{"id":"https://openalex.org/W2899401372","doi":"https://doi.org/10.1186/s12911-018-0680-0","title":"SwissMTB: establishing comprehensive molecular cancer diagnostics in Swiss clinics","display_name":"SwissMTB: establishing comprehensive molecular cancer diagnostics in Swiss clinics","publication_year":2018,"publication_date":"2018-10-29","ids":{"openalex":"https://openalex.org/W2899401372","doi":"https://doi.org/10.1186/s12911-018-0680-0","mag":"2899401372","pmid":"https://pubmed.ncbi.nlm.nih.gov/30373609"},"language":"en","primary_location":{"id":"doi:10.1186/s12911-018-0680-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-018-0680-0","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-018-0680-0","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-018-0680-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005041697","display_name":"Franziska Singer","orcid":"https://orcid.org/0000-0002-6017-1595"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Franziska Singer","raw_affiliation_strings":["NEXUS Personalized Health Technologies, ETH Zurich, Otto-Stern-Weg 7, 8093, Zurich, Switzerland","SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NEXUS Personalized Health Technologies, ETH Zurich, Otto-Stern-Weg 7, 8093, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066422713","display_name":"Anja Irmisch","orcid":"https://orcid.org/0000-0001-9820-1844"},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital of Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"funder","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Anja Irmisch","raw_affiliation_strings":["Department of Dermatology, University Hospital Zurich, 8091, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University Hospital Zurich, 8091, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078378799","display_name":"Nora C. Toussaint","orcid":"https://orcid.org/0000-0001-7911-7647"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nora C. Toussaint","raw_affiliation_strings":["NEXUS Personalized Health Technologies, ETH Zurich, Otto-Stern-Weg 7, 8093, Zurich, Switzerland","SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NEXUS Personalized Health Technologies, ETH Zurich, Otto-Stern-Weg 7, 8093, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014610359","display_name":"Linda Grob","orcid":"https://orcid.org/0000-0003-3817-7613"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Linda Grob","raw_affiliation_strings":["NEXUS Personalized Health Technologies, ETH Zurich, Otto-Stern-Weg 7, 8093, Zurich, Switzerland","SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NEXUS Personalized Health Technologies, ETH Zurich, Otto-Stern-Weg 7, 8093, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054504245","display_name":"Jochen Singer","orcid":"https://orcid.org/0000-0003-0001-8625"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jochen Singer","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, 4058, Basel, Switzerland","SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, 4058, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013321226","display_name":"Thomas Thurnherr","orcid":null},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thomas Thurnherr","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, 4058, Basel, Switzerland","SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, 4058, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035497488","display_name":"Niko Beerenwinkel","orcid":"https://orcid.org/0000-0002-0573-6119"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Niko Beerenwinkel","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, 4058, Basel, Switzerland","SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, 4058, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102813612","display_name":"Mitchell P. Levesque","orcid":"https://orcid.org/0000-0002-1830-6265"},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital of Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"funder","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mitchell P. Levesque","raw_affiliation_strings":["Department of Dermatology, University Hospital Zurich, 8091, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University Hospital Zurich, 8091, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089297467","display_name":"Reinhard Dummer","orcid":"https://orcid.org/0000-0002-2279-6906"},"institutions":[{"id":"https://openalex.org/I4210100468","display_name":"University Hospital of Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"funder","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Reinhard