{"id":"https://openalex.org/W7147078527","doi":"https://doi.org/10.1186/s12880-026-02319-x","title":"Multimodal MRI and machine learning for identifying depression in cerebral small vessel disease: a multicenter study","display_name":"Multimodal MRI and machine learning for identifying depression in cerebral small vessel disease: a multicenter study","publication_year":2026,"publication_date":"2026-03-31","ids":{"openalex":"https://openalex.org/W7147078527","doi":"https://doi.org/10.1186/s12880-026-02319-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/41917839"},"language":"en","primary_location":{"id":"doi:10.1186/s12880-026-02319-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-026-02319-x","pdf_url":null,"source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12880-026-02319-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101318387","display_name":"Guihan Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210113281","display_name":"Lishui Central Hospital","ror":"https://ror.org/023e72x78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guihan Lin","raw_affiliation_strings":["Department of Radiology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China","Zhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China","institution_ids":["https://openalex.org/I4210113281","https://openalex.org/I27781120"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123874446","display_name":"Weiyue Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210113281","display_name":"Lishui Central Hospital","ror":"https://ror.org/023e72x78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiyue Chen","raw_affiliation_strings":["Department of Radiology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China","Zhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China","institution_ids":["https://openalex.org/I4210113281","https://openalex.org/I27781120"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027861927","display_name":"Yongjun Chen","orcid":"https://orcid.org/0000-0003-4614-7836"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongjun Chen","raw_affiliation_strings":["Department of Radiology, The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132642244","display_name":"Lei Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Xu","raw_affiliation_strings":["Department of Radiology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017486387","display_name":"Ting Zhao","orcid":"https://orcid.org/0000-0003-3502-6043"},"institutions":[{"id":"https://openalex.org/I4210113281","display_name":"Lishui Central Hospital","ror":"https://ror.org/023e72x78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Zhao","raw_affiliation_strings":["Department of Vascular Surgery, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Vascular Surgery, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China","institution_ids":["https://openalex.org/I4210113281"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111133399","display_name":"Z. Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210113281","display_name":"Lishui Central Hospital","ror":"https://ror.org/023e72x78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zufei Wang","raw_affiliation_strings":["Department of Radiology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China","Zhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China","institution_ids":["https://openalex.org/I4210113281","https://openalex.org/I27781120"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049072744","display_name":"Mei\u2010Yan Xu","orcid":"https://orcid.org/0000-0002-4234-4296"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210113281","display_name":"Lishui Central Hospital","ror":"https://ror.org/023e72x78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Xu","raw_affiliation_strings":["Department of Radiology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China","Zhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China","institution_ids":["https://openalex.org/I4210113281","https://openalex.org/I27781120"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124271718","display_name":"Chenying Lu","orcid":null},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210113281","display_name":"Lishui Central Hospital","ror":"https://ror.org/023e72x78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenying Lu","raw_affiliation_strings":["Department of Radiology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China","Zhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China","institution_ids":["https://openalex.org/I4210113281","https://openalex.org/I27781120"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132576529","display_name":"Minjiang Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210113281","display_name":"Lishui Central Hospital","ror":"https://ror.org/023e72x78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minjiang Chen","raw_affiliation_strings":["Department of Radiology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China","Zhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China","institution_ids":["https://openalex.org/I4210113281","https://openalex.org/I27781120"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053668837","display_name":"Shuiwei Xia","orcid":null},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210113281","display_name":"Lishui