{"id":"https://openalex.org/W4415382265","doi":"https://doi.org/10.1186/s12880-025-01946-0","title":"Predictive power of combined inflammatory markers and magnetic resonance imaging features for glioma grading using machine learning: a retrospective study","display_name":"Predictive power of combined inflammatory markers and magnetic resonance imaging features for glioma grading using machine learning: a retrospective study","publication_year":2025,"publication_date":"2025-10-21","ids":{"openalex":"https://openalex.org/W4415382265","doi":"https://doi.org/10.1186/s12880-025-01946-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/41120880"},"language":"en","primary_location":{"id":"doi:10.1186/s12880-025-01946-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-025-01946-0","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-025-01946-0","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-025-01946-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100674172","display_name":"Yaohua Liu","orcid":"https://orcid.org/0000-0002-5867-5065"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaohua Liu","raw_affiliation_strings":["Department of Pediatrics, Tongji Hospital, Tongji University School of Medicine, Xincun Road No. 389, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Tongji Hospital, Tongji University School of Medicine, Xincun Road No. 389, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210160344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100384208","display_name":"Yuting Wang","orcid":"https://orcid.org/0000-0002-7267-4026"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuting Wang","raw_affiliation_strings":["Department of Medical Imaging, Tongji Hospital, Tongji University School of Medicine, Xincun Road No. 389, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Imaging, Tongji Hospital, Tongji University School of Medicine, Xincun Road No. 389, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210160344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100566030","display_name":"Junle Zhu","orcid":null},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junle Zhu","raw_affiliation_strings":["Department of Neurosurgery, Tongji Hospital, Tongji University School of Medicine, Xincun Road No. 389, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Tongji Hospital, Tongji University School of Medicine, Xincun Road No. 389, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210160344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103062487","display_name":"Shuang Qin","orcid":"https://orcid.org/0000-0001-9264-6850"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuang Qin","raw_affiliation_strings":["Department of Medical Imaging, Tongji Hospital, Tongji University School of Medicine, Xincun Road No. 389, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Imaging, Tongji Hospital, Tongji University School of Medicine, Xincun Road No. 389, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210160344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086411156","display_name":"Hong Yi","orcid":"https://orcid.org/0000-0002-3337-1452"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Hong","raw_affiliation_strings":["Department of Medical Imaging, Tongji Hospital, Tongji University School of Medicine, Xincun Road No. 389, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Imaging, Tongji Hospital, Tongji University School of Medicine, Xincun Road No. 389, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210160344"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Saifei Sun","orcid":null},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Saifei Sun","raw_affiliation_strings":["Department of Medical Imaging, Tongji Hospital, Tongji University School of Medicine, Xincun Road No. 389, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Imaging, Tongji Hospital, Tongji University School of Medicine, Xincun Road No. 389, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210160344"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100418233","display_name":"Qin Zhang","orcid":"https://orcid.org/0000-0003-0187-0844"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qin Zhang","raw_affiliation_strings":["Department of Clinical Research Center, Tongji Hospital, Tongji University School of Medicine, Xincun Road No. 389, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Research Center, Tongji Hospital, Tongji University School of Medicine, Xincun Road No. 389, Shanghai, China","institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210160344"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5120313776","display_name":"Qi Lv","orcid":"https://orcid.org/0000-0002-4675-5447"},"institutions":[{"id":"https://openalex.org/I4210117527","display_name":"Shanghai Xuhui Central