"OmniSeq, Inc., Buffalo, NY, 14203, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048078683","display_name":"Blake Burgher","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Blake Burgher","raw_affiliation_strings":["OmniSeq, Inc., Buffalo, NY, 14203, USA"],"affiliations":[{"raw_affiliation_string":"OmniSeq, Inc., Buffalo, NY, 14203, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110532419","display_name":"Jonathan Andreas","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan Andreas","raw_affiliation_strings":["OmniSeq, Inc., Buffalo, NY, 14203, USA"],"affiliations":[{"raw_affiliation_string":"OmniSeq, Inc., Buffalo, NY, 14203, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063874520","display_name":"Vincent Giamo","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vincent Giamo","raw_affiliation_strings":["OmniSeq, Inc., Buffalo, NY, 14203, USA"],"affiliations":[{"raw_affiliation_string":"OmniSeq, Inc., Buffalo, NY, 14203, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046333101","display_name":"Maochun Qin","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maochun Qin","raw_affiliation_strings":["OmniSeq, Inc., Buffalo, NY, 14203, USA"],"affiliations":[{"raw_affiliation_string":"OmniSeq, Inc., Buffalo, NY, 14203, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100676295","display_name":"Yirong Wang","orcid":"https://orcid.org/0000-0002-1995-2728"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yirong Wang","raw_affiliation_strings":["OmniSeq, Inc., Buffalo, NY, 14203, USA"],"affiliations":[{"raw_affiliation_string":"OmniSeq, Inc., Buffalo, NY, 14203, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033856452","display_name":"Kazunori Kanehira","orcid":null},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kazunori Kanehira","raw_affiliation_strings":["Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA"],"affiliations":[{"raw_affiliation_string":"Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044114322","display_name":"Felicia L. Lenzo","orcid":"https://orcid.org/0000-0002-7583-8727"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Felicia L. Lenzo","raw_affiliation_strings":["OmniSeq, Inc., Buffalo, NY, 14203, USA"],"affiliations":[{"raw_affiliation_string":"OmniSeq, Inc., Buffalo, NY, 14203, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103432916","display_name":"Peter J. Frederick","orcid":null},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Frederick","raw_affiliation_strings":["Division of Gynecologic Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA"],"affiliations":[{"raw_affiliation_string":"Division of Gynecologic Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056321055","display_name":"Shashikant Lele","orcid":"https://orcid.org/0000-0002-6207-8159"},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shashikant Lele","raw_affiliation_strings":["Division of Gynecologic Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA"],"affiliations":[{"raw_affiliation_string":"Division of Gynecologic Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071827163","display_name":"Lorenzo Galluzzi","orcid":"https://orcid.org/0000-0003-2257-8500"},"institutions":[{"id":"https://openalex.org/I110736937","display_name":"D\u00e9l\u00e9gation Paris 5","ror":"https://ror.org/02e0y6e06","country_code":"FR","type":"government","lineage":["https://openalex.org/I110736937","https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["FR","US"],"is_corresponding":false,"raw_author_name":"Lorenzo Galluzzi","raw_affiliation_strings":["Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, 10065, USA","Sandra and Edward Meyer Cancer Center, New York, NY, 10065, USA","Universit\u00e9 Paris Descartes/Paris V, Paris, France"],"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Sandra and Edward Meyer Cancer Center, New York, NY, 10065, USA","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 Paris Descartes/Paris V, Paris, France","institution_ids":["https://openalex.org/I110736937","https://openalex.org/I204730241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044034621","display_name":"Boris W. Kuvshinoff","orcid":"https://orcid.org/0000-0002-2550-792X"},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boris Kuvshinoff","raw_affiliation_strings":["Department of Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA"],"affiliations":[{"raw_affiliation_string":"Department of Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059394561","display_name":"Carl Morrison","orcid":"https://orcid.org/0000-0002-3441-8363"},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]},{"id":"https://openalex.org/I4210144447","display_name":"OMNI Institute","ror":"https://ror.org/044z3jj38","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210144447"]},{"id":"https://openalex.org/I4210145812","display_name":"Cancer Genetics (United States)","ror":"https://ror.org/05feyya22","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145812"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl Morrison","raw_affiliation_strings":["Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA. Carl.Morrison@Omniseq.com","Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA. Carl.Morrison@Omniseq.com","OmniSeq, Inc., Buffalo, NY, 14203, USA. Carl.Morrison@Omniseq.com","Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA"],"affiliations":[{"raw_affiliation_string":"Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA. Carl.Morrison@Omniseq.com","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"Department of Pathology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA. Carl.Morrison@Omniseq.com","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"OmniSeq, Inc., Buffalo, NY, 14203, USA. Carl.Morrison@Omniseq.com","institution_ids":["https://openalex.org/I4210144447"]},{"raw_affiliation_string":"Cancer Genetics and Genomics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, 14263, USA","institution_ids":["https://openalex.org/I1292894508","https://openalex.org/I4210145812"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":31,"corresponding_author_ids":["https://openalex.org/A5025646273"],"corresponding_institution_ids":["https://openalex.org/I1292894508"],"apc_list":{"value":1570,"currency":"GBP","value_usd":1925},"apc_paid":{"value":1570,"currency":"GBP","value_usd":1925},"fwci":1.2229,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.7492163,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"19","issue":"1","first_page":"14","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.9805999994277954,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.8607720136642456},{"id":"https://openalex.org/keywords/neuroblastoma-ras-viral-oncogene-homolog","display_name":"Neuroblastoma