Central Hospital","ror":"https://ror.org/023e72x78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113281"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuiwei Xia","raw_affiliation_strings":["Department of Radiology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China","Zhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China","institution_ids":["https://openalex.org/I4210113281","https://openalex.org/I27781120"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China","institution_ids":["https://openalex.org/I27781120"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5115600005","display_name":"Jiansong Ji","orcid":"https://orcid.org/0009-0003-7402-9316"},"institutions":[{"id":"https://openalex.org/I4210113281","display_name":"Lishui Central Hospital","ror":"https://ror.org/023e72x78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210113281"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiansong Ji","raw_affiliation_strings":["Department of Radiology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China. jjstcty@wmu.edu.cn","Zhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China. jjstcty@wmu.edu.cn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Lishui Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China. jjstcty@wmu.edu.cn","institution_ids":["https://openalex.org/I4210113281"]},{"raw_affiliation_string":"Zhejiang Key Laboratory of Imaging and Interventional Medicine, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, China. jjstcty@wmu.edu.cn","institution_ids":["https://openalex.org/I4210113281"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5115600005"],"corresponding_institution_ids":["https://openalex.org/I4210113281"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.47480779,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.4250999987125397,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.4250999987125397,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.12800000607967377,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.10920000076293945,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fractional-anisotropy","display_name":"Fractional anisotropy","score":0.6226999759674072},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"Diffusion MRI","score":0.5503000020980835},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.5421000123023987},{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.3982999920845032},{"id":"https://openalex.org/keywords/default-mode-network","display_name":"Default mode network","score":0.3944999873638153},{"id":"https://openalex.org/keywords/modalities","display_name":"Modalities","score":0.39160001277923584},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"Major depressive disorder","score":0.3790000081062317},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.35010001063346863}],"concepts":[{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7271999716758728},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.6391000151634216},{"id":"https://openalex.org/C89916169","wikidata":"https://www.wikidata.org/wiki/Q17014600","display_name":"Fractional anisotropy","level":4,"score":0.6226999759674072},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5838000178337097},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.5503000020980835},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5421000123023987},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4099999964237213},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.3982999920845032},{"id":"https://openalex.org/C141516989","wikidata":"https://www.wikidata.org/wiki/Q1182555","display_name":"Default mode network","level":3,"score":0.3944999873638153},{"id":"https://openalex.org/C2779903281","wikidata":"https://www.wikidata.org/wiki/Q6888026","display_name":"Modalities","level":2,"score":0.39160001277923584},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.3790000081062317},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.35010001063346863},{"id":"https://openalex.org/C46686674","wikidata":"https://www.wikidata.org/wiki/Q466303","display_name":"Boosting (machine learning)","level":2,"score":0.34130001068115234},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.3398999869823456},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.32659998536109924},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.302700012922287},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.29750001430511475},{"id":"https://openalex.org/C70153297","wikidata":"https://www.wikidata.org/wiki/Q5591907","display_name":"Gradient boosting","level":3,"score":0.2937000095844269},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.2669999897480011},{"id":"https://openalex.org/C2776641880","wikidata":"https://www.wikidata.org/wiki/Q944142","display_name":"Suicidal ideation","level":4,"score":0.26170000433921814},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.25450000166893005},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.2515000104904175}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s12880-026-02319-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-026-02319-x","pdf_url":null,"source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},{"id":"pmid:41917839","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41917839","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical