{"id":"https://openalex.org/W7118081292","doi":"https://doi.org/10.1186/s12880-025-02140-y","title":"IDH mutation prediction in non-enhancing gliomas with relaxed T2-FLAIR mismatch and fractal dimension: a two-center study","display_name":"IDH mutation prediction in non-enhancing gliomas with relaxed T2-FLAIR mismatch and fractal dimension: a two-center study","publication_year":2026,"publication_date":"2026-01-03","ids":{"openalex":"https://openalex.org/W7118081292","doi":"https://doi.org/10.1186/s12880-025-02140-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/41484861"},"language":"en","primary_location":{"id":"doi:10.1186/s12880-025-02140-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-025-02140-y","pdf_url":null,"source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12880-025-02140-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5121873334","display_name":"Yu Han","orcid":null},"institutions":[{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yu Han","raw_affiliation_strings":["Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an, Shaanxi, 710038, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an, Shaanxi, 710038, P. R. China","institution_ids":["https://openalex.org/I9916479","https://openalex.org/I4210154136"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121862972","display_name":"Jin Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin Zhang","raw_affiliation_strings":["Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an, Shaanxi, 710038, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an, Shaanxi, 710038, P. R. China","institution_ids":["https://openalex.org/I9916479","https://openalex.org/I4210154136"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112267892","display_name":"Yi-Bin Xi","orcid":null},"institutions":[{"id":"https://openalex.org/I4210088110","display_name":"The Fourth People's Hospital","ror":"https://ror.org/001v2ey71","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088110"]},{"id":"https://openalex.org/I4210142339","display_name":"Xi\u2019an Children\u2019s Hospital","ror":"https://ror.org/04595zj73","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142339"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi-bin Xi","raw_affiliation_strings":["Department of Radiology, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, Shaanxi, 710199, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an, Shaanxi, 710199, P. R. China","institution_ids":["https://openalex.org/I4210088110","https://openalex.org/I4210142339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036808909","display_name":"Si-jie Xiu","orcid":null},"institutions":[{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Si-jie Xiu","raw_affiliation_strings":["Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an, Shaanxi, 710038, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an, Shaanxi, 710038, P. R. China","institution_ids":["https://openalex.org/I9916479","https://openalex.org/I4210154136"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121863068","display_name":"Yang Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Yang","raw_affiliation_strings":["Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an, Shaanxi, 710038, P. R. China. yyang507@126.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an, Shaanxi, 710038, P. R. China. yyang507@126.com","institution_ids":["https://openalex.org/I9916479","https://openalex.org/I4210154136"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114210231","display_name":"Yu-yao Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I4210154136","display_name":"Tang Du Hospital","ror":"https://ror.org/04yvdan45","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154136"]},{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu-yao Wang","raw_affiliation_strings":["Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an, Shaanxi, 710038, P. R. China. wyy2007154030@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, 569 Xinsi Road, Xi'an, Shaanxi, 