{"id":"https://openalex.org/W7159662605","doi":"https://doi.org/10.1186/s12880-026-02388-y","title":"Gray matter volume and structural covariance alterations in young males with childhood-onset growth hormone deficiency","display_name":"Gray matter volume and structural covariance alterations in young males with childhood-onset growth hormone deficiency","publication_year":2026,"publication_date":"2026-04-30","ids":{"openalex":"https://openalex.org/W7159662605","doi":"https://doi.org/10.1186/s12880-026-02388-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/42062975"},"language":"en","primary_location":{"id":"doi:10.1186/s12880-026-02388-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-026-02388-y","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12880-026-02388-y.pdf","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s12880-026-02388-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110450155","display_name":"Shengyu Wang","orcid":"https://orcid.org/0000-0002-9774-8319"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengyu Wang","raw_affiliation_strings":["Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I2801556517","https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134973699","display_name":"Wenting Su","orcid":null},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenting Su","raw_affiliation_strings":["Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I2801556517","https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134948016","display_name":"Xiao Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Liu","raw_affiliation_strings":["Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I2801556517","https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134992440","display_name":"Yue Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Zhao","raw_affiliation_strings":["Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I2801556517","https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100296446","display_name":"Ming Zhang","orcid":"https://orcid.org/0009-0002-2420-2590"},"institutions":[{"id":"https://openalex.org/I4210088329","display_name":"Jiading District Central Hospital","ror":"https://ror.org/004j26v17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088329"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Zhang","raw_affiliation_strings":["Department of Radiology, Jiading District Central Hospital Affiliated, Shanghai University of Medicine & Health Sciences, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Jiading District Central Hospital Affiliated, Shanghai University of Medicine & Health Sciences, Shanghai, China","institution_ids":["https://openalex.org/I4210088329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020407352","display_name":"Lunbo Lu","orcid":null},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lunbo Lu","raw_affiliation_strings":["Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I2801556517","https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128755013","display_name":"Suzhen Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2802690428","display_name":"Shanghai Mental Health Center","ror":"https://ror.org/05bd2wa15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802690428"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Suzhen Zhang","raw_affiliation_strings":["Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I2802690428","https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037719001","display_name":"D Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210132741","display_name":"Shanghai Tenth People's Hospital","ror":"https://ror.org/03vjkf643","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210132741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongmei Wang","raw_affiliation_strings":["Department of Radiology, Shanghai Tenth People's Hospital, Affiliated with Tongji University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Shanghai Tenth People's Hospital, Affiliated with Tongji University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I4210132741"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010466648","display_name":"Wenjie Yang","orcid":"https://orcid.org/0000-0002-3959-5043"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjie Yang","raw_affiliation_strings":["Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I2801556517","https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5134971519","display_name":"Yuwen Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I2801556517","display_name":"Ruijin Hospital","ror":"https://ror.org/01hv94n30","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801556517"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuwen Zhang","raw_affiliation_strings":["Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. bfzyw@163.com","Shanghai National Clinical Research Center for metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. bfzyw@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. bfzyw@163.com","institution_ids":["https://openalex.org/I2801556517"]},{"raw_affiliation_string":"Shanghai National Clinical Research Center for metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. bfzyw@163.com","institution_ids":["https://openalex.org/I2801556517"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056429407","display_name":"Xinping Kuai","orcid":null},"institutions":[{"id":"https://openalex.org/I2802690428","display_name":"Shanghai Mental Health Center","ror":"https://ror.org/05bd2wa15","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802690428"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xinping Kuai","raw_affiliation_strings":["Department of Radiology, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. kuaixinping@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. kuaixinping@163.com","institution_ids":["https://openalex.org/I2802690428"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5056429407","https://openalex.org/A5134971519"],"corresponding_institution_ids":["https://openalex.org/I2801556517","https://openalex.org/I2802690428"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.49975196,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.8930000066757202,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.8930000066757202,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11374","display_name":"Cleft Lip and Palate Research","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covariance","display_name":"Covariance","score":0.4413999915122986},{"id":"https://openalex.org/keywords/gray","display_name":"Gray (unit)","score":0.4302999973297119},{"id":"https://openalex.org/keywords/growth-hormone","display_name":"Growth hormone","score":0.4025999903678894},{"id":"https://openalex.org/keywords/volume","display_name":"Volume (thermodynamics)","score":0.3197999894618988}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4921000003814697},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4702000021934509},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4478999972343445},{"id":"https://openalex.org/C178650346","wikidata":"https://www.wikidata.org/wiki/Q201984","display_name":"Covariance","level":2,"score":0.4413999915122986},{"id":"https://openalex.org/C166275286","wikidata":"https://www.wikidata.org/wiki/Q190095","display_name":"Gray (unit)","level":2,"score":0.4302999973297119},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.4025999903678894},{"id":"https://openalex.org/C20556612","wikidata":"https://www.wikidata.org/wiki/Q4469374","display_name":"Volume (thermodynamics)","level":2,"score":0.3197999894618988},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.26249998807907104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2515999972820282},{"id":"https://openalex.org/C119340705","wikidata":"https://www.wikidata.org/wiki/Q1628597","display_name":"Analysis of covariance","level":2,"score":0.24819999933242798}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D066128","descriptor_name":"Gray Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12880-026-02388-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-026-02388-y","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12880-026-02388-y.pdf","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},{"id":"pmid:42062975","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42062975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical imaging","raw_type":null},{"id":"pmh:oai:doaj.org/article:2eeccf1087ec4f968d881cdae1593e15","is_oa":false,"landing_page_url":"https://doaj.org/article/2eeccf1087ec4f968d881cdae1593e15","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Imaging, Vol 26, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13277119","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13277119/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Med Imaging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12880-026-02388-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-026-02388-y","pdf_url":"https://link.springer.com/content/pdf/10.1186/s12880-026-02388-y.pdf","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5753758549690247,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"awards":[{"id":"https://openalex.org/G3877126208","display_name":null,"funder_award_id":"2021M702170","funder_id":"https://openalex.org/F4320321543","funder_display_name":"China Postdoctoral Science Foundation"},{"id":"https://openalex.org/G4718513352","display_name":null,"funder_award_id":"YG2024QNA55","funder_id":"https://openalex.org/F4320322999","funder_display_name":"Shanghai Jiao Tong University"}],"funders":[{"id":"https://openalex.org/F4320321543","display_name":"China Postdoctoral Science Foundation","ror":"https://ror.org/0426zh255"},{"id":"https://openalex.org/F4320322999","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7159662605.pdf","grobid_xml":"https://content.openalex.org/works/W7159662605.