{"id":"https://openalex.org/W2810543949","doi":"https://doi.org/10.1186/s12911-018-0619-5","title":"Development and evaluating multimarker models for guiding treatment decisions","display_name":"Development and evaluating multimarker models for guiding treatment decisions","publication_year":2018,"publication_date":"2018-06-28","ids":{"openalex":"https://openalex.org/W2810543949","doi":"https://doi.org/10.1186/s12911-018-0619-5","mag":"2810543949","pmid":"https://pubmed.ncbi.nlm.nih.gov/29954372"},"language":"en","primary_location":{"id":"doi:10.1186/s12911-018-0619-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-018-0619-5","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-018-0619-5","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-018-0619-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057057049","display_name":"Parvin Tajik","orcid":"https://orcid.org/0000-0003-3945-853X"},"institutions":[{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Parvin Tajik","raw_affiliation_strings":["Department of Pathology, Department of Clinical Epidemiology, Biostatistics & Bioinformatics, Department of Obstetrics & Gynaecology, Academic Medical Centre - University of Amsterdam, Room J1b-210, PO Box 22700, 1100, DE, Amsterdam, the Netherlands. p.tajik@amc.uva.nl","Department of Pathology, Department of Clinical Epidemiology, Biostatistics & Bioinformatics, Department of Obstetrics & Gynaecology, Academic Medical Centre - University of Amsterdam, Room J1b-210, PO Box 22700, 1100, DE, Amsterdam, the Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-3945-853X","affiliations":[{"raw_affiliation_string":"Department of Pathology, Department of Clinical Epidemiology, Biostatistics & Bioinformatics, Department of Obstetrics & Gynaecology, Academic Medical Centre - University of Amsterdam, Room J1b-210, PO Box 22700, 1100, DE, Amsterdam, the Netherlands. p.tajik@amc.uva.nl","institution_ids":["https://openalex.org/I887064364"]},{"raw_affiliation_string":"Department of Pathology, Department of Clinical Epidemiology, Biostatistics & Bioinformatics, Department of Obstetrics & Gynaecology, Academic Medical Centre - University of Amsterdam, Room J1b-210, PO Box 22700, 1100, DE, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I887064364"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053922719","display_name":"Mohammad Hadi Zafarmand","orcid":"https://orcid.org/0000-0002-0792-3911"},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Mohammad Hadi Zafarmand","raw_affiliation_strings":["Department of Clinical Epidemiology, Biostatistics & Bioinformatics, Department of Obstetrics & Gynaecology, Academic Medical Centre, Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Epidemiology, Biostatistics & Bioinformatics, Department of Obstetrics & Gynaecology, Academic Medical Centre, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051056050","display_name":"Aeilko H. Zwinderman","orcid":"https://orcid.org/0000-0003-0361-3139"},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Aeilko H. Zwinderman","raw_affiliation_strings":["Department of Clinical Epidemiology, Biostatistics & Bioinformatics, Academic Medical Centre, Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Epidemiology, Biostatistics & Bioinformatics, Academic Medical Centre, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090795384","display_name":"Ben W. Mol","orcid":"https://orcid.org/0000-0001-8337-550X"},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ben W. Mol","raw_affiliation_strings":["Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics and Gynaecology, Monash University, Clayton, VIC, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061726857","display_name":"Patrick M. Bossuyt","orcid":"https://orcid.org/0000-0003-4427-0128"},"institutions":[{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Patrick M. Bossuyt","raw_affiliation_strings":["Department of Clinical Epidemiology, Biostatistics & Bioinformatics, Academic Medical Centre, Amsterdam, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Epidemiology, Biostatistics & Bioinformatics, Academic Medical Centre, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802928900"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5057057049"],"corresponding_institution_ids":["https://openalex.org/I887064364"],"apc_list":{"value":1570,"currency":"GBP","value_usd":1925},"apc_paid":{"value":1570,"currency":"GBP","value_usd":1925},"fwci":0.3255,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.62446664,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"18","issue":"1","first_page":"52","last_page":"52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":0.9017000198364258,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":0.9017000198364258,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.024000000208616257,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10453","display_name":"Maternal