Hospital","ror":"https://ror.org/01whmzn59","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210117527"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qi Lv","raw_affiliation_strings":["Department of Medical Imaging, Fudan University Affiliated Xuhui Hospital (Shanghai Xuhui Central Hospital), 366 Longchuan North Road, Xuhui District, Shanghai, 200031, China. lye3210@vip.sina.com","Department of Medical Imaging, Fudan University Affiliated Xuhui Hospital (Shanghai Xuhui Central Hospital), 366 Longchuan North Road, Xuhui District, Shanghai, 200031, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Imaging, Fudan University Affiliated Xuhui Hospital (Shanghai Xuhui Central Hospital), 366 Longchuan North Road, Xuhui District, Shanghai, 200031, China. lye3210@vip.sina.com","institution_ids":["https://openalex.org/I4210117527"]},{"raw_affiliation_string":"Department of Medical Imaging, Fudan University Affiliated Xuhui Hospital (Shanghai Xuhui Central Hospital), 366 Longchuan North Road, Xuhui District, Shanghai, 200031, China","institution_ids":["https://openalex.org/I4210117527"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5120313776"],"corresponding_institution_ids":["https://openalex.org/I4210117527"],"apc_list":{"value":2890,"currency":"USD","value_usd":2890},"apc_paid":{"value":2890,"currency":"USD","value_usd":2890},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.34049943,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"1","first_page":"421","last_page":"421"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.9968000054359436,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioma","display_name":"Glioma","score":0.7114999890327454},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.7081999778747559},{"id":"https://openalex.org/keywords/grading","display_name":"Grading (engineering)","score":0.6607000231742859},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.6270999908447266},{"id":"https://openalex.org/keywords/test-set","display_name":"Test set","score":0.6176999807357788},{"id":"https://openalex.org/keywords/retrospective-cohort-study","display_name":"Retrospective cohort study","score":0.34880000352859497},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.32199999690055847},{"id":"https://openalex.org/keywords/effective-diffusion-coefficient","display_name":"Effective diffusion coefficient","score":0.3142000138759613}],"concepts":[{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.7114999890327454},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.7081999778747559},{"id":"https://openalex.org/C2777286243","wikidata":"https://www.wikidata.org/wiki/Q5591926","display_name":"Grading (engineering)","level":2,"score":0.6607000231742859},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.6270999908447266},{"id":"https://openalex.org/C169903167","wikidata":"https://www.wikidata.org/wiki/Q3985153","display_name":"Test set","level":2,"score":0.6176999807357788},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5992000102996826},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5442000031471252},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48330000042915344},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.44749999046325684},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.35120001435279846},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.34880000352859497},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.32199999690055847},{"id":"https://openalex.org/C70816921","wikidata":"https://www.wikidata.org/wiki/Q258852","display_name":"Effective diffusion coefficient","level":3,"score":0.3142000138759613},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.3043999969959259},{"id":"https://openalex.org/C51632099","wikidata":"https://www.wikidata.org/wiki/Q3985153","display_name":"Training set","level":2,"score":0.3009999990463257},{"id":"https://openalex.org/C3020225094","wikidata":"https://www.wikidata.org/wiki/Q80091","display_name":"Area under curve","level":3,"score":0.296999990940094},{"id":"https://openalex.org/C2778136018","wikidata":"https://www.wikidata.org/wiki/Q10350689","display_name":"Predictive power","level":2,"score":0.29089999198913574},{"id":"https://openalex.org/C52622490","wikidata":"https://www.wikidata.org/wiki/Q1026626","display_name":"Feature extraction","level":2,"score":0.2840999960899353},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.28369998931884766},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.28060001134872437},{"id":"https://openalex.org/C71472368","wikidata":"https://www.wikidata.org/wiki/Q676880","display_name":"Text mining","level":2,"score":0.26600000262260437},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.26170000433921814},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.2547000050544739},{"id":"https://openalex.org/C31601959","wikidata":"https://www.wikidata.org/wiki/Q931309","display_name":"Medical