{"id":"https://openalex.org/W7127430547","doi":"https://doi.org/10.1186/s12880-026-02200-x","title":"Predicting neoadjuvant chemotherapy response in osteosarcoma using T2-based MRI delta-radiomics: a retrospective study","display_name":"Predicting neoadjuvant chemotherapy response in osteosarcoma using T2-based MRI delta-radiomics: a retrospective study","publication_year":2026,"publication_date":"2026-02-03","ids":{"openalex":"https://openalex.org/W7127430547","doi":"https://doi.org/10.1186/s12880-026-02200-x","pmid":"https://pubmed.ncbi.nlm.nih.gov/41634603"},"language":"en","primary_location":{"id":"doi:10.1186/s12880-026-02200-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-026-02200-x","pdf_url":null,"source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12880-026-02200-x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124970313","display_name":"Ping Yin","orcid":null},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Ping Yin","raw_affiliation_strings":["Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY, 10021, USA","Department of Radiology, Peking University People's Hospital, 11 Xizhimen Nandajie, Xicheng District, Beijing, 100044, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY, 10021, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Department of Radiology, Peking University People's Hospital, 11 Xizhimen Nandajie, Xicheng District, Beijing, 100044, P. R. China","institution_ids":["https://openalex.org/I4210124809","https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124963373","display_name":"Fei Zheng","orcid":null},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Zheng","raw_affiliation_strings":["Department of Radiology, Peking University People's Hospital, 11 Xizhimen Nandajie, Xicheng District, Beijing, 100044, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Peking University People's Hospital, 11 Xizhimen Nandajie, Xicheng District, Beijing, 100044, P. R. China","institution_ids":["https://openalex.org/I4210124809","https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124893273","display_name":"Ying Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Liu","raw_affiliation_strings":["Department of Radiology, Peking University People's Hospital, 11 Xizhimen Nandajie, Xicheng District, Beijing, 100044, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Peking University People's Hospital, 11 Xizhimen Nandajie, Xicheng District, Beijing, 100044, P. R. China","institution_ids":["https://openalex.org/I4210124809","https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080543004","display_name":"Simon Sun","orcid":"https://orcid.org/0000-0002-0062-197X"},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon Sun","raw_affiliation_strings":["Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY, 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY, 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124916566","display_name":"Lin Lu","orcid":null},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lin Lu","raw_affiliation_strings":["Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY, 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY, 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124903613","display_name":"Hao Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Yang","raw_affiliation_strings":["Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY, 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY, 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124950519","display_name":"Pengfei Geng","orcid":null},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pengfei Geng","raw_affiliation_strings":["Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY, 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY, 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066759303","display_name":"Jialiang Ren","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jialiang Ren","raw_affiliation_strings":["Department of Pharmaceuticals Diagnostics, GE HealthCare, Beijing, 100176, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceuticals Diagnostics, GE HealthCare, Beijing, 100176, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124921497","display_name":"Binsheng Zhao","orcid":null},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Binsheng Zhao","raw_affiliation_strings":["Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY, 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY, 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124879778","display_name":"Lawrence H. Schwartz","orcid":null},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lawrence H. Schwartz","raw_affiliation_strings":["Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY, 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY, 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5124966112","display_name":"Nan Hong","orcid":null},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]},{"id":"https://openalex.org/I4210124809","display_name":"Peking University People's Hospital","ror":"https://ror.org/035adwg89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210124809"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Nan Hong","raw_affiliation_strings":["Department of Radiology, Peking University People's Hospital, 11 Xizhimen Nandajie, Xicheng District, Beijing, 100044, P. R. China. hongnan1968@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Peking University People's Hospital, 11 Xizhimen Nandajie, Xicheng District, Beijing, 100044, P. R. China. hongnan1968@163.com","institution_ids":["https://openalex.org/I4210124809","https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5124966112"],"corresponding_institution_ids":["https://openalex.org/I20231570","https://openalex.org/I4210124809"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19944194,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.6947000026702881,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.6947000026702881,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.24580000340938568,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiomics","display_name":"Radiomics","score":0.6478999853134155},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"Osteosarcoma","score":0.6396999955177307},{"id":"https://openalex.org/keywords/retrospective-cohort-study","display_name":"Retrospective cohort study","score":0.6179999709129333},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"Chemotherapy","score":0.5924000144004822},{"id":"https://openalex.org/keywords/predictive-value","display_name":"Predictive value","score":0.5519000291824341},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.5439000129699707},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.48170000314712524},{"id":"https://openalex.org/keywords/area-under-the-curve","display_name":"Area under