Dummer","raw_affiliation_strings":["Department of Dermatology, University Hospital Zurich, 8091, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University Hospital Zurich, 8091, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020138514","display_name":"Luca Quagliata","orcid":"https://orcid.org/0000-0001-8249-9914"},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Luca Quagliata","raw_affiliation_strings":["Department of Pathology, University Hospital Basel, Sch\u00f6nbeinstrasse 40, 4056, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University Hospital Basel, Sch\u00f6nbeinstrasse 40, 4056, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007155024","display_name":"Sacha I. Rothschild","orcid":"https://orcid.org/0000-0003-1304-9340"},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Sacha I. Rothschild","raw_affiliation_strings":["Division of Oncology, Department of Biomedicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Biomedicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012693904","display_name":"Andreas Wicki","orcid":"https://orcid.org/0000-0002-2924-8080"},"institutions":[{"id":"https://openalex.org/I2802542264","display_name":"University Hospital of Basel","ror":"https://ror.org/04k51q396","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802542264"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Andreas Wicki","raw_affiliation_strings":["Division of Oncology, Department of Biomedicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Biomedicine, University Hospital Basel, Petersgraben 4, 4031, Basel, Switzerland","institution_ids":["https://openalex.org/I2802542264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053668445","display_name":"Christian Beisel","orcid":"https://orcid.org/0000-0001-5360-2193"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Christian Beisel","raw_affiliation_strings":["Department of Biosystems Science and Engineering, ETH Zurich, 4058, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biosystems Science and Engineering, ETH Zurich, 4058, Basel, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085494082","display_name":"Daniel J. Stekhoven","orcid":"https://orcid.org/0000-0003-3163-3161"},"institutions":[{"id":"https://openalex.org/I12708293","display_name":"SIB Swiss Institute of Bioinformatics","ror":"https://ror.org/002n09z45","country_code":"CH","type":"nonprofit","lineage":["https://openalex.org/I12708293"]},{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Daniel J. Stekhoven","raw_affiliation_strings":["NEXUS Personalized Health Technologies, ETH Zurich, Otto-Stern-Weg 7, 8093, Zurich, Switzerland. stekhoven@nexus.ethz.ch","SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland. stekhoven@nexus.ethz.ch","SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-3163-3161","affiliations":[{"raw_affiliation_string":"NEXUS Personalized Health Technologies, ETH Zurich, Otto-Stern-Weg 7, 8093, Zurich, Switzerland. stekhoven@nexus.ethz.ch","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland. stekhoven@nexus.ethz.ch","institution_ids":["https://openalex.org/I12708293"]},{"raw_affiliation_string":"SIB Swiss Institute of Bioinformatics, 4058, Basel, Switzerland","institution_ids":["https://openalex.org/I12708293"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5005041697"],"corresponding_institution_ids":["https://openalex.org/I12708293","https://openalex.org/I35440088"],"apc_list":{"value":1570,"currency":"GBP","value_usd":1925},"apc_paid":{"value":1570,"currency":"GBP","value_usd":1925},"fwci":1.1206,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.74314309,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"18","issue":"1","first_page":"89","last_page":"89"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.7886000275611877,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.7886000275611877,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.023099999874830246,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.022199999541044235,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.692404568195343},{"id":"https://openalex.org/keywords/workflow","display_name":"Workflow","score":0.5893736481666565},{"id":"https://openalex.org/keywords/molecular-diagnostics","display_name":"Molecular diagnostics","score":0.5605291724205017},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.497754842042923},{"id":"https://openalex.org/keywords/profiling","display_name":"Profiling (computer programming)","score":0.4729200005531311},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.4678405523300171},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"Personalized