and Perinatal Health Interventions","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6754399538040161},{"id":"https://openalex.org/keywords/randomized-controlled-trial","display_name":"Randomized controlled trial","score":0.5328341722488403},{"id":"https://openalex.org/keywords/pessary","display_name":"Pessary","score":0.5208694934844971},{"id":"https://openalex.org/keywords/confidence-interval","display_name":"Confidence interval","score":0.5115790963172913},{"id":"https://openalex.org/keywords/adverse-effect","display_name":"Adverse effect","score":0.48491841554641724},{"id":"https://openalex.org/keywords/logistic-regression","display_name":"Logistic regression","score":0.44972115755081177},{"id":"https://openalex.org/keywords/intensive-care-medicine","display_name":"Intensive care medicine","score":0.333529531955719},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.2856484055519104},{"id":"https://openalex.org/keywords/obstetrics","display_name":"Obstetrics","score":0.16890284419059753}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6754399538040161},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5328341722488403},{"id":"https://openalex.org/C2776443887","wikidata":"https://www.wikidata.org/wiki/Q174952","display_name":"Pessary","level":2,"score":0.5208694934844971},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5115790963172913},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.48491841554641724},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.44972115755081177},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.333529531955719},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2856484055519104},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.16890284419059753}],"mesh":[{"descriptor_ui":"D000066491","descriptor_name":"Clinical Decision-Making","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000066491","descriptor_name":"Clinical Decision-Making","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000066491","descriptor_name":"Clinical Decision-Making","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010570","descriptor_name":"Pessaries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010570","descriptor_name":"Pessaries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010570","descriptor_name":"Pessaries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D011248","descriptor_name":"Pregnancy Complications","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D011272","descriptor_name":"Pregnancy, Multiple","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011272","descriptor_name":"Pregnancy, Multiple","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011272","descriptor_name":"Pregnancy, Multiple","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017063","descriptor_name":"Outcome Assessment, Health Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.1186/s12911-018-0619-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-018-0619-5","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-018-0619-5","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},{"id":"pmid:29954372","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29954372","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical informatics and decision making","raw_type":null},{"id":"pmh:oai:pure.amsterdamumc.nl:publications/ac3cb7b0-f044-4ed9-af39-0e8334d32e23","is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/ac3cb7b0-f044-4ed9-af39-0e8334d32e23","pdf_url":"https://pure.amsterdamumc.nl/ws/files/158937133/Development-and-evaluating-multimarker-models-for-guiding-treatment-decisions.pdf","source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tajik, P, Zafarmand, M H, Zwinderman, A H, Mol, B W & Bossuyt, P M 2018, 'Development and evaluating multimarker models for guiding treatment decisions', BMC medical informatics and decision making, vol. 18, no. 1, 52. https://doi.org/10.1186/s12911-018-0619-5","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:monash.edu:publications/4f86caff-28c3-4b5a-8857-0756c6ffd1c1","is_oa":true,"landing_page_url":"https://research.monash.edu/en/publications/4f86caff-28c3-4b5a-8857-0756c6ffd1c1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402625","display_name":"Monash University Research Portal (Monash University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I56590836","host_organization_name":"Monash University","host_organization_lineage":["https://openalex.org/I56590836"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tajik, P, Zafarmand, M H, Zwinderman, A H, Mol, B W & Bossuyt, P M 2018, 'Development and evaluating multimarker models for guiding treatment decisions', BMC Medical Informatics and Decision Making, vol. 18, no. 1, 52. https://doi.org/10.1186/s12911-018-0619-5","raw_type":"article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/856e9792-169d-48a0-a7b0-d7be84d46107","is_oa":true,"landing_page_url":"https://pure.amc.nl/en/publications/development-and-evaluating-multimarker-models-for-guiding-treatment-decisions(856e9792-169d-48a0-a7b0-d7be84d46107).