{"id":"https://openalex.org/W7124438930","doi":"https://doi.org/10.1186/s12880-026-02160-2","title":"Early prediction of pathologic complete response to neoadjuvant chemotherapy based on longitudinal total choline of MR spectroscopy in patients with breast cancer","display_name":"Early prediction of pathologic complete response to neoadjuvant chemotherapy based on longitudinal total choline of MR spectroscopy in patients with breast cancer","publication_year":2026,"publication_date":"2026-01-16","ids":{"openalex":"https://openalex.org/W7124438930","doi":"https://doi.org/10.1186/s12880-026-02160-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/41545976"},"language":"en","primary_location":{"id":"doi:10.1186/s12880-026-02160-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-026-02160-2","pdf_url":null,"source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12880-026-02160-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102877331","display_name":"Shuling Liu","orcid":"https://orcid.org/0000-0002-1255-9894"},"institutions":[{"id":"https://openalex.org/I4210154480","display_name":"Chongqing Cancer Hospital","ror":"https://ror.org/047d8yx24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuling Liu","raw_affiliation_strings":["Department of Radiology, Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC), No.181 Hanyu Road, Shapingba District, Chongqing, 400030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC), No.181 Hanyu Road, Shapingba District, Chongqing, 400030, China","institution_ids":["https://openalex.org/I4210154480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078299981","display_name":"X. Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210154480","display_name":"Chongqing Cancer Hospital","ror":"https://ror.org/047d8yx24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoxia Wang","raw_affiliation_strings":["Department of Radiology, Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC), No.181 Hanyu Road, Shapingba District, Chongqing, 400030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC), No.181 Hanyu Road, Shapingba District, Chongqing, 400030, China","institution_ids":["https://openalex.org/I4210154480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101667615","display_name":"Fujie Jiang","orcid":"https://orcid.org/0000-0002-6273-3571"},"institutions":[{"id":"https://openalex.org/I191996457","display_name":"Dalian Medical University","ror":"https://ror.org/04c8eg608","country_code":"CN","type":"education","lineage":["https://openalex.org/I191996457"]},{"id":"https://openalex.org/I4210097509","display_name":"Second Affiliated Hospital of Chongqing Medical University","ror":"https://ror.org/00r67fz39","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097509"]},{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fujie Jiang","raw_affiliation_strings":["Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, No. 74 Linjiang Rd, Yuzhong District, Chongqing, 400010, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Second Affiliated Hospital of Chongqing Medical University, No. 74 Linjiang Rd, Yuzhong District, Chongqing, 400010, P.R. China","institution_ids":["https://openalex.org/I191996457","https://openalex.org/I4210097509","https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123183242","display_name":"Sun Tang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210154480","display_name":"Chongqing Cancer Hospital","ror":"https://ror.org/047d8yx24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sun Tang","raw_affiliation_strings":["Department of Radiology, Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC), No.181 Hanyu Road, Shapingba District, Chongqing, 400030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC), No.181 Hanyu Road, Shapingba District, Chongqing, 400030, China","institution_ids":["https://openalex.org/I4210154480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123201961","display_name":"Ying Cao","orcid":null},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Cao","raw_affiliation_strings":["School of Medicine, Chongqing University, Chongqing, 400030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Chongqing University, Chongqing, 400030, China","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123239549","display_name":"Lu Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210154480","display_name":"Chongqing Cancer Hospital","ror":"https://ror.org/047d8yx24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lu Wang","raw_affiliation_strings":["Department of Radiology, Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC), No.181 Hanyu Road, Shapingba District, Chongqing, 400030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC), No.181 Hanyu Road, Shapingba District, Chongqing, 400030, China","institution_ids":["https://openalex.org/I4210154480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123239080","display_name":"Huifang Chen","orcid":null},"institutions":[{"id":"https://openalex.org/I4210154480","display_name":"Chongqing Cancer Hospital","ror":"https://ror.org/047d8yx24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huifang Chen","raw_affiliation_strings":["Department of Radiology, Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC), No.181 Hanyu Road, Shapingba District, Chongqing, 400030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC), No.181 Hanyu Road, Shapingba District, Chongqing, 400030, China","institution_ids":["https://openalex.org/I4210154480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123250900","display_name":"Xiangfei Zeng","orcid":null},"institutions":[{"id":"https://openalex.org/I4210154480","display_name":"Chongqing Cancer Hospital","ror":"https://ror.org/047d8yx24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangfei Zeng","raw_affiliation_strings":["Department of Radiology, Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC), No.181 Hanyu Road, Shapingba District, Chongqing, 400030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC), No.181 Hanyu