medicine","score":0.44885751605033875},{"id":"https://openalex.org/keywords/observational-study","display_name":"Observational study","score":0.4394301772117615},{"id":"https://openalex.org/keywords/health-informatics","display_name":"Health informatics","score":0.41150689125061035},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.4025382101535797},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.3843918442726135},{"id":"https://openalex.org/keywords/medical-physics","display_name":"Medical physics","score":0.3803408145904541},{"id":"https://openalex.org/keywords/intensive-care-medicine","display_name":"Intensive care medicine","score":0.36929798126220703},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.36889469623565674},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.18080580234527588},{"id":"https://openalex.org/keywords/public-health","display_name":"Public health","score":0.14104601740837097},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.0877794623374939}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.692404568195343},{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.5893736481666565},{"id":"https://openalex.org/C179786068","wikidata":"https://www.wikidata.org/wiki/Q16257937","display_name":"Molecular diagnostics","level":2,"score":0.5605291724205017},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.497754842042923},{"id":"https://openalex.org/C187191949","wikidata":"https://www.wikidata.org/wiki/Q1138496","display_name":"Profiling (computer programming)","level":2,"score":0.4729200005531311},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4678405523300171},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.44885751605033875},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.4394301772117615},{"id":"https://openalex.org/C145642194","wikidata":"https://www.wikidata.org/wiki/Q870895","display_name":"Health informatics","level":3,"score":0.41150689125061035},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4025382101535797},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3843918442726135},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.3803408145904541},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.36929798126220703},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36889469623565674},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18080580234527588},{"id":"https://openalex.org/C138816342","wikidata":"https://www.wikidata.org/wiki/Q189603","display_name":"Public health","level":2,"score":0.14104601740837097},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0877794623374939},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013557","descriptor_name":"Switzerland","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013557","descriptor_name":"Switzerland","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013557","descriptor_name":"Switzerland","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057089","descriptor_name":"Pathology, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057089","descriptor_name":"Pathology, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057089","descriptor_name":"Pathology, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1186/s12911-018-0680-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-018-0680-0","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-018-0680-0","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},{"id":"pmid:30373609","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30373609","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical informatics and decision making","raw_type":null},{"id":"pmh:oai:www.research-collection.ethz.ch:20.500.11850/302453","is_oa":true,"landing_page_url":"http://hdl.handle.net/20.500.11850/302453","pdf_url":null,"source":{"id":"https://openalex.org/S4306402302","display_name":"Repository for Publications and Research Data (ETH Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I35440088","host_organization_name":"ETH Zurich","host_organization_lineage":["https://openalex.org/I35440088"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making, 18 (1)","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:www.zora.uzh.ch:157621","is_oa":true,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Singer, Franziska; Irmisch, Anja; Toussaint, Nora C; Grob, Linda; Singer, Jochen; Thurnherr, Thomas; Beerenwinkel, Niko; Levesque, Mitchell P; Dummer, Reinhard; Quagliata, Luca; Rothschild, Sacha I; Wicki, Andreas; Beisel, Christian; Stekhoven, Daniel J  (2018). SwissMTB: establishing comprehensive molecular cancer diagnostics in Swiss clinics.  