710038, P. R. China. wyy2007154030@163.com","institution_ids":["https://openalex.org/I9916479","https://openalex.org/I4210154136"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5121873334"],"corresponding_institution_ids":["https://openalex.org/I4210154136","https://openalex.org/I9916479"],"apc_list":{"value":1690,"currency":"GBP","value_usd":2072},"apc_paid":{"value":1690,"currency":"GBP","value_usd":2072},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01082775,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"1","first_page":"61","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.949999988079071,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.949999988079071,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.02500000037252903,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.6136999726295471},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.5497999787330627},{"id":"https://openalex.org/keywords/estimator","display_name":"Estimator","score":0.46480000019073486},{"id":"https://openalex.org/keywords/mutation-testing","display_name":"Mutation testing","score":0.4523000121116638},{"id":"https://openalex.org/keywords/cutoff","display_name":"Cutoff","score":0.44749999046325684},{"id":"https://openalex.org/keywords/cohort","display_name":"Cohort","score":0.41600000858306885},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.40070000290870667},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.3666999936103821}],"concepts":[{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6136999726295471},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5497999787330627},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.47450000047683716},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4675000011920929},{"id":"https://openalex.org/C185429906","wikidata":"https://www.wikidata.org/wiki/Q1130160","display_name":"Estimator","level":2,"score":0.46480000019073486},{"id":"https://openalex.org/C163565370","wikidata":"https://www.wikidata.org/wiki/Q4308623","display_name":"Mutation testing","level":4,"score":0.4523000121116638},{"id":"https://openalex.org/C2778217198","wikidata":"https://www.wikidata.org/wiki/Q556977","display_name":"Cutoff","level":2,"score":0.44749999046325684},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.41600000858306885},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.40070000290870667},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.3666999936103821},{"id":"https://openalex.org/C26546657","wikidata":"https://www.wikidata.org/wiki/Q1412452","display_name":"Fractal dimension","level":3,"score":0.3580999970436096},{"id":"https://openalex.org/C139676723","wikidata":"https://www.wikidata.org/wiki/Q1193832","display_name":"Sign (mathematics)","level":2,"score":0.32330000400543213},{"id":"https://openalex.org/C3020132585","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic accuracy","level":2,"score":0.3027999997138977},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.30250000953674316},{"id":"https://openalex.org/C3020225094","wikidata":"https://www.wikidata.org/wiki/Q80091","display_name":"Area under curve","level":3,"score":0.2919999957084656},{"id":"https://openalex.org/C169903167","wikidata":"https://www.wikidata.org/wiki/Q3985153","display_name":"Test set","level":2,"score":0.28299999237060547},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.28290000557899475},{"id":"https://openalex.org/C40636538","wikidata":"https://www.wikidata.org/wiki/Q81392","display_name":"Fractal","level":2,"score":0.28220000863075256},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.28130000829696655},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.27900001406669617},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.27320000529289246},{"id":"https://openalex.org/C45804977","wikidata":"https://www.wikidata.org/wiki/Q7239673","display_name":"Predictive modelling","level":2,"score":0.26809999346733093},{"id":"https://openalex.org/C47432892","wikidata":"https://www.wikidata.org/wiki/Q831390","display_name":"Wavelet","level":2,"score":0.2554999887943268},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25200000405311584}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s12880-025-02140-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-025-02140-y","pdf_url":null,"source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},{"id":"pmid:41484861","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41484861","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical imaging","raw_type":null},{"id":"pmh:oai:doaj.org/article:9850ddb9beaf4076b91b1481258006b4","is_oa":true,"landing_page_url":"https://doaj.org/article/9850ddb9beaf4076b91b1481258006b4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Imaging, Vol 26, Iss 1, Pp 1-11 (2026)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:11673550","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12866136","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12880-025-02140-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-025-02140-y","pdf_url":null,"source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4179413797","display_name":null,"funder_award_id":"82102127","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8726259422","display_name":null,"funder_award_id":"82371936","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1965262908","https://openalex.org/W2206592217","https://openalex.org/W2324314515","https://openalex.org/W2610486821","https://openalex.org/W2686678464","https://openalex.org/W2739357331","https://openalex.org/W2741009225","https://openalex.org/W2768069205","https://openalex.org/W2804070274","https://openalex.org/W2965399740","https://openalex.org/W2967282134","https://openalex.org/W2986317110","https://openalex.org/W3022019539","https://openalex.org/W3045249197","https://openalex.org/W3082155378","https://openalex.org/W3141908830","https://openalex.org/W3174246647","https://openalex.org/W3212069556","https://openalex.org/W3215341866","https://openalex.org/W3217463677","https://openalex.org/W4213275873","https://openalex.org/W4213348398","https://openalex.org/W4280556240","https://openalex.org/W4281383900","https://openalex.org/W4283585902","https://openalex.org/W4289538642","https://openalex.org/W4293105427","https://openalex.org/W4311572904","https://openalex.org/W4362559443","https://openalex.org/W4384818276","https://openalex.org/W4387765494","https://openalex.org/W4388342857","https://openalex.org/W4388409309","https://openalex.org/W4390967665","https://openalex.org/W4391784849","https://openalex.org/W4396692984","https://openalex.org/W4398204564","https://openalex.org/W4401439179","https://openalex.org/W4401503494","https://openalex.org/W4403146147"],"related_works":[],"abstract_inverted_index":{"To":[0],"explore":[1],"the":[2,95,161,164,193,205],"relationship":[3],"between":[4],"relaxed":[5],"T2-FLAIR":[6],"mismatch":[7],"(RT2FM)":[8],"sign,":[9],"fractal":[10],"dimension":[11],"(FD)":[12],"of":[13,116,159,199],"tumor":[14,189],"contour":[15],"and":[16,20,54,66,74,78,98,114,119,124,127,167,175,188,202,209,215],"IDH":[17,24,108,141,145,171,224,238],"mutation":[18,25,109,172,239],"status,":[19],"construct":[21],"models":[22,91,179],"for":[23,48,60,169,222,237],"prediction":[26,240],"in":[27,121,129,140,144,204,241],"non-enhancing":[28,37,242],"gliomas.":[29,243],"This":[30],"retrospective":[31],"study":[32],"enrolled":[33],"364":[34],"patients":[35],"with":[36,110,197],"gliomas":[38],"from":[39],"two":[40],"independent":[41],"cohorts:":[42],"cohort":[43,55,122,130,134],"A":[44],"(n":[45,57],"=":[46,58],"267)":[47],"training":[49],"&":[50],"internal":[51,207],"validation":[52,208],"set":[53],"B":[56],"97)":[59],"external":[61,210],"testing":[62,211],"set.":[63],"RT2FM,":[64,186],"FD,":[65],"other":[67],"MRI":[68],"semantic":[69],"features":[70,97,184,232],"were":[71,82,92,137,173],"extracted.":[72],"Boruta":[73],"least":[75],"absolute":[76],"shrinkage":[77],"selection":[79],"operator":[80],"algorithms":[81],"employed":[83],"to":[84],"select":[85],"intersecting":[86,96,183],"features.":[87],"Four":[88],"machine":[89],"learning":[90],"constructed":[93,180,229],"using":[94,181],"their":[99],"diagnostic":[100,235],"performance":[101,236],"was":[102],"evaluated.":[103],"The":[104,226],"RT2FM":[105,214],"sign":[106],"predicted":[107],"an":[111,155],"accuracy,":[112],"sensitivity,":[113],"specificity":[115],"0.969,":[117],"0.650,":[118],"0.921":[120],"A,":[123,135],"0.924,":[125],"0.419,":[126],"0.762":[128],"B,":[131],"respectively.":[132,177,213],"In":[133],"FD":[136,156,216],"significantly":[138],"higher":[139],"wild-type":[142],"than":[143],"mutant":[146],"groups":[147],"(1.264":[148],"vs.":[149],"1.190;":[150],"P":[151],"<":[152],"0.001).":[153],"Using":[154],"cutoff":[157],"value":[158],"1.225,":[160],"area":[162],"under":[163],"curve":[165],"(AUC)":[166],"accuracy":[168],"predicting":[170,223],"0.884":[174],"0.839,":[176],"Among":[178],"four":[182],"(FD,":[185],"multifocal/multicentric,":[187],"location),":[190],"XGBoost":[191,227],"demonstrated":[192,233],"optimal":[194],"predictive":[195],"performance,":[196],"AUCs":[198],"0.974,":[200],"0.968":[201],"0.895":[203],"training,":[206],"set,":[212],"can":[217],"provide":[218],"informative":[219],"imaging":[220],"biomarkers":[221],"mutation.":[225],"model":[228],"by":[230],"these":[231],"favorable":[234],"Not":[244],"applicable.":[245]},"counts_by_year":[],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2026-01-03T00:00:00"}