{"id":"https://openalex.org/W7153268117","doi":"https://doi.org/10.1186/s12880-026-02337-9","title":"Nano-radiomics of molecular MRI for early amyloid associated patterns in an Alzheimer\u2019s disease mouse model via an automatic pipeline","display_name":"Nano-radiomics of molecular MRI for early amyloid associated patterns in an Alzheimer\u2019s disease mouse model via an automatic pipeline","publication_year":2026,"publication_date":"2026-04-10","ids":{"openalex":"https://openalex.org/W7153268117","doi":"https://doi.org/10.1186/s12880-026-02337-9","pmid":"https://pubmed.ncbi.nlm.nih.gov/41963831"},"language":"en","primary_location":{"id":"doi:10.1186/s12880-026-02337-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-026-02337-9","pdf_url":null,"source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12880-026-02337-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041772014","display_name":"Esw Ngan","orcid":"https://orcid.org/0000-0002-0022-7999"},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esther Ngan","raw_affiliation_strings":["Department of Radiology, Baylor College of Medicine, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Baylor College of Medicine, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090605589","display_name":"Prajwal Bhandari","orcid":null},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prajwal Bhandari","raw_affiliation_strings":["Department of Radiology, Baylor College of Medicine, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Baylor College of Medicine, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133384951","display_name":"Parag A. Parekh","orcid":null},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Parag A. Parekh","raw_affiliation_strings":["Department of Radiology, Baylor College of Medicine, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Baylor College of Medicine, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045999242","display_name":"Andrew Badachhape","orcid":"https://orcid.org/0000-0002-5857-9495"},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew A. Badachhape","raw_affiliation_strings":["Department of Radiology, Baylor College of Medicine, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Baylor College of Medicine, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082450718","display_name":"Ananth Annapragada","orcid":"https://orcid.org/0000-0002-3156-9617"},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ananth V. Annapragada","raw_affiliation_strings":["Department of Radiology, Baylor College of Medicine, Houston, TX, 77030, USA","Department of Radiology, Texas Children's Hospital, 6701 Fannin Street, Suite 450, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Baylor College of Medicine, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Radiology, Texas Children's Hospital, 6701 Fannin Street, Suite 450, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I4210147586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002648895","display_name":"Ketan B. Ghaghada","orcid":"https://orcid.org/0000-0003-1012-8668"},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ketan B. Ghaghada","raw_affiliation_strings":["Department of Radiology, Baylor College of Medicine, Houston, TX, 77030, USA","Department of Radiology, Texas Children's Hospital, 6701 Fannin Street, Suite 450, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Baylor College of Medicine, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Radiology, Texas Children's Hospital, 6701 Fannin Street, Suite 450, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I4210147586"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083171466","display_name":"Zbigniew Starosolski","orcid":"https://orcid.org/0000-0003-4295-4227"},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4210147586","display_name":"Texas Children's Hospital","ror":"https://ror.org/05cz92x43","country_code":"US","type":"funder","lineage":["https://openalex.org/I4210147586"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zbigniew A. Starosolski","raw_affiliation_strings":["Department of Radiology, Baylor College of Medicine, Houston, TX, 77030, USA. starosol@bcm.edu","Department of Radiology, Texas Children's Hospital, 6701 Fannin Street, Suite 450, Houston, TX, 77030, USA. starosol@bcm.