BMC Medical Informatics and Decision Making, 18:89.","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:doaj.org/article:fc0a60e3820f4bb481a3a59f28c85971","is_oa":false,"landing_page_url":"https://doaj.org/article/fc0a60e3820f4bb481a3a59f28c85971","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Informatics and Decision Making, Vol 18, Iss 1, Pp 1-18 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:5160980","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6206832","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6206832","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6206832","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Med Inform Decis Mak","raw_type":"Text"},{"id":"doi:10.3929/ethz-b-000302453","is_oa":true,"landing_page_url":"https://doi.org/10.3929/ethz-b-000302453","pdf_url":null,"source":{"id":"https://openalex.org/S7407051236","display_name":"ETH Z\u00fcrich Research Collection","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.5167/uzh-157621","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-157621","pdf_url":null,"source":{"id":"https://openalex.org/S7407051291","display_name":"Universit\u00e4t Z\u00fcrich, ZORA","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1186/s12911-018-0680-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-018-0680-0","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-018-0680-0","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320316261","display_name":"Universit\u00e4tsspital Basel","ror":"https://ror.org/04k51q396"},{"id":"https://openalex.org/F4320321652","display_name":"Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich","ror":"https://ror.org/05a28rw58"},{"id":"https://openalex.org/F4320323874","display_name":"Universit\u00e4t Z\u00fcrich","ror":"https://ror.org/02crff812"},{"id":"https://openalex.org/F4320325738","display_name":"Universit\u00e4tsspital Z\u00fcrich","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2899401372.pdf","grobid_xml":"https://content.openalex.org/works/W2899401372.grobid-xml"},"referenced_works_count":99,"referenced_works":["https://openalex.org/W1565378970","https://openalex.org/W1791160312","https://openalex.org/W1828658677","https://openalex.org/W1911918948","https://openalex.org/W1919257374","https://openalex.org/W1926851645","https://openalex.org/W1936243389","https://openalex.org/W1950829641","https://openalex.org/W1963717547","https://openalex.org/W1965919119","https://openalex.org/W1970564438","https://openalex.org/W1975522056","https://openalex.org/W1980291961","https://openalex.org/W1985928174","https://openalex.org/W1987370132","https://openalex.org/W1991106952","https://openalex.org/W1995068068","https://openalex.org/W2014668683","https://openalex.org/W2022667262","https://openalex.org/W2023289001","https://openalex.org/W2025725799","https://openalex.org/W2027902974","https://openalex.org/W2049497373","https://openalex.org/W2085085481","https://openalex.org/W2088371069","https://openalex.org/W2102099949","https://openalex.org/W2104268925","https://openalex.org/W2104885590","https://openalex.org/W2106410630","https://openalex.org/W2110417468","https://openalex.org/W2113800457","https://openalex.org/W2114843025","https://openalex.org/W2118084349","https://openalex.org/W2118151336","https://openalex.org/W2122732537","https://openalex.org/W2123394258","https://openalex.org/W2123507520","https://openalex.org/W2124465358","https://openalex.org/W2128542677","https://openalex.org/W2129337972","https://openalex.org/W2131487381","https://openalex.org/W2133339454","https://openalex.org/W2133811295","https://openalex.org/W2138199375","https://openalex.org/W2138601221","https://openalex.org/W2141420424","https://openalex.org/W2141432783","https://openalex.org/W2143204311","https://openalex.org/W2146290346","https://openalex.org/W2146737519","https://openalex.org/W2147482894","https://openalex.org/W2149372853","https://openalex.org/W2149441684","https://openalex.org/W2152061559","https://openalex.org/W2154866190","https://openalex.org/W2155943701","https://openalex.org/W2166662937","https://openalex.org/W2168057516","https://openalex.org/W2169036407","https://openalex.org/W2169456326","https://openalex.org/W2170146596","https://openalex.org/W2202954603","https://openalex.org/W2209368665","https://openalex.org/W2330613226","https://openalex.org/W2332094695","https://openalex.org/W2419048055","https://openalex.org/W2419528132","https://openalex.org/W2482598544","https://openalex.org/W2513047692","https://openalex.org/W2533139534","https://openalex.org/W2538042552","https://openalex.org/W2564365886","https://openalex.org/W2566723262","