the curve","score":0.41269999742507935}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8438000082969666},{"id":"https://openalex.org/C2778559731","wikidata":"https://www.wikidata.org/wiki/Q23808793","display_name":"Radiomics","level":2,"score":0.6478999853134155},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.6396999955177307},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.6179999709129333},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5924000144004822},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.5536999702453613},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.5519000291824341},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5439000129699707},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.48170000314712524},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.41269999742507935},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.3926999866962433},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.39010000228881836},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.334199994802475},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.31310001015663147},{"id":"https://openalex.org/C3019096185","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Complete response","level":3,"score":0.30219998955726624},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.289000004529953},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2849999964237213},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.2678999900817871},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.2612000107765198},{"id":"https://openalex.org/C71472368","wikidata":"https://www.wikidata.org/wiki/Q676880","display_name":"Text mining","level":2,"score":0.2556999921798706},{"id":"https://openalex.org/C3020225094","wikidata":"https://www.wikidata.org/wiki/Q80091","display_name":"Area under curve","level":3,"score":0.2526000142097473}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1186/s12880-026-02200-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-026-02200-x","pdf_url":null,"source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},{"id":"pmid:41634603","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41634603","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical imaging","raw_type":null},{"id":"pmh:oai:doaj.org/article:06b49bc98f82405e9f43c9e0941d176f","is_oa":true,"landing_page_url":"https://doaj.org/article/06b49bc98f82405e9f43c9e0941d176f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Imaging, Vol 26, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12880-026-02200-x","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-026-02200-x","pdf_url":null,"source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6819388617","display_name":null,"funder_award_id":"NO.82001764","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W2019607817","https://openalex.org/W2128739912","https://openalex.org/W2327203407","https://openalex.org/W2513951655","https://openalex.org/W2590827495","https://openalex.org/W2807792940","https://openalex.org/W2894974756","https://openalex.org/W2905890314","https://openalex.org/W2921909353","https://openalex.org/W2952603267","https://openalex.org/W3006362810","https://openalex.org/W3011899248","https://openalex.org/W3033186726","https://openalex.org/W3081959002","https://openalex.org/W3093706924","https://openalex.org/W3118342167","https://openalex.org/W3143273750","https://openalex.org/W3196582427","https://openalex.org/W3197355167","https://openalex.org/W4229006968","https://openalex.org/W4252591451","https://openalex.org/W4283757210","https://openalex.org/W4317951874","https://openalex.org/W4328108590","https://openalex.org/W4361209241","https://openalex.org/W4390276512","https://openalex.org/W4390751189","https://openalex.org/W4400733447","https://openalex.org/W4401088403","https://openalex.org/W4402768926"],"related_works":[],"abstract_inverted_index":{"This":[0,224],"study":[1],"aimed":[2],"to":[3,161],"investigate":[4],"the":[5,67,76,84,88,93,101,104,147,186,190,202,241],"application":[6],"of":[7,167,170,173,176,179,183],"T2-based":[8,210],"MRI":[9,44,211],"delta-radiomics":[10,212],"as":[11],"a":[12],"novel":[13],"predictive":[14,158,215],"tool":[15],"for":[16,139,217,228],"neoadjuvant":[17],"chemotherapy":[18],"(NACT)":[19],"response":[20,219],"in":[21,136,185,220,240],"patients":[22,31,117,221],"with":[23,32,222],"osteosarcoma.":[24,223],"We":[25,70],"retrospectively":[26],"analyzed":[27],"data":[28],"from":[29,66],"152":[30],"pathologically":[33],"confirmed":[34],"osteosarcoma":[35],"who":[36],"underwent":[37],"NACT":[38,54,218],"at":[39,49],"our":[40],"institution.":[41],"Axial":[42],"T2-weighted":[43,68],"sequences":[45],"were":[46,64,118,144],"acquired":[47],"both":[48],"baseline":[50],"(pre-NACT)":[51],"and":[52,59,72,92,110,128,142,181,204,232],"after":[53],"(post-NACT).":[55],"After":[56],"image":[57],"segmentation":[58],"preprocessing,":[60],"1158":[61],"radiomic":[62],"features":[63],"extracted":[65],"images.":[69],"developed":[71],"compared":[73,160],"four":[74],"models:":[75],"conventional":[77],"quantitative":[78],"imaging":[79],"features-based":[80],"model":[81,155,225],"(CQIF":[82],"model),":[83],"pre-NACT":[85],"radiomics":[86,90],"model,":[87,91],"post-NACT":[89],"Delta-Radiomics":[94,154,205],"model.":[95],"Model":[96],"performance":[97,159],"was":[98],"assessed":[99],"using":[100],"area":[102],"under":[103],"receiver":[105],"operating":[106],"characteristic":[107],"curve":[108],"(AUC)":[109],"accuracy":[111],"(ACC).":[112],"Based":[113],"on":[114],"histopathological":[115],"assessment,":[116],"divided":[119],"into":[120],"two":[121,148],"groups:":[122],"good":[123],"responders":[124,130,238],"(n":[125,131],"=":[126,132],"57)":[127],"poor":[129],"95).":[133],"Significant":[134],"differences":[135,196],"change":[137],"rates":[138],"tumor":[140],"diameter":[141],"volume":[143],"observed":[145],"between":[146,201],"groups":[149],"(P":[150,207],"<":[151,208],"0.001).":[152],"The":[153],"demonstrated":[156],"superior":[157],"other":[162],"models,":[163,199],"achieving":[164],"an":[165],"AUC":[166],"0.796,":[168],"ACC":[169],"0.756,":[171],"sensitivity":[172],"0.529,":[174],"specificity":[175],"0.893,":[177],"PPV":[178],"0.750,":[180],"NPV":[182],"0.758":[184],"test":[187,192],"set.":[188],"However,":[189],"Delong":[191],"revealed":[193],"no":[194],"significant":[195],"among":[197],"these":[198],"except":[200],"Post-NACT":[203],"models":[206],"0.05).":[209],"showed":[213],"strong":[214],"value":[216],"holds":[226],"potential":[227],"guiding":[229],"clinical":[230],"decision-making":[231],"improving":[233],"patient":[234],"management":[235],"by":[236],"identifying":[237],"early":[239],"treatment":[242],"course.":[243]},"counts_by_year":[],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2026-02-04T00:00:00"}
