{"id":"https://openalex.org/W7127655191","doi":"https://doi.org/10.1186/s12880-026-02188-4","title":"Noninvasive preoperative prediction of perineural invasion in intrahepatic cholangiocarcinoma based on dynamic contrast-enhanced MRI","display_name":"Noninvasive preoperative prediction of perineural invasion in intrahepatic cholangiocarcinoma based on dynamic contrast-enhanced MRI","publication_year":2026,"publication_date":"2026-02-04","ids":{"openalex":"https://openalex.org/W7127655191","doi":"https://doi.org/10.1186/s12880-026-02188-4","pmid":"https://pubmed.ncbi.nlm.nih.gov/41639768"},"language":"en","primary_location":{"id":"doi:10.1186/s12880-026-02188-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-026-02188-4","pdf_url":null,"source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12880-026-02188-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5125018605","display_name":"Sisi Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210137389","display_name":"Eastern Hepatobiliary Surgery Hospital","ror":"https://ror.org/043sbvg03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137389"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sisi Zhang","raw_affiliation_strings":["Department of Radiology, Eastern Hepatobiliary Surgery Hospital, The Third Affiliated Hospital of Shanghai Naval Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Eastern Hepatobiliary Surgery Hospital, The Third Affiliated Hospital of Shanghai Naval Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I4210137389","https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5125099038","display_name":"Yayuan Feng","orcid":null},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210137389","display_name":"Eastern Hepatobiliary Surgery Hospital","ror":"https://ror.org/043sbvg03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137389"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yayuan Feng","raw_affiliation_strings":["Department of Radiology, Eastern Hepatobiliary Surgery Hospital, The Third Affiliated Hospital of Shanghai Naval Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Eastern Hepatobiliary Surgery Hospital, The Third Affiliated Hospital of Shanghai Naval Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I4210137389","https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027218508","display_name":"Da He","orcid":"https://orcid.org/0009-0005-2162-6197"},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210137389","display_name":"Eastern Hepatobiliary Surgery Hospital","ror":"https://ror.org/043sbvg03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137389"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Da He","raw_affiliation_strings":["Department of Radiology, Eastern Hepatobiliary Surgery Hospital, The Third Affiliated Hospital of Shanghai Naval Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Eastern Hepatobiliary Surgery Hospital, The Third Affiliated Hospital of Shanghai Naval Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I4210137389","https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032282208","display_name":"Yuxian Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210137389","display_name":"Eastern Hepatobiliary Surgery Hospital","ror":"https://ror.org/043sbvg03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137389"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxian Wu","raw_affiliation_strings":["Department of Radiology, Eastern Hepatobiliary Surgery Hospital, The Third Affiliated Hospital of Shanghai Naval Military Medical University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Eastern Hepatobiliary Surgery Hospital, The Third Affiliated Hospital of Shanghai Naval Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I4210137389","https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047898476","display_name":"Ning-yang JIA","orcid":null},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210137389","display_name":"Eastern Hepatobiliary Surgery Hospital","ror":"https://ror.org/043sbvg03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137389"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ningyang Jia","raw_affiliation_strings":["Department of Radiology, Eastern Hepatobiliary Surgery Hospital, The Third Affiliated Hospital of Shanghai Naval Military Medical University, Shanghai, China. ningyangjia@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Eastern Hepatobiliary Surgery Hospital, The Third Affiliated Hospital of Shanghai Naval Military Medical University, Shanghai, China. ningyangjia@163.com","institution_ids":["https://openalex.org/I4210137389","https://openalex.org/I177933477"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049988011","display_name":"XingPeng Pan","orcid":null},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210137389","display_name":"Eastern Hepatobiliary Surgery Hospital","ror":"https://ror.org/043sbvg03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137389"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xingpeng Pan","raw_affiliation_strings":["Department of Radiology, Eastern Hepatobiliary Surgery Hospital, The Third Affiliated Hospital of Shanghai Naval Military Medical University, Shanghai, China. 