Road, Shapingba District, Chongqing, 400030, China","institution_ids":["https://openalex.org/I4210154480"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yao Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yao Huang","raw_affiliation_strings":["School of Medicine, Chongqing University, Chongqing, 400030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Chongqing University, Chongqing, 400030, China","institution_ids":["https://openalex.org/I158842170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101529588","display_name":"Lan Li","orcid":"https://orcid.org/0000-0002-4113-1969"},"institutions":[{"id":"https://openalex.org/I4210154480","display_name":"Chongqing Cancer Hospital","ror":"https://ror.org/047d8yx24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lan Li","raw_affiliation_strings":["Department of Radiology, Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC), No.181 Hanyu Road, Shapingba District, Chongqing, 400030, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC), No.181 Hanyu Road, Shapingba District, Chongqing, 400030, China","institution_ids":["https://openalex.org/I4210154480"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122960266","display_name":"Renzhi Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210089431","display_name":"National Cancer Center","ror":"https://ror.org/0065zqt33","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089431"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Renzhi Zhang","raw_affiliation_strings":["National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, Nanli, Panjiaohai, Chaoyang District, Beijing, 100021, China. zhangrenzhi7790@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17, Nanli, Panjiaohai, Chaoyang District, Beijing, 100021, China. zhangrenzhi7790@126.com","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210089431"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049395278","display_name":"Jiuquan Zhang","orcid":"https://orcid.org/0000-0003-0239-6988"},"institutions":[{"id":"https://openalex.org/I4210154480","display_name":"Chongqing Cancer Hospital","ror":"https://ror.org/047d8yx24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154480"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiuquan Zhang","raw_affiliation_strings":["Department of Radiology, Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC), No.181 Hanyu Road, Shapingba District, Chongqing, 400030, China. zhangjq_radiol@foxmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Chongqing University Cancer Hospital, Chongqing Key Laboratory for Intelligent Oncology in Breast Cancer (iCQBC), No.181 Hanyu Road, Shapingba District, Chongqing, 400030, China. zhangjq_radiol@foxmail.com","institution_ids":["https://openalex.org/I4210154480"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5049395278","https://openalex.org/A5122960266"],"corresponding_institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210089431","https://openalex.org/I4210154480"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03958846,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"1","first_page":"82","last_page":"82"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.8277000188827515,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.8277000188827515,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.08590000122785568,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.05550000071525574,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.7810999751091003},{"id":"https://openalex.org/keywords/choline","display_name":"Choline","score":0.559499979019165},{"id":"https://openalex.org/keywords/in-vivo-magnetic-resonance-spectroscopy","display_name":"In vivo magnetic resonance spectroscopy","score":0.5392000079154968},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"Chemotherapy","score":0.5354999899864197},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.4357999861240387},{"id":"https://openalex.org/keywords/stage","display_name":"Stage (stratigraphy)","score":0.4296000003814697},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.40639999508857727},{"id":"https://openalex.org/keywords/neoadjuvant-therapy","display_name":"Neoadjuvant therapy","score":0.3991999924182892}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7810999751091003},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7534999847412109},{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.559499979019165},{"id":"https://openalex.org/C103191249","wikidata":"https://www.wikidata.org/wiki/Q624073","display_name":"In vivo magnetic resonance spectroscopy","level":3,"score":0.5392000079154968},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5382999777793884},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5354999899864197},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.47209998965263367},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.4357999861240387},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4296000003814697},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.40639999508857727},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.3991999924182892},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.37880000472068787},{"id":"https://openalex.org/C3019096185","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Complete response","level":3,"score":0.37689998745918274},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.3093999922275543},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.2921000123023987},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.28619998693466187},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.25440001487731934},{"id":"https://openalex.org/C3019816032","wikidata":"https://www.wikidata.org/wiki/Q2575340","display_name":"Cancer treatment","level":3,"score":0.2529999911785126},{"id":"https://openalex.org/C2780073493","wikidata":"https://www.wikidata.org/wiki/Q7523837","display_name":"Single Center","level":2,"score":0.2517000138759613}],"mesh":[{"descriptor_ui":"D000095384","descriptor_name":"Pathologic Complete