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Baylor College of Medicine, Houston, TX, 77030, USA. starosol@bcm.edu","institution_ids":["https://openalex.org/I181547552"]},{"raw_affiliation_string":"Department of Radiology, Texas Children's Hospital, 6701 Fannin Street, Suite 450, Houston, TX, 77030, USA. starosol@bcm.edu","institution_ids":["https://openalex.org/I4210147586"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5083171466"],"corresponding_institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4210147586"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.54517683,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.8355000019073486,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.8355000019073486,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.6556000113487244},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.6520000100135803},{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.45669999718666077},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.3865000009536743},{"id":"https://openalex.org/keywords/genetically-modified-mouse","display_name":"Genetically modified mouse","score":0.3774999976158142},{"id":"https://openalex.org/keywords/contrast","display_name":"Contrast (vision)","score":0.3727000057697296},{"id":"https://openalex.org/keywords/pittsburgh-compound-b","display_name":"Pittsburgh compound B","score":0.37229999899864197},{"id":"https://openalex.org/keywords/amyloid","display_name":"Amyloid (mycology)","score":0.36070001125335693}],"concepts":[{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.6556000113487244},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.6520000100135803},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4781000018119812},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.45669999718666077},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.44859999418258667},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.3865000009536743},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3853999972343445},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38359999656677246},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.3774999976158142},{"id":"https://openalex.org/C2776502983","wikidata":"https://www.wikidata.org/wiki/Q690182","display_name":"Contrast (vision)","level":2,"score":0.3727000057697296},{"id":"https://openalex.org/C2781073650","wikidata":"https://www.wikidata.org/wiki/Q4047010","display_name":"Pittsburgh compound B","level":4,"score":0.37229999899864197},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.36070001125335693},{"id":"https://openalex.org/C163500349","wikidata":"https://www.wikidata.org/wiki/Q7281263","display_name":"Radiogenomics","level":3,"score":0.35899999737739563},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3425999879837036},{"id":"https://openalex.org/C2778559731","wikidata":"https://www.wikidata.org/wiki/Q23808793","display_name":"Radiomics","level":2,"score":0.33070001006126404},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.3068000078201294},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.30090001225471497},{"id":"https://openalex.org/C163892561","wikidata":"https://www.wikidata.org/wiki/Q2613728","display_name":"S\u00f8rensen\u2013Dice coefficient","level":4,"score":0.2962000072002411},{"id":"https://openalex.org/C2780972224","wikidata":"https://www.wikidata.org/wiki/Q17047956","display_name":"Brain atlas","level":2,"score":0.2921999990940094},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.2687000036239624},{"id":"https://openalex.org/C2909607560","wikidata":"https://www.wikidata.org/wiki/Q6740853","display_name":"Amyloid disease","level":5,"score":0.2678000032901764},{"id":"https://openalex.org/C3019060180","wikidata":"https://www.wikidata.org/wiki/Q184199","display_name":"Automated method","level":2,"score":0.2614000141620636},{"id":"https://openalex.org/C9417928","wikidata":"https://www.wikidata.org/wiki/Q1070689","display_name":"Image processing","level":3,"score":0.25859999656677246},{"id":"https://openalex.org/C3019447875","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid \u03b2","level":3,"score":0.25699999928474426}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s12880-026-02337-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-026-02337-9","pdf_url":null,"source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},{"id":"pmid:41963831","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41963831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical imaging","raw_type":null},{"id":"pmh:oai:doaj.org/article:d5c83d45b4544f05a4c2865d13a27718","is_oa":true,"landing_page_url":"https://doaj.org/article/d5c83d45b4544f05a4c2865d13a27718","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Imaging, Vol 26, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13224451","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13224451/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Med Imaging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12880-026-02337-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-026-02337-9","pdf_url":null,"source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1901129140","https://openalex.org/W1972163528","https://openalex.org/W1990729297","https://openalex.org/W2005719973","https://openalex.org/W2021672014","https://openalex.org/W2026527241","https://openalex.org/W2026616100","https://openalex.org/W2052507258","https://openalex.org/W2076934502","https://openalex.org/W2099698084","https://openalex.org/W2111876935","https://openalex.org/W2128739912","https://openalex.org/W2132513126","https://openalex.org/W2141602245","https://openalex.org/W2142943752","https://openalex.org/W2312448942","https://openalex.org/W2465