22590118@qq.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Eastern Hepatobiliary Surgery Hospital, The Third Affiliated Hospital of Shanghai Naval Military Medical University, Shanghai, China. 22590118@qq.com","institution_ids":["https://openalex.org/I4210137389","https://openalex.org/I177933477"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059779511","display_name":"Y. Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210137389","display_name":"Eastern Hepatobiliary Surgery Hospital","ror":"https://ror.org/043sbvg03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210137389"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiping Liu","raw_affiliation_strings":["Department of Radiology, Eastern Hepatobiliary Surgery Hospital, The Third Affiliated Hospital of Shanghai Naval Military Medical University, Shanghai, China. liuyiping108@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Eastern Hepatobiliary Surgery Hospital, The Third Affiliated Hospital of Shanghai Naval Military Medical University, Shanghai, China. liuyiping108@126.com","institution_ids":["https://openalex.org/I4210137389","https://openalex.org/I177933477"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5049988011"],"corresponding_institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210137389"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13058133,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9430000185966492,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9430000185966492,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10518","display_name":"Gallbladder and Bile Duct Disorders","score":0.041600000113248825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perineural-invasion","display_name":"Perineural invasion","score":0.7627999782562256},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.6448000073432922},{"id":"https://openalex.org/keywords/intrahepatic-cholangiocarcinoma","display_name":"Intrahepatic Cholangiocarcinoma","score":0.6445000171661377},{"id":"https://openalex.org/keywords/logistic-regression","display_name":"Logistic regression","score":0.6011999845504761},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.5270000100135803},{"id":"https://openalex.org/keywords/discriminative-model","display_name":"Discriminative model","score":0.3806000053882599},{"id":"https://openalex.org/keywords/area-under-the-curve","display_name":"Area under the curve","score":0.3634999990463257}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8960000276565552},{"id":"https://openalex.org/C2777154038","wikidata":"https://www.wikidata.org/wiki/Q7168585","display_name":"Perineural invasion","level":3,"score":0.7627999782562256},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.6626999974250793},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.6448000073432922},{"id":"https://openalex.org/C2909135397","wikidata":"https://www.wikidata.org/wiki/Q124292","display_name":"Intrahepatic Cholangiocarcinoma","level":2,"score":0.6445000171661377},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.6011999845504761},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5270000100135803},{"id":"https://openalex.org/C97931131","wikidata":"https://www.wikidata.org/wiki/Q5282087","display_name":"Discriminative model","level":2,"score":0.3806000053882599},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.3634999990463257},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.3343000113964081},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.3109000027179718},{"id":"https://openalex.org/C3020225094","wikidata":"https://www.wikidata.org/wiki/Q80091","display_name":"Area under curve","level":3,"score":0.3050999939441681},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.2971000075340271},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.2651999890804291},{"id":"https://openalex.org/C2994142346","wikidata":"https://www.wikidata.org/wiki/Q353268","display_name":"Dynamic contrast","level":3,"score":0.2612999975681305},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.25040000677108765}],"mesh":[{"descriptor_ui":"D000098543","descriptor_name":"Dynamic Contrast Enhanced Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001650","descriptor_name":"Bile Duct Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D010525","descriptor_name":"Peripheral Nerves","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D019786","descriptor_name":"Gadolinium DTPA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049451","descriptor_name":"Nomograms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1186/s12880-026-02188-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-026-02188-4","pdf_url":null,"source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},{"id":"pmid:41639768","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41639768","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical imaging","raw_type":null},{"id":"pmh:oai:doaj.org/article:06c76f400073448ab811eae041752481","is_oa":true,"landing_page_url":"https://doaj.org/article/06c76f400073448ab811eae041752481","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Imaging, Vol 26, Iss 1 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12880-026-02188-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-026-02188-4","pdf_url":null,"source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","score":0.7193859815597534,"display_name":"Reduced inequalities"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1532654778","https://openalex.org/W1970145694","https://openalex.org/W1987049028","https://openalex.org/W2029854125","https://openalex.org/W2030288325","https://openalex.org/W2040835705","https://openalex.org/W2082329290","https://openalex.org/W2122047548","https://openalex.org/W2191988973","https://openalex.org/W2789983547","https://openalex.org/W2942285817","https://openalex.org/W3007119058","https://openalex.org/W3010532021","https://openalex.org/W3011860645","https://openalex.org/W3013395753","https://openalex.org/W3112258248","https://openalex.org/W3186452207","https://openalex.org/W4200475175","https://openalex.org/W4206709372","https://openalex.org/W4210717628","https://openalex.org/W4306147177","https://openalex.org/W4309927438","https://openalex.org/W4375858987","https://openalex.org/W4382727811","https://openalex.org/W4388336524","https://openalex.org/W4390452537","https://openalex.org/W4391055736","https://openalex.org/W4402932183","https://openalex.org/W4403400309","https://openalex.org/W4409830610","https://openalex.org/W4410768789","https://openalex.org/W4413054821","https://openalex.org/W4415569465"],"related_works":[],"abstract_inverted_index":{"PURPOSE:":[0],"The":[1,108,176,223],"present":[2],"study":[3],"aimed":[4],"to":[5,35,76,90,169,253,265],"develop":[6],"and":[7,19,41,42,51,78,97,103,118,154,172,200,221,242,277],"validate":[8],"a":[9,54,82,98,106,244],"preoperative":[10,65,246,269],"model":[11,100,109,177,232,247,261],"based":[12],"on":[13,144],"Gd-DTPA-enhanced":[14,250],"magnetic":[15],"resonance":[16],"imaging":[17],"(MRI)":[18],"clinical":[20,119,235],"factors":[21,168],"for":[22],"predicting":[23],"perineural":[24],"invasion":[25],"(PNI)":[26],"in":[27,113,204,210,257,268],"patients":[28,58,72],"with":[29,59,182],"intrahepatic":[30],"cholangiocarcinoma":[31],"(ICC),":[32],"enabling":[33],"clinicians":[34,267],"perform":[36],"more":[37],"accurate":[38],"patient":[39],"evaluation":[40],"make":[43],"individualized":[44],"therapeutic":[45],"decisions.":[46],"METHODS:":[47],"Between":[48],"July":[49],"2019":[50],"February":[52],"2024,":[53],"total":[55],"of":[56,94,115,189,195,198,202,280],"173":[57],"pathologically":[60],"confirmed":[61],"ICC":[62,258],"who":[63],"underwent":[64],"Gd\u2011DTPA\u2011enhanced":[66],"MRI":[67,251],"were":[68,73,165,214],"retrospectively":[69],"enrolled.":[70],"These":[71],"randomly":[74],"assigned":[75],"training":[77,206],"test":[79],"cohorts":[80],"at":[81],"7:3":[83],"ratio.":[84],"Multivariate":[85],"logistic":[86],"regression":[87],"was":[88,101,111],"used":[89],"identify":[91],"independent":[92,166],"predictors":[93],"PNI":[95,170,256],"status":[96,171],"predictive":[99],"developed":[102,241],"presented":[104],"as":[105],"nomogram.":[107],"performance":[110],"assessed":[112],"terms":[114],"discrimination,":[116],"calibration,":[117],"utility.":[120],"RESULTS:":[121],"Peritumoral":[122],"arterial":[123],"hyper-enhancement":[124],"(OR":[125,134,146,157],"14.99,":[126],"95%":[127,136,148,159],"CI:1.95,115.22,":[128],"P":[129,139,151,162],"=":[130,140,152,163],"0.009),":[131],"satellite":[132],"nodules":[133],"10.07,":[135],"CI:":[137,149,160,192,217],"1.34,75.48,":[138],"0.025),":[141],"target":[142],"sign":[143],"DWI":[145],"0.03,":[147,158],"0.00,0.38,":[150],"0.007),":[153],"tumor":[155],"location":[156],"0.00,0.28,":[161],"0.003)":[164],"risk":[167,270],"constituted":[173],"the":[174,186,205,211,231,278],"model.":[175],"exhibited":[178],"strong":[179],"discriminative":[180],"ability,":[181],"an":[183],"area":[184],"under":[185],"curve":[187,225,228],"(AUC)":[188],"0.939":[190],"(95%":[191,216],"0.891\u20130.988),":[193],"sensitivity":[194],"0.907,":[196],"specificity":[197],"0.870,":[199],"accuracy":[201],"0.893":[203],"set;":[207],"corresponding":[208],"values":[209],"testing":[212],"set":[213],"0.866":[215],"0.767\u20130.966),":[218],"0.750,":[219],"0.800,":[220],"0.769.":[222],"decision":[224],"analysis":[226],"(DCA)":[227],"showed":[229],"that":[230,248],"achieved":[233],"great":[234],"benefits.":[236],"CONCLUSION:":[237],"In":[238],"conclusion,":[239],"we":[240],"validated":[243],"noninvasive":[245],"integrates":[249],"features":[252],"accurately":[254],"predict":[255],"patients.":[259],"This":[260],"shows":[262],"significant":[263],"potential":[264],"assist":[266],"assessment,":[271],"thus":[272],"facilitating":[273],"improved":[274],"prognostic":[275],"stratification":[276],"formulation":[279],"personalized":[281],"treatment":[282],"strategies.":[283]},"counts_by_year":[],"updated_date":"2026-06-28T08:01:55.173337","created_date":"2026-02-06T00:00:00"}