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC medical informatics and decision making, 18(1):52. BioMed Central","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:aura.abdn.ac.uk:2164/17487","is_oa":false,"landing_page_url":"https://hdl.handle.net/2164/17487","pdf_url":null,"source":{"id":"https://openalex.org/S4306400966","display_name":"Aberdeen University Research Archive (Aberdeen University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I195460627","host_organization_name":"University of Aberdeen","host_organization_lineage":["https://openalex.org/I195460627"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal article"},{"id":"pmh:oai:doaj.org/article:2571f9d710304e69b351d210c1c73505","is_oa":true,"landing_page_url":"https://doaj.org/article/2571f9d710304e69b351d210c1c73505","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Informatics and Decision Making, Vol 18, Iss 1, Pp 1-10 (2018)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:4988171","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6022448","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:monash.edu:publications/4f86caff-28c3-4b5a-8857-0756c6ffd1c1","is_oa":true,"landing_page_url":"http://www.scopus.com/inward/record.url?scp=85049197409&partnerID=8YFLogxK","pdf_url":null,"source":{"id":"https://openalex.org/S4306402625","display_name":"Monash University Research Portal (Monash University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I56590836","host_organization_name":"Monash University","host_organization_lineage":["https://openalex.org/I56590836"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tajik , P , Zafarmand , M H , Zwinderman , A H , Mol , B W &amp; Bossuyt , P M 2018 , ' Development and evaluating multimarker models for guiding treatment decisions ' , BMC Medical Informatics and Decision Making , vol. 18 , no. 1 , 52 . https://doi.org/10.1186/s12911-018-0619-5","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12911-018-0619-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12911-018-0619-5","pdf_url":"https://bmcmedinformdecismak.biomedcentral.com/track/pdf/10.1186/s12911-018-0619-5","source":{"id":"https://openalex.org/S107516304","display_name":"BMC Medical Informatics and Decision Making","issn_l":"1472-6947","issn":["1472-6947"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Informatics and Decision Making","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7799999713897705}],"awards":[{"id":"https://openalex.org/G1108579157","display_name":null,"funder_award_id":"200310004","funder_id":"https://openalex.org/F4320321007","funder_display_name":"ZonMw"}],"funders":[{"id":"https://openalex.org/F4320321007","display_name":"ZonMw","ror":"https://ror.org/01yaj9a77"},{"id":"https://openalex.org/F4320321048","display_name":"AXA Research Fund","ror":"https://ror.org/02zxqxw53"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2810543949.pdf","grobid_xml":"https://content.openalex.org/works/W2810543949.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W119744528","https://openalex.org/W388091869","https://openalex.org/W1481678990","https://openalex.org/W1569910515","https://openalex.org/W1750038386","https://openalex.org/W1965784614","https://openalex.org/W1976459932","https://openalex.org/W1979859909","https://openalex.org/W1980881195","https://openalex.org/W1982474109","https://openalex.org/W1992532690","https://openalex.org/W1994224528","https://openalex.org/W1994857208","https://openalex.org/W1999550436","https://openalex.org/W2003336670","https://openalex.org/W2015113632","https://openalex.org/W2037559873","https://openalex.org/W2038451218","https://openalex.org/W2039671563","https://openalex.org/W2042080283","https://openalex.org/W2047753213","https://openalex.org/W2055316985","https://openalex.org/W2066153095","https://openalex.org/W2076491225","https://openalex.org/W2082335023","https://openalex.org/W2106244104","https://openalex.org/W2106298710","https://openalex.org/W2119673582","https://openalex.org/W2123350643","https://openalex.org/W2125173098","https://openalex.org/W2128780239","https