688795","https://openalex.org/W2740893736","https://openalex.org/W2751538714","https://openalex.org/W2767128594","https://openalex.org/W2782896508","https://openalex.org/W2903150666","https://openalex.org/W2998529369","https://openalex.org/W2998789541","https://openalex.org/W3003587036","https://openalex.org/W3011390968","https://openalex.org/W3016156567","https://openalex.org/W3042059812","https://openalex.org/W3091669276","https://openalex.org/W3112385165","https://openalex.org/W3119018229","https://openalex.org/W3126197619","https://openalex.org/W3137659085","https://openalex.org/W3138516171","https://openalex.org/W3171158316","https://openalex.org/W4200247394","https://openalex.org/W4285820536","https://openalex.org/W4293030512","https://openalex.org/W4294305479","https://openalex.org/W4316096019","https://openalex.org/W4380886217","https://openalex.org/W4385330340","https://openalex.org/W4386417666","https://openalex.org/W4386582469","https://openalex.org/W4400088916"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,64,197,270],"combination":[2],"of":[3,36,43,56,292,309,321],"nanoparticle":[4,227,311],"contrast":[5,110,230],"agents":[6],"with":[7,87,98,157,200,245,287],"advanced":[8],"image":[9],"analysis":[10,35,308],"techniques":[11],"like":[12],"radiomics":[13],"offers":[14],"a":[15,27],"powerful":[16],"new":[17],"approach":[18,250,275,289],"for":[19,31,318],"disease":[20,49],"detection":[21,55,320],"and":[22,33,91,140,176,186,211,239,290],"characterization.":[23],"This":[24],"study":[25,65],"presents":[26],"novel":[28],"automated":[29],"pipeline":[30,45],"segmentation":[32,149,221,288,331],"nano-radiomic":[34],"nanoprobe-enhanced":[37],"images.":[38],"We":[39],"demonstrate":[40],"the":[41,67,141,204,248,252,264,296,336],"effectiveness":[42],"this":[44],"in":[46,220,325],"an":[47,326],"Alzheimer\u2019s":[48],"(AD)":[50],"mouse":[51,131,328],"model,":[52],"showing":[53],"improved":[54],"amyloid":[57,89,100,225,323],"pathology":[58],"compared":[59,144,192],"to":[60,114,122,134,145,155,193,335],"conventional":[61,180,315],"methods.":[62],"METHODS:":[63],"used":[66],"magnetic":[68],"resonance":[69],"imaging":[70,316],"(MRI)":[71],"data":[72],"collected":[73],"from":[74,147,273],"double":[75],"transgenic":[76],"(TG)":[77],"AD":[78,327],"mice,":[79,116,283],"including":[80],"13":[81],"mice":[82,93,105,244],"aged":[83,94],"6\u20138":[84],"month":[85,96],"old":[86,97],"lower":[88],"burden":[90],"36":[92],"11\u201318":[95],"higher":[99],"burden.":[101],"Wild":[102],"type":[103],"(WT)":[104],"served":[106],"as":[107],"controls.":[108],"Three":[109],"doses":[111],"were":[112,143,167],"administered":[113],"older":[115,243],"while":[117,339],"one":[118,302],"dose":[119],"was":[120,128,191,235],"applied":[121],"younger":[123,282],"mice.":[124],"A":[125],"UNet-based":[126,198],"model":[127,199],"trained":[129],"on":[130,224],"brain":[132,152],"scans":[133],"automatically":[135],"segment":[136],"two":[137,304],"specific":[138],"regions,":[139],"results":[142],"those":[146],"semi-automatic":[148,240,253,337],"(i.e.":[150],"manual":[151],"atlas":[153],"registration":[154],"MRIs":[156,313],"automatic":[158,238,249,274],"region":[159,166],"extraction).":[160],"89":[161],"radiomic":[162],"features":[163],"(RFs)":[164],"per":[165],"computed,":[168],"followed":[169],"by":[170],"genotype":[171],"classification":[172,233,284],"using":[173],"machine":[174],"learning":[175],"sensitivity":[177],"analyses.":[178],"Image-based":[179],"metric":[181],"(percentage":[182],"change":[183],"between":[184,209,237],"pre-":[185],"post-contrast":[187],"MRI":[188],"intensity":[189],"signal)":[190],"radiomics-based":[194],"approaches.":[195,241],"RESULTS:":[196],"SWIN":[201],"transformer":[202],"performed":[203],"best,":[205],"achieving":[206],"Dice":[207],"coefficients":[208],"0.80":[210],"0.95.":[212],"Non-parametric":[213],"statistical":[214],"tests":[215],"showed":[216],"no":[217],"significant":[218],"difference":[219],"performance":[222,234,285,333],"based":[223],"burden,":[226],"contrast,":[228],"or":[229,303],"doses.":[231],"RF-based":[232],"similar":[236],"In":[242,281],"good-quality":[246],"segmentation,":[247],"outperformed":[251,314],"method":[254],"across":[255],"all":[256],"dose-specific":[257],"test":[258],"sets":[259],"(all":[260],"1.0)":[261],"but":[262],"not":[263],"validation":[265],"set":[266],"(0.90":[267],"vs.":[268],"1.0).":[269],"top":[271,297],"classifier":[272],"also":[276],"required":[277,300],"2x":[278],"less":[279],"RFs.":[280,305],"varied":[286],"inclusion":[291],"fair-quality":[293],"segmentation.":[294],"Yet":[295],"classifiers":[298],"typically":[299],"only":[301],"CONCLUSIONS:":[306],"Nano-radiomic":[307],"targeted":[310],"contrast-enhanced":[312],"metrics":[317],"early":[319],"pathological":[322],"deposition":[324],"model.":[329],"Automated":[330],"achieved":[332],"comparable":[334],"method,":[338],"improving":[340],"efficiency.":[341]},"counts_by_year":[],"updated_date":"2026-06-16T09:24:06.705377","created_date":"2026-04-11T00:00:00"}