imaging","raw_type":null},{"id":"pmh:oai:doaj.org/article:75cff829970844be95cb3053407be7f6","is_oa":true,"landing_page_url":"https://doaj.org/article/75cff829970844be95cb3053407be7f6","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Imaging, Vol 26, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13162360","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13162360/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Med Imaging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12880-026-02319-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-026-02319-x","pdf_url":null,"source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1125373727","https://openalex.org/W2007704605","https://openalex.org/W2023316221","https://openalex.org/W2032274515","https://openalex.org/W2127749891","https://openalex.org/W2129500763","https://openalex.org/W2132699864","https://openalex.org/W2158742097","https://openalex.org/W2617097054","https://openalex.org/W2784037480","https://openalex.org/W2888841096","https://openalex.org/W2897620540","https://openalex.org/W2902392516","https://openalex.org/W2947924379","https://openalex.org/W2954308429","https://openalex.org/W2967073344","https://openalex.org/W3005937372","https://openalex.org/W3013786603","https://openalex.org/W3017142950","https://openalex.org/W3017163794","https://openalex.org/W3021820807","https://openalex.org/W3045014501","https://openalex.org/W3046526879","https://openalex.org/W3046738083","https://openalex.org/W3084293538","https://openalex.org/W3084546953","https://openalex.org/W3106893611","https://openalex.org/W4210681529","https://openalex.org/W4220667458","https://openalex.org/W4225380018","https://openalex.org/W4284991005","https://openalex.org/W4303185985","https://openalex.org/W4313417586","https://openalex.org/W4366609043","https://openalex.org/W4380992875","https://openalex.org/W4386914216","https://openalex.org/W4389340959","https://openalex.org/W4396940506","https://openalex.org/W4401494368","https://openalex.org/W4404838421"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"This":[1,40],"study":[2,42],"sought":[3],"to":[4,107,113],"evaluate":[5],"the":[6,125,130,145,164,183,192,213,224,233,245,254,262],"effectiveness":[7],"of":[8,124,186,203,220,257,264],"a":[9],"machine":[10],"learning":[11],"(ML)":[12],"model":[13,169],"utilizing":[14],"multimodal":[15,152,168,239,258],"MRI":[16,153,240],"in":[17,191,223,232,261],"distinguishing":[18],"cerebral":[19],"small":[20],"vessel":[21],"disease":[22],"(CSVD)":[23],"patients":[24],"with":[25,180],"depression":[26,33],"(CSVD":[27,34],"+":[28,58,74,89,251],"D)":[29],"from":[30,46,151,172],"those":[31],"without":[32],"\u2212":[35,63,79,94],"D).":[36],"MATERIALS":[37],"AND":[38],"METHODS:":[39],"retrospective":[41],"involved":[43],"198":[44],"participants":[45],"three":[47,174],"centers,":[48],"who":[49],"were":[50,111,154],"divided":[51],"into":[52,144],"training":[53],"(n":[54,70,85],"=":[55,60,65,71,76,81,86,91,96],"113;":[56],"CSVD":[57,62,73,78,88,93,250],"D":[59,64,75,80,90,95],"56,":[61],"57),":[66],"external":[67,194],"validation":[68,195],"1":[69,196],"85;":[72],"31,":[77],"54),":[82],"and":[83,101,189,197,201,206,228,241],"2":[84,198],"102;":[87],"39,":[92],"63)":[97],"cohorts.":[98],"Structural,":[99],"functional,":[100],"diffusion":[102],"tensor":[103],"imaging":[104,259],"was":[105,127],"used":[106],"extract":[108],"features,":[109],"which":[110],"utilized":[112],"construct":[114],"ML":[115,120,242],"models":[116,126],"based":[117],"on":[118],"nine":[119],"classifiers.":[121],"The":[122,157,166,208],"efficacy":[123],"evaluated":[128],"through":[129],"receiver":[131],"operating":[132],"characteristic":[133],"(ROC)":[134],"analysis.":[135],"SHapley":[136],"additive":[137],"explanations":[138],"(SHAP)":[139],"analysis":[140],"provided":[141],"deep":[142],"insights":[143],"model\u2019s":[146],"interpretability.":[147],"RESULTS:":[148],"Twelve":[149],"features":[150,171,216],"finally":[155],"identified.":[156],"eXtreme":[158],"Gradient":[159],"Boosting":[160],"(XGBoost)":[161],"classifier":[162],"performed":[163],"best.":[165],"XGBoost-based":[167],"integrating":[170],"all":[173],"modalities":[175],"achieved":[176],"high":[177],"diagnostic":[178],"performance,":[179],"areas":[181],"under":[182],"ROC":[184],"curves":[185],"0.958,":[187],"0.893,":[188],"0.917":[190],"training,":[193],"cohorts,":[199],"respectively,":[200],"accuracies":[202],"0.929,":[204],"0.871,":[205],"0.853.":[207],"SHAP":[209],"results":[210],"revealed":[211],"that":[212],"key":[214],"contributing":[215],"included":[217],"elevated":[218],"amplitude":[219],"low-frequency":[221],"fluctuations":[222],"superior":[225],"frontal":[226],"gyrus":[227],"reduced":[229],"fractional":[230],"anisotropy":[231],"default":[234],"mode":[235],"network.":[236],"CONCLUSION:":[237],"Integrating":[238],"may":[243],"improve":[244],"classification":[246],"performance":[247],"for":[248],"identifying":[249],"D,":[252],"suggesting":[253],"potential":[255],"value":[256],"markers":[260],"assessment":[263],"CSVD-related":[265],"depressive":[266],"symptoms.":[267],"CLINICAL":[268],"TRIAL":[269],"NUMBER:":[270],"Not":[271],"applicable.":[272]},"counts_by_year":[],"updated_date":"2026-06-16T09:24:06.705377","created_date":"2026-04-02T00:00:00"}