://openalex.org/W2135046866","https://openalex.org/W2136085913","https://openalex.org/W2146404132","https://openalex.org/W2146719470","https://openalex.org/W2149974876","https://openalex.org/W2150079193","https://openalex.org/W2151056789","https://openalex.org/W2153646525","https://openalex.org/W2154079699","https://openalex.org/W2154286581","https://openalex.org/W2164985671","https://openalex.org/W2165272000","https://openalex.org/W2226880313","https://openalex.org/W2227653658","https://openalex.org/W2297716127","https://openalex.org/W2317150018","https://openalex.org/W2326746642","https://openalex.org/W2605975631","https://openalex.org/W3102650760","https://openalex.org/W3106017199","https://openalex.org/W3175417087","https://openalex.org/W4213256119","https://openalex.org/W4213286494"],"related_works":["https://openalex.org/W2043066419","https://openalex.org/W2068134263","https://openalex.org/W2169491674","https://openalex.org/W2012231337","https://openalex.org/W2745968431","https://openalex.org/W4385620088","https://openalex.org/W2656060974","https://openalex.org/W2944481953","https://openalex.org/W4385783472","https://openalex.org/W1975073195"],"abstract_inverted_index":{"BACKGROUND:":[0],"Despite":[1],"the":[2,44,61,68,78,81,93,100,163,190,214,225],"growing":[3],"interest":[4],"in":[5,92,138,273,281,296,310],"developing":[6],"markers":[7,25,183],"for":[8,36,51,113,306],"predicting":[9,120],"treatment":[10,14,62,69,86,171,192,274,290,308],"response":[11],"and":[12,22,88,184,193,203],"optimizing":[13],"decisions,":[15],"an":[16],"appropriate":[17],"methodology":[18],"to":[19,29,83,147,152,211,235,243,269,289],"identify,":[20],"combine":[21],"evaluate":[23,89],"such":[24],"has":[26],"been":[27],"slow":[28],"develop.":[30],"We":[31,57,128,175,222,263],"propose":[32],"a":[33,48,72,135,177,186],"step-by-step":[34],"strategy":[35],"analysing":[37],"data":[38,133,268],"from":[39,122,134,219,233],"existing":[40,266,298],"randomised":[41,136],"trials":[42,267],"with":[43,59,66,142],"aim":[45],"of":[46,74,96,165,180,213,227,258,284],"identifying":[47],"multi-marker":[49],"model":[50,82,90,188,199],"guiding":[52,307],"decisions":[53,309],"about":[54],"treatment.":[55],"METHODS:":[56],"start":[58],"formulating":[60],"selection":[63,291],"problem,":[64],"continue":[65],"defining":[67],"threshold,":[70],"prepare":[71],"list":[73,179],"candidate":[75],"markers,":[76,191],"develop":[77],"model,":[79],"apply":[80],"estimate":[84],"individual":[85],"effects,":[87],"performance":[91],"study":[94],"group":[95],"patients":[97],"who":[98],"meet":[99],"trial":[101,137,215,260],"eligibility":[102],"criteria.":[103],"In":[104],"this":[105],"process,":[106],"we":[107],"rely":[108],"on":[109,119],"some":[110],"well-known":[111],"techniques":[112],"multivariable":[114],"prediction":[115],"modelling,":[116],"but":[117],"focus":[118],"benefit":[121,275],"treatment,":[123],"rather":[124],"than":[125],"outcome":[126,229],"itself.":[127],"present":[129],"our":[130],"approach":[131],"using":[132],"which":[139],"808":[140],"women":[141],"multiple":[143],"pregnancy":[144],"were":[145],"assigned":[146],"cervical":[148,158],"pessary":[149,159,220,248],"or":[150],"control,":[151],"prevent":[153],"adverse":[154,166,228],"perinatal":[155,167],"outcomes.":[156,168],"Overall,":[157],"did":[160],"not":[161],"reduce":[162],"risk":[164,226,238],"RESULTS:":[169],"The":[170,198,250],"threshold":[172],"was":[173,200],"zero.":[174],"had":[176],"preselected":[178],"5":[181],"potential":[182],"developed":[185],"logistic":[187],"including":[189],"all":[194],"marker-by-treatment":[195],"interaction":[196],"terms.":[197],"well":[201],"calibrated":[202],"identified":[204],"35%":[205],"(95%":[206],"confidence":[207],"interval":[208],"(CI)":[209],"32":[210],"39%)":[212],"participants":[216],"as":[217],"benefitting":[218],"insertion.":[221,249],"estimated":[223],"that":[224],"could":[230,287],"be":[231,277,301],"reduced":[232],"13.5":[234],"8.1%":[236],"(5.4%":[237],"reduction;":[239],"95%":[240],"CI":[241],"2.1":[242],"8.6%)":[244],"through":[245],"model-based":[246],"selective":[247],"next":[251],"step":[252],"is":[253],"external":[254],"validation":[255,295],"upon":[256],"existence":[257],"independent":[259],"data.":[261],"CONCLUSIONS:":[262],"suggest":[264],"revisiting":[265],"explore":[270],"whether":[271],"differences":[272,280],"can":[276,300],"explained":[278],"by":[279],"baseline":[282],"characteristics":[283],"patients.":[285,312],"This":[286],"lead":[288],"tools":[292],"which,":[293],"after":[294],"comparable":[297],"trials,":[299],"introduced":[302],"into":[303],"clinical":[304],"practice":[305],"future":[311]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}