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W1991207201","https://openalex.org/W1994239403","https://openalex.org/W1999653836","https://openalex.org/W2008781224","https://openalex.org/W2040073285","https://openalex.org/W2111552999","https://openalex.org/W2130046029","https://openalex.org/W2295433647","https://openalex.org/W2473979215","https://openalex.org/W2771739049","https://openalex.org/W2802678685","https://openalex.org/W2981527918","https://openalex.org/W3007736625","https://openalex.org/W3039610235","https://openalex.org/W3081932851","https://openalex.org/W3094298198","https://openalex.org/W3130829294","https://openalex.org/W3140502976","https://openalex.org/W3182429619","https://openalex.org/W3196357336","https://openalex.org/W3203695044","https://openalex.org/W4224040865","https://openalex.org/W4292687491","https://openalex.org/W4385406390","https://openalex.org/W4388639457","https://openalex.org/W4392109698","https://openalex.org/W4398182163","https://openalex.org/W4399066729","https://openalex.org/W4399873316","https://openalex.org/W4400642845","https://openalex.org/W4401892362","https://openalex.org/W4405947932","https://openalex.org/W4408416006","https://openalex.org/W4409620027","https://openalex.org/W4410456259","https://openalex.org/W4411022811","https://openalex.org/W4411528248","https://openalex.org/W4414838131"],"related_works":[],"abstract_inverted_index":{"PURPOSE:":[0],"This":[1],"study":[2],"investigated":[3],"the":[4,92,109,129,133,145,181],"differences":[5,175],"in":[6,91,105,128,167,176,192,201,251],"gray":[7],"matter":[8],"volume":[9],"(GMV),":[10],"structural":[11,14,169,243],"covariance,":[12],"and":[13,25,42,69,78,95,114,137,151,197,205,210,240,254],"covariance":[15,61,123],"networks":[16],"between":[17,132,144],"adults":[18],"with":[19,172,208],"childhood-onset":[20,234],"growth":[21],"hormone":[22],"deficiency":[23],"(GHD)":[24],"healthy":[26],"controls":[27],"(HCs).":[28],"MATERIALS":[29],"AND":[30],"METHODS:":[31],"A":[32],"total":[33],"of":[34,184],"70":[35],"right-handed":[36],"male":[37],"participants":[38],"(32":[39],"GHD":[40,85,130,235],"patients":[41],"38":[43],"HCs)":[44],"underwent":[45],"high-resolution":[46],"T1-weighted":[47],"magnetic":[48],"resonance":[49],"imaging.":[50],"Atlas-based":[51],"morphometry":[52],"was":[53],"conducted":[54],"to":[55,75,99,186],"examine":[56],"regional":[57,79,215],"GMV":[58,90,104,238],"differences.":[59],"Structural":[60,122],"matrices":[62],"were":[63,73],"generated":[64],"using":[65],"inter-regional":[66],"partial":[67],"correlations,":[68],"graph-based":[70],"network":[71,80,178,203,232],"analyses":[72,189],"performed":[74],"assess":[76],"global":[77,177,230],"topological":[81],"properties.":[82],"RESULTS:":[83],"The":[84],"group":[86,131],"exhibited":[87],"significantly":[88],"reduced":[89],"bilateral":[93,138],"pallidum":[94],"nucleus":[96],"accumbens":[97],"compared":[98],"HCs,":[100],"while":[101],"showing":[102],"increased":[103,126],"regions":[106,204,249],"such":[107],"as":[108,141,143],"frontal,":[110],"parietal,":[111],"temporal":[112,139],"lobes,":[113],"thalamus":[115],"(family":[116],"wise":[117],"error-corrected":[118],"P":[119,159],"<":[120,160],"0.05).":[121],"analysis":[124],"indicated":[125],"connectivity":[127],"left":[134],"precentral":[135],"gyrus":[136,155],"poles,":[140],"well":[142],"right":[146,152],"subgenual":[147],"anterior":[148],"cingulate":[149],"cortex":[150],"superior":[153],"parietal":[154],"(false":[156],"discovery":[157,221],"rate-corrected":[158],"0.001).":[161],"Both":[162],"groups":[163],"demonstrated":[164],"small-world":[165],"organization":[166],"their":[168],"brain":[170,231,248],"networks,":[171],"no":[173],"significant":[174],"metrics":[179],"across":[180],"density":[182],"range":[183],"0.1":[185],"0.5.":[187],"Regional":[188],"revealed":[190],"variations":[191],"clustering":[193],"coefficient,":[194],"nodal":[195],"degree,":[196],"betweenness":[198],"centrality,":[199],"predominantly":[200],"somatomotor":[202],"areas":[206],"associated":[207],"self-reflection":[209],"semantic":[211],"processing.":[212],"However,":[213],"these":[214],"findings":[216],"did":[217],"not":[218],"survive":[219],"false":[220],"rate":[222],"correction":[223],"for":[224],"multiple":[225],"comparisons.":[226],"CONCLUSION:":[227],"Despite":[228],"preserved":[229],"organization,":[233],"demonstrates":[236],"region-specific":[237],"abnormalities":[239],"altered":[241],"local":[242],"connectivity,":[244],"which":[245],"may":[246],"impact":[247],"involved":[250],"motor,":[252],"cognitive,":[253],"emotional":[255],"regulation.":[256]},"counts_by_year":[],"updated_date":"2026-06-20T20:08:15.867695","created_date":"2026-05-02T00:00:00"}