Response","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000095384","descriptor_name":"Pathologic Complete Response","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020360","descriptor_name":"Neoadjuvant Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066244","descriptor_name":"Proton Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066244","descriptor_name":"Proton Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s12880-026-02160-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-026-02160-2","pdf_url":null,"source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},{"id":"pmid:41545976","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41545976","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical imaging","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:11703454","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12896254","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d1b2d0dccbbe42ecbd7a8d121176eb95","is_oa":true,"landing_page_url":"https://doaj.org/article/d1b2d0dccbbe42ecbd7a8d121176eb95","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Imaging, Vol 26, Iss 1 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12896254","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12896254/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Med Imaging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12880-026-02160-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-026-02160-2","pdf_url":null,"source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8396036624908447}],"awards":[{"id":"https://openalex.org/G403968965","display_name":null,"funder_award_id":"2023CDJYGRH-YB04","funder_id":"https://openalex.org/F4320335787","funder_display_name":"Fundamental Research Funds for the Central Universities"}],"funders":[{"id":"https://openalex.org/F4320335787","display_name":"Fundamental Research Funds for the Central Universities","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1974728996","https://openalex.org/W1998166655","https://openalex.org/W2004742583","https://openalex.org/W2030058244","https://openalex.org/W2043038410","https://openalex.org/W2049196436","https://openalex.org/W2067453349","https://openalex.org/W2071856539","https://openalex.org/W2083166156","https://openalex.org/W2091006673","https://openalex.org/W2101979288","https://openalex.org/W2137853125","https://openalex.org/W2336794604","https://openalex.org/W2726349398","https://openalex.org/W2736222137","https://openalex.org/W2801226193","https://openalex.org/W2803669118","https://openalex.org/W2900839476","https://openalex.org/W2916703039","https://openalex.org/W2921520311","https://openalex.org/W2966739672","https://openalex.org/W2999417355","https://openalex.org/W3006134372","https://openalex.org/W3006441495","https://openalex.org/W3007170910","https://openalex.org/W3142429513","https://openalex.org/W3183498360","https://openalex.org/W3200719581","https://openalex.org/W4230786063","https://openalex.org/W4283029993"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"Accurately":[1],"predicting":[2,251],"pathological":[3],"complete":[4],"response":[5],"(pCR)":[6],"to":[7,54,58,82],"neoadjuvant":[8],"chemotherapy":[9],"(NAC)":[10],"early":[11,35,55,265],"during":[12,165,269],"treatment":[13,287],"could":[14,260],"enable":[15],"therapy":[16],"adaptation.":[17],"Total":[18],"choline":[19],"(tCho)":[20],"measured":[21,90],"by":[22],"Proton":[23],"MR":[24],"spectroscopy":[25],"(1H-MRS)":[26],"reflects":[27],"tumor":[28],"metabolism":[29],"and":[30,101,106,120,123,151,173,202,215,245,285],"may":[31,276],"serve":[32],"as":[33,263],"an":[34,204,254,264],"biomarker,":[36],"but":[37],"its":[38],"predictive":[39],"performance":[40,48,128],"requires":[41],"further":[42],"validation.":[43],"OBJECTIVES:":[44],"To":[45],"investigate":[46],"the":[47,116,132,135,168,178,189,195,211,224,230,243,280],"of":[49,87,159,206,256,267,283],"tCho":[50,88,112,160,181,218,240,259],"in":[51,60,167,188,194,223,229,271,278],"singlevoxel":[52],"1H-MRS":[53,92],"predict":[56],"pCR":[57,122,169,196,231,268],"NAC":[59,75,108,166,270],"breast":[61,71,272],"cancer":[62,72,273],"patients.":[63,274],"MATERIALS":[64],"&":[65],"METHODS:":[66],"Patients":[67],"with":[68,91,149,154,203,242,253],"primary":[69],"invasive":[70],"scheduled":[73],"for":[74],"were":[76,113,144,186,221],"prospectively":[77],"enrolled":[78],"from":[79],"August":[80],"2021":[81],"October":[83],"2023.":[84],"The":[85,111,126,156],"concentration":[86],"was":[89,129],"at":[93,182,208,219,247],"four":[94,117,183],"time":[95,118,184],"points:":[96],"T0":[97,220,248],"(pretreatment),":[98],"T1,":[99],"T2,":[100],"T3":[102],"(after":[103],"2,":[104],"4,":[105],"6":[107],"cycles":[109],"respectively).":[110],"compared":[114],"among":[115],"points":[119,185],"between":[121],"non-pCR":[124,150,171,190,225],"groups.":[125],"diagnostic":[127],"evaluated":[130],"using":[131],"area":[133],"under":[134],"receiver":[136],"operating":[137],"characteristic":[138],"curves":[139],"(AUC).":[140],"RESULTS:":[141],"191":[142],"patients":[143,148,153],"enrolled,":[145],"including":[146],"136":[147],"55":[152],"pCR.":[155],"dynamic":[157],"changes":[158],"showed":[161,249],"a":[162],"downward":[163],"trend":[164],"group,":[170,172],"all":[174,238],"molecular":[175],"subtypes.":[176],"Among":[177],"total":[179],"patients,":[180,239],"higher":[187,222],"group":[191,197,226,232],"than":[192,227],"those":[193],"(all":[198,233],"P":[199,234],"<":[200,235],"0.05),":[201],"AUC":[205,255],"0.72":[207],"T0.":[209],"In":[210,237],"Luminal":[212],"B,":[213],"HER2-enriched":[214],"triple-negative":[216],"subgroups,":[217],"that":[228],"0.05).":[236],"combined":[241],"PR":[244],"HER2":[246],"good":[250],"performance,":[252],"0.85.":[257],"CONCLUSIONS:":[258],"be":[261],"used":[262],"predictor":[266],"This":[275],"assist":[277],"guiding":[279],"clinical":[281],"selection":[282],"individualized":[284],"effective":[286],"programs.":[288]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2026-01-17T00:00:00"}