RAS viral oncogene homolog","score":0.5362982153892517},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.5221736431121826},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.5189868807792664},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.5056805610656738},{"id":"https://openalex.org/keywords/kras","display_name":"KRAS","score":0.5037817358970642},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"Targeted therapy","score":0.4880322515964508},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.42204397916793823},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3916740417480469},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.38564375042915344},{"id":"https://openalex.org/keywords/medical-physics","display_name":"Medical physics","score":0.37463808059692383},{"id":"https://openalex.org/keywords/family-medicine","display_name":"Family medicine","score":0.36803120374679565},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"Colorectal cancer","score":0.1577700674533844},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.1470475196838379}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8607720136642456},{"id":"https://openalex.org/C21790070","wikidata":"https://www.wikidata.org/wiki/Q18030215","display_name":"Neuroblastoma RAS viral oncogene homolog","level":5,"score":0.5362982153892517},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.5221736431121826},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5189868807792664},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5056805610656738},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.5037817358970642},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.4880322515964508},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.42204397916793823},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3916740417480469},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38564375042915344},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.37463808059692383},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.36803120374679565},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.1577700674533844},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1470475196838379},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000071185","descriptor_name":"Pharmacogenomic Testing","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D000071185","descriptor_name":"Pharmacogenomic Testing","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D000071185","descriptor_name":"Pharmacogenomic Testing","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D000076610","descriptor_name":"Genetic Profile","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000076610","descriptor_name":"Genetic Profile","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000076610","descriptor_name":"Genetic Profile","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014486","descriptor_name":"United States Food and Drug Administration","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D014486","descriptor_name":"United States Food and Drug Administration","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D014486","descriptor_name":"United States Food and Drug Administration","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12911-019-0743-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-019-0743-x","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-019-0743-x","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},{"id":"pmid:30658646","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30658646","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical informatics and decision making","raw_type":null},{"id":"pmh:oai:doaj.org/article:5167cae0cf364fa38ba58c2973088fd1","is_oa":true,"landing_page_url":"https://doaj.org/article/5167cae0cf364fa38ba58c2973088fd1","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Informatics and Decision Making, Vol 19, Iss 1, Pp 1-10 (2019)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5323043","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6339275","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6339275","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6339275","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Med Inform Decis Mak","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12911-019-0743-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-019-0743-x","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-019-0743-x","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6499999761581421,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2911876118.pdf","grobid_xml":"https://content.openalex.org/works/W2911876118.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W2101328245","https://openalex.org/W2145922766","https://openalex.org/W2161375781","https://openalex.org/W2538407824","https://openalex.org/W2563438326","https://openalex.org/W2589779797","https://openalex.org/W2593592675","https://openalex.org/W2603411876","https://openalex.org/W2700576167","https://openalex.org/W2727809020","https://openalex.org/W2751199652","https://openalex.org/W2787507991"],"related_works":["https://openalex.org/W3107421140","https://openalex.org/W1551540110","https://openalex.org/W4290998609","https://openalex.org/W1999993116","https://openalex.org/W2407092213","https://openalex.org/W2803208177","https://openalex.org/W2561800150","https://openalex.org/W3007730235","https://openalex.org/W2518932857","https://openalex.org/W2789840033"],"abstract_inverted_index":{"We":[0],"found":[1],"an":[2],"appropriate":[3],"\"dose-response\"":[4],"relationship":[5],"between":[6],"the":[7],"strength":[8],"of":[9,19,37],"clinical":[10],"evidence":[11],"supporting":[12],"biomarker-directed":[13],"targeted":[14],"therapy":[15],"based":[16,56],"on":[17,57],"application":[18],"FDA":[20],"guidance":[21],"for":[22,53],"NGS":[23,54],"test":[24],"variant":[25],"classification,":[26],"and":[27,49],"subsequent":[28],"treatment":[29],"recommendations":[30],"made":[31],"by":[32],"treating":[33],"physicians.":[34],"In":[35],"view":[36],"recent":[38],"changes":[39],"at":[40],"FDA,":[41],"it":[42],"is":[43],"paramount":[44],"to":[45],"define":[46],"regulatory":[47],"grounds":[48],"medical":[50],"policy":[51],"coverage":[52],"testing":[55],"this":[58],"guidance.":[59]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}