https://openalex.org/W2567652848","https://openalex.org/W2572174216","https://openalex.org/W2579563793","https://openalex.org/W2586159641","https://openalex.org/W2587175061","https://openalex.org/W2587992857","https://openalex.org/W2588220266","https://openalex.org/W2591662301","https://openalex.org/W2595713273","https://openalex.org/W2601520864","https://openalex.org/W2613342381","https://openalex.org/W2614443510","https://openalex.org/W2748728020","https://openalex.org/W2751417344","https://openalex.org/W2753385986","https://openalex.org/W2759206428","https://openalex.org/W2762040794","https://openalex.org/W2766445261","https://openalex.org/W2768211711","https://openalex.org/W2770622467","https://openalex.org/W2778160167","https://openalex.org/W2785610956","https://openalex.org/W2786268518","https://openalex.org/W2950753203","https://openalex.org/W4255085073","https://openalex.org/W6637304570"],"related_works":["https://openalex.org/W3082935376","https://openalex.org/W3193951088","https://openalex.org/W4322484660","https://openalex.org/W2899657781","https://openalex.org/W4386960999","https://openalex.org/W2770866531","https://openalex.org/W4388011470","https://openalex.org/W4230423494","https://openalex.org/W4298001029","https://openalex.org/W3176719936"],"abstract_inverted_index":{"BACKGROUND:":[0],"Molecular":[1,141],"precision":[2],"oncology":[3],"is":[4],"an":[5,188],"emerging":[6],"practice":[7,78],"to":[8,151,178,203],"improve":[9],"cancer":[10,195],"therapy":[11,180,230],"by":[12],"decreasing":[13],"the":[14,27,45,53,62,97,107,114,134,176,215,241,250,267],"risk":[15],"of":[16,29,47,55,64,87,92,100,102,109,131,214,229,235,255,258,274],"choosing":[17],"treatments":[18],"that":[19,119],"lack":[20,99,228],"efficacy":[21],"or":[22],"cause":[23],"adverse":[24],"events.":[25],"However,":[26],"challenges":[28],"integrating":[30,73],"molecular":[31,74,172,261,276],"profiling":[32],"into":[33,76],"routine":[34],"clinical":[35,77,155,166,253],"care":[36,93],"are":[37,79,113,162],"manifold.":[38],"From":[39],"a":[40,48,121,165,171,270],"computational":[41],"perspective":[42],"these":[43],"include":[44],"importance":[46],"short":[49],"analysis":[50,251],"turnaround":[51],"time,":[52],"interpretation":[54,254],"complex":[56],"drug-gene":[57],"and":[58,61,84,148,154,168,207,252],"gene-gene":[59],"interactions,":[60],"necessity":[63],"standardized":[65],"high-quality":[66],"workflows.":[67],"In":[68,197,220],"addition,":[69],"difficulties":[70],"faced":[71],"when":[72],"diagnostics":[75,125,277],"ethical":[80],"concerns,":[81],"legal":[82],"requirements,":[83],"limited":[85],"availability":[86],"treatment":[88,160,240,245],"options":[89,153],"beyond":[90],"standard":[91],"as":[94,96],"well":[95],"overall":[98],"awareness":[101],"their":[103],"existence.":[104],"METHODS:":[105],"To":[106],"best":[108],"our":[110,264],"knowledge,":[111],"we":[112,184,200,223],"first":[115],"group":[116],"in":[117,164,170,278],"Switzerland":[118],"established":[120],"workflow":[122,265],"for":[123,210],"personalized":[124],"based":[126],"on":[127],"comprehensive":[128,275],"high-throughput":[129],"sequencing":[130],"tumors":[132],"at":[133,175],"clinic.":[135],"Our":[136],"workflow,":[137],"named":[138],"SwissMTB":[139,242,248],"(Swiss":[140],"Tumor":[142],"Board),":[143],"links":[144],"genetic":[145],"tumor":[146,173],"alterations":[147],"gene":[149],"expression":[150],"therapeutic":[152],"trial":[156],"opportunities.":[157],"The":[158],"resulting":[159],"recommendations":[161],"summarized":[163],"report":[167],"discussed":[169],"board":[174],"clinic":[177],"support":[179],"decisions.":[181],"RESULTS:":[182],"Here":[183],"present":[185],"results":[186],"from":[187],"observational":[189],"pilot":[190],"study":[191,199],"including":[192],"22":[193],"late-stage":[194],"patients.":[196,212],"this":[198],"were":[201,217],"able":[202],"identify":[204],"actionable":[205,260],"variants":[206,226],"corresponding":[208],"therapies":[209],"19":[211],"Half":[213],"patients":[216,222,237],"analyzed":[218,238],"retrospectively.":[219],"two":[221],"identified":[224],"resistance-associated":[225],"explaining":[227],"response.":[231],"For":[232],"five":[233],"out":[234],"eleven":[236],"before":[239],"diagnostic":[243],"influenced":[244],"decision.":[246],"CONCLUSIONS:":[247],"enables":[249],"large":[256],"numbers":[257],"potentially":[259],"targets.":[262],"Thus,":[263],"paves":[266],"way":[268],"towards":[269],"more":[271],"frequent":[272],"use":[273],"Swiss":[279],"hospitals.":[280]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-05-12T08:28:47.272897","created_date":"2025-10-10T00:00:00"}