imaging","level":2,"score":0.2515000104904175}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000098412","descriptor_name":"Predictive Learning Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000098412","descriptor_name":"Predictive Learning Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005910","descriptor_name":"Glioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060787","descriptor_name":"Neoplasm Grading","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12880-025-01946-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-025-01946-0","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-025-01946-0","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},{"id":"pmid:41120880","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41120880","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC medical imaging","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:f3423041504e4c459b5241ccd9d9d0db","is_oa":true,"landing_page_url":"https://doaj.org/article/f3423041504e4c459b5241ccd9d9d0db","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Medical Imaging, Vol 25, Iss 1, Pp 1-13 (2025)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:11349876","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12542063","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1186/s12880-025-01946-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12880-025-01946-0","pdf_url":"https://bmcmedimaging.biomedcentral.com/counter/pdf/10.1186/s12880-025-01946-0","source":{"id":"https://openalex.org/S6505649","display_name":"BMC Medical Imaging","issn_l":"1471-2342","issn":["1471-2342"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Medical Imaging","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4415382265.pdf"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W1984775626","https://openalex.org/W2020788438","https://openalex.org/W2071045537","https://openalex.org/W2151538032","https://openalex.org/W2569219946","https://openalex.org/W2750704020","https://openalex.org/W2811334349","https://openalex.org/W2830175972","https://openalex.org/W3092339715","https://openalex.org/W3093564234","https://openalex.org/W3132899766","https://openalex.org/W3199392882","https://openalex.org/W3207137289","https://openalex.org/W4309720133","https://openalex.org/W4368360332","https://openalex.org/W4378905872","https://openalex.org/W4379599231","https://openalex.org/W4381252205","https://openalex.org/W4387170243","https://openalex.org/W4393120739","https://openalex.org/W4396735748","https://openalex.org/W4402135196","https://openalex.org/W4412726117"],"related_works":[],"abstract_inverted_index":{"BACKGROUND:":[0],"This":[1],"study":[2],"aimed":[3],"to":[4,18,51],"explore":[5],"the":[6,63,108],"potential":[7],"of":[8,29,128,134,146],"integrating":[9],"magnetic":[10],"resonance":[11],"imaging":[12],"(MRI)":[13],"features":[14,68,148],"with":[15],"inflammatory":[16,70,150],"markers":[17],"predict":[19],"glioma":[20,31,164],"grading":[21],"using":[22,102],"machine":[23,95,119,154],"learning":[24,96,155],"models.":[25],"METHODS:":[26],"A":[27],"total":[28],"179":[30],"patients":[32],"were":[33,87],"analyzed.":[34],"The":[35,116,144],"dataset":[36],"was":[37,59,100],"randomly":[38],"split":[39],"into":[40],"a":[41],"training":[42,64],"set":[43,49],"(75%)":[44],"and":[45,69,83,89,112,130,140,149,166],"an":[46,126,131],"independent":[47],"test":[48,52],"(25%)":[50],"hyperparameter.":[53],"To":[54],"enhance":[55],"reliability,":[56],"five-fold":[57],"cross-validation":[58],"also":[60],"applied":[61],"during":[62],"phase.":[65],"Key":[66],"MRI":[67,147],"markers,":[71,151],"including":[72],"relative":[73],"apparent":[74],"diffusion":[75],"coefficient":[76],"(rADC),":[77],"monocyte":[78],"count,":[79],"lymphocyte-to-CRP":[80],"ratio":[81],"(LCR)":[82],"hemoglobin-albumin-lymphocyte-platelet":[84],"index":[85],"(HALP),":[86],"extracted":[88],"used":[90],"as":[91,105],"inputs":[92],"for":[93,162],"multiple":[94],"classifiers.":[97],"Model":[98],"performance":[99],"assessed":[101],"metrics":[103],"such":[104],"area":[106],"under":[107],"curve":[109],"(AUC),":[110],"accuracy,":[111],"F1":[113,132],"score.":[114],"RESULTS:":[115],"support":[117],"vector":[118],"model":[120],"exhibited":[121],"superior":[122],"predictive":[123],"performance,":[124],"achieving":[125],"AUC":[127],"0.92":[129],"score":[133],"0.91,":[135],"effectively":[136],"distinguishing":[137],"between":[138],"high-grade":[139],"low-grade":[141],"gliomas.":[142],"CONCLUSIONS:":[143],"combination":[145],"analyzed":[152],"through":[153],"models":[156],"like":[157],"SVM,":[158],"provides":[159],"some":[160],"clues":[161],"refining":[163],"prognosis":[165],"guiding":[167],"personalized":[168],"treatment":[169],"strategies.":[170]},"counts_by_year":[],"updated_date":"2026-07-31T08:31:51.225901","